List of works - Kyeong-Ryoon Lee

A Machine Learning-Based Identification of Genes Affecting the Pharmacokinetics of Tacrolimus Using the DMETTM Plus Platform

scientific article published on 04 April 2020

A physiologically-based pharmacokinetic model adequately predicted the human pharmacokinetic profiles of YH4808, a novel K+-competitive acid blocker

scientific article published on 11 January 2019

A strategy for reducing particulate contamination on opening glass ampoules and development of evaluation methods for its application

scientific article published on 27 June 2011

Bioanalysis of alpelisib using liquid chromatography–tandem mass spectrometry and application to pharmacokinetic study

scientific article published in 2022

Determination of 2-aryl-7(3',4'-dialkoxyphenyl)-pyrazolo [1,5-alpha] pyrimidine, a novel phosphodiesterase-4 inhibitor, in rat plasma by liquid chromatography-tandem mass spectrometry

scientific article published on 06 November 2012

Determination of PF-04620110, a novel inhibitor of diacylglycerol acyltransferase-1, in rat plasma using liquid chromatography-tandem mass spectrometry and its application in pharmacokinetic studies

scientific article

Determination of Penicillium griseofulvum-oriented pyripyropene A, a selective inhibitor of acyl-coenzyme A:cholesterol acyltransferase 2, in mouse plasma using liquid chromatography-tandem mass spectrometry and its application to pharmacokinetic st

scientific article published on 30 October 2018

Determination of a novel TAZ modulator, 2-butyl-5-methyl-6-(pyridine-3-yl)-3-[2'-(1H-tetrazole-5-yl)-biphenyl-4-ylmethyl]-3H imidazo[4,5-b]pyridine] (TM-25659) in rat plasma by liquid chromatography-tandem mass spectrometry

scientific article published on 07 February 2012

Determination of motolimod concentration in rat plasma by liquid chromatography-tandem mass spectrometry and its application in a pharmacokinetic study

scientific article published on 12 November 2019

Determination of zabofloxacin in rat plasma by liquid chromatography with mass spectrometry and its application to pharmacokinetic study ⬇️

scientific article published on 09 November 2010

Development of a LC-MS method for quantification of FK-3000 and its application to in vivo pharmacokinetic study in drug development.

scientific article published on 4 June 2012

Development of a Polo-like Kinase-1 Polo-Box Domain Inhibitor as a Tumor Growth Suppressor in Mice Models

scientific article published on 03 November 2020

Development of a liquid chromatography-tandem mass spectrometry method for assaying cenobamate in rat plasma

scholarly article

Engineering Yarrowia lipolytica for de novo production of tetraacetyl phytosphingosine

scientific article published on 15 November 2020

Evidence of carrier-mediated transport in the penetration of donepezil into the rat brain

scientific article

Extrapolation of In Vivo Hepatic Clearance from In Vitro Uptake Clearance by Suspended Human Hepatocytes for Anionic Drugs with High Binding to Human Albumin: Improvement of In Vitro-to-In Vivo Extrapolation by Considering the "Albumin-Mediated" Hep

scientific article published on 30 November 2018

Feasibility of the functional expression of the human organic anion transporting polypeptide 1B1 (OATP1B1) and its genetic variant 521T/C in the mouse liver

scientific article published on 10 September 2016

Functional consequences of genetic variations in the human organic anion transporting polypeptide 1B3 (OATP1B3) in the Korean population

scientific article

HS-133, a novel fluorescent phosphatidylinositol 3-kinase inhibitor as a potential imaging and anticancer agent for targeted therapy

scientific article

Identification of metabolites of MDR-1339, an inhibitor of β-amyloid protein aggregation, and kinetic characterization of the major metabolites in rats.

scientific article published on 3 January 2018

In vitro and in vivo anti-inflammatory effects of a novel 4,6-bis ((E)-4-hydroxy-3-methoxystyryl)-1-phenethylpyrimidine-2(1H)-thione

scientific article published on 17 December 2013

Inhibition of Skin Inflammation by Scytonemin, an Ultraviolet Sunscreen Pigment

scientific article published on 04 June 2020

Lack of a primary physicochemical determinant in the direct transport of drugs to the brain after nasal administration in rats: potential involvement of transporters in the pathway

scientific article published on 30 September 2010

Model-based pharmacokinetic and pharmacodynamic analysis for acute effects of a small molecule inhibitor of diacylglycerol acyltransferase-1 in the TallyHo/JngJ polygenic mouse

scientific article published on 05 September 2018

Neurochemical and behavioral analysis by acute exposure to bisphenol A in zebrafish larvae model

scientific article published on 04 September 2019

Pharmacokinetic characterization of decursinol derived from Angelica gigas Nakai in rats

scientific article published on 09 June 2011

Pharmacokinetic characterization of the novel TAZ modulator TM-25659 using a multicompartment kinetic model in rats and a possibility of its drug-drug interactions in humans

scientific article published on 3 August 2012

Pharmacokinetic interactions of niclosamide in rats: Involvement of organic anion transporters 1 and 3 and organic cation transporter 2

scholarly article

Pharmacokinetics and pharmacodynamics of KR-66223, a novel DPP-4 inhibitor

scientific article published on 13 January 2012

Pharmacokinetics of enzalutamide, an anti-prostate cancer drug, in rats

scientific article

Pharmacokinetics of lurasidone, a novel atypical anti-psychotic drug, in rats.

scientific article published on 13 August 2011

Pharmacokinetics of tafamidis, a transthyretin amyloidosis drug, in rats.

scientific article published on 14 August 2017

Physiologically based pharmacokinetic modeling of SNU-0039, an anti-Alzheimer's agent, in rats

scientific article published on 25 August 2011

Predicted drug-induced bradycardia related cardio toxicity using a zebrafish in vivo model is highly correlated with results from in vitro tests.

scientific article published on 5 November 2012

Quantification of oltipraz using liquid chromatography-tandem mass spectrometry and its application to a pharmacokinetic study in rat plasma.

scientific article published on 25 June 2011

Quercetin Is a Flavonoid Breast Cancer Resistance Protein Inhibitor with an Impact on the Oral Pharmacokinetics of Sulfasalazine in Rats

scientific article published on 26 April 2020

Role of the efflux transporters Abcb1 and Abcg2 in the brain distribution of olaparib in mice

scientific article published in 2022

Simultaneous Determination of Artesunate and Dihydroartemisinin Concentrations in Human Plasma by High Performance Liquid Chromatography-Mass Spectrometry with Electro-Spray Ionization

article by Kyeong-Ryoon Lee et al published 12 January 2010 in Analytical Letters

Specific Inhibition of the Distribution of Lobeglitazone to the Liver by Atorvastatin in Rats: Evidence for a Rat Organic Anion Transporting Polypeptide 1B2-Mediated Interaction in Hepatic Transport

scientific article

The phenomenon of "albumin-mediated" hepatic uptake of organic anion transport polypeptide substrates: Prediction of the in vivo uptake clearance from the in vitro uptake by isolated hepatocytes using a "facilitated-dissociation" model

scientific article published on 3 January 2018

Zebrafish as a Screening Model for Testing the Permeability of Blood-Brain Barrier to Small Molecules

scientific article published on 10 May 2017

List of works by Kyeong-Ryoon Lee

A Machine Learning-Based Identification of Genes Affecting the Pharmacokinetics of Tacrolimus Using the DMETTM Plus Platform

A physiologically-based pharmacokinetic model adequately predicted the human pharmacokinetic profiles of YH4808, a novel K+-competitive acid blocker

A strategy for reducing particulate contamination on opening glass ampoules and development of evaluation methods for its application

Bioanalysis of alpelisib using liquid chromatography–tandem mass spectrometry and application to pharmacokinetic study

Determination of 2-aryl-7(3',4'-dialkoxyphenyl)-pyrazolo [1,5-alpha] pyrimidine, a novel phosphodiesterase-4 inhibitor, in rat plasma by liquid chromatography-tandem mass spectrometry

Determination of PF-04620110, a novel inhibitor of diacylglycerol acyltransferase-1, in rat plasma using liquid chromatography-tandem mass spectrometry and its application in pharmacokinetic studies

Determination of Penicillium griseofulvum-oriented pyripyropene A, a selective inhibitor of acyl-coenzyme A:cholesterol acyltransferase 2, in mouse plasma using liquid chromatography-tandem mass spectrometry and its application to pharmacokinetic st

Determination of a novel TAZ modulator, 2-butyl-5-methyl-6-(pyridine-3-yl)-3-[2'-(1H-tetrazole-5-yl)-biphenyl-4-ylmethyl]-3H imidazo[4,5-b]pyridine] (TM-25659) in rat plasma by liquid chromatography-tandem mass spectrometry

Determination of motolimod concentration in rat plasma by liquid chromatography-tandem mass spectrometry and its application in a pharmacokinetic study

Determination of zabofloxacin in rat plasma by liquid chromatography with mass spectrometry and its application to pharmacokinetic study ⬇️

Development of a LC-MS method for quantification of FK-3000 and its application to in vivo pharmacokinetic study in drug development.

Development of a Polo-like Kinase-1 Polo-Box Domain Inhibitor as a Tumor Growth Suppressor in Mice Models

Development of a liquid chromatography-tandem mass spectrometry method for assaying cenobamate in rat plasma

Engineering Yarrowia lipolytica for de novo production of tetraacetyl phytosphingosine

Evidence of carrier-mediated transport in the penetration of donepezil into the rat brain

Extrapolation of In Vivo Hepatic Clearance from In Vitro Uptake Clearance by Suspended Human Hepatocytes for Anionic Drugs with High Binding to Human Albumin: Improvement of In Vitro-to-In Vivo Extrapolation by Considering the "Albumin-Mediated" Hep

Feasibility of the functional expression of the human organic anion transporting polypeptide 1B1 (OATP1B1) and its genetic variant 521T/C in the mouse liver

Functional consequences of genetic variations in the human organic anion transporting polypeptide 1B3 (OATP1B3) in the Korean population

HS-133, a novel fluorescent phosphatidylinositol 3-kinase inhibitor as a potential imaging and anticancer agent for targeted therapy

Identification of metabolites of MDR-1339, an inhibitor of β-amyloid protein aggregation, and kinetic characterization of the major metabolites in rats.

In vitro and in vivo anti-inflammatory effects of a novel 4,6-bis ((E)-4-hydroxy-3-methoxystyryl)-1-phenethylpyrimidine-2(1H)-thione

Inhibition of Skin Inflammation by Scytonemin, an Ultraviolet Sunscreen Pigment

Lack of a primary physicochemical determinant in the direct transport of drugs to the brain after nasal administration in rats: potential involvement of transporters in the pathway

Model-based pharmacokinetic and pharmacodynamic analysis for acute effects of a small molecule inhibitor of diacylglycerol acyltransferase-1 in the TallyHo/JngJ polygenic mouse

Neurochemical and behavioral analysis by acute exposure to bisphenol A in zebrafish larvae model

Pharmacokinetic characterization of decursinol derived from Angelica gigas Nakai in rats

Pharmacokinetic characterization of the novel TAZ modulator TM-25659 using a multicompartment kinetic model in rats and a possibility of its drug-drug interactions in humans

Pharmacokinetic interactions of niclosamide in rats: Involvement of organic anion transporters 1 and 3 and organic cation transporter 2

Pharmacokinetics and pharmacodynamics of KR-66223, a novel DPP-4 inhibitor

Pharmacokinetics of enzalutamide, an anti-prostate cancer drug, in rats

Pharmacokinetics of lurasidone, a novel atypical anti-psychotic drug, in rats.

Pharmacokinetics of tafamidis, a transthyretin amyloidosis drug, in rats.

Physiologically based pharmacokinetic modeling of SNU-0039, an anti-Alzheimer's agent, in rats

Predicted drug-induced bradycardia related cardio toxicity using a zebrafish in vivo model is highly correlated with results from in vitro tests.

Quantification of oltipraz using liquid chromatography-tandem mass spectrometry and its application to a pharmacokinetic study in rat plasma.

Quercetin Is a Flavonoid Breast Cancer Resistance Protein Inhibitor with an Impact on the Oral Pharmacokinetics of Sulfasalazine in Rats

Role of the efflux transporters Abcb1 and Abcg2 in the brain distribution of olaparib in mice

Simultaneous Determination of Artesunate and Dihydroartemisinin Concentrations in Human Plasma by High Performance Liquid Chromatography-Mass Spectrometry with Electro-Spray Ionization

Specific Inhibition of the Distribution of Lobeglitazone to the Liver by Atorvastatin in Rats: Evidence for a Rat Organic Anion Transporting Polypeptide 1B2-Mediated Interaction in Hepatic Transport

The phenomenon of "albumin-mediated" hepatic uptake of organic anion transport polypeptide substrates: Prediction of the in vivo uptake clearance from the in vitro uptake by isolated hepatocytes using a "facilitated-dissociation" model

Zebrafish as a Screening Model for Testing the Permeability of Blood-Brain Barrier to Small Molecules