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List of works by Roger Le Grand

Activation of the DNA Damage Response by RNA Viruses

scientific article

Adipose Tissue Is a Neglected Viral Reservoir and an Inflammatory Site during Chronic HIV and SIV Infection

scientific article

Animal models for COVID-19

scientific article published on 23 September 2020

Antiinflammatory profiles during primary SIV infection in African green monkeys are associated with protection against AIDS.

scientific article

Antiviral efficacy of favipiravir against Zika and SARS-CoV-2 viruses in non-human primates

scientific article published in 2022

Attenuated and vectored vaccines protect nonhuman primates against Chikungunya virus

scientific article published on 23 March 2017

C-type lectin-like receptor LOX-1 promotes dendritic cell-mediated class-switched B cell responses

scientific article

COVA1-18 neutralizing antibody protects against SARS-CoV-2 in three preclinical models

scientific article published in 2021

Cell-associated HIV mucosal transmission: the neglected pathway

scientific article

Chikungunya disease in nonhuman primates involves long-term viral persistence in macrophages

scientific article

Chikungunya disease: infection-associated markers from the acute to the chronic phase of arbovirus-induced arthralgia

scientific article

DC-SIGN from African green monkeys is expressed in lymph nodes and mediates infection in trans of simian immunodeficiency virus SIVagm

scientific article published on January 2004

Delivering HIV Gagp24 to DCIR Induces Strong Antibody Responses In Vivo

scientific article

Discovery of naturally occurring transmissible chronic hepatitis B virus infection among Macaca fascicularis from Mauritius Island.

scientific article

Early neutralizing IgG response to Chikungunya virus in infected patients targets a dominant linear epitope on the E2 glycoprotein

scientific article

Effect of a short-term HAART on SIV load in macaque tissues is dependent on time of initiation and antiviral diffusion

scientific article

Effectiveness of CHIKV vaccine VLA1553 demonstrated by passive transfer of human sera

scientific article published on 14 June 2022

Electroporation as a vaccine delivery system and a natural adjuvant to intradermal administration of plasmid DNA in macaques

scientific article

Emerging preclinical evidence does not support broad use of hydroxychloroquine in COVID-19 patients

scientific article published on 26 August 2020

Expression of chemokines and their receptors in human and simian astrocytes: evidence for a central role of TNF alpha and IFN gamma in CXCR4 and CCR5 modulation

scientific article (publication date: March 2003)

FOXO1 transcription factor plays a key role in T cell-HIV-1 interaction.

scientific article published in May 2019

First Dominique Dormont International Conference on "Host-pathogen interactions in chronic infections - viral and host determinants of HCV, HCMV, and HIV infections"

scientific article

Hydroxychloroquine use against SARS-CoV-2 infection in non-human primates

scientific article published on 22 July 2020

Impact of short-term HAART initiated during the chronic stage or shortly post-exposure on SIV infection of male genital organs

scientific article

In vivo imaging in NHP models of malaria: challenges, progress and outlooks

scientific article

Infection of semen-producing organs by SIV during the acute and chronic stages of the disease

scientific article

Innate Molecular and Cellular Signature in the Skin Preceding Long-Lasting T Cell Responses after Electroporated DNA Vaccination

scientific article published on 08 May 2020

Innate immune responses and rapid control of inflammation in African green monkeys treated or not with interferon-alpha during primary SIVagm infection

scientific article (publication date: July 2014)

Long-term control of simian immunodeficiency virus (SIV) in cynomolgus macaques not associated with efficient SIV-specific CD8+ T-cell responses

scientific article

Low autocrine interferon beta production as a gene therapy approach for AIDS: Infusion of interferon beta-engineered lymphocytes in macaques chronically infected with SIVmac251

scientific article

Macrophage- and neutrophil-derived TNF-α instructs skin langerhans cells to prime antiviral immune responses

scientific article

MiniCD4 microbicide prevents HIV infection of human mucosal explants and vaginal transmission of SHIV(162P3) in cynomolgus macaques

scientific article (publication date: 2012)

Modulation of DNA damage and repair pathways by human tumour viruses

scientific article

Neutralizing Antibody-Based Prevention of Cell-Associated HIV-1 Infection

article

Novel attenuated Chikungunya vaccine candidates elicit protective immunity in C57BL/6 mice

scientific article

On chikungunya acute infection and chloroquine treatment

scientific article

Optimization of HIV-1 Envelope DNA Vaccine Candidates within Three Different Animal Models, Guinea Pigs, Rabbits and Cynomolgus Macaques

scientific article published on 19 July 2013

Paradoxical Effect of Chloroquine Treatment in Enhancing Chikungunya Virus Infection

scientific article

Plasmacytoid dendritic cell dynamics tune interferon-alfa production in SIV-infected cynomolgus macaques

scientific article

Prime-boost immunization strategies against Chikungunya virus

scientific article

Proceedings of the Frontiers of Retrovirology Conference 2016.

scientific article published on 26 September 2016

RNA-Seq analysis of chikungunya virus infection and identification of granzyme A as a major promoter of arthritic inflammation

scientific article (publication date: 16 February 2017)

Regulated Expression of Sodium‐dependent Glutamate Transporters and Synthetase: a Neuroprotective Role for Activated Microglia and Macrophages in HIV Infection? ⬇️

scientific article published on April 1, 2003

SIV-induced terminally differentiated adaptive NK cells in lymph nodes associated with enhanced MHC-E restricted activity

scientific article published on 24 February 2021

Semen CD4+ T cells and macrophages are productively infected at all stages of SIV infection in macaques

scientific article

Systemic DPP4 activity is reduced during primary HIV-1 infection and is associated with intestinal RORC+ CD4+ cell levels: a surrogate marker candidate of HIV-induced intestinal damage.

scientific article published in July 2018

Targeting self- and foreign antigens to dendritic cells via DC-ASGPR generates IL-10-producing suppressive CD4+ T cells

scientific article published on 2 January 2012

The APC/C and CBP/p300 cooperate to regulate transcription and cell-cycle progression

scientific article

Thermosensitive and mucoadhesive pluronic-hydroxypropylmethylcellulose hydrogel containing the mini-CD4 M48U1 is a promising efficient barrier against HIV diffusion through macaque cervicovaginal mucus

scientific article

Tissue-specific B-cell dysfunction and generalized memory B-cell loss during acute SIV infection

scientific article

Towards an in vitro model of Plasmodium hypnozoites suitable for drug discovery

scientific article

Unique epitopes recognized by antibodies induced in Chikungunya virus-infected non-human primates: implications for the study of immunopathology and vaccine development

scientific article

Vaccine-Induced Linear Epitope-Specific Antibodies to Simian Immunodeficiency Virus SIVmac239 Envelope Are Distinct from Those Induced to the Human Immunodeficiency Virus Type 1 Envelope in Nonhuman Primates

scientific article published on 27 May 2015

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