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List of works by Henry Brem

A novel rat model for the study of intraosseous metastatic spine cancer

scientific article published on 01 March 2005

A safety and efficacy study of local delivery of interleukin-12 transgene by PPC polymer in a model of experimental glioma.

scientific article published in February 2008

A systematic review and meta-analysis of supratotal versus gross total resection for glioblastoma

scientific article published on 19 June 2020

ATPS-89LOCAL DELIVERY OF A SMALL-MOLECULE INHIBITOR OF HYPOXIA INDUCIBLE FACTOR-1: A NEW CANDIDATE DRUG FOR BRAIN TUMOR THERAPY.

scientific article

ATPS-90EFFICACY OF NON-VIRAL ENGINEERED ADIPOSE MESENCHYMAL STEM CELLS FOR BRAIN TUMOR THERAPY.

scientific article

Adult Cranioplasty Reconstruction With Customized Cranial Implants: Preferred Technique, Timing, and Biomaterials

scientific article published on 27 February 2018

Advancing the field of drug delivery: taking aim at cancer

scientific article published on November 2003

Agonist anti-GITR monoclonal antibody and stereotactic radiation induce immune-mediated survival advantage in murine intracranial glioma.

scientific article published on 17 May 2016

Agonist anti-GITR monoclonal antibody and stereotactic radiation induce immune-mediated survival advantage in murine intracranial glioma.

scientific article published on 4 November 2015

Anti-PD-1 antitumor immunity is enhanced by local and abrogated by systemic chemotherapy in GBM.

scientific article published in December 2016

Anti-PD-1 blockade and stereotactic radiation produce long-term survival in mice with intracranial gliomas

scientific article published on 22 February 2013

Association of preoperative depression and survival after resection of malignant brain astrocytoma

scientific article

Biodegradable wafers releasing Temozolomide and Carmustine for the treatment of brain cancer

scientific article published on 31 December 2018

Brain biocompatibility of a biodegradable controlled release polymer consisting of anhydride copolymer of fatty acid dimer and sebacic acid

scholarly article by Henry Brem et al published March 1992 in Journal of Controlled Release

Camptothecin analogs in malignant gliomas: comparative analysis and characterization

scientific article published on March 2003

Carmustine wafers (Gliadel) plus concomitant temozolomide therapy after resection of malignant astrocytoma: growing evidence for safety and efficacy

scientific article published in July 2010

Cationic Polysaccharides for Gene Delivery

article

Central Nervous System Cancers, Version 1.2015.

scientific article published on October 2015

Central nervous system cancers

scientific article

Central nervous system cancers: Clinical Practice Guidelines in Oncology

scientific article published in September 2005

Clinical course and pathologic findings after Gliadel and radiotherapy for newly diagnosed malignant glioma: implications for patient management.

scientific article published on January 2004

Combination Therapy with Anti-PD-1, Anti-TIM-3, and Focal Radiation Results in Regression of Murine Gliomas

scientific article published on 29 June 2016

Combination anti-CXCR4 and anti-PD-1 immunotherapy provides survival benefit in glioblastoma through immune cell modulation of tumor microenvironment

scientific article published on 25 April 2019

Combination of anti-VEGF therapy and temozolomide in two experimental human glioma models.

scientific article published on 2 November 2013

Combination of intracranial temozolomide with intracranial carmustine improves survival when compared with either treatment alone in a rodent glioma model

scientific article

Combination of paclitaxel thermal gel depot with temozolomide and radiotherapy significantly prolongs survival in an experimental rodent glioma model ⬇️

scientific article published on December 7, 2012

Comparison of Complications, Trends, and Costs in Endoscopic vs Microscopic Pituitary Surgery: Analysis From a US Health Claims Database

scientific article published on September 2017

Complications and death among elderly patients undergoing pituitary tumour surgery

scientific article published on 23 April 2010

Contrasting impact of corticosteroids on anti-PD-1 immunotherapy efficacy for tumor histologies located within or outside the central nervous system

scientific article published on 06 September 2018

Convection enhanced delivery of cisplatin-loaded brain penetrating nanoparticles cures malignant glioma in rats

scientific article published on 6 March 2017

Costs and Their Predictors in Transsphenoidal Pituitary Surgery

scientific article published on 01 November 2019

Deep venous thrombosis and pulmonary embolisms in adult patients undergoing craniotomy for brain tumors

scientific article published on 13 December 2012

Deferred Radiotherapy After Debulking of Non-functioning Pituitary Macroadenomas: Clinical Outcomes

Defining Glioblastoma Resectability Through the Wisdom of the Crowd: A Proof-of-Principle Study.

scientific article published on 4 August 2016

Delivery of local therapeutics to the brain: working toward advancing treatment for malignant gliomas

scientific article published on March 2015

Dendritic cell activation enhances anti-PD-1 mediated immunotherapy against glioblastoma.

scientific article published on 17 April 2018

Detection of circulating tumor DNA in early- and late-stage human malignancies

scientific article (publication date: 19 February 2014)

Detection of tumor-derived DNA in cerebrospinal fluid of patients with primary tumors of the brain and spinal cord

scientific article

Developing Therapies for Brain Tumors: The Impact of the Johns Hopkins Hunterian Neurosurgical Research Laboratory

scientific article published on January 2017

Dexamethasone mediated inhibition of local IL-2 immunotherapy is dose dependent in experimental brain tumors

scientific article

Discussion on: Usefulness of an Osteotomy Template for Skull Tumorectomy and Simultaneous Skull Reconstruction

scientific article published on 12 August 2016

Disparities in access to neuro-oncologic care in the United States

scientific article published in March 2010

Disulfiram and copper combination therapy targets NPL4, cancer stem cells and extends survival in a medulloblastoma model

scientific article published on 03 November 2021

Dural Reconstruction With Autologous Rectus Fascia: A New Technique for Addressing Large-Sized Defects During Cranioplasty

scientific article published on 01 March 2019

EAPH-07. CHILDREN’S BRAIN TUMOUR DRUG DELIVERY CONSORTIUM

ET-37EFFICACY OF INTRACRANIAL DELIVERY OF DICHLOROACETATE AND CARBOPLATIN VIA AN LCP POLYMER MICROCAPSULE DEVICE IN AN EXPERIMENTAL GLIOMA MODEL

scientific article published in November 2014

Ectopic recurrence of craniopharyngioma after an interhemispheric transcallosal approach: case report

scientific article

Effect of radiation therapy on overall survival following subtotal resection of adult pilocytic astrocytoma

scientific article published on 21 October 2020

Efficacy of local polymer-based and systemic delivery of the anti-glutamatergic agents riluzole and memantine in rat glioma models

scientific article

Emerging insights into barriers to effective brain tumor therapeutics

scientific article published on 21 July 2014

Epirubicin exhibits potent anti-tumor activity in an animal model of malignant glioma when administered via controlled-release polymers

scientific article

Erratum to: Agonist anti-GITR monoclonal antibody and stereotactic radiation induce immune-mediated survival advantage in murine intracranial glioma

scientific article published on 4 November 2016

Establishing percent resection and residual volume thresholds affecting survival and recurrence for patients with newly diagnosed intracranial glioblastoma

scientific article

Establishment and Biological Characterization of a Panel of Glioblastoma Multiforme (GBM) and GBM Variant Oncosphere Cell Lines

scientific article

Expression of LAG-3 and efficacy of combination treatment with anti-LAG-3 and anti-PD-1 monoclonal antibodies in glioblastoma

scientific article published on 24 September 2018

Extent of surgical resection is independently associated with survival in patients with hemispheric infiltrating low-grade gliomas

scientific article published on 01 October 2008

Extreme drug resistance in primary brain tumors: in vitro analysis of 64 resection specimens

scientific article published in June 2002

Factors associated with survival and recurrence for patients undergoing surgery of cerebellar metastases

scientific article

Factors associated with survival for patients with glioblastoma with poor pre-operative functional status.

scientific article published on 29 April 2013

Factors involved in maintaining prolonged functional independence following supratentorial glioblastoma resection. Clinical article

scientific article published on 04 June 2010

First In-Human Experience With Complete Integration of Neuromodulation Device Within a Customized Cranial Implant

scientific article

Focal radiation therapy combined with 4-1BB activation and CTLA-4 blockade yields long-term survival and a protective antigen-specific memory response in a murine glioma model

scientific article

Full-Thickness Skin Grafting for Local Defect Coverage Following Scalp Adjacent Tissue Transfer in the Setting of Cranioplasty

scientific article published on 01 January 2019

Gene therapy for experimental brain tumors using a xenogenic cell line engineered to secrete hIL-2.

scientific article published on August 2003

Gene therapy for malignant brain tumors

scientific article published on September 2003

Genome-wide investigation of intragenic DNA methylation identifies ZMIZ1 gene as a prognostic marker in glioblastoma and multiple cancer types

scientific article published on 09 August 2019

Geographic Variation in Costs of Transsphenoidal Pituitary Surgery in the United States

scientific article published on 04 March 2020

Gliadel (BCNU) wafer plus concomitant temozolomide therapy after primary resection of glioblastoma multiforme

scientific article

HIF-1α- Targeting Acriflavine Provides Long Term Survival and Radiological Tumor Response in Brain Cancer Therapy.

scientific article published on 2 November 2017

Highlights of Children with Cancer UK's Workshop on Drug Delivery in Paediatric Brain Tumours

scientific article published on 31 March 2016

Hypertonic saline ameliorates cerebral edema associated with experimental brain tumor

scientific article published in July 2002

IMPS-20COMBINATION THERAPY WITH ANTI-PD-1, ANTI-TIM-3, AND FOCAL RADIATION RESULTS IN REGRESSION OF MURINE GLIOMAS.

scientific article

IT-20OVEREXPRESSION OF IL13Ra2: ASSESSMENT OF PRO-AGGRESSIVE AND PRO-INVASIVE PHENOTYPES OF MALIGNANT GLIOMA IN A SYNGENEIC ANIMAL MODEL

scientific article published in November 2014

IT-21PD-1 BLOCKADE SHOWS SYNERGISTIC SURVIVAL, ANTI-TUMOR IMMUNE RESPONSE AND LONG-TERM MEMORY WITH INTERSTITIAL BUT NOT SYSTEMIC CHEMOTHERAPY: STUDY IN A MURINE GLIOBLASTOMA MODEL.

scientific article published in November 2014

Identifying better surgical candidates among recursive partitioning analysis class 2 patients who underwent surgery for intracranial metastases

scientific article

Immediate Single-Stage Cranioplasty Following Calvarial Resection for Benign and Malignant Skull Neoplasms Using Customized Craniofacial Implants

scientific article published on July 2015

Impact of COVID-19 on an Academic Neurosurgery Department: The Johns Hopkins Experience

scientific article published on 24 May 2020

Improving medical student recruitment to neurosurgery

scientific article published on 09 August 2019

In vitro drug response and molecular markers associated with drug resistance in malignant gliomas.

scientific article published in August 2006

In vivo delivery of BCNU from a MEMS device to a tumor model

scientific article published in August 2005

In vivo release from a drug delivery MEMS device

scientific article published in November 2004

Increased expression of glutamate transporter GLT-1 in peritumoral tissue associated with prolonged survival and decreases in tumor growth in a rat model of experimental malignant glioma

scientific article published on 2 August 2013

Independent association of extent of resection with survival in patients with malignant brain astrocytoma

scientific article

Inhibition of Corneal Neovascularization by Subconjunctival Injection of Fc-Endostatin, a Novel Inhibitor of Angiogenesis

scientific article published on 28 September 2015

Interstitial chemotherapy for malignant glioma: Future prospects in the era of multimodal therapy ⬇️

scientific article published on 13 February 2015

Interstitial chemotherapy for malignant gliomas: the Johns Hopkins experience

scientific article

Interstitial docetaxel (taxotere), carmustine and combined interstitial therapy: a novel treatment for experimental malignant glioma.

scientific article published on 25 April 2006

Intracavernous trigeminal ganglion amyloidoma: case report

scientific article

Intracranial microcapsule chemotherapy delivery for the localized treatment of rodent metastatic breast adenocarcinoma in the brain.

scientific article

Intraoperative Laser Speckle Contrast Imaging For Real-Time Visualization of Cerebral Blood Flow in Cerebrovascular Surgery: Results From Pre-Clinical Studies

scientific article published on 06 May 2020

Lactacystin exhibits potent anti-tumor activity in an animal model of malignant glioma when administered via controlled-release polymers

scientific article

Local controlled delivery of anti-neoplastic RNAse to the brain

scientific article

Local delivery of a synthetic endostatin fragment for the treatment of experimental gliomas

scientific article

Local delivery of angiogenesis-inhibitor minocycline combined with radiotherapy and oral temozolomide chemotherapy in 9L glioma

scientific article published on 20 December 2013

Local delivery of antineoplastic agents by controlled-release polymers for the treatment of malignant brain tumours

scientific article

Local delivery of antineoplastic agents using biodegradable polymers for the treatment of malignant brain tumors

scientific article published in July 2003

Local delivery of cancer-cell glycolytic inhibitors in high-grade glioma

scientific article published on 22 July 2014

Local delivery of doxorubicin for the treatment of malignant brain tumors in rats.

scientific article

Local delivery of interleukin-2 and adriamycin is synergistic in the treatment of experimental malignant glioma

scientific article published in September 2005

Local delivery of minocycline and systemic BCNU have synergistic activity in the treatment of intracranial glioma

scientific article published in September 2003

Local delivery of mitoxantrone for the treatment of malignant brain tumors in rats

scientific article published on November 2002

Local delivery of temozolomide by biodegradable polymers is superior to oral administration in a rodent glioma model

scientific article

Local immunotherapy with interleukin-2 delivered from biodegradable polymer microspheres combined with interstitial chemotherapy: a novel treatment for experimental malignant glioma

scientific article published in April 2003

Local intracerebral administration of Paclitaxel with the paclimer delivery system: toxicity study in a canine model

scientific article

Local treatment of malignant brain tumors using implantable chemotherapeutic polymers

scientific article

MGMT inactivation and clinical response in newly diagnosed GBM patients treated with Gliadel

scientific article published on 3 August 2015

Metastatic Atypical and Anaplastic Meningioma: A Case Series and Review of the Literature

scientific article published on 28 January 2017

Metformin inhibits growth of human glioblastoma cells and enhances therapeutic response

scientific article published on 13 April 2015

Microdialysis measurement of intratumoral temozolomide concentration after cediranib, a pan-VEGF receptor tyrosine kinase inhibitor, in a U87 glioma model.

scientific article

Multi-layered core-sheath fiber membranes for controlled drug release in the local treatment of brain tumor

scientific article published on 29 November 2019

Multi-pulse drug delivery from a resorbable polymeric microchip device

scientific article published in November 2003

Multiple resections for patients with glioblastoma: prolonging survival

scientific article published on 19 October 2012

NY-ESO-1 expression in meningioma suggests a rationale for new immunotherapeutic approaches.

scientific article

Nanobiotechnology-based delivery strategies: New frontiers in brain tumor targeted therapies

scientific article

Neuroplastic Surgery

scientific article published on 26 October 2017

New directions in the delivery of drugs and other substances to the central nervous system

scientific article published on January 1991

Non-virally engineered human adipose mesenchymal stem cells produce BMP4, target brain tumors, and extend survival

scientific article published on 21 May 2016

Nonviral polymeric nanoparticles for gene therapy in pediatric CNS malignancies

scientific article published on 23 October 2019

Novel therapeutics for brain tumors: current practice and future prospects

scientific article published on 01 January 2020

Optimizing the delivery of chemotherapy in the setting of immunotherapy in a preclinical glioblastoma model.

scientific article published on 4 November 2015

Outcome and Cost of Craniotomy Performed to Treat Tumors in Regional Academic Referral Centers ⬇️

scientific article published on May 1, 2003

Overall Survival in Malignant Glioma Is Significantly Prolonged by Neurosurgical Delivery of Etoposide and Temozolomide from a Thermo-Responsive Biodegradable Paste

scientific article published on 21 May 2019

Overall survival in an orthotopic GBM model is significantly prolonged by neurosurgical delivery of PLGA/PEG interstitial chemotherapy

scientific article published on 31 January 2018

P-selectin axis plays a key role in microglia immunophenotype and glioblastoma progression

scientific article published on 26 March 2021

PD-1+ Monocytes Mediate Cerebral Vasospasm Following Subarachnoid Hemorrhage

scientific article published on 28 December 2020

Paclitaxel: a review of adverse toxicities and novel delivery strategies.

scientific article published on September 2007

Patient-perceived long-term communication and swallow function following cerebellopontine angle surgery.

scientific article published on 26 June 2013

Patients undergoing surgery of intracranial metastases have different outcomes based on their primary pathology

scientific article

Persistent outpatient hyperglycemia is independently associated with survival, recurrence and malignant degeneration following surgery for hemispheric low grade gliomas.

scientific article published on 8 July 2009

Phase I trial of temozolomide plus O6-benzylguanine for patients with recurrent or progressive malignant glioma

scientific article

Pilocytic and pilomyxoid hypothalamic/chiasmatic astrocytomas

scientific article

Polilactofate microspheres for Paclitaxel delivery to central nervous system malignancies

scientific article published on August 2003

Polylactic acid (PLA) controlled delivery carriers for biomedical applications

scientific article

Polymer delivery of camptothecin against 9L gliosarcoma: release, distribution, and efficacy

scientific article

Polymeric nanoparticles for nonviral gene therapy extend brain tumor survival in vivo.

scientific article

Post-Neurosurgical Temporal Deformities: Various Techniques for Correction and Associated Complications

scientific article published on 01 October 2018

Predictors of Nonroutine Discharge Disposition Among Parasagittal/Parafalcine Meningioma Patients

scientific article published on 08 July 2020

Predictors of inpatient death and complications among postoperative elderly patients with metastatic brain tumors

scientific article published on 31 August 2010

Predictors of visual outcome following surgical resection of medial sphenoid wing meningiomas

scientific article published on October 2012

Preservation of glial cytoarchitecture from ex vivo human tumor and non-tumor cerebral cortical explants: A human model to study neurological diseases

scientific article published on 16 May 2007

Prognostic significance of contrast-enhancing anaplastic astrocytomas in adults

scientific article published in August 2010

Quantifying the utility of a multidisciplinary neuro-oncology tumor board

scientific article published on 18 September 2020

Radiosensitization of malignant gliomas following intracranial delivery of paclitaxel biodegradable polymer microspheres

scientific article

Recent advances in brain tumor therapy: local intracerebral drug delivery by polymers.

scientific article published on January 2004

Reduction of cerebrospinal fluid rhinorrhea after vestibular schwannoma surgery by reconstruction of the drilled porus acusticus with hydroxyapatite bone cement

scientific article published on 01 August 2007

Regression of intracranial meningioma following intratumoral hemorrhage

scientific article published on 26 June 2009

Repurposing the FDA-Approved Antiviral Drug Ribavirin as Targeted Therapy for Nasopharyngeal Carcinoma

scientific article published on 30 June 2020

Resorbable polymer microchips releasing BCNU inhibit tumor growth in the rat 9L flank model

scientific article published on 15 August 2007

Rhabdoid meningioma occurring in an unrelated resection cavity with leptomeningeal carcinomatosis. Case report

scientific article published on 01 February 2005

Ribavirin as a potential therapeutic for atypical teratoid/rhabdoid tumors

scientific article published on 3 January 2018

Risk Factors for Preoperative Seizures and Loss of Seizure Control in Patients Undergoing Surgery for Metastatic Brain Tumors

scientific article published on 13 May 2017

Risk of Complications in Primary Versus Revision-Type Cranioplasty

scientific article published on 01 March 2020

Risk of Developing Postoperative Deficits Based on Tumor Location after Surgical Resection of an Intracranial Meningioma

scientific article published on 17 July 2018

Risk of surgical site infection in 401 consecutive patients with glioblastoma with and without carmustine wafer implantation

scientific article

SC-17BMP4-SECRETING hAdMSCs ENGINEERED WITH NANOPARTICLES: A NON-VIRAL MSC-BASED THERAPY FOR GLIOBLASTOMA.

scientific article published in November 2014

SCDT-10. OVERALL SURVIVAL IN AN ORTHOTOPIC MALIGNANT GLIOMA MODEL IS SIGNIFICANTLY PROLONGED BY NEUROSURGICAL DELIVERY OF PLGA/PEG INTERSTITIAL CHEMOTHERAPY PASTE

SCDT-27. CHILDREN’S BRAIN TUMOUR DRUG DELIVERY CONSORTIUM ⬇️

SURG-24. OVERALL SURVIVAL IN A SYNGENEIC RODENT ORTHOTOPIC HIGH-GRADE GLIOMA MODEL IS SIGNIFICANTLY PROLONGED BY NEUROSURGICAL DELIVERY OF PLGA/PEG INTERSTITIAL CHEMOTHERAPY

scientific article published on 6 November 2017

Seizure control for patients undergoing meningioma surgery

scientific article published on 30 March 2012

Supratentorial glioblastoma multiforme: the role of surgical resection versus biopsy among older patients

scientific article

Surgical outcomes of craniocervial junction meningiomas: a series of 22 consecutive patients.

scientific article

Survival and recurrence for patients undergoing surgery of skull base intracranial metastases.

scientific article published on 03 April 2013

Synthesis, characterization, and self-assembly with plasmid DNA of a quaternary ammonium derivative of pectic galactan and its fluorescent labeling for bioimaging applications.

scientific article published on 10 May 2016

Systemic BCNU enhances the efficacy of local delivery of a topoisomerase I inhibitor against malignant glioma

scientific article published on 10 June 2004

Systemic Tolerance Mediated by Melanoma Brain Tumors Is Reversible by Radiotherapy and Vaccination

scientific article published on 21 October 2015

TIGIT and PD-1 dual checkpoint blockade enhances antitumor immunity and survival in GBM.

scientific article published on 24 May 2018

TR-09THE EFFECT OF REGADENOSON-INDUCED TRANSIENT DISRUPTION OF THE BLOOD BRAIN BARRIER ON TEMOZOLOMIDE DELIVERY TO RAT BRAIN PARENCHYMA.

scientific article published on 21 April 2015

TRTH-06. CHILDREN’S BRAIN TUMOUR DRUG DELIVERY CONSORTIUM.

scientific article

TRTH-21. GLIOMA SURVIVAL BENEFITS FROM NEUROSURGICAL DELIVERY OF PLGA/PEG INTERSTITIAL THERAPY.

scientific article published on 31 May 2017

Targeted Local Therapy for Management of Intracranial High-Grade Gliomas

scientific article published on 10 July 2018

Targeted therapy for brain tumours

scientific article published on June 2004

The 5-factor modified frailty index: an effective predictor of mortality in brain tumor patients

scientific article published on 14 August 2020

The Hunterian Neurosurgical Laboratory: The First 100 Years of Neurosurgical Research

The Johns Hopkins Hunterian Laboratory Philosophy: Mentoring Students in a Scientific Neurosurgical Research Laboratory.

scientific article

The Neuroplastic Surgery Fellowship Experience: Where Tradition Meets Innovation

scientific article published on 29 October 2020

The Relevance of Simpson Grade Resections in Modern Neurosurgical Treatment of World Health Organization Grade I, II, and III Meningiomas

scientific article published on 14 October 2017

The Use of Ribavirin as an Anticancer Therapeutic: Will It Go Viral?

scientific article published on 01 July 2019

The effect of regadenoson-induced transient disruption of the blood-brain barrier on temozolomide delivery to normal rat brain

scientific article published on December 2015

The efficacy of lapatinib and nilotinib in combination with radiation therapy in a model of NF2 associated peripheral schwannoma.

scientific article

The surgical bed after BCNU polymer wafer placement for recurrent glioma: serial assessment on CT and MR imaging.

scientific article published in May 2003

Translucent Customized Cranial Implants Made of Clear Polymethylmethacrylate: An Early Outcome Analysis of 55 Consecutive Cranioplasty Cases

scientific article published on 01 December 2020

Uniform brain tumor distribution and tumor associated macrophage targeting of systemically administered dendrimers.

scientific article

Use of Gliadel (BCNU) wafer in the surgical treatment of malignant glioma: a 10-year institutional experience

scientific article published on 18 July 2008

Vaccine strategies for glioblastoma: progress and future directions

scientific article published on February 2013

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