List of works - George K. Lewis

A Highly Conserved Residue of the HIV-1 gp120 Inner Domain Is Important for Antibody-Dependent Cellular Cytotoxicity Responses Mediated by Anti-cluster A Antibodies

scientific article

Antibodies to CD4-induced sites in HIV gp120 correlate with the control of SHIV challenge in macaques vaccinated with subunit immunogens

scholarly article

Antibody Fab-Fc properties outperform titer in predictive models of SIV vaccine-induced protection

scientific article published on 02 May 2019

Antibody persistence and T-cell balance: two key factors confronting HIV vaccine development

scientific article

Antibody-dependent cellular cytotoxicity-mediating antibodies from an HIV-1 vaccine efficacy trial target multiple epitopes and preferentially use the VH1 gene family

scientific article

Antigenic properties of the HIV envelope on virions in solution

scientific article

Antigenic properties of the human immunodeficiency virus envelope glycoprotein gp120 on virions bound to target cells

scientific article (publication date: March 2015)

Antigenic properties of the human immunodeficiency virus transmembrane glycoprotein during cell-cell fusion

scientific article

Balance of cellular and humoral immunity determines the level of protection by HIV vaccines in rhesus macaque models of HIV infection

scientific article

Beyond Viral Neutralization

scientific article published on 13 January 2017

CCR5 density levels on primary CD4 T cells impact the replication and Enfuvirtide susceptibility of R5 HIV-1.

scientific article published on June 2007

Cell-targeting antibodies in immunity to Ebola

scientific article

Cocrystal Structures of Antibody N60-i3 and Antibody JR4 in Complex with gp120 Define More Cluster A Epitopes Involved in Effective Antibody-Dependent Effector Function against HIV-1

scientific article published on 17 June 2015

Conformational Masking and Receptor-Dependent Unmasking of Highly Conserved Env Epitopes Recognized by Non-Neutralizing Antibodies That Mediate Potent ADCC against HIV-1

scientific article

Conserved molecular signatures in gp120 are associated with the genetic bottleneck during simian immunodeficiency virus (SIV), SIV-human immunodeficiency virus (SHIV), and HIV type 1 (HIV-1) transmission

scientific article

Correlates of nontransmission in US women at high risk of human immunodeficiency virus type 1 infection through sexual exposure

scientific article published on 17 January 2002

Correlation between circulating HIV-1 RNA and broad HIV-1 neutralizing antibody activity.

scientific article

Deciphering Fc-mediated Antiviral Antibody Functions in Animal Models

scientific article published on 17 July 2019

Development of an oral prime-boost strategy to elicit broadly neutralizing antibodies against HIV-1.

scientific article

Development of vaccination strategies that elicit broadly neutralizing antibodies against human immunodeficiency virus type 1 in both the mucosal and systemic immune compartments

scientific article

Discordant memory B cell and circulating anti-Env antibody responses in HIV-1 infection

scientific article

Diverse specificity and effector function among human antibodies to HIV-1 envelope glycoprotein epitopes exposed by CD4 binding

scientific article

Epitope mapping of broadly neutralizing HIV-2 human monoclonal antibodies

scientific article published on 29 August 2012

Epitope target structures of Fc-mediated effector function during HIV-1 acquisition

scientific article

From Rhesus macaque to human: structural evolutionary pathways for immunoglobulin G subclasses

scientific article published on 02 April 2019

HIV-1 CD4-induced (CD4i) gp120 epitope vaccines promote B and T-cell responses that contribute to reduced viral loads in rhesus macaques

scientific article

HIV-1-suppressive factors are secreted by CD4+ T cells during primary immune responses

scientific article

Identification and Characterization of an Immunogenic Hybrid Epitope Formed by both HIV gp120 and Human CD4 Proteins.

scientific article published in May 2012

Identification and characterization of an immunogenic hybrid epitope formed by both HIV gp120 and human CD4 proteins

scientific article published on 12 October 2011

Immune-correlates analysis of an HIV-1 vaccine efficacy trial

scientific article (publication date: 5 April 2012)

Molecular basis for epitope recognition by non-neutralizing anti-gp41 antibody F240

scientific article

Paring Down HIV Env: Design and Crystal Structure of a Stabilized Inner Domain of HIV-1 gp120 Displaying a Major ADCC Target of the A32 Region

scientific article

Role of HIV-1 Envelope Glycoproteins Conformation and Accessory Proteins on ADCC Responses.

scientific article published on 26 August 2015

Self-protection of individual CD4+ T cells against R5 HIV-1 infection by the synthesis of anti-viral CCR5 ligands

scientific article

Signature biochemical properties of broadly cross-reactive HIV-1 neutralizing antibodies in human plasma.

scientific article

Structural Definition of an Antibody-Dependent Cellular Cytotoxicity Response Implicated in Reduced Risk for HIV-1 Infection

scientific article (publication date: November 2014)

Survivors Remorse: antibody-mediated protection against HIV-1.

scientific article

Targeting the Late Stage of HIV-1 Entry for Antibody-Dependent Cellular Cytotoxicity: Structural Basis for Env Epitopes in the C11 Region.

scientific article

λ Light Chain Bias Associated With Enhanced Binding and Function of Anti-HIV Env Glycoprotein Antibodies

scientific article

List of works by George K. Lewis

A Highly Conserved Residue of the HIV-1 gp120 Inner Domain Is Important for Antibody-Dependent Cellular Cytotoxicity Responses Mediated by Anti-cluster A Antibodies

Antibodies to CD4-induced sites in HIV gp120 correlate with the control of SHIV challenge in macaques vaccinated with subunit immunogens

Antibody Fab-Fc properties outperform titer in predictive models of SIV vaccine-induced protection

Antibody persistence and T-cell balance: two key factors confronting HIV vaccine development

Antibody-dependent cellular cytotoxicity-mediating antibodies from an HIV-1 vaccine efficacy trial target multiple epitopes and preferentially use the VH1 gene family

Antigenic properties of the HIV envelope on virions in solution

Antigenic properties of the human immunodeficiency virus envelope glycoprotein gp120 on virions bound to target cells

Antigenic properties of the human immunodeficiency virus transmembrane glycoprotein during cell-cell fusion

Balance of cellular and humoral immunity determines the level of protection by HIV vaccines in rhesus macaque models of HIV infection

Beyond Viral Neutralization

CCR5 density levels on primary CD4 T cells impact the replication and Enfuvirtide susceptibility of R5 HIV-1.

Cell-targeting antibodies in immunity to Ebola

Cocrystal Structures of Antibody N60-i3 and Antibody JR4 in Complex with gp120 Define More Cluster A Epitopes Involved in Effective Antibody-Dependent Effector Function against HIV-1

Conformational Masking and Receptor-Dependent Unmasking of Highly Conserved Env Epitopes Recognized by Non-Neutralizing Antibodies That Mediate Potent ADCC against HIV-1

Conserved molecular signatures in gp120 are associated with the genetic bottleneck during simian immunodeficiency virus (SIV), SIV-human immunodeficiency virus (SHIV), and HIV type 1 (HIV-1) transmission

Correlates of nontransmission in US women at high risk of human immunodeficiency virus type 1 infection through sexual exposure

Correlation between circulating HIV-1 RNA and broad HIV-1 neutralizing antibody activity.

Deciphering Fc-mediated Antiviral Antibody Functions in Animal Models

Development of an oral prime-boost strategy to elicit broadly neutralizing antibodies against HIV-1.

Development of vaccination strategies that elicit broadly neutralizing antibodies against human immunodeficiency virus type 1 in both the mucosal and systemic immune compartments

Discordant memory B cell and circulating anti-Env antibody responses in HIV-1 infection

Diverse specificity and effector function among human antibodies to HIV-1 envelope glycoprotein epitopes exposed by CD4 binding

Epitope mapping of broadly neutralizing HIV-2 human monoclonal antibodies

Epitope target structures of Fc-mediated effector function during HIV-1 acquisition

From Rhesus macaque to human: structural evolutionary pathways for immunoglobulin G subclasses

HIV-1 CD4-induced (CD4i) gp120 epitope vaccines promote B and T-cell responses that contribute to reduced viral loads in rhesus macaques

HIV-1-suppressive factors are secreted by CD4+ T cells during primary immune responses

Identification and Characterization of an Immunogenic Hybrid Epitope Formed by both HIV gp120 and Human CD4 Proteins.

Identification and characterization of an immunogenic hybrid epitope formed by both HIV gp120 and human CD4 proteins

Immune-correlates analysis of an HIV-1 vaccine efficacy trial

Molecular basis for epitope recognition by non-neutralizing anti-gp41 antibody F240

Paring Down HIV Env: Design and Crystal Structure of a Stabilized Inner Domain of HIV-1 gp120 Displaying a Major ADCC Target of the A32 Region

Role of HIV-1 Envelope Glycoproteins Conformation and Accessory Proteins on ADCC Responses.

Self-protection of individual CD4+ T cells against R5 HIV-1 infection by the synthesis of anti-viral CCR5 ligands

Signature biochemical properties of broadly cross-reactive HIV-1 neutralizing antibodies in human plasma.

Structural Definition of an Antibody-Dependent Cellular Cytotoxicity Response Implicated in Reduced Risk for HIV-1 Infection

Survivors Remorse: antibody-mediated protection against HIV-1.

Targeting the Late Stage of HIV-1 Entry for Antibody-Dependent Cellular Cytotoxicity: Structural Basis for Env Epitopes in the C11 Region.

λ Light Chain Bias Associated With Enhanced Binding and Function of Anti-HIV Env Glycoprotein Antibodies