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List of works by Edward J Pearce

14-3-3 proteins in Schistosoma mansoni; identification of a second epsilon isoform

scientific article

A bone morphogenetic protein homologue in the parasitic flatworm, Schistosoma mansoni

scientific article

A common framework of monocyte-derived macrophage activation

scientific article published on 15 April 2022

Acetate Promotes T Cell Effector Function during Glucose Restriction.

scientific article

Alternatively activated macrophage-derived RELM-{alpha} is a negative regulator of type 2 inflammation in the lung.

scientific article published on 06 April 2009

Alternatively activated macrophage-derived RELM-α is a negative regulator of type 2 inflammation in the lung

An essential role of Th1 responses and interferon gamma in infection-mediated suppression of neoplastic growth

scientific article published on November 2003

CD154 plays a central role in regulating dendritic cell activation during infections that induce Th1 or Th2 responses

scientific article published on 01 January 2003

CD25+CD4+ cells contribute to Th2 polarization during helminth infection by suppressing Th1 response development

scientific journal article

CD8 memory T cells have a bioenergetic advantage that underlies their rapid recall ability.

scientific article published on 12 August 2013

Cell death and reproductive regression in female Schistosoma mansoni

scientific article

Cell-intrinsic lysosomal lipolysis is essential for alternative activation of macrophages

scientific article

Cell-intrinsic metabolic regulation of mononuclear phagocyte activation: Findings from the tip of the iceberg

scientific article published on 03 April 2020

Central Role for Interleukin-4 in Regulating Nitric Oxide-Mediated Inhibition of T-Cell Proliferation and Gamma Interferon Production in Schistosomiasis ⬇️

scientific article published on January 1, 2002

Commitment to glycolysis sustains survival of NO-producing inflammatory dendritic cells.

scientific article

Conserved role for 14-3-3epsilon downstream of type I TGFbeta receptors

scientific article (publication date: 9 February 2001)

Cutting Edge: Th2 Response Induction by Dendritic Cells: A Role for CD40 ⬇️

scientific article published on January 15, 2002

Cutting edge: Helminth infection induces IgE in the absence of mu- or delta-chain expression

scientific article

Cutting edge: IPSE/alpha-1, a glycoprotein from Schistosoma mansoni eggs, induces IgE-dependent, antigen-independent IL-4 production by murine basophils in vivo

scientific article published on May 2007

Cutting edge: dendritic cells copulsed with microbial and helminth antigens undergo modified maturation, segregate the antigens to distinct intracellular compartments, and concurrently induce microbe-specific Th1 and helminth-specific Th2 responses

scientific article published in February 2004

Cutting edge: polarized Th cell response induction by transferred antigen-pulsed dendritic cells is dependent on IL-4 or IL-12 production by recipient cells

scientific article published on 01 April 2002

Dendritic cell metabolism

scientific article

Dendritic cell-intrinsic expression of NF-kappa B1 is required to promote optimal Th2 cell differentiation

scientific article published on 01 June 2005

Discovery of anthelmintic drug targets and drugs using chokepoints in nematode metabolic pathways

scientific article

Disrupting metabolism to treat autoimmunity

scientific article published in April 2018

Distinct sources and targets of IL-10 during dendritic cell-driven Th1 and Th2 responses in vivo.

scientific article published in September 2006

Dynamic Cardiolipin Synthesis Is Required for CD8<sup>+</sup> T Cell Immunity

scientific article published on 01 December 2020

Eukaryotic initiation factor 2 alpha subunit associates with TGF beta receptors and 14-3-3 epsilon and acts as a modulator of the TGF beta response

scientific article (publication date: 15 January 2002)

Fatty acid oxidation is essential for egg production by the parasitic flatworm Schistosoma mansoni

scientific article

For macrophages, Ndufs is enough

scientific article published on 01 September 2014

Functional Inactivation of Immature Dendritic Cells by the Intracellular Parasite Toxoplasma gondii

scientific article published on 01 August 2004

Functional dichotomy of dendritic cells following interaction with Leishmania braziliensis: infected cells produce high levels of TNF-alpha, whereas bystander dendritic cells are activated to promote T cell responses

scientific article

Functional plasticity in memory T helper cell responses

scientific article published in April 2007

GAM: a web-service for integrated transcriptional and metabolic network analysis.

scientific article published on 20 April 2016

Gata6 regulates aspartoacylase expression in resident peritoneal macrophages and controls their survival

scientific article

Gene-selective transcription promotes the inhibition of tissue reparative macrophages by TNF

scientific article published in April 2022

Genetic manipulation of schistosomes

scientific article published on 4 January 2007

Growth factors and chemotactic factors from parasitic helminths: molecular evidence for roles in host-parasite interactions versus parasite development

scientific article published on 30 March 2010

Helminth antigens modulate TLR-initiated dendritic cell activation

scientific article published on 01 December 2004

Helminth egg derivatives as proregenerative immunotherapies

scientific article published on 21 February 2023

Helminth infections: the great neglected tropical diseases

scientific article

Helminth-induced arginase-1 exacerbates lung inflammation and disease severity in tuberculosis

scientific article

Host-pathogen interactions: pas de deux

scientific article published on 16 August 2007

IL-10R blockade during chronic schistosomiasis mansoni results in the loss of B cells from the liver and the development of severe pulmonary disease.

scientific article

IL-27 signalling regulates glycolysis in Th1 cells to limit immunopathology during infection

scientific article published on 13 October 2020

IL-31-IL-31R interactions negatively regulate type 2 inflammation in the lung

scientific article

IL-33 expression in response to SARS-CoV-2 correlates with seropositivity in COVID-19 convalescent individuals

scholarly article by Michal A Stanczak published in 2021

IL-4-secreting secondary T follicular helper (Tfh) cells arise from memory T cells, not persisting Tfh cells, through a B cell-dependent mechanism.

scientific article published on 23 February 2015

Ikaros silences T-bet expression and interferon-gamma production during T helper 2 differentiation

scientific article

Immunology of parasitic helminth infections

scientific article

Immunometabolism governs dendritic cell and macrophage function

scientific article

Immunometabolism in 2017: Driving immunity: all roads lead to metabolism.

scientific article published on 11 December 2017

Impaired Th2 development and increased mortality during Schistosoma mansoni infection in the absence of CD40/CD154 interaction

scientific article published on 01 May 2002

Infection-Induced Transcriptional Changes in Hepatic Macrophage Metabolism Correlate With an Athero-Protective Phenotype

scientific article published on 12 November 2018

Inflammation by way of macrophage metabolism

scientific article published on 01 May 2017

Inflammatory macrophage dependence on NAD+ salvage is a consequence of reactive oxygen species-mediated DNA damage

scientific article published on 11 March 2019

Inhibition of mechanistic target of rapamycin promotes dendritic cell activation and enhances therapeutic autologous vaccination in mice.

scientific article published on 23 July 2012

Itaconate Links Inhibition of Succinate Dehydrogenase with Macrophage Metabolic Remodeling and Regulation of Inflammation

scientific article published on 28 June 2016

Klf4 expression in conventional dendritic cells is required for T helper 2 cell responses.

scientific article

Lack of C3 affects Th2 response development and the sequelae of chemotherapy in schistosomiasis

scientific article published in January 2003

Leptin Signaling Suppression in Macrophages Improves Immunometabolic Outcomes in Obesity

scientific article published in 2022

Long-term suppression of cathepsin B levels by RNA interference retards schistosome growth.

scientific article published in October 2005

Ly6Chi monocyte recruitment is responsible for Th2 associated host-protective macrophage accumulation in liver inflammation due to schistosomiasis

scientific article

MHC class II-dependent basophil-CD4+ T cell interactions promote T(H)2 cytokine-dependent immunity.

scientific article published on 24 May 2009

MZB1 enables efficient interferon α secretion in stimulated plasmacytoid dendritic cells

scientific article published on 14 December 2020

Macrophages acquire a TNF-dependent inflammatory memory in allergic asthma

scientific article published in 2022

Mechanistic target of rapamycin inhibition extends cellular lifespan in dendritic cells by preserving mitochondrial function.

scientific article

Memory CD4 T cells enhance primary CD8 T-cell responses

scientific article published on 16 April 2007

Memory CD8 T Cells Use Cell-Intrinsic Lipolysis to Support the Metabolic Programming Necessary for Development

article

Memory CD8(+) T cells use cell-intrinsic lipolysis to support the metabolic programming necessary for development.

scientific article

MenTORing Immunity: mTOR Signaling in the Development and Function of Tissue-Resident Immune Cells

scientific article

Metabolic Competition in the Tumor Microenvironment Is a Driver of Cancer Progression

scientific article published on 26 August 2015

Metabolic Pathways in Immune Cell Activation and Quiescence ⬇️

scientific article published on April 18, 2013

Metabolic Reprogramming Mediated by the mTORC2-IRF4 Signaling Axis Is Essential for Macrophage Alternative Activation

scientific article published on October 2016

Metabolic adaptations of tissue-resident immune cells

scientific article published on 18 June 2019

Metabolic conditioning of CD8+ effector T cells for adoptive cell therapy

scientific article published on 03 August 2020

Metabolic control of dendritic cell activation and function: recent advances and clinical implications

scientific article

Metabolic interventions in the immune response to cancer

scientific article published on 01 May 2019

Metabolic reprogramming of the immune response in the tumor microenvironment ⬇️

scientific article published on January 28, 2013

Metabolism and acetylation in innate immune cell function and fate

scientific article published on 27 October 2016

Microbiota-derived acetate enables the metabolic fitness of the brain innate immune system during health and disease

scientific article published in 2021

Migratory CD103+ dendritic cells suppress helminth-driven type 2 immunity through constitutive expression of IL-12

scientific article

Mitochondrial Dynamics Controls T Cell Fate through Metabolic Programming.

scientific article published on 8 June 2016

Mitochondrial Integrity Regulated by Lipid Metabolism Is a Cell-Intrinsic Checkpoint for Treg Suppressive Function

scientific article published on 26 December 2019

Mitochondrial Membrane Potential Regulates Nuclear Gene Expression in Macrophages Exposed to Prostaglandin E2

scientific article published on 01 December 2018

Mitochondrial Priming by CD28.

scientific article

Mitochondrial metabolism coordinates stage-specific repair processes in macrophages during wound healing

scientific article published in 2021

Mitochondrial respiratory capacity is a critical regulator of CD8+ T cell memory development

scientific article

Network integration of parallel metabolic and transcriptional data reveals metabolic modules that regulate macrophage polarization

scientific article

Osteopontin Expression Identifies a Subset of Recruited Macrophages Distinct from Kupffer Cells in the Fatty Liver

scientific article published on 26 August 2020

Persistent loss of IL-27 responsiveness in CD8+ memory T cells abrogates IL-10 expression in a recall response

scientific article

Pillars article: downregulation of Th1 cytokine production accompanies induction of Th2 responses by a parasitic helminth, Schistosoma mansoni. J. Exp. Med. 1991. 173: 159-166

scientific article published on August 1, 2012

Polyamine metabolism is a central determinant of helper T cell lineage fidelity

scientific article published in 2021

Polyamines and eIF5A Hypusination Modulate Mitochondrial Respiration and Macrophage Activation

scientific article published on 23 May 2019

Posttranscriptional control of T cell effector function by aerobic glycolysis

scientific article

Progress towards a vaccine for schistosomiasis ⬇️

scientific article published on May 1, 2003

Regulation and biological function of helminth-induced cytokine responses

article

Regulation of dendritic cell function by pathogen-derived molecules plays a key role in dictating the outcome of the adaptive immune response

scientific article

Regulation of pathogenesis and immunity in helminth infections

scientific article published on 21 September 2009

Regulation of the development of the hepatic B cell compartment during Schistosoma mansoni infection

scientific article published on 13 September 2013

Regulatory T cell responses develop in parallel to Th responses and control the magnitude and phenotype of the Th effector population

scientific article published on 01 May 2006

Resident T cells orchestrate adipose tissue remodeling in a site peripheral to infection

scientific article published on 26 February 2022

Review series on helminths, immune modulation and the hygiene hypothesis: mechanisms underlying helminth modulation of dendritic cell function

scientific article

Schistosoma mansoni egg antigen-mediated modulation of Toll-like receptor (TLR)-induced activation occurs independently of TLR2, TLR4, and MyD88

scientific article published on 29 September 2008

Schistosome-derived omega-1 drives Th2 polarization by suppressing protein synthesis following internalization by the mannose receptor

scientific article

Schistosomiasis delays lesion resolution during Leishmania major infection by impairing parasite killing by macrophages

scientific article

Shaping the immune response to parasites: role of dendritic cells

scientific article

SnapShot: Immunometabolism

scientific article published on July 2015

Special issue: Translatability of helminth therapy ⬇️

scientific article published on 01 March 2013

Suppression of Th2 cell development by Notch ligands Delta1 and Delta4

scientific article published on February 2008

Suppression of early IL-4 production underlies the failure of CD4 T cells activated by TLR-stimulated dendritic cells to differentiate into Th2 cells

scientific article published on 01 February 2007

Suppression of mRNAs encoding tegument tetraspanins from Schistosoma mansoni results in impaired tegument turnover

scientific article

T follicular helper cells differentiate from Th2 cells in response to helminth antigens

scientific article

TGF-beta signaling controls embryo development in the parasitic flatworm Schistosoma mansoni

scientific article

TLR ligands can activate dendritic cells to provide a MyD88-dependent negative signal for Th2 cell development

scientific article published in January 2005

TLR-driven early glycolytic reprogramming via the kinases TBK1-IKKɛ supports the anabolic demands of dendritic cell activation

scientific article

TPL-2 Regulates Macrophage Lipid Metabolism and M2 Differentiation to Control TH2-Mediated Immunopathology.

scientific article

Tegumental expression of a novel type II receptor serine/threonine kinase (SmRK2) in Schistosoma mansoni

scientific article published in August 2004

Th1 and Th2 cells help CD8 T-cell responses

scientific article published on 26 February 2007

Th2 cell hyporesponsiveness during chronic murine schistosomiasis is cell intrinsic and linked to GRAIL expression

scientific article published on 02 March 2009

Th2 cell hyporesponsiveness during chronic murine schistosomiasis is cell intrinsic and linked to GRAIL expression.

scientific article

Th2 differentiation is unaffected by Jagged2 expression on dendritic cells

scientific article published on June 2008

Th2 response polarization during infection with the helminth parasite Schistosoma mansoni

scientific article published in October 2004

Th2 responses in schistosomiasis.

scientific article

The Colonic Crypt Protects Stem Cells from Microbiota-Derived Metabolites

scientific article

The Colonic Crypt Protects Stem Cells from Microbiota-Derived Metabolites

scientific article published on 01 November 2016

The Transcriptional Repressor Polycomb Group Factor 6, PCGF6, Negatively Regulates Dendritic Cell Activation and Promotes Quiescence.

scientific article published on 3 August 2016

The cell identity of cytotoxic T lymphocytes.

scientific article

The immunobiology of schistosomiasis

scientific article

The metabolic control of schistosome egg production

scientific article published on 30 April 2015

Toll-like receptor-induced changes in glycolytic metabolism regulate dendritic cell activation

scientific article

Transfection of Schistosoma mansoni by electroporation and the description of a new promoter sequence for transgene expression

scientific article published on 18 March 2007

Transforming growth factor-beta and insulin-like signalling pathways in parasitic helminths

scientific article

Transgene expression in Schistosoma mansoni: introduction of RNA into schistosomula by electroporation

scientific article published on 01 September 2004

Transgenesis in the parasitic nematode Strongyloides ratti.

scientific article

Transposon-mediated chromosomal integration of transgenes in the parasitic nematode Strongyloides ratti and establishment of stable transgenic lines

scientific article

Treg Cells Survive and Thrive in Inhospitable Environments

scientific article published on 01 June 2017

Triacylglycerol synthesis enhances macrophage inflammatory function

scientific article published on 14 August 2020

Type 1 Interferons Induce Changes in Core Metabolism that Are Critical for Immune Function

scientific article published on June 2016

Uncoupling of induced protein processing from maturation in dendritic cells exposed to a highly antigenic preparation from a helminth parasite

scientific article published on December 2008

Worms tame mast cells

scientific article published on 01 November 2007

piggyBac transposon mediated transgenesis of the human blood fluke, Schistosoma mansoni

scientific article

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