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List of works by Brigitte Schlegelberger

A critical appraisal of tools available for monitoring epigenetic changes in clinical samples from patients with myeloid malignancies

scientific article

A novel murine model of myeloproliferative disorders generated by overexpression of the transcription factor NF-E2.

scientific article published on 9 January 2012

A physical map of the human genome

scientific article

A tumor-derived population (SCCOHT-1) as cellular model for a small cell ovarian carcinoma of the hypercalcemic type

scientific article published on 8 May 2012

Acute lymphoblastic leukemia and lymphoma in the context of constitutional mismatch repair deficiency syndrome

scientific article

All-trans retinoic acid as adjunct to intensive treatment in younger adult patients with acute myeloid leukemia: results of the randomized AMLSG 07-04 study

scientific article

Altered NFE2 activity predisposes to leukemic transformation and myelosarcoma with AML-specific aberrations

scientific article published on 12 February 2019

Analysis of array-CGH data using the R and Bioconductor software suite

scientific article

BCR-ABL gene amplification and overexpression in a patient with chronic myeloid leukemia treated with imatinib

scientific article published in June 2005

Breast cancer susceptibility: current knowledge and implications for genetic counselling

scientific article

CRISPR-Cas9-induced t(11;19)/MLL-ENL translocations initiate leukemia in human hematopoietic progenitor cells in vivo

scientific article published on June 2017

Cd14, Gbp1, and Pla2g2a: three major candidate genes for experimental IBD identified by combining QTL and microarray analyses

scientific article published on May 2006

Characterization of genomic breakpoints in MLL and CBP in leukemia patients with t(11;16).

scientific article

Clinical impact of DNMT3A mutations in younger adult patients with acute myeloid leukemia: results of the AML Study Group (AMLSG) ⬇️

scientific article published on April 30, 2013

Clinical utility gene card for: Lynch syndrome (MLH1, MSH2, MSH6, PMS2)

scientific article

Clinical utility gene card for: Lynch syndrome (MLH1, MSH2, MSH6, PMS2, EPCAM) - update 2012.

scientific article

Clonal Evolution and Blast Crisis Correlate with Enhanced Proteolytic Activity of Separase in BCR-ABL b3a2 Fusion Type CML under Imatinib Therapy

scientific article published on 18 June 2015

Clonal heterogeneity in the 5q- syndrome: p53 expressing progenitors prevail during lenalidomide treatment and expand at disease progression

scientific article published on October 2009

Comparison of different methods for telomere length measurement in whole blood and blood cell subsets: Recommendations for telomere length measurement in hematological diseases

scientific article published on 08 June 2017

Comprehensive MALDI-TOF biotyping of the non-redundant Harvard Pseudomonas aeruginosa PA14 transposon insertion mutant library

scientific article published on 9 February 2015

Comprehensive genetic and functional characterization of IPH-926: a novel CDH1-null tumour cell line from human lobular breast cancer

scientific article published on April 2009

Concise review: managing genotoxicity in the therapeutic modification of stem cells ⬇️

scientific article published on October 1, 2011

Constitutional mismatch repair deficiency and childhood leukemia/lymphoma--report on a novel biallelic MSH6 mutation

scientific article

Constitutional trisomy 8p11.21-q11.21 mosaicism: a germline alteration predisposing to myeloid leukaemia

scientific article published on 18 August 2011

CpG motifs of bacterial DNA essentially contribute to the perpetuation of chronic intestinal inflammation

scientific article

Cytogenetic and molecular study of the PRDX4 gene in a t(X;18)(p22;q23): a cautionary tale

scientific article

Cytogenetic characterization of a BCR-ABL transduced mouse cell line

scientific article

Cytogenetic follow-up by karyotyping and fluorescence in situ hybridization: implications for monitoring patients with myelodysplastic syndrome and deletion 5q treated with lenalidomide ⬇️

scientific article published on November 25, 2010

Diagnostic accuracy of methods for the detection of BRCA1 and BRCA2 mutations: a systematic review

scientific article published on 7 March 2007

Disease evolution and outcomes in familial AML with germline CEBPA mutations

scientific article published on 10 July 2015

Establishment and Characterization of a Pair of Patient-derived Human Non-small Cell Lung Cancer Cell Lines from a Primary Tumor and Corresponding Lymph Node Metastasis

scientific article published on April 2016

Establishment of immortalized multipotent hematopoietic progenitor cell lines by retroviral-mediated gene transfer of beta-catenin

scientific article published on February 2008

Exonuclease-1 deletion impairs DNA damage signaling and prolongs lifespan of telomere-dysfunctional mice

scientific article

Expression of the ETS transcription factor GABPα is positively correlated to the BCR-ABL1/ABL1 ratio in CML patients and affects imatinib sensitivity in vitro

scientific article

FLT3-internal tandem duplication and age are the major prognostic factors in patients with relapsed acute myeloid leukemia with normal karyotype ⬇️

scientific article published on January 17, 2011

Frequency and prognostic impact of mutations in SRSF2, U2AF1, and ZRSR2 in patients with myelodysplastic syndromes

scientific article published on 2 March 2012

From a variant of unknown significance to pathogenic: Reclassification of a large novel duplication in BRCA2 by high-throughput sequencing

scientific article published on 13 November 2019

GT198 (PSMC3IP) germline variants in early-onset breast cancer patients from hereditary breast and ovarian cancer families

scientific article published on January 2017

Gene therapy for Wiskott-Aldrich syndrome--long-term efficacy and genotoxicity

scientific article

Genetic instability of modified stem cells - a first step towards malignant transformation? ⬇️

scientific article published on 08 March 2013

Genetic testing for familial/hereditary breast cancer-comparison of guidelines and recommendations from the UK, France, the Netherlands and Germany

scientific article

Genomic instability and myelodysplasia with monosomy 7 consequent to EVI1 activation after gene therapy for chronic granulomatous disease

scientific article

HDAC inhibition activates the apoptosome via Apaf1 upregulation in hepatocellular carcinoma

scientific article published on 24 June 2016

Haploinsufficiency of ETV6 and CDKN1B in patients with acute myeloid leukemia and complex karyotype

scientific article

Hematopoietic stem cell transplantation in children and young adults with secondary myelodysplastic syndrome and acute myelogenous leukemia after aplastic anemia

scientific article

High-affinity neurotrophin receptors and ligands promote leukemogenesis

scientific article published on 04 December 2008

Histone Deacetylases Activate Hepatocyte Growth Factor Signaling by Repressing MicroRNA-449 in Hepatocellular Carcinoma Cells ⬇️

scientific article published on May 26, 2012

IDH1 mutations in patients with myelodysplastic syndromes are associated with an unfavorable prognosis.

scientific article

Identification of candidate tumor-suppressor genes in 6q27 by combined deletion mapping and electronic expression profiling in lymphoid neoplasms

scientific article published on August 2003

Impact of IDH1 R132 mutations and an IDH1 single nucleotide polymorphism in cytogenetically normal acute myeloid leukemia: SNP rs11554137 is an adverse prognostic factor

scientific article

Impact of unbalanced minor route versus major route karyotypes at diagnosis on prognosis of CML.

scientific article published on 18 September 2015

In memoriam: Prof. Dr. rer. nat. Dr. med. h.c. Lore Zech; 24.9.1923 – 13.3.2013: Honorary member of the European Society of Human Genetics, Honorary member of the German Society of Human Genetics, Doctor laureate, the University of Kiel, Germany ⬇️

scientific article published on May 21, 2013

Incidence and Prognostic Influence of DNMT3A Mutations in Acute Myeloid Leukemia ⬇️

scientific article published on June 13, 2011

Individual outcome prediction for myelodysplastic syndrome (MDS) and secondary acute myeloid leukemia from MDS after allogeneic hematopoietic cell transplantation

scientific article published on 13 June 2017

Induction of Chromosomal Instability via Telomere Dysfunction and Epigenetic Alterations in Myeloid Neoplasia

scientific article published on 04 July 2013

Induction of aneuploidy by increasing chromosomal instability during dedifferentiation of hepatocellular carcinoma

scholarly article

Lenalidomide in the context of complex karyotype or interrupted treatment: case reviews of del(5q)MDS patients with unexpected responses

scientific article

Lentiviral Vector Induced Insertional Haploinsufficiency of Ebf1 Causes Murine Leukemia ⬇️

scientific article published on April 3, 2012

Loss of Dnd1 facilitates the cultivation of genital ridge-derived rat embryonic germ cells ⬇️

scientific article published on May 3, 2011

Loss of p53 accelerates the complications of myelodysplastic syndrome in a NUP98-HOXD13–driven mouse model ⬇️

scientific article published on August 27, 2012

MDR-1-overexpression in HT 29 colon cancer cells grown in SCID mice

scientific article

MN1 overexpression induces acute myeloid leukemia in mice and predicts ATRA resistance in patients with AML.

scientific article

Mass spectrometry for the detection of differentially expressed proteins: a comparison of surface-enhanced laser desorption/ionization and capillary electrophoresis/mass spectrometry

scientific article

MicroRNA miR-335 is crucial for the BRCA1 regulatory cascade in breast cancer development

scientific article published on 25 May 2011

MicroRNA miR-548d is a superior regulator in pancreatic cancer

scientific article published on March 2012

Mitotic recombination and compound-heterozygous mutations are predominant NF1-inactivating mechanisms in children with juvenile myelomonocytic leukemia and neurofibromatosis type 1.

scientific article

Monitoring CSF proteome alterations in amyotrophic lateral sclerosis: obstacles and perspectives in translating a novel marker panel to the clinic

scientific article

Monitoring of minimal residual disease in NPM1-mutated acute myeloid leukemia: a study from the German-Austrian acute myeloid leukemia study group

scientific article

Mutations and treatment outcome in cytogenetically normal acute myeloid leukemia

scientific article

Mutations in the let-7 binding site - a mechanism of RAS activation in juvenile myelomonocytic leukemia?

scientific article

Myelodysplastic Syndromes Are Propagated by Rare and Distinct Human Cancer Stem Cells In Vivo

Myelodysplastic Syndromes Are Propagated by Rare and Distinct Human Cancer Stem Cells In Vivo

Myelodysplastic syndromes are propagated by rare and distinct human cancer stem cells in vivo

scientific article published on 15 May 2014

On metabolic reprogramming and tumor biology: A comprehensive survey of metabolism in breast cancer

scientific article

Outcomes in RBC transfusion-dependent patients with Low-/Intermediate-1-risk myelodysplastic syndromes with isolated deletion 5q treated with lenalidomide: a subset analysis from the MDS-004 study

scientific article

Parthenogenetic stem cells for tissue-engineered heart repair

scientific article

Persistent malignant stem cells in del(5q) myelodysplasia in remission

scientific article

Polymorphisms of methylenetetrahydrofolate reductase (MTHFR) and susceptibility to pediatric acute lymphoblastic leukemia in a German study population

scientific article

Preferential loss of porcine chromosomes in reprogrammed interspecies cell hybrids

scientific article

Prevalence, clinical characteristics, and prognosis of GATA2-related myelodysplastic syndromes in children and adolescents

scientific article published on 23 December 2015

Prognostic factors in adult patients up to 60 years old with acute myeloid leukemia and translocations of chromosome band 11q23: individual patient data-based meta-analysis of the German Acute Myeloid Leukemia Intergroup

scientific article

Prognostic impact of IDH2 mutations in cytogenetically normal acute myeloid leukemia

scientific article

Prognostic impact of WT1 mutations in cytogenetically normal acute myeloid leukemia: a study of the German-Austrian AML Study Group

scientific article

Prognostic significance of ASXL1 mutations in patients with myelodysplastic syndromes

scientific article

Prognostic significance of expression levels of stem cell regulators MSI2 and NUMB in acute myeloid leukemia

scientific article published on 12 December 2012

Promoter methylation of PARG1, a novel candidate tumor suppressor gene in mantle-cell lymphomas

scientific article published on April 2007

Proteomic bronchiolitis obliterans syndrome risk monitoring in lung transplant recipients

scientific article

RUNX1 Mutations in Acute Myeloid Leukemia: Results From a Comprehensive Genetic and Clinical Analysis From the AML Study Group ⬇️

scientific article published on February 22, 2011

RUNX1 deficiency (familial platelet disorder with predisposition to myeloid leukemia, FPDMM).

scientific article

Radiation Rescue: Mesenchymal Stromal Cells Protect from Lethal Irradiation ⬇️

scientific article published on January 5, 2011

Recurrent trisomy and Robertsonian translocation of chromosome 14 in murine iPS cell lines

scientific article

SNP array analysis of acute promyelocytic leukemia may be of prognostic relevance and identifies a potential high risk group with recurrent deletions on chromosomal subband 1q31.3.

scientific article

Serum- and stromal cell-free hypoxic generation of embryonic stem cell-derived hematopoietic cells in vitro, capable of multilineage repopulation of immunocompetent mice

scientific article published on 6 August 2012

Significant inverse correlation of microRNA-150/MYB and microRNA-222/p27 in myelodysplastic syndrome

scientific article

Single nucleotide polymorphism in the mutational hotspot of WT1 predicts a favorable outcome in patients with cytogenetically normal acute myeloid leukemia

scientific article published on 28 December 2009

Subclonal analysis in a lobular breast cancer with classical and solid growth pattern mimicking a solid-papillary carcinoma

scientific article published on 19 July 2017

TET2 mutations in cytogenetically normal acute myeloid leukemia: clinical implications and evolutionary patterns

scientific article published on 05 June 2014

The CpG island methylator phenotype in breast cancer is associated with the lobular subtype

scientific article published on 27 October 2014

The differentiation/retrodifferentiation program of human U937 leukemia cells is accompanied by changes of VCP/p97

scientific article

The heteromeric transcription factor GABP activates the ITGAM/CD11b promoter and induces myeloid differentiation

scientific article published on 10 July 2015

The hypomorphic TERT A1062T variant is associated with increased treatment-related toxicity in acute myeloid leukemia

scientific article published on 22 March 2017

The identification of pathogenic variants in BRCA1/2 negative, high risk, hereditary breast and/or ovarian cancer patients: High frequency of FANCM pathogenic variants

scientific article published on 11 January 2019

The stem cell zinc finger 1 (SZF1)/ZNF589 protein has a human-specific evolutionary nucleotide DNA change and acts as a regulator of cell viability in the hematopoietic system

scientific article published on 28 December 2015

The t(8;9)(p22;p24) is a recurrent abnormality in chronic and acute leukemia that fuses PCM1 to JAK2

scientific article (publication date: April 2005)

Tumor cells escape suicide gene therapy by genetic and epigenetic instability

scientific article published on 12 August 2004

Update on cytogenetic and molecular changes in myelodysplastic syndromes ⬇️

scientific article published on November 15, 2011

Women's experiences of undergoing BRCA1 and BRCA2 testing: organisation of the German Hereditary Breast and Ovarian Cancer Consortium Survey and Preliminary Data from Münster

scientific article published in January 2003

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