List of works - Tarik Möröy

A novel regulatory circuit between p53 and GFI1 controls induction of apoptosis in T cells

scientific article published on 19 April 2019

A variant allele of Growth Factor Independence 1 (GFI1) is associated with acute myeloid leukemia

scientific article

Alternative splicing controlled by heterogeneous nuclear ribonucleoprotein L regulates development, proliferation, and migration of thymic pre-T cells

scientific journal article

Auxiliary splice factor U2AF26 and transcription factor Gfi1 cooperate directly in regulating CD45 alternative splicing

scientific journal article

CD8 lineage-specific regulation of interleukin-7 receptor expression by the transcriptional repressor Gfi1.

scientific article

Crosstalk Between MYC and lncRNAs in Hematological Malignancies

scientific article published on 08 October 2020

Cyclin E.

scientific article published on August 2004

DNA Microarrays in Medicine: Can the Promises Be Kept?

scientific article

Deletion of the Miz-1 POZ Domain Increases Efficacy of Cytarabine Treatment in T- and B-ALL/Lymphoma Mouse Models

scientific article published on 04 July 2019

Differential impact of the transcriptional repressor Gfi1 on mature CD4+ and CD8+ T lymphocyte function

scientific article

Differential isoform expression and interaction with the P32 regulatory protein controls the subcellular localization of the splicing factor U2AF26

scientific journal article

Direct transcriptional repression of the genes encoding the zinc-finger proteins Gfi1b and Gfi1 by Gfi1b

scientific article

Dominant negative Gfi1b mutations cause moderate thrombocytopenia and an impaired stress thrombopoiesis associated with mild erythropoietic abnormalities in mice

scientific article published on 21 November 2019

Epigenetic therapy as a novel approach for GFI136N-associated murine/human AML.

scientific article published on 20 May 2016

Evidence that growth factor independence 1b regulates dormancy and peripheral blood mobilization of hematopoietic stem cells.

scientific article published on 8 September 2010

Expression of ribosomal and translation-associated genes is correlated with a favorable clinical course in chronic lymphocytic leukemia.

scientific article published on 27 November 2002

From cytopenia to leukemia: the role of Gfi1 and Gfi1b in blood formation

scientific article

GFI1 and GFI1B control the loss of endothelial identity of hemogenic endothelium during hematopoietic commitment

scientific article

GFI1 facilitates efficient DNA repair by regulating PRMT1 dependent methylation of MRE11 and 53BP1.

scientific article published on 12 April 2018

GFI1 is required for RUNX1/ETO positive acute myeloid leukemia.

scientific article published on 19 April 2018

GFI1 proteins orchestrate the emergence of haematopoietic stem cells through recruitment of LSD1.

scientific article

GFI1 tethers the NuRD complex to open and transcriptionally active chromatin in myeloid progenitors

scientific article published on 02 December 2021

GFI1's role in DNA repair suggests implications for tumour cell response to treatment

scientific article published on 24 July 2018

GFI1(36N) as a therapeutic and prognostic marker for myelodysplastic syndrome

scientific article published on 11 April 2016

Gene expression of the POU factor Brn-3a is regulated by two different promoters

scientific article (publication date: 12 December 2002)

Generation and characterization of human iPSC line MML-6838-Cl2 from mobilized peripheral blood derived megakaryoblasts.

scientific article published on 10 December 2016

Gfi1 and Gfi1b act equivalently in haematopoiesis, but have distinct, non-overlapping functions in inner ear development

scientific article

Gfi1 negatively regulates T(h)17 differentiation by inhibiting RORgammat activity

scientific article

Gfi1:green fluorescent protein knock-in mutant reveals differential expression and autoregulation of the growth factor independence 1 (Gfi1) gene during lymphocyte development

scientific article published on 13 July 2004

Gfi1b alters histone methylation at target gene promoters and sites of gamma-satellite containing heterochromatin

scientific journal article

Gfi1b controls integrin signaling-dependent cytoskeleton dynamics and organization in megakaryocytes

scientific article

Gfi1b negatively regulates Rag expression directly and via the repression of FoxO1

scientific article

Gfi1b regulates the level of Wnt/β-catenin signaling in hematopoietic stem cells and megakaryocytes

scientific article published on 20 March 2019

Gfi1b:green fluorescent protein knock-in mice reveal a dynamic expression pattern of Gfi1b during hematopoiesis that is largely complementary to Gfi1.

scientific article published on 9 November 2006

Growth factor independence 1 (Gfi1) as a regulator of lymphocyte development and activation

scientific article published on 14 September 2011

Growth factor independence 1 (Gfi1) as a regulator of p53 activity and a new therapeutical target for ALL.

scientific article

Growth factor independence 1 (Gfi1) regulates cell-fate decision of a bipotential granulocytic-monocytic precursor defined by expression of Gfi1 and CD48.

scientific article

Growth factor independence 1 antagonizes a p53-induced DNA damage response pathway in lymphoblastic leukemia.

scientific article

Growth factor independence 1 protects hematopoietic stem cells against apoptosis but also prevents the development of a myeloproliferative-like disease.

scientific article

Growth factor independence 1b (gfi1b) is important for the maturation of erythroid cells and the regulation of embryonic globin expression

scientific article

Growth factor independent 1b (Gfi1b) and a new splice variant of Gfi1b are highly expressed in patients with acute and chronic leukemia.

scientific article

Growth factor independent-1 maintains Notch1-dependent transcriptional programming of lymphoid precursors.

scientific article

Heterogeneous Nuclear Ribonucleoprotein L is required for the survival and functional integrity of murine hematopoietic stem cells

scientific article

High levels of the onco-protein Gfi-1 accelerate T-cell proliferation and inhibit activation induced T-cell death in Jurkat T-cells

scientific article published in February 2002

IL-7R-dependent survival and differentiation of early T-lineage progenitors is regulated by the BTB/POZ domain transcription factor Miz-1

scientific article published on 21 January 2011

Identification of Tcf-4 as a transcriptional target of p53 signalling

scientific article published on April 2004

Identification of a novel Krüppel-associated box domain protein, Krim-1, that interacts with c-Myc and inhibits its oncogenic activity

scientific article published on 13 May 2003

Identification of potent Ras signaling inhibitors by pathway-selective phenotype-based screening

scientific article published on January 2004

Inflammatory reactions and severe neutropenia in mice lacking the transcriptional repressor Gfi1

scientific article published on 28 January 2002

Loss of p27(Kip1) cooperates with cyclin E in T-cell lymphomagenesis

scientific article published on 01 March 2003

Miz-1 is required to coordinate the expression of TCRbeta and p53 effector genes at the pre-TCR "beta-selection" checkpoint

scientific article published on 12 August 2011

Miz-1 regulates translation of Trp53 via ribosomal protein L22 in cells undergoing V(D)J recombination

scientific article

Miz1 is required for early embryonic development during gastrulation

scientific journal article

Miz1 is required for hair follicle structure and hair morphogenesis

scientific article

Multifaceted Actions of GFI1 and GFI1B in Hematopoietic Stem Cell Self-Renewal and Lineage Commitment

scientific article published on 26 October 2020

Neural differentiation modulates the vertebrate brain specific splicing program

scientific article published on 19 May 2015

New indene-derivatives with anti-proliferative properties

scientific article published in February 2002

Novel target genes of the Wnt pathway and statistical insights into Wnt target promoter regulation

scientific article

Nuclear interaction of the dynein light chain LC8a with the TRPS1 transcription factor suppresses the transcriptional repression activity of TRPS1

scientific article published on 01 June 2003

Origin of the brush cell lineage in the mouse intestinal epithelium.

scientific article published on 13 December 2011

Prox1 interacts with Atoh1 and Gfi1, and regulates cellular differentiation in the inner ear sensory epithelia

scientific article

Reduced expression but not deficiency of GFI1 causes a fatal myeloproliferative disease in mice

scientific article published on 20 June 2018

Regulation of pulmonary Pseudomonas aeruginosa infection by the transcriptional repressor Gfi1

scientific article published on 01 July 2006

Rhythmic U2af26 alternative splicing controls PERIOD1 stability and the circadian clock in mice

scientific article published on 15 May 2014

Role of GFI1 in Epigenetic Regulation of MDS and AML Pathogenesis: Mechanisms and Therapeutic Implications

scientific article published on 27 August 2019

Runx3 regulates integrin alpha E/CD103 and CD4 expression during development of CD4-/CD8+ T cells

scientific article published on August 2005

SMAF-1 inhibits the APC/beta-catenin pathway and shows properties similar to those of the tumor suppressor protein APC.

scientific article published on September 2004

Systemic lupus-erythematosus: deoxyribonuclease 1 in necrotic chromatin disposal.

scientific article published on 28 November 2005

The RING finger protein RNF4, a co-regulator of transcription, interacts with the TRPS1 transcription factor

scientific article

The human GFI136N variant induces epigenetic changes at the Hoxa9 locus and accelerates K-RAS driven myeloproliferative disorder in mice.

scientific article published on 28 August 2012

The impact of alternative splicing in vivo: mouse models show the way.

scientific article published on 11 June 2007

The interaction between Myc and Miz1 is required to antagonize TGFbeta-dependent autocrine signaling during lymphoma formation and maintenance

scientific article

The new sulindac derivative IND 12 reverses Ras-induced cell transformation

scientific article published on March 2002

The oncogenic activity of cyclin E is not confined to Cdk2 activation alone but relies on several other, distinct functions of the protein

scientific article published on 30 July 2002

The oncogenic serine/threonine kinase Pim-1 directly phosphorylates and activates the G2/M specific phosphatase Cdc25C.

scientific article published on 8 November 2005

The oncogenic serine/threonine kinase Pim-1 phosphorylates and inhibits the activity of Cdc25C-associated kinase 1 (C-TAK1): a novel role for Pim-1 at the G2/M cell cycle checkpoint

scientific article

The p150 subunit of the histone chaperone Caf-1 interacts with the transcriptional repressor Gfi1

scientific article

The role of the transcription factor Miz-1 in lymphocyte development and lymphomagenesis-Binding Myc makes the difference

scientific article published on 13 October 2011

The role of the transcriptional repressor growth factor independent 1 in the formation of myeloid cells

scientific article published on 4 November 2016

The serine/threonine kinase Pim-1

scientific article

The transcription factor Miz-1 is required for embryonic and stress-induced erythropoiesis but dispensable for adult erythropoiesis

scientific article published on 5 September 2014

The transcriptional repressor Gfi1 affects development of early, uncommitted c-Kit+ T cell progenitors and CD4/CD8 lineage decision in the thymus

scientific article

The transcriptional repressor Gfi1 controls STAT3-dependent dendritic cell development and function.

scientific article published in June 2005

The zinc finger protein Gfi1 acts upstream of TNF to attenuate endotoxin-mediated inflammatory responses in the lung

scientific article published on 01 February 2006

The zinc finger protein Gfi1 is implicated in the regulation of IgG2b production and the expression of Igamma2b germline transcripts

scientific article published on 01 November 2008

The zinc finger protein and transcriptional repressor Gfi1 as a regulator of the innate immune response

scientific article published on 03 January 2008

The zinc finger transcription factor Growth factor independence 1 (Gfi1).

scientific article

Threshold Levels of Gfi1 Maintain E2A Activity for B Cell Commitment via Repression of Id1

scientific article

Transcription factor Gfi1 regulates self-renewal and engraftment of hematopoietic stem cells

scientific article published on 23 September 2004

Transcription factor miz-1 is required to regulate interleukin-7 receptor signaling at early commitment stages of B cell differentiation

scientific article published in December 2010

Transcription profiling of inner ears from Pou4f3(ddl/ddl) identifies Gfi1 as a target of the Pou4f3 deafness gene

scientific article

Yaf2 inhibits Myc biological function

scientific article

Zinc finger protein Gfi1 controls the endotoxin-mediated Toll-like receptor inflammatory response by antagonizing NF-kappaB p65

scientific article

List of works by Tarik Möröy

A novel regulatory circuit between p53 and GFI1 controls induction of apoptosis in T cells

A variant allele of Growth Factor Independence 1 (GFI1) is associated with acute myeloid leukemia

Alternative splicing controlled by heterogeneous nuclear ribonucleoprotein L regulates development, proliferation, and migration of thymic pre-T cells

Auxiliary splice factor U2AF26 and transcription factor Gfi1 cooperate directly in regulating CD45 alternative splicing

CD8 lineage-specific regulation of interleukin-7 receptor expression by the transcriptional repressor Gfi1.

Crosstalk Between MYC and lncRNAs in Hematological Malignancies

Cyclin E.

DNA Microarrays in Medicine: Can the Promises Be Kept?

Deletion of the Miz-1 POZ Domain Increases Efficacy of Cytarabine Treatment in T- and B-ALL/Lymphoma Mouse Models

Differential impact of the transcriptional repressor Gfi1 on mature CD4+ and CD8+ T lymphocyte function

Differential isoform expression and interaction with the P32 regulatory protein controls the subcellular localization of the splicing factor U2AF26

Direct transcriptional repression of the genes encoding the zinc-finger proteins Gfi1b and Gfi1 by Gfi1b

Dominant negative Gfi1b mutations cause moderate thrombocytopenia and an impaired stress thrombopoiesis associated with mild erythropoietic abnormalities in mice

Epigenetic therapy as a novel approach for GFI136N-associated murine/human AML.

Evidence that growth factor independence 1b regulates dormancy and peripheral blood mobilization of hematopoietic stem cells.

Expression of ribosomal and translation-associated genes is correlated with a favorable clinical course in chronic lymphocytic leukemia.

From cytopenia to leukemia: the role of Gfi1 and Gfi1b in blood formation

GFI1 and GFI1B control the loss of endothelial identity of hemogenic endothelium during hematopoietic commitment

GFI1 facilitates efficient DNA repair by regulating PRMT1 dependent methylation of MRE11 and 53BP1.

GFI1 is required for RUNX1/ETO positive acute myeloid leukemia.

GFI1 proteins orchestrate the emergence of haematopoietic stem cells through recruitment of LSD1.

GFI1 tethers the NuRD complex to open and transcriptionally active chromatin in myeloid progenitors

GFI1's role in DNA repair suggests implications for tumour cell response to treatment

GFI1(36N) as a therapeutic and prognostic marker for myelodysplastic syndrome

Gene expression of the POU factor Brn-3a is regulated by two different promoters

Generation and characterization of human iPSC line MML-6838-Cl2 from mobilized peripheral blood derived megakaryoblasts.

Gfi1 and Gfi1b act equivalently in haematopoiesis, but have distinct, non-overlapping functions in inner ear development

Gfi1 negatively regulates T(h)17 differentiation by inhibiting RORgammat activity

Gfi1:green fluorescent protein knock-in mutant reveals differential expression and autoregulation of the growth factor independence 1 (Gfi1) gene during lymphocyte development

Gfi1b alters histone methylation at target gene promoters and sites of gamma-satellite containing heterochromatin

Gfi1b controls integrin signaling-dependent cytoskeleton dynamics and organization in megakaryocytes

Gfi1b negatively regulates Rag expression directly and via the repression of FoxO1

Gfi1b regulates the level of Wnt/β-catenin signaling in hematopoietic stem cells and megakaryocytes

Gfi1b:green fluorescent protein knock-in mice reveal a dynamic expression pattern of Gfi1b during hematopoiesis that is largely complementary to Gfi1.

Growth factor independence 1 (Gfi1) as a regulator of lymphocyte development and activation

Growth factor independence 1 (Gfi1) as a regulator of p53 activity and a new therapeutical target for ALL.

Growth factor independence 1 (Gfi1) regulates cell-fate decision of a bipotential granulocytic-monocytic precursor defined by expression of Gfi1 and CD48.

Growth factor independence 1 antagonizes a p53-induced DNA damage response pathway in lymphoblastic leukemia.

Growth factor independence 1 protects hematopoietic stem cells against apoptosis but also prevents the development of a myeloproliferative-like disease.

Growth factor independence 1b (gfi1b) is important for the maturation of erythroid cells and the regulation of embryonic globin expression

Growth factor independent 1b (Gfi1b) and a new splice variant of Gfi1b are highly expressed in patients with acute and chronic leukemia.

Growth factor independent-1 maintains Notch1-dependent transcriptional programming of lymphoid precursors.

Heterogeneous Nuclear Ribonucleoprotein L is required for the survival and functional integrity of murine hematopoietic stem cells

High levels of the onco-protein Gfi-1 accelerate T-cell proliferation and inhibit activation induced T-cell death in Jurkat T-cells

IL-7R-dependent survival and differentiation of early T-lineage progenitors is regulated by the BTB/POZ domain transcription factor Miz-1

Identification of Tcf-4 as a transcriptional target of p53 signalling

Identification of a novel Krüppel-associated box domain protein, Krim-1, that interacts with c-Myc and inhibits its oncogenic activity

Identification of potent Ras signaling inhibitors by pathway-selective phenotype-based screening

Inflammatory reactions and severe neutropenia in mice lacking the transcriptional repressor Gfi1

Loss of p27(Kip1) cooperates with cyclin E in T-cell lymphomagenesis

Miz-1 is required to coordinate the expression of TCRbeta and p53 effector genes at the pre-TCR "beta-selection" checkpoint

Miz-1 regulates translation of Trp53 via ribosomal protein L22 in cells undergoing V(D)J recombination

Miz1 is required for early embryonic development during gastrulation

Miz1 is required for hair follicle structure and hair morphogenesis

Multifaceted Actions of GFI1 and GFI1B in Hematopoietic Stem Cell Self-Renewal and Lineage Commitment

Neural differentiation modulates the vertebrate brain specific splicing program

New indene-derivatives with anti-proliferative properties

Novel target genes of the Wnt pathway and statistical insights into Wnt target promoter regulation

Nuclear interaction of the dynein light chain LC8a with the TRPS1 transcription factor suppresses the transcriptional repression activity of TRPS1

Origin of the brush cell lineage in the mouse intestinal epithelium.

Prox1 interacts with Atoh1 and Gfi1, and regulates cellular differentiation in the inner ear sensory epithelia

Reduced expression but not deficiency of GFI1 causes a fatal myeloproliferative disease in mice

Regulation of pulmonary Pseudomonas aeruginosa infection by the transcriptional repressor Gfi1

Rhythmic U2af26 alternative splicing controls PERIOD1 stability and the circadian clock in mice

Role of GFI1 in Epigenetic Regulation of MDS and AML Pathogenesis: Mechanisms and Therapeutic Implications

Runx3 regulates integrin alpha E/CD103 and CD4 expression during development of CD4-/CD8+ T cells

SMAF-1 inhibits the APC/beta-catenin pathway and shows properties similar to those of the tumor suppressor protein APC.

Systemic lupus-erythematosus: deoxyribonuclease 1 in necrotic chromatin disposal.

The RING finger protein RNF4, a co-regulator of transcription, interacts with the TRPS1 transcription factor

The human GFI136N variant induces epigenetic changes at the Hoxa9 locus and accelerates K-RAS driven myeloproliferative disorder in mice.

The impact of alternative splicing in vivo: mouse models show the way.

The interaction between Myc and Miz1 is required to antagonize TGFbeta-dependent autocrine signaling during lymphoma formation and maintenance

The new sulindac derivative IND 12 reverses Ras-induced cell transformation

The oncogenic activity of cyclin E is not confined to Cdk2 activation alone but relies on several other, distinct functions of the protein

The oncogenic serine/threonine kinase Pim-1 directly phosphorylates and activates the G2/M specific phosphatase Cdc25C.

The oncogenic serine/threonine kinase Pim-1 phosphorylates and inhibits the activity of Cdc25C-associated kinase 1 (C-TAK1): a novel role for Pim-1 at the G2/M cell cycle checkpoint

The p150 subunit of the histone chaperone Caf-1 interacts with the transcriptional repressor Gfi1

The role of the transcription factor Miz-1 in lymphocyte development and lymphomagenesis-Binding Myc makes the difference

The role of the transcriptional repressor growth factor independent 1 in the formation of myeloid cells