List of works by Ralph W. Kupka

A 24-week, randomized, controlled trial of adjunctive sibutramine versus topiramate in the treatment of weight gain in overweight or obese patients with bipolar disorders

scientific article published in June 2007

A cognitive behavioural group therapy for bipolar disorder using daily mood monitoring

scientific article published on 22 April 2020

A discriminating messenger RNA signature for bipolar disorder formed by an aberrant expression of inflammatory genes in monocytes.

scientific article

A multi-center naturalistic study of a newly designed 12-sessions group psychoeducation program for patients with bipolar disorder and their caregivers

scientific article published on 01 September 2020

A nationwide study on concordance with multimodal treatment guidelines in bipolar disorder

scientific article published on 20 October 2018

A pilot study of a combined group and individual functional remediation program for patients with bipolar I disorder

scientific article

A re-evaluation of the role of antidepressants in the treatment of bipolar depression: data from the Stanley Foundation Bipolar Network.

scientific article

A relative resistance of T cells to dexamethasone in bipolar disorder.

scientific article published in December 2006

A research agenda for bipolar disorder developed from a patients' perspective

scientific article published on 19 June 2018

Adding Increased Energy or Activity to Criterion (A) of the DSM-5 Definition of Hypomania and Mania: Effect on the Diagnoses of 907 Patients From the Bipolar Collaborative Network

scientific article published on 29 October 2019

Age at Onset of Bipolar Disorder Related to Parental and Grandparental Illness Burden.

scientific article published on 13 September 2016

Age of onset of bipolar disorder: Combined effect of childhood adversity and familial loading of psychiatric disorders

scientific article published on 16 June 2016

Alcoholism and anxiety in bipolar illness: differential lifetime anxiety comorbidity in bipolar I women with and without alcoholism

scientific article

An imbalance in the production of IL-1beta and IL-6 by monocytes of bipolar patients: restoration by lithium treatment.

scientific article published in November 2007

An overview of recent findings of the Stanley Foundation Bipolar Network (Part I).

scientific article

Are bipolar mood symptoms affected by the phase of the menstrual cycle?

scientific article published on April 2008

Axis I psychiatric comorbidity and its relationship to historical illness variables in 288 patients with bipolar disorder

scientific article

Axis II Personality Disorders Are Linked to an Adverse Course of Bipolar Disorder

B-positive: a randomized controlled trial of a multicomponent positive psychology intervention for euthymic patients with bipolar disorder - study protocol and intervention development

article

Bipolar disorder and alcohol use disorder: practical recommendations for treatment, based on a literature review

scientific article published in January 2018

Bipolar disorder in the elderly

Clinical correlates of sustained response to individual drugs used in naturalistic treatment of patients with bipolar disorder

scientific article

Collaborative care for patients with bipolar disorder: Effects on functioning and quality of life

scientific article published on 11 March 2015

Collaborative care for patients with bipolar disorder: a randomised controlled trial

scientific article

Collaborative care for patients with bipolar disorder: randomised controlled trial

scientific article published on 19 March 2015

Combined oral anticonceptives and the pill-free week in two bipolar patients treated with lamotrigine

scientific article published on 27 February 2019

Comorbidity of anxiety and depressive disorders: a comparative population study in Western and non-Western inhabitants in the Netherlands

scientific article

Comparison of rapid-cycling and non-rapid-cycling bipolar disorder based on prospective mood ratings in 539 outpatients.

scientific article published in July 2005

Complexity of pharmacologic treatment required for sustained improvement in outpatients with bipolar disorder

scientific article published on September 2010

Correlates of 1-year prospective outcome in bipolar disorder: results from the Stanley Foundation Bipolar Network.

scientific article published in August 2004

Correlates of overweight and obesity in 644 patients with bipolar disorder

scientific article published on 01 March 2002

Correlates of treatment-emergent mania associated with antidepressant treatment in bipolar depression.

scientific article published on 17 November 2008

Differential clinical characteristics, medication usage, and treatment response of bipolar disorder in the US versus The Netherlands and Germany

scientific article

Does the number of previous mood episodes moderate the relationship between alcohol use, smoking and mood in bipolar outpatients?

scientific article

Double jeopardy in the United States: Early onset bipolar disorder and treatment delay

scientific article published on 03 July 2020

Double-blind, randomized, placebo-controlled trials of ethyl-eicosapentanoate in the treatment of bipolar depression and rapid cycling bipolar disorder.

scientific article published on 30 June 2006

Early physical and sexual abuse associated with an adverse course of bipolar illness

scientific article published in February 2002

Early-onset bipolar disorder and treatment delay are risk factors for poor outcome in adulthood

scientific article published in July 2010

Economic evaluations of non-pharmacological interventions and cost-of-illness studies in bipolar disorder: A systematic review

scientific article published on 15 July 2020

Ethnic differences in the association between cardiovascular risk factors and psychological distress in a population study in the Netherlands

scientific article

Evaluation of clarity of presentation and applicability of monitoring instructions for patients using lithium in clinical practice guidelines for treatment of bipolar disorder

scientific article published on 13 August 2018

Evidence that the immunopathogenic mechanism of lithium-induced psoriasis differs from that of regular psoriasis

scientific article published on 01 August 2005

Exploring the clinical utility of two staging models for bipolar disorder

scientific article published on 04 September 2019

Factors associated with suicide attempts in 648 patients with bipolar disorder in the Stanley Foundation Bipolar Network

scientific article published in May 2003

First-onset psychosis occurring in the postpartum period: a prospective cohort study

scientific article published on 23 August 2011

Functional versus syndromal recovery in patients with major depressive disorder and bipolar disorder

scientific article

Further Evidence of a Cohort Effect in Bipolar Disorder: More Early Onsets and Family History of Psychiatric Illness in More Recent Epochs

scientific article published on 5 July 2016

Gabapentin in the acute treatment of refractory bipolar disorder.

scientific article

Gender and depressive symptoms in 711 patients with bipolar disorder evaluated prospectively in the Stanley Foundation bipolar treatment outcome network

scientific article

Gender differences in prevalence, risk, and clinical correlates of alcoholism comorbidity in bipolar disorder

scientific article published in May 2003

Genome-wide association study identifies 30 loci associated with bipolar disorder.

scientific article

Genome-wide association study of more than 40,000 bipolar disorder cases provides new insights into the underlying biology

scientific article published in June 2021

Genomic dissection of bipolar disorder and schizophrenia including 28 subphenotypes

scientific article published on 8 August 2017

High educational performance is a distinctive feature of bipolar disorder: a study on cognition in bipolar disorder, schizophrenia patients, relatives and controls

scientific article published on December 2015

High numbers of circulating activated T cells and raised levels of serum IL-2 receptor in bipolar disorder

scientific article published on 01 January 2003

High rate of autoimmune thyroiditis in bipolar disorder: lack of association with lithium exposure.

scientific article published in February 2002

Hypercalcemia in patients with bipolar disorder treated with lithium: a cross-sectional study

scientific article

Illness progression as a function of independent and accumulating poor prognosis factors in outpatients with bipolar disorder in the United States

scientific article

Illnesses in siblings of US patients with bipolar disorder relate to multigenerational family history and patients severity of illness

scientific article

Immune activation, steroid resistancy and bipolar disorder.

scientific article published in January 2002

Immunological aspects of bipolar disorder

scientific article published on 01 September 2000

Impact of antidepressant continuation after acute positive or partial treatment response for bipolar depression: a blinded, randomized study

scientific article

Impact of antidepressant discontinuation after acute bipolar depression remission on rates of depressive relapse at 1-year follow-up

scientific article (publication date: July 2003)

Implicit and explicit self-associations in bipolar disorder: A comparison with healthy controls and unipolar depressive disorder

scientific article (publication date: February 2014)

Incidence of childhood-onset bipolar illness in the USA and Europe

scientific article published on 01 February 2008

Increased parental history of bipolar disorder in the United States: association with early age of onset

scientific article

Increases in multiple psychiatric disorders in parents and grandparents of patients with bipolar disorder from the USA compared with The Netherlands and Germany

scientific article

Lamotrigine for the treatment of bipolar disorder: a clinical case series.

scientific article

Low self-recognition and awareness of past hypomanic and manic episodes in the general population

scientific article

Lower Switch Rate in Depressed Patients With Bipolar II Than Bipolar I Disorder Treated Adjunctively With Second-Generation Antidepressants

scientific article published on 16 July 2019

Lower switch rate in depressed patients with bipolar II than bipolar I disorder treated adjunctively with second-generation antidepressants

scientific article

Measuring personal recovery in people with bipolar disorder and exploring its relationship with well-being and social role participation

scientific article published on 10 June 2019

Mixed Depression in Bipolar Disorder: Prevalence Rate and Clinical Correlates During Naturalistic Follow-Up in the Stanley Bipolar Network

scientific article

Mixed Hypomania in 908 Patients With Bipolar Disorder Evaluated Prospectively in the Stanley Foundation Bipolar Treatment Network

scientific article published on 01 October 2005

Monitoring of patients treated with lithium for bipolar disorder: an international survey.

scientific article published on 14 April 2018

Monocyte-derived dendritic cells in bipolar disorder

scientific article published on 13 September 2005

Mood switch in bipolar depression: comparison of adjunctive venlafaxine, bupropion and sertraline

scientific article published in August 2006

Morbidity in 258 bipolar outpatients followed for 1 year with daily prospective ratings on the NIMH life chart method.

scientific article published in June 2003

More assortative mating in US compared to European parents and spouses of patients with bipolar disorder: implications for psychiatric illness in the offspring

More childhood onset bipolar disorder in the United States than Canada or Europe: Implications for treatment and prevention

scientific article published on 21 January 2017

More illness in offspring of bipolar patients from the U.S. compared to Europe

scientific article

More medical comorbidities in patients with bipolar disorder from the United States than from the Netherlands and Germany

scientific article

More pernicious course of bipolar disorder in the United States than in many European countries: implications for policy and treatment

scientific article published on 10 February 2014

More stressors prior to and during the course of bipolar illness in patients from the United States compared with the Netherlands and Germany

scientific article published on 8 September 2013

Multigenerational Positive Family History of Psychiatric Disorders Is Associated With a Poor Prognosis in Bipolar Disorder

scientific article published on 10 August 2015

Multigenerational transmission of liability to psychiatric illness in offspring of parents with bipolar disorder

article

New findings from the Bipolar Collaborative Network: clinical implications for therapeutics

scientific article published on December 2006

Olanzapine in treatment-resistant bipolar disorder

scientific article published on May 1998

Open-label adjunctive topiramate in the treatment of bipolar disorders.

scientific article

Open-label adjunctive zonisamide in the treatment of bipolar disorders: a prospective trial.

scientific article

Postpartum mania in a man with bipolar disorder: case report and a review of the role of sleep loss

scientific article

Predictors of psychosocial outcome of bipolar disorder: data from the Stanley Foundation Bipolar Network

scientific article published on 16 December 2019

Predictors of the onset of manic symptoms and a (hypo)manic episode in patients with major depressive disorder

scientific article

Preliminary observations on the effectiveness of levetiracetam in the open adjunctive treatment of refractory bipolar disorder

scientific article

Prevalence and correlates of eating disorders in 875 patients with bipolar disorder

scientific article

Prevalence of axis II comorbidities in bipolar disorder: relationship to mood state.

scientific article published on 25 January 2018

Psychiatric Symptoms during the COVID-19 outbreak in Older Adults with Bipolar Disorder

scientific article published on 26 December 2020

Psychiatric and medical comorbidities: results from a bipolar elderly cohort study

scientific article published on 04 January 2014

Psychometric properties and utility of the Responses to Positive Affect questionnaire (RPA) in a sample of people with bipolar disorder

scientific article published on 25 June 2019

Psychosis in bipolar disorder: phenomenology and impact on morbidity and course of illness.

scientific article published in July 2003

Quetiapine for the continuation treatment of bipolar depression: naturalistic prospective case series from the Stanley Bipolar Treatment Network

scientific article published on November 2007

Rapid and non-rapid cycling bipolar disorder: a meta-analysis of clinical studies.

scientific article published in December 2003

Rapid cycling bipolar disorder - diagnostic concepts

scientific article

Rate of switch in bipolar patients prospectively treated with second-generation antidepressants as augmentation to mood stabilizers

scientific article published in October 2001

Rate of switch in bipolar patients prospectively treated with second-generation antidepressants as augmentation to mood stabilizers

Relationship of clinical course of illness variables to medical comorbidities in 900 adult outpatients with bipolar disorder

scientific article published on 23 August 2014

Relationship of comorbid personality disorders to prospective outcome in bipolar disorder

scientific article published on 16 July 2020

Relationship of prior antidepressant exposure to long-term prospective outcome in bipolar I disorder outpatients

scientific article published on 20 March 2012

Reliability and validity of the functioning assessment short test for older adults with bipolar disorder (FAST-O)

scientific article published on 02 October 2020

Reproductive function and risk for PCOS in women treated for bipolar disorder

scientific article published in June 2005

Risk of recurrence of mood disorders during pregnancy and the impact of medication: A systematic review

scientific article published on 07 February 2019

Risk of switch in mood polarity to hypomania or mania in patients with bipolar depression during acute and continuation trials of venlafaxine, sertraline, and bupropion as adjuncts to mood stabilizers

scientific article published in February 2006

Role of childhood adversity in the development of medical co-morbidities associated with bipolar disorder

scientific article published on 18 January 2013

Similar associations between personality dimensions and anxiety or depressive disorders in a population study of Turkish-Dutch, Moroccan-Dutch, and native Dutch subjects

scientific article

Similarity in depressive symptom profile in a population-based study of migrants in the Netherlands

scientific article

Staging and profiling in bipolar disorders

scientific article

Staging systems in bipolar disorder: an International Society for Bipolar Disorders Task Force Report

scientific article published on 25 June 2014

Study protocol of a multicenter randomized controlled trial of mindfulness-based cognitive therapy and treatment as usual in bipolar disorder

scientific article published on 30 April 2019

Subsyndromal depressive symptoms are associated with functional impairment in patients with bipolar disorder: results of a large, multisite study.

scientific article published in October 2006

Testing a clinical staging model for bipolar disorder using longitudinal life chart data

scientific article published on 12 December 2018

The Mood Disorder Questionnaire (MDQ) for detecting (hypo)manic episodes: its validity and impact of recall bias

scientific article published on 20 June 2013

The Stanley Foundation Bipolar Network. 2. Preliminary summary of demographics, course of illness and response to novel treatments

scientific article

The Stanley Foundation Bipolar Network. I. Rationale and methods

scientific article

The Stanley Foundation Bipolar Treatment Outcome Network

scientific article published on 01 December 2001

The Stanley Foundation Bipolar Treatment Outcome Network. I. Longitudinal methodology.

scientific article published on December 2001

The Working Alliance Between Patients With Bipolar Disorder and the Nurse: Helpful and Obstructive Elements During a Depressive Episode From the Patients' Perspective

scientific article

The addition of STEPPS in the treatment of patients with bipolar disorder and comorbid borderline personality features: a protocol for a randomized controlled trial

scientific article

The care needs of older patients with bipolar disorder

scientific article published on 5 June 2015

The challenges of living with bipolar disorder: a qualitative study of the implications for health care and research

article

The characteristics of psychotic features in bipolar disorder

article

The clinical course of late-life bipolar disorder, looking back and forward.

scientific article published on 11 December 2017

The effectiveness of restarted lithium treatment after discontinuation: reviewing the evidence for discontinuation-induced refractoriness

scientific article published on 05 August 2013

The efficacy of valproate, lamotrigine and gabapentin in bipolar disorder; review of double-blind controlled studies

scientific article published on September 2000

The influence of social, psychological and cognitive factors on the clinical course in older patients with bipolar disorder

scientific article published on 10 September 2020

The poor prognosis of childhood-onset bipolar disorder

scientific article published in May 2007

The predictive performance of the bipolarity index in a Dutch epidemiological sample manuscript

scientific article published on 30 October 2019

The prevalence and management of side effects of lithium and anticonvulsants as mood stabilizers in bipolar disorder from a clinical perspective: a review.

scientific article

The prevalence of late-life mania: a review

scientific article published on 06 August 2013

The relationship between self-reported borderline personality features and prospective illness course in bipolar disorder.

scientific article published on 25 September 2017

The user experiences and clinical outcomes of an online personal health record to support self-management of bipolar disorder: A pretest-posttest pilot study

article

Three times more days depressed than manic or hypomanic in both bipolar I and bipolar II disorder.

scientific article published in August 2007

Tiagabine in treatment refractory bipolar disorder: a clinical case series.

scientific article published on October 2002

Translating big data to better treatment in bipolar disorder - a manifesto for coordinated action

scientific article published on 11 June 2020

Tranylcypromine vs. lamotrigine in the treatment of refractory bipolar depression: a failed but clinically useful study

scientific article published on 01 May 2007

Treatment of bipolar disorder in the Netherlands and concordance with treatment guidelines: study protocol of an observational, longitudinal study on naturalistic treatment of bipolar disorder in everyday clinical practice

scientific article

Validation of the prospective NIMH-Life-Chart Method (NIMH-LCM-p) for longitudinal assessment of bipolar illness.

scientific article published in November 2000

Verbal abuse, like physical and sexual abuse, in childhood is associated with an earlier onset and more difficult course of bipolar disorder

scientific article

What is the optimal serum level for lithium in the maintenance treatment of bipolar disorder? A systematic review and recommendations from the ISBD/IGSLI Task Force on treatment with lithium

scientific article published on 20 June 2019

[Are appearances deceptive? Evidence-based instead of marketing-based psychiatry]

article by Iris Sommer et al published 2016 in Tijdschrift voor psychiatrie

[Earlier recognition of bipolar disorder - necessity and advice for clinical practice]

scientific article published on 01 January 2019

[Forcing patients with bipolar disorder to make a financial contribution to secondary psychiatric care may make them forsake care completely]

scientific article published on 01 January 2013

[Lithium-induced hyperparathyroidism]

scientific article published on 01 January 2012

[The effects of pharmacological and psychotherapeutic treatment of comorbid anxiety disorders in patients with bipolar disorder]

scientific article published in January 2018

[The general practitioner in charge of treatment of patients with bipolar disorder: an exploratory study]

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