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List of works by Rhea N Coler

A Formulated TLR7/8 Agonist is a Flexible, Highly Potent and Effective Adjuvant for Pandemic Influenza Vaccines

scientific article

A Nanostructured Lipid Carrier for Delivery of a Replicating Viral RNA Provides Single, Low-Dose Protection against Zika

scholarly article by Jesse H Erasmus et al published 2 August 2018 in Molecular Therapy

A Novel Synthetic TLR-4 Agonist Adjuvant Increases the Protective Response to a Clinical-Stage West Nile Virus Vaccine Antigen in Multiple Formulations

scientific article (publication date: 2016)

A clinical trial to evaluate the safety and immunogenicity of the LEISH-F1+MPL-SE vaccine for use in the prevention of visceral leishmaniasis

article by Jaya Chakravarty et al published April 2011 in Vaccine

A clinical trial to evaluate the safety and immunogenicity of the LEISH-F1+MPL-SE vaccine when used in combination with meglumine antimoniate for the treatment of cutaneous leishmaniasis

scientific article published on 3 August 2010

A clinical trial to evaluate the safety and immunogenicity of the LEISH-F1+MPL-SE vaccine when used in combination with sodium stibogluconate for the treatment of mucosal leishmaniasis

scientific article published on 17 September 2010

A combination of TLR-4 agonist and saponin adjuvants increases antibody diversity and protective efficacy of a recombinant West Nile Virus antigen

article published in 2018

A defined subunit vaccine that protects against vector-borne visceral leishmaniasis

scientific article published on 21 August 2017

A defined tuberculosis vaccine candidate boosts BCG and protects against multidrug-resistant Mycobacterium tuberculosis

scientific article

A dual TLR agonist adjuvant enhances the immunogenicity and protective efficacy of the tuberculosis vaccine antigen ID93.

scientific article published on 03 January 2014

A phase 1 antigen dose escalation trial to evaluate safety, tolerability and immunogenicity of the leprosy vaccine candidate LepVax (LEP-F1 + GLA-SE) in healthy adults

scientific article published on 30 December 2019

A structure-function approach to optimizing TLR4 ligands for human vaccines

scientific article (publication date: November 2016)

A synthetic adjuvant to enhance and expand immune responses to influenza vaccines

scientific article (publication date: 27 October 2010)

Adjuvant formulation structure and composition are critical for the development of an effective vaccine against tuberculosis

scientific article published on 09 August 2013

Adjuvanted pandemic influenza vaccine: variation of emulsion components affects stability, antigen structure, and vaccine efficacy

scientific article

Advancing Translational Science for Pulmonary NTM Infections: A Roadmap for Research

scientific article published on 01 April 2019

An mRNA Vaccine against SARS-CoV-2 - Preliminary Report

scientific article published on 14 July 2020

Antigen presentation by B cells guides programing of memory CD4+ T-cell responses to a TLR4-agonist containing vaccine in mice

scientific article published on 4 October 2016

Bioinformatic identification of tandem repeat antigens of the Leishmania donovani complex

scientific article published on 6 November 2006

Broadened immunity and protective responses with emulsion-adjuvanted H5 COBRA-VLP vaccines

scientific article published on 5 August 2017

CD11a and CD49d enhance the detection of antigen-specific T cells following human vaccination

scientific article published on 26 June 2017

Chitin microneedles for an easy-to-use tuberculosis skin test

scientific article published on 26 August 2013

Cloning, characterization, and serodiagnostic evaluation of Leishmania infantum tandem repeat proteins

scientific article published in July 2006

Comparative Systems Analyses Reveal Molecular Signatures of Clinically tested Vaccine Adjuvants

scientific article published on 13 December 2016

Cryogenic transmission electron microscopy of recombinant tuberculosis vaccine antigen with anionic liposomes reveals formation of flattened liposomes

scientific article published on 11 March 2014

Defined tuberculosis vaccine, Mtb72F/AS02A, evidence of protection in cynomolgus monkeys

scholarly article

Development and characterization of synthetic glucopyranosyl lipid adjuvant system as a vaccine adjuvant

scientific article published on 26 January 2011

Development of a leishmaniasis vaccine: the importance of MPL.

scientific article

Different human vaccine adjuvants promote distinct antigen-independent immunological signatures tailored to different pathogens

scientific article published on 21 January 2016

Dissecting mechanisms of immunodominance to the common tuberculosis antigens ESAT-6, CFP10, Rv2031c (hspX), Rv2654c (TB7.7), and Rv1038c (EsxJ)

scientific article

E114 Rational Design and Clinical Development of New Adjuvants

article

Effect of chemotherapy on whole-blood cytokine responses to Mycobacterium tuberculosis antigens in a small cohort of patients with pulmonary tuberculosis

scientific article

Elimination of the cold-chain dependence of a nanoemulsion adjuvanted vaccine against tuberculosis by lyophilization

scientific article published on 29 December 2013

Enhanced Anti-Mycobacterium tuberculosis Immunity over Time with Combined Drug and Immunotherapy Treatment.

scientific article published on 24 May 2018

Enhanced humoral and Type 1 cellular immune responses with Fluzone adjuvanted with a synthetic TLR4 agonist formulated in an emulsion

scientific article

Evaluation of diagnostic performance of rK28 ELISA using urine for diagnosis of visceral leishmaniasis

scientific article published on 04 July 2016

From mouse to man: safety, immunogenicity and efficacy of a candidate leishmaniasis vaccine LEISH-F3+GLA-SE.

scientific article published on 10 April 2015

Glucopyranosyl Lipid Adjuvant (GLA), a Synthetic TLR4 agonist, promotes potent systemic and mucosal responses to intranasal immunization with HIVgp140.

scientific article

Identification and characterization of novel recombinant vaccine antigens for immunization against genital Chlamydia trachomatis

scientific article published on March 2009

Identification of Mycobacterium tuberculosis vaccine candidates using human CD4+ T-cells expression cloning

scientific article

Identification of human T cell antigens for the development of vaccines against Mycobacterium tuberculosis

scientific article published on December 2008

Immune subdominant antigens as vaccine candidates against Mycobacterium tuberculosis

scientific article

Immunisation with ID83 fusion protein induces antigen-specific cell mediated and humoral immune responses in cattle

scientific article published on 05 September 2013

Immunization with a polyprotein vaccine consisting of the T-Cell antigens thiol-specific antioxidant, Leishmania major stress-inducible protein 1, and Leishmania elongation initiation factor protects against leishmaniasis

scientific article

Immunologic correlates of protection and potential role for adjuvants to improve influenza vaccines in older adults ⬇️

scientific article published on July 1, 2013

Immunotherapy for drug-refractory mucosal leishmaniasis

scientific article published on 15 September 2006

Improved Immune Responses in Young and Aged Mice with Adjuvanted Vaccines against H1N1 Influenza Infection

scientific article published on 19 February 2018

Increased potency of an inactivated trivalent polio vaccine with oil-in-water emulsions

scientific article published on 04 December 2010

Interferon γ and Tumor Necrosis Factor Are Not Essential Parameters of CD4+ T-Cell Responses for Vaccine Control of Tuberculosis

scientific article

Intradermal immunization improves protective efficacy of a novel TB vaccine candidate

scientific article published on 26 March 2009

Intramuscular Delivery of Replicon RNA Encoding ZIKV-117 Human Monoclonal Antibody Protects against Zika Virus Infection

scientific article published on 18 June 2020

Leish-111f, a recombinant polyprotein vaccine that protects against visceral Leishmaniasis by elicitation of CD4+ T cells

scientific article

Leishmania infantum sterol 24-c-methyltransferase formulated with MPL-SE induces cross-protection against L. major infection

scientific article published on 09 March 2009

Long-term protective efficacy with a BCG-prime ID93/GLA-SE boost regimen against the hyper-virulent Mycobacterium tuberculosis strain K in a mouse model

scientific article published on 29 October 2019

Memory CD4+ T cells enhance B-cell responses to drifting influenza immunization

scientific article published on 21 December 2018

Mucosal delivery switches the response to an adjuvanted tuberculosis vaccine from systemic TH1 to tissue-resident TH17 responses without impacting the protective efficacy

scientific article

MyD88 and TRIF synergistic interaction is required for TH1-cell polarization with a synthetic TLR4 agonist adjuvant

scientific article published on 03 July 2013

Mycobacterium tuberculosis Rv0198c, a putative matrix metalloprotease is involved in pathogenicity ⬇️

scientific article published on January 8, 2011

New horizons in adjuvants for vaccine development

scientific article published on 06 December 2008

Optimized subunit vaccine protects against experimental leishmaniasis

scientific article published on 26 September 2009

Optimizing Immunization Strategies for the Induction of Antigen-Specific CD4 and CD8 T Cell Responses for Protection against Intracellular Parasites.

scientific article published on 27 July 2016

Overcoming Steric Restrictions of VRC01 HIV-1 Neutralizing Antibodies through Immunization

scientific article published on 01 December 2019

Overcoming the Neonatal Limitations of Inducing Germinal Centers through Liposome-Based Adjuvants Including C-Type Lectin Agonists Trehalose Dibehenate or Curdlan

scientific article published on 28 February 2018

Physicochemical characterization and biological activity of synthetic TLR4 agonist formulations

scientific article

Pre-clinical antigenicity studies of an innovative multivalent vaccine for human visceral leishmaniasis

scientific article published on 27 November 2017

Prophylaxis of Mycobacterium tuberculosis H37Rv Infection in a Preclinical Mouse Model via Inhalation of Nebulized Bacteriophage D29

scientific article published on 16 September 2019

Protection against Mycobacterium leprae infection by the ID83/GLA-SE and ID93/GLA-SE vaccines developed for tuberculosis

scientific article

Protection against tuberculosis with homologous or heterologous protein/vector vaccine approaches is not dependent on CD8+ T cells

scientific article published on 31 July 2013

Protection and Long-Lived Immunity Induced by the ID93/GLA-SE Vaccine Candidate against a Clinical Mycobacterium tuberculosis Isolate

scientific article published on 9 December 2015

Protection of mice from Mycobacterium tuberculosis by ID87/GLA-SE, a novel tuberculosis subunit vaccine candidate.

scientific article

Protective efficacy of a tandemly linked, multi-subunit recombinant leishmanial vaccine (Leish-111f) formulated in MPL adjuvant

scientific article published in September 2002

Protective immunization against visceral leishmaniasis using Leishmania sterol 24-c-methyltransferase formulated in adjuvant

scientific article

Pulmonary immunity and durable protection induced by the ID93/GLA-SE vaccine candidate against the hyper-virulent Korean Beijing Mycobacterium tuberculosis strain K.

scientific article published on 19 March 2016

Recombinant polymorphic membrane protein D in combination with a novel, second-generation lipid adjuvant protects against intra-vaginal Chlamydia trachomatis infection in mice

scientific article published on 04 July 2016

Safety and immunogenicity of a defined vaccine for the prevention of cutaneous leishmaniasis

scientific article published in 2009

Safety and immunogenicity of the novel tuberculosis vaccine ID93 + GLA-SE in BCG-vaccinated healthy adults in South Africa: a randomised, double-blind, placebo-controlled phase 1 trial

scientific article published in April 2018

Schistosomiasis vaccine candidate Sm14/GLA-SE: Phase 1 safety and immunogenicity clinical trial in healthy, male adults.

scientific article published on 10 November 2015

Second-generation vaccines against leishmaniasis

scientific article

Strategic evaluation of vaccine candidate antigens for the prevention of Visceral Leishmaniasis

scientific article published on 30 April 2016

TLR4 ligand formulation causes distinct effects on antigen-specific cell-mediated and humoral immune responses

scientific article published on 10 October 2013

Taking toll: lipid A mimetics as adjuvants and immunomodulators

scientific article

The ID93 tuberculosis vaccine candidate does not induce sensitivity to purified protein derivative

scientific article

The TLR-4 agonist adjuvant, GLA-SE, improves magnitude and quality of immune responses elicited by the ID93 tuberculosis vaccine: first-in-human trial

article

The TLR4 Agonist Vaccine Adjuvant, GLA-SE, Requires Canonical and Atypical Mechanisms of Action for TH1 Induction

scientific article published on 5 January 2016

The complexities and challenges of preventing and treating nontuberculous mycobacterial diseases

scientific article published on 14 February 2019

The importance of adjuvant formulation in the development of a tuberculosis vaccine

scientific article published on 30 January 2012

The stimulatory effect of the TLR4-mediated adjuvant glucopyranosyl lipid A is well preserved in old age.

scientific article

Therapeutic immunization against Mycobacterium tuberculosis is an effective adjunct to antibiotic treatment

scientific article published on 13 August 2012

Therapeutic vaccination against relevant high virulence clinical isolates of Mycobacterium tuberculosis

scientific article published on 07 September 2013

Transcriptional profiling of TLR-4/7/8-stimulated guinea pig splenocytes and whole blood by bDNA assay ⬇️

scientific article published on August 3, 2011

Vaccination Produces CD4 T Cells with a Novel CD154-CD40-Dependent Cytolytic Mechanism

scientific article

Vaccination of aged mice with adjuvanted recombinant influenza nucleoprotein enhances protective immunity

scientific article published on 12 June 2020

Vaccination with heat-killed leishmania antigen or recombinant leishmanial protein and CpG oligodeoxynucleotides induces long-term memory CD4+ and CD8+ T cell responses and protection against leishmania major infection

scientific article

Vaccine Adjuvants a

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