List of works - Kazuhito Tomizawa

A cautionary tale: the non-causal association between type 2 diabetes risk SNP, rs7756992, and levels of non-coding RNA, CDKAL1-v1

scientific article

A protein transduction method using oligo-arginine (3R) for the delivery of transcription factors into cell nuclei.

scientific article

Amphiphysin 1 is important for actin polymerization during phagocytosis

scientific article

Amphiphysin I and regulation of synaptic vesicle endocytosis

scientific article published on December 2009

Anks4b, a novel target of HNF4α protein, interacts with GRP78 protein and regulates endoplasmic reticulum stress-induced apoptosis in pancreatic β-cells

scientific journal article

CaM kinase I alpha-induced phosphorylation of Drp1 regulates mitochondrial morphology

scientific article published on August 2008

Calpain-calcineurin signaling in the pathogenesis of calcium-dependent disorder

scientific article published on June 2007

Cdk5rap1-mediated 2-methylthio modification of mitochondrial tRNAs governs protein translation and contributes to myopathy in mice and humans

scientific journal article

Cell-Penetrating Peptide as a Means of Directing the Differentiation of Induced-Pluripotent Stem Cells

scientific article

Cell-penetrating D-isomer peptides of p53 C-terminus: long-term inhibitory effect on the growth of bladder cancer.

scientific article

Ciliary transition zone activation of phosphorylated Tctex-1 controls ciliary resorption, S-phase entry and fate of neural progenitors

scientific article published on 13 March 2011

Combining poly-arginine with the hydrophobic counter-anion 4-(1-pyrenyl)-butyric acid for protein transduction in transdermal delivery

scientific article

Critical role of calpain-mediated cleavage of calcineurin in excitotoxic neurodegeneration.

scientific article published on 19 November 2003

Cyclin G2 promotes hypoxia-driven local invasion of glioblastoma by orchestrating cytoskeletal dynamics.

scientific article published in November 2013

Cyclin-dependent kinase 5 (Cdk5): a potential therapeutic target for the treatment of neurodegenerative diseases and diabetes mellitus

scientific article published on October 2007

Deficit of tRNA(Lys) modification by Cdkal1 causes the development of type 2 diabetes in mice

scientific journal article

Development of a bifunctional immunoliposome system for combined drug delivery and imaging in vivo

scientific article

Enhanced intracellular delivery using arginine-rich peptides by the addition of penetration accelerating sequences (Pas).

scientific article

Expression of a constitutively active calcineurin encoded by an intron-retaining mRNA in follicular keratinocytes

scientific article

Functional loss of Cdkal1, a novel tRNA modification enzyme, causes the development of type 2 diabetes

scientific article published on 08 September 2011

Generation of functional insulin-producing cells from mouse embryonic stem cells through 804G cell-derived extracellular matrix and protein transduction of transcription factors

scientific article

HDAC9 regulates the alternative lengthening of telomere (ALT) pathway via the formation of ALT-associated PML bodies

scientific article published on 7 November 2016

High oxygen condition facilitates the differentiation of mouse and human pluripotent stem cells into pancreatic progenitors and insulin-producing cells

scientific article published on 19 February 2014

Identification of eukaryotic and prokaryotic methylthiotransferase for biosynthesis of 2-methylthio-N6-threonylcarbamoyladenosine in tRNA

scientific journal article

Inactivation of TRPM7 kinase activity does not impair its channel function in mice

scientific article

Induction of autophagic cell death of glioma-initiating cells by cell-penetrating D-isomer peptides consisting of Pas and the p53 C-terminus.

scientific article

Lack of tRNA-i6A modification causes mitochondrial-like metabolic deficiency in S. pombe by limiting activity of cytosolic tRNATyr, not mito-tRNA.

scientific article published on 8 February 2016

Major Cdk5-dependent phosphorylation sites of amphiphysin 1 are implicated in the regulation of the membrane binding and endocytosis

scientific article

Mtu1-Mediated Thiouridine Formation of Mitochondrial tRNAs Is Required for Mitochondrial Translation and Is Involved in Reversible Infantile Liver Injury

scientific article

Oxytocin Protects against Stress-Induced Cell Death in Murine Pancreatic β-Cells

scientific article published on 4 May 2016

Oxytocin: a therapeutic target for mental disorders

scientific article published on 25 September 2012

Possible role of cortactin phosphorylation by protein kinase Cα in actin-bundle formation at growth cone

scientific article published on June 2015

Protein Therapy: in vivo protein transduction by polyarginine (11R) PTD and subcellular targeting delivery

scientific article

Protein therapy using heme-oxygenase-1 fused to a polyarginine transduction domain attenuates cerebral vasospasm after experimental subarachnoid hemorrhage

scientific article

Protein transduction method for cerebrovascular disorders

scientific article published on February 2009

Protein transduction therapy into cochleae via the round window niche in guinea pigs.

scientific article

Reactive sulfur species regulate tRNA methylthiolation and contribute to insulin secretion.

scientific article published on 27 August 2016

Regulation of mitochondrial dynamics and neurodegenerative diseases.

scientific article published on February 2011

Resistance to chemical carcinogenesis induction via a dampened inflammatory response in naked mole-rats

scientific article published on 30 March 2022

Stabilization of actin bundles by a dynamin 1/cortactin ring complex is necessary for growth cone filopodia.

scientific article

Theranostic protein targeting ErbB2 for bioluminescence imaging and therapy for cancer

scientific article

Transformation of eEF1Bδ into heat-shock response transcription factor by alternative splicing

scientific article

p53 protein transduction therapy: successful targeting and inhibition of the growth of the bladder cancer cells.

scientific article

tRNA modifications and islet function

scientific article published on 01 September 2018

List of works by Kazuhito Tomizawa

A cautionary tale: the non-causal association between type 2 diabetes risk SNP, rs7756992, and levels of non-coding RNA, CDKAL1-v1

A protein transduction method using oligo-arginine (3R) for the delivery of transcription factors into cell nuclei.

Amphiphysin 1 is important for actin polymerization during phagocytosis

Amphiphysin I and regulation of synaptic vesicle endocytosis

Anks4b, a novel target of HNF4α protein, interacts with GRP78 protein and regulates endoplasmic reticulum stress-induced apoptosis in pancreatic β-cells

CaM kinase I alpha-induced phosphorylation of Drp1 regulates mitochondrial morphology

Calpain-calcineurin signaling in the pathogenesis of calcium-dependent disorder

Cdk5rap1-mediated 2-methylthio modification of mitochondrial tRNAs governs protein translation and contributes to myopathy in mice and humans

Cell-Penetrating Peptide as a Means of Directing the Differentiation of Induced-Pluripotent Stem Cells

Cell-penetrating D-isomer peptides of p53 C-terminus: long-term inhibitory effect on the growth of bladder cancer.

Ciliary transition zone activation of phosphorylated Tctex-1 controls ciliary resorption, S-phase entry and fate of neural progenitors

Combining poly-arginine with the hydrophobic counter-anion 4-(1-pyrenyl)-butyric acid for protein transduction in transdermal delivery

Critical role of calpain-mediated cleavage of calcineurin in excitotoxic neurodegeneration.

Cyclin G2 promotes hypoxia-driven local invasion of glioblastoma by orchestrating cytoskeletal dynamics.

Cyclin-dependent kinase 5 (Cdk5): a potential therapeutic target for the treatment of neurodegenerative diseases and diabetes mellitus

Deficit of tRNA(Lys) modification by Cdkal1 causes the development of type 2 diabetes in mice

Development of a bifunctional immunoliposome system for combined drug delivery and imaging in vivo

Enhanced intracellular delivery using arginine-rich peptides by the addition of penetration accelerating sequences (Pas).

Expression of a constitutively active calcineurin encoded by an intron-retaining mRNA in follicular keratinocytes

Functional loss of Cdkal1, a novel tRNA modification enzyme, causes the development of type 2 diabetes

Generation of functional insulin-producing cells from mouse embryonic stem cells through 804G cell-derived extracellular matrix and protein transduction of transcription factors

HDAC9 regulates the alternative lengthening of telomere (ALT) pathway via the formation of ALT-associated PML bodies

High oxygen condition facilitates the differentiation of mouse and human pluripotent stem cells into pancreatic progenitors and insulin-producing cells

Identification of eukaryotic and prokaryotic methylthiotransferase for biosynthesis of 2-methylthio-N6-threonylcarbamoyladenosine in tRNA

Inactivation of TRPM7 kinase activity does not impair its channel function in mice

Induction of autophagic cell death of glioma-initiating cells by cell-penetrating D-isomer peptides consisting of Pas and the p53 C-terminus.

Lack of tRNA-i6A modification causes mitochondrial-like metabolic deficiency in S. pombe by limiting activity of cytosolic tRNATyr, not mito-tRNA.

Major Cdk5-dependent phosphorylation sites of amphiphysin 1 are implicated in the regulation of the membrane binding and endocytosis

Mtu1-Mediated Thiouridine Formation of Mitochondrial tRNAs Is Required for Mitochondrial Translation and Is Involved in Reversible Infantile Liver Injury

Oxytocin Protects against Stress-Induced Cell Death in Murine Pancreatic β-Cells

Oxytocin: a therapeutic target for mental disorders

Possible role of cortactin phosphorylation by protein kinase Cα in actin-bundle formation at growth cone

Protein Therapy: in vivo protein transduction by polyarginine (11R) PTD and subcellular targeting delivery

Protein therapy using heme-oxygenase-1 fused to a polyarginine transduction domain attenuates cerebral vasospasm after experimental subarachnoid hemorrhage

Protein transduction method for cerebrovascular disorders

Protein transduction therapy into cochleae via the round window niche in guinea pigs.

Reactive sulfur species regulate tRNA methylthiolation and contribute to insulin secretion.

Regulation of mitochondrial dynamics and neurodegenerative diseases.

Resistance to chemical carcinogenesis induction via a dampened inflammatory response in naked mole-rats

Stabilization of actin bundles by a dynamin 1/cortactin ring complex is necessary for growth cone filopodia.

Theranostic protein targeting ErbB2 for bioluminescence imaging and therapy for cancer

Transformation of eEF1Bδ into heat-shock response transcription factor by alternative splicing

p53 protein transduction therapy: successful targeting and inhibition of the growth of the bladder cancer cells.

tRNA modifications and islet function