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List of works by Gregory J Gores

"Will all liver transplantation patients eventually die from cancer?".

scientific article

232 Mixed Lineage Kinase 3 Mediates the Release of Proinflammatory Extracellular Vesicles in Nonalcoholic Steatohepatitis

453Association of Clostridium difficile Infection (CDI) with Excess Mortality after Liver Transplantation (LT) for Hilar Cholangiocarcinoma (CCA).

scientific article published in December 2014

459 Hedgehog Signaling Antagonist GDC-0449 Reverses Inflammation and Fibrosis in a Diet-Induced Mouse Model of Nonalcoholic Steatohepatitis (NASH)

A Bax-mediated mechanism for obatoclax-induced apoptosis of cholangiocarcinoma cells

scientific article

A Comparison of Routine Cytology and Fluorescence in situ Hybridization for the Detection of Malignant Bile Duct Strictures

article

A Hippo and Fibroblast Growth Factor Receptor Autocrine Pathway in Cholangiocarcinoma

scientific article published on 29 January 2016

A Klothoβ Variant Mediates Protein Stability and Associates With Colon Transit in Irritable Bowel Syndrome With Diarrhea

scientific article published on March 9, 2011

A Positive TGF-β/c-KIT Feedback Loop Drives Tumor Progression in Advanced Primary Liver Cancer

scientific article published on June 2016

A conceptual proposal for staging ductal cholangiocarcinoma

scientific article

A global view of hepatocellular carcinoma: trends, risk, prevention and management

scientific article published on 22 August 2019

A hedgehog survival pathway in 'undead' lipotoxic hepatocytes.

scientific article published on 26 May 2012

A longitudinal study of whole body, tissue, and cellular physiology in a mouse model of fibrosing NASH with high fidelity to the human condition.

scientific article published on 23 February 2017

A multivariable model using advanced cytologic methods for the evaluation of indeterminate pancreatobiliary strictures

scientific article published on 14 February 2009

A new TRAIL to therapy of hepatocellular carcinoma: blocking the proteasome

scientific article published on 01 September 2005

A new clinically based staging system for perihilar cholangiocarcinoma

scientific article

A novel endoscopic approach to brachytherapy in the management of Hilar cholangiocarcinoma

scientific article

A novel, minimally invasive technique for management of peristomal varices.

scientific article

A pilot study of the safety and tolerability of etanercept in patients with alcoholic hepatitis

scientific article published in February 2004

A prospective comparison of digital image analysis and routine cytology for the identification of malignancy in biliary tract strictures

scientific article published on March 2004

A randomized, double-blinded, placebo-controlled multicenter trial of etanercept in the treatment of alcoholic hepatitis

scientific article published on 13 September 2008

A role for miR-296 in the regulation of lipoapoptosis by targeting PUMA

scientific article

A smac mimetic reduces TNF related apoptosis inducing ligand (TRAIL)-induced invasion and metastasis of cholangiocarcinoma cells

scientific article

A spotlight on cholangiocarcinoma

scientific article published on November 1, 2003

A strategic vision to promote advances in biliary tract disorders

scientific article published on May 2008

A stunning year for advances in biliary tract disease

scientific article published on May 1, 2011

AIP1: a new player in TNF signaling

scientific article

Academic gastroenterology and hepatology: training tracts and competencies

scientific article published on 01 May 2010

Acetaminophen knocks on death's door and receptor interacting protein 1 kinase answers

scientific article published on 6 August 2015

Activated stellate cells express the TRAIL receptor-2/death receptor-5 and undergo TRAIL-mediated apoptosis.

scientific article published on January 2003

Acute Alcoholic Hepatitis: Natural History and Predictors of Mortality Using a Multicenter Prospective Study

scientific article published on 28 April 2017

Addressing unmet clinical needs: FISHing for bile duct cancer

scientific article published on 01 October 2014

Adequacy of endoscopic ultrasound core needle biopsy specimen of nonmalignant hepatic parenchymal disease

scientific article published on 26 July 2008

Advanced cytologic techniques for the detection of malignant pancreatobiliary strictures

scientific article published on 16 August 2006

Advances in cholangiocarcinoma research: report from the third Cholangiocarcinoma Foundation Annual Conference

scientific article published on December 2016

Advances in the diagnosis of cholangiocarcinoma in patients with primary sclerosing cholangitis

scientific article published on 01 November 2006

Alcohol stimulates macrophage activation through caspase-dependent hepatocyte derived release of CD40L containing extracellular vesicles.

scientific article published on 26 November 2015

Alcoholic Hepatitis: Current Challenges and Future Directions

scientific article published on June 28, 2013

American Association for the Study of Liver Diseases endpoints conference: design and endpoints for clinical trials in primary biliary cirrhosis

scientific article published on 01 July 2010

An Open Label, Dose Escalation Study To Assess The Safety And Efficacy Of IL-22 Agonist F-652 In Patients With Alcoholic Hepatitis

scientific article published on 27 November 2019

An Optimized Set of Fluorescence In Situ Hybridization Probes for Detection of Pancreatobiliary Tract Cancer in Cytology Brush Samples.

scientific article published on 28 August 2015

An apoptosis biomarker goes to the HCV clinic

scientific article published on 01 November 2004

Animal Models of Nonalcoholic Steatohepatitis: Eat, Delete, and Inflame

scientific article

Animal models of cholangiocarcinoma

scientific article published on 5 April 2018

Anti-GP2 IgA: a biomarker for disease severity and/or cholangiocarcinoma in primary sclerosing cholangitis?

scientific article published on September 2016

Apoptosis and Necrosis in the Liver

scientific article published on April 1, 2013

Apoptosis and cellular activation in the pathogenesis of acute vascular rejection

scientific article published on 01 December 2002

Apoptosis and hepatic necroinflammation

scientific article published on June 1, 2008

Apoptosis and necrosis in the liver: a tale of two deaths?

scientific article

Apoptosis as a Mechanism for Liver Disease Progression

scientific article published on October 19, 2010

Apoptosis in alcoholic and nonalcoholic steatohepatitis

scientific article

Apoptosis in cancer: cause and cure

Apoptosis: the nexus of liver injury and fibrosis.

scientific article published on February 2004

Apoptotic body engulfment by a human stellate cell line is profibrogenic.

scientific article published on May 2003

Apoptotic cell death and function of cryopreserved porcine hepatocytes in a bioartificial liver.

scientific article

Apotopes and the biliary specificity of primary biliary cirrhosis

scientific article

Augmented Curation of Unstructured Clinical Notes from a Massive EHR System Reveals Specific Phenotypic Signature of Impending COVID-19 Diagnosis

scientific article published on 23 April 2020

Authors' response to the letter: Liver resection for patients with hepatocellular carcinoma and macrovascular invasion, multiple tumours or portal hypertension by Zhong et al.

scientific article published on 13 October 2014

Awareness of tract seeding with endoscopic ultrasound tissue acquisition in perihilar cholangiocarcinoma

scientific article published on January 2015

BH3-only protein mimetic obatoclax sensitizes cholangiocarcinoma cells to Apo2L/TRAIL-induced apoptosis

scientific article

Ballooned hepatocytes, undead cells, sonic hedgehog, and vitamin E: therapeutic implications for nonalcoholic steatohepatitis

scientific article

Bax inhibition protects against free fatty acid-induced lysosomal permeabilization

scientific article

Bid is upstream of lysosome-mediated caspase 2 activation in tumor necrosis factor alpha-induced hepatocyte apoptosis

scientific article published on July 2005

Bile acid regulation of hepatic physiology: IV. Bile acids and death receptors

scientific article

Bile acids activate EGF receptor via a TGF-alpha-dependent mechanism in human cholangiocyte cell lines

scientific article published on 26 February 2003

Bile acids induce cyclooxygenase-2 expression via the epidermal growth factor receptor in a human cholangiocarcinoma cell line

scientific article published on April 2002

Bile acids inhibit Mcl-1 protein turnover via an epidermal growth factor receptor/Raf-1-dependent mechanism

scientific article published in November 2002

Bile acids stimulate cFLIP phosphorylation enhancing TRAIL-mediated apoptosis

scientific article published on 28 October 2002

Bile acids up-regulate death receptor 5/TRAIL-receptor 2 expression via a c-Jun N-terminal kinase-dependent pathway involving Sp1.

scientific article published on 14 October 2003

Biliary apotopes and anti-mitochondrial antibodies activate innate immune responses in primary biliary cirrhosis

scientific article

Biliary multifocal chromosomal polysomy and cholangiocarcinoma in primary sclerosing cholangitis

scientific article

Biliary repair and carcinogenesis are mediated by IL-33-dependent cholangiocyte proliferation

scientific article

Biliary tract cancer patient-derived xenografts: Surgeon impact on individualized medicine

scientific article published on 16 January 2020

Biliary tract cancers in Olmsted County, Minnesota, 1976-2008.

scientific article published on 3 July 2012

Biliary tract instillation of a SMAC mimetic induces TRAIL-dependent acute sclerosing cholangitis-like injury in mice

scientific article published on 5 January 2017

Building a staircase to precision medicine for biliary tract cancer

scientific article published on 01 September 2015

CHOP and AP-1 cooperatively mediate PUMA expression during lipoapoptosis

scientific article

COX-2 inhibits Fas-mediated apoptosis in cholangiocarcinoma cells

scientific article published on March 2002

Calpains can do it alone: implications for cancer therapy.

scientific article published in March 2003

Cancer surveillance in patients with primary sclerosing cholangitis

scientific article

Cancer therapy: back to metabolism

scientific article

Caspase induction by IgA antimitochondrial antibody: IgA-mediated biliary injury in primary biliary cirrhosis

scientific article published on May 2004

Caspase inhibitors for the treatment of hepatitis C.

scientific article published on August 2009

Caspase-8, death-receptor signaling, and hepatocarcinogenesis: the Fas and the furious

scientific article published on 01 November 2005

Cathepsin B inactivation attenuates hepatic injury and fibrosis during cholestasis

scientific article published on July 2003

Caveolin-1 can regulate vascular smooth muscle cell fate by switching platelet-derived growth factor signaling from a proliferative to an apoptotic pathway

scientific article published on 19 June 2003

Cell stress gives a red light to the mitochondrial cell death pathway

scientific article published on 19 February 2008

Cellular and molecular mechanisms of liver injury

scientific article published on May 2008

Cellular inhibitor of apoptosis (cIAP)-mediated ubiquitination of phosphofurin acidic cluster sorting protein 2 (PACS-2) negatively regulates tumor necrosis factor-related apoptosis-inducing ligand (TRAIL) cytotoxicity

scientific article (publication date: 2014)

Cellular inhibitor of apoptosis 1 (cIAP-1) degradation by caspase 8 during TNF-related apoptosis-inducing ligand (TRAIL)-induced apoptosis

scientific article published on 14 October 2010

Changes in Liver Stiffness, Measured by Magnetic Resonance Elastography, Associated With Hepatic Decompensation in Patients With Primary Sclerosing Cholangitis

scientific article published on 01 November 2019

Cheating death in the liver

scientific article

Cholangiocarcinoma

scientific article

Cholangiocarcinoma

scientific article published on 01 February 2008

Cholangiocarcinoma

scientific article published on 01 May 2005

Cholangiocarcinoma - evolving concepts and therapeutic strategies

scientific article published on 10 October 2017

Cholangiocarcinoma 2020: the next horizon in mechanisms and management

scientific article published on 30 June 2020

Cholangiocarcinoma: Current concepts and insights

scientific article published on May 1, 2003

Cholangiocarcinoma: advances in pathogenesis, diagnosis, and treatment

scientific article published on July 2008

Cholangiocarcinoma: is transplantation an option? For whom?

scientific article published on 25 July 2007

Cholangiocarcinoma: modern advances in understanding a deadly old disease

scientific article

Cholangiocarcinoma: molecular pathways and therapeutic opportunities

scientific article

Cholangiocarcinoma: preventing invasion as anti-cancer strategy

scientific article published on 01 May 2003

Cholangiocarcinomas can originate from hepatocytes in mice

scientific article published on July 17, 2012

Cholangiocyte pathobiology.

scientific article

Cholangioscopy Biopsies Improve Detection of Cholangiocarcinoma When Combined with Cytology and FISH, but Not in Patients with PSC

scientific article published on 30 September 2019

Cholestasis increases tumor necrosis factor-related apoptotis-inducing ligand (TRAIL)-R2/DR5 expression and sensitizes the liver to TRAIL-mediated cytotoxicity

scientific article published on November 2002

Cholestatic hepatocellular injury: what do we know and how should we proceed

scientific article published in March 2005

Classification, Diagnosis, and Management of Cholangiocarcinoma

scientific article published on September 13, 2012

Clinical diagnosis and staging of cholangiocarcinoma

scientific article

Clinicopathological correlates of aspartyl (asparaginyl) beta-hydroxylase over-expression in cholangiocarcinoma

scientific article published on 01 January 2004

Combination of gemcitabine and cisplatin for biliary tract cancer: A platform to build on

scientific article published on October 29, 2010

Commentary: Gastroenterology and hepatology: an evolving marriage, not an imminent divorce

scientific article published on 01 January 2009

Comparison of KRAS mutation analysis and FISH for detecting pancreatobiliary tract cancer in cytology specimens collected during endoscopic retrograde cholangiopancreatography

scientific article

Comparison of methods to detect neoplasia in patients undergoing endoscopic ultrasound-guided fine-needle aspiration

scientific article published on 7 February 2012

Complete lysosomal disruption: A route to necrosis, not to the inflammasome

scientific article published on June 11, 2013

Constitutive androstane receptor (CAR) ligand, TCPOBOP, attenuates Fas-induced murine liver injury by altering Bcl-2 proteins

scientific article published in July 2006

Correlating routine cytology, quantitative nuclear morphometry by digital image analysis, and genetic alterations by fluorescence in situ hybridization to assess the sensitivity of cytology for detecting pancreatobiliary tract malignancy

scientific article

Current diagnostic and management options in perihilar cholangiocarcinoma

scientific article

Current status of liver transplantation for hilar cholangiocarcinoma

scientific article

DNMT1 and DNMT3b silencing sensitizes human hepatoma cells to TRAIL-mediated apoptosis via up-regulation of TRAIL-R2/DR5 and caspase-8.

scientific article published on 13 March 2010

Death Receptor 5 Signaling Promotes Hepatocyte Lipoapoptosis

scientific article published on September 22, 2011

Death Receptor-Mediated Cell Death and Proinflammatory Signaling in Nonalcoholic Steatohepatitis

scientific article

Death receptor 5 internalization is required for lysosomal permeabilization by TRAIL in malignant liver cell lines.

scientific article published on 9 March 2009

Death receptor-mediated apoptosis and the liver

scientific article

Death receptor-mediated liver injury

scientific article published on November 2007

Deaths on the liver transplant waiting list: an analysis of competing risks

scientific article published on 01 February 2006

Decade in review-hepatocellular carcinoma: HCC-subtypes, stratification and sorafenib

scientific article

Decreasing mitochondrial fission prevents cholestatic liver injury

scientific article

Degradation of cIAPs contributes to hepatocyte lipoapoptosis

scientific article published on 5 September 2013

Deleted in breast cancer-1 regulates SIRT1 activity and contributes to high-fat diet-induced liver steatosis in mice

scientific article

Design and endpoints of clinical trials in hepatocellular carcinoma.

scientific article published on 13 May 2008

Desmoplastic stroma and cholangiocarcinoma: clinical implications and therapeutic targeting

scientific article published on 09 April 2014

Development and characterization of cholangioids from normal and diseased human cholangiocytes as an in vitro model to study primary sclerosing cholangitis

scientific article published on 11 September 2017

Diagnosis and management of primary sclerosing cholangitis

scientific article published in February 2010

Diagnosis and staging of hepatocellular carcinoma

scientific article published in November 2004

Diagnosis, Staging, and Treatment of Cholangiocarcinoma

scientific article published on April 2003

Diet Mimicking "Fast Food" Causes Structural Changes to the Retina Relevant to Age-Related Macular Degeneration

scientific article published on 02 December 2019

Diet associated hepatic steatosis sensitizes to Fas mediated liver injury in mice

scientific article published on December 2003

Differences between early and late posttransplant lymphoproliferative disorders in solid organ transplant patients: are they two different diseases?

scientific article published on 01 January 2005

Differential requirement for de novo lipogenesis in cholangiocarcinoma and hepatocellular carcinoma of mice and humans.

scientific article published on 22 February 2016

Direct acting antiviral therapy and tumor recurrence after liver transplantation for hepatitis C-associated hepatocellular carcinoma.

scientific article

Does Cirrhosis Associated with Well Controlled Viral Hepatitis Confer a Risk for Extrahepatic Cancer?

scientific article

Drop-out rates of patients with hepatocellular cancer listed for liver transplantation: outcome with chemoembolization

scientific article published on 01 March 2004

EUS-guided FNA of regional lymph nodes in patients with unresectable hilar cholangiocarcinoma

scientific article published on 03 December 2007

Early hepatic stellate cell activation predicts severe hepatitis C recurrence after liver transplantation

scientific article published in October 2005

Effect of local anesthetic on neuronal cytoplasmic calcium and plasma membrane lysis (necrosis) in a cell culture model

scientific article published in December 2002

Efficacy and safety of transarterial radioembolization versus chemoembolization in patients with hepatocellular carcinoma.

scientific article published on 24 October 2012

Efficacy of neoadjuvant chemoradiation, followed by liver transplantation, for perihilar cholangiocarcinoma at 12 US centers

scientific article published on 12 April 2012

Emerging Technologies for the Diagnosis of Perihilar Cholangiocarcinoma

scientific article published on 01 May 2018

Emerging drugs for hepatocellular carcinoma.

scientific article published on September 2006

Emerging molecular therapeutic targets for cholangiocarcinoma

scientific article published on 4 April 2017

Emerging pharmacologic therapies for primary sclerosing cholangitis

scientific article published on 2 March 2017

Endoscopic ultrasound staging of cholangiocarcinoma

scientific article published on May 2012

Endoscopically inserted nasobiliary catheters for high dose-rate brachytherapy as part of neoadjuvant therapy for perihilar cholangiocarcinoma

scientific article published on 11 May 2015

Enhanced epidermal growth factor receptor activation in human cholangiocarcinoma cells

scientific article

Epidemiology, risk factors, and outcomes of infections in patients undergoing liver transplantation for hilar cholangiocarcinoma.

scientific article published on 2 June 2017

Epigenetics in the Primary Biliary Cholangitis and Primary Sclerosing Cholangitis

scientific article published on 31 May 2017

Epithelial cell specificity and apotope recognition by serum autoantibodies in primary biliary cirrhosis

scientific article

Erratum: Corrigendum: Diabetes Mellitus Heightens the Risk of Hepatocellular Carcinoma Except in Patients With Hepatitis C Cirrhosis

scientific article published on 01 February 2017

Excellent quality of life after liver transplantation for patients with perihilar cholangiocarcinoma who have undergone neoadjuvant chemoradiation.

scientific article

Exome sequencing identifies frequent inactivating mutations in BAP1, ARID1A and PBRM1 in intrahepatic cholangiocarcinomas

scientific article

Extracellular vesicles in liver pathobiology: Small particles with big impact.

scientific article published on 15 September 2016

Factors predicting initial career choices in gastroenterology fellows

scientific article published on May 2007

Fas enhances fibrogenesis in the bile duct ligated mouse: a link between apoptosis and fibrosis.

scientific article published on October 2002

Fast food diet mouse: novel small animal model of NASH with ballooning, progressive fibrosis, and high physiological fidelity to the human condition

scientific article published on August 11, 2011

Fibroblast Growth Factor Receptor Inhibition for Cholangiocarcinoma: Looking Through a Door Half-Opened

scientific article published on 07 November 2018

Fibroblast Growth Factor Receptor Inhibition induces loss of matrix MCL1 and necrosis in Cholangiocarcinoma

scientific article published on 2 February 2018

Fibroblast growth factor receptor 2 fusions as a target for treating cholangiocarcinoma

scientific article

Fibroblast growth factor receptor 2 translocations in intrahepatic cholangiocarcinoma

scientific article

Free fatty acids induce JNK-dependent hepatocyte lipoapoptosis

scientific article published on 27 February 2006

Free fatty acids promote hepatic lipotoxicity by stimulating TNF-alpha expression via a lysosomal pathway

scientific article published in July 2004

Free fatty acids sensitise hepatocytes to TRAIL mediated cytotoxicity

scientific article published on 30 April 2007

Frequency, clinical presentation, and outcomes of drug-induced liver injury after liver transplantation.

scientific article

Future trends in hepatology: challenges and opportunities

scientific article published on 01 August 2008

Glycogen synthase kinase-3 (GSK-3) inhibition attenuates hepatocyte lipoapoptosis

scientific article published on November 23, 2010

Good News-Bad News: Current Status of GI Cancers

scientific article published on 20 May 2016

Guidelines for the diagnosis and management of intrahepatic cholangiocarcinoma

scientific article published on 27 March 2014

Hedgehog inhibition promotes a switch from Type II to Type I cell death receptor signaling in cancer cells

scientific article

Hepatic adenomatosis in a young woman with glucose intolerance

scientific article published in September 2006

Hepatic stellate cells and fibrosis progression in patients with nonalcoholic fatty liver disease

scientific article published on 01 April 2005

Hepatic stellate cells: Partners in crime for liver metastases?

scientific article published on August 1, 2011

Hepatitis B virus enhances tumor necrosis factor-related apoptosis-inducing ligand (TRAIL) cytotoxicity by increasing TRAIL-R1/death receptor 4 expression

scientific article published in September 2003

Hepatitis C-related hepatocellular carcinoma in the United States: influence of ethnic status.

scientific article

Hepatocellular Carcinoma

Hepatocellular Carcinoma Is the Most Common Indication for Liver Transplantation and Placement on the Waitlist in the United States

scientific article published on 21 December 2016

Hepatocellular Carcinoma: Consensus Recommendations of the National Cancer Institute Clinical Trials Planning Meeting

scientific article published on August 2, 2010

Hepatocellular carcinoma

Hepatocellular carcinoma in the setting of liver transplantation

article

Hepatocellular carcinoma: gardening strategies and bridges to transplantation

scientific article published on 01 February 2003

Hepatocellular carcinoma: molecular pathways and new therapeutic targets.

scientific article

Hepatocyte Death: A Clear and Present Danger

scientific article published on July 1, 2010

Hepatocyte Lethal and Nonlethal Lipotoxic Injury

Hepatocyte apoptosis and fas expression are prominent features of human nonalcoholic steatohepatitis

scientific article published on 01 August 2003

Hepatocyte apoptosis is tumor promoting in murine nonalcoholic steatohepatitis

scientific article published on 03 February 2020

Hepatocyte-specific NEMO deletion promotes NK/NKT cell- and TRAIL-dependent liver damage

scientific article published on 27 July 2009

Hepatology: a home for hepatocellular cancer publications

scientific article published on July 2009

High cell surface death receptor expression determines type I versus type II signaling

scientific article

Hypoxia stimulates proliferation of human hepatoma cells through the induction of hexokinase II expression.

scientific article published on March 2005

IL-33 facilitates oncogene-induced cholangiocarcinoma in mice by an interleukin-6-sensitive mechanism

scientific article published on 20 March 2015

IQGAP1 promotes CXCR4 chemokine receptor function and trafficking via EEA-1+ endosomes

scientific article published in July 2015

Imatinib mesylate (STI-571), a c-Abl kinase inhibitor, indirectly blocks receptor tyrosine kinase activation and induces apoptosis in a human cholangiocarcinoma cell line

Imatinib mesylate induces apoptosis in human cholangiocarcinoma cells

scientific article

Immunobiology of cholangiocarcinoma

scientific article published on 10 July 2019

Impact of Surveillance for Hepatocellular Carcinoma on Survival in Patients with Compensated Cirrhosis.

scientific article published on 12 October 2017

Impact of country of birth on age at the time of diagnosis of hepatocellular carcinoma in the United States

scientific article published on 29 August 2016

Impact of multiple transarterial chemoembolization treatments on hepatocellular carcinoma for patients awaiting liver transplantation

scientific article published in February 2015

Implications of CA19-9 elevation for survival, staging, and treatment sequencing in intrahepatic cholangiocarcinoma: A national cohort analysis.

scientific article published on 20 July 2016

Improved Performance of Serum Alpha-Fetoprotein for Hepatocellular Carcinoma Diagnosis in HCV Cirrhosis with Normal Alanine Transaminase

scientific article

In primary sclerosing cholangitis, gallbladder polyps are frequently malignant

scientific article

Increased expression of cyclooxygenase-2 in human pancreatic neoplasms and potential for chemoprevention by cyclooxygenase inhibitors

scientific article published on 01 March 2002

Inducible nitric oxide synthase up-regulates Notch-1 in mouse cholangiocytes: implications for carcinogenesis

scientific article

Inducible nitric oxide synthase upregulates cyclooxygenase-2 in mouse cholangiocytes promoting cell growth

scientific article published on 19 February 2004

Induction of intrahepatic cholangiocellular carcinoma by liver-specific disruption of Smad4 and Pten in mice

scientific article

Inheriting a Jewel: A Thrilling Challenge

scientific article published on 12 February 2016

Interleukin 6 upregulates myeloid cell leukemia-1 expression through a STAT3 pathway in cholangiocarcinoma cells

scientific article published on December 2005

Interleukin-6 contributes to Mcl-1 up-regulation and TRAIL resistance via an Akt-signaling pathway in cholangiocarcinoma cells

scientific article published in June 2005

Isocitrate dehydrogenase 1 and 2 mutations in cholangiocarcinoma

scientific article published on 12 April 2012

JNK1-dependent PUMA expression contributes to hepatocyte lipoapoptosis

scientific article published on 28 July 2009

Keratin, fas, and cryptogenic liver failure

scientific article published on 01 December 2002

Kupffer cell engulfment of apoptotic bodies stimulates death ligand and cytokine expression

scientific article published on 01 November 2003

Lack of gp130 expression results in more bacterial infection and higher mortality during chronic cholestasis in mice

scientific article published on 01 November 2005

Life and death by death receptors

scientific article published on 13 January 2009

Lipid-Induced Signaling Causes Release of Inflammatory Extracellular Vesicles From Hepatocytes.

scientific article published on 4 January 2016

Lipoapoptosis induced by saturated free fatty acids stimulates monocyte migration: a novel role for Pannexin1 in liver cells

scientific article

Lipotoxic lethal and sublethal stress signaling in hepatocytes: relevance to NASH pathogenesis.

scientific article published on 5 April 2016

Liver Matrix in Benign and Malignant Biliary Tract Disease

scientific article published on 11 March 2020

Liver cancer: Approaching a personalized care

scientific article published in April 2015

Liver capsule: Cholangiocarcinoma (CCA).

scientific article

Liver graft protection by antiapoptotic drugs: a step further

scientific article published on 01 March 2007

Liver transplantation for cholangiocarcinoma

scientific article published on 20 May 2010

Liver transplantation for cholangiocarcinoma

scientific article published on 01 November 2015

Liver transplantation for gastroenteropancreatic neuroendocrine cancers: Defining selection criteria to improve survival

scientific article published on 01 March 2006

Liver transplantation for intrahepatic cholangiocarcinoma--Authors' reply

scientific article published in The Lancet

Liver transplantation for perihilar cholangiocarcinoma

scientific article published on 17 June 2013

Liver transplantation for perihilar cholangiocarcinoma after aggressive neoadjuvant therapy: a new paradigm for liver and biliary malignancies?

scientific article published on September 2006

Liver transplantation for unresectable perihilar cholangiocarcinoma

scientific article

Liver transplantation with neoadjuvant chemoradiation is more effective than resection for hilar cholangiocarcinoma

scientific article published on 01 September 2005

Living Donor Liver Transplantation for Perihilar Cholangiocarcinoma: Outcomes and Complications

scientific article published on 06 February 2020

Long-term outcomes of positive fluorescence in situ hybridization tests in primary sclerosing cholangitis

scientific article

Long-term probability of and mortality from de novo malignancy after liver transplantation

scientific article published on 18 September 2009

Lumican, an extracellular matrix proteoglycan, is a novel requisite for hepatic fibrosis

scientific article published on September 24, 2012

Lysosomes in cell death

scientific article published on April 2004

Macrophages contribute to the pathogenesis of sclerosing cholangitis in mice

scientific article published on 24 May 2018

Matrix metalloproteinase inhibitor, CTS-1027, attenuates liver injury and fibrosis in the bile duct-ligated mouse.

scientific article

Mcl-1 degradation during hepatocyte lipoapoptosis

scientific article published on 05 September 2009

Mcl-1 mediates tumor necrosis factor-related apoptosis-inducing ligand resistance in human cholangiocarcinoma cells.

scientific article published on May 2004

Mechanisms and clinical implications of hepatocyte lipoapoptosis

scientific article

Mechanisms of Lipotoxicity in NAFLD and Clinical Implications

scientific article published on August 1, 2011

Mechanisms of Liver Injury: An Overview

scientific article published on September 1, 2003

Mechanisms of hepatotoxicity

scientific article (publication date: February 2002)

Mechanisms of lysophosphatidylcholine-induced hepatocyte lipoapoptosis

scientific article

Mesothelin as a Potential Therapeutic Target in Human Cholangiocarcinoma

scientific article published on October 1, 2010

Metformin does not improve survival in patients with hepatocellular carcinoma.

scientific article

Metformin requires 4E-BPs to induce apoptosis and repress translation of Mcl-1 in hepatocellular carcinoma cells

scientific article published on 18 July 2016

MicroRNA down-regulated in human cholangiocarcinoma control cell cycle through multiple targets involved in the G1/S checkpoint.

scientific article published on December 2011

MicroRNA-21 is overexpressed in human cholangiocarcinoma and regulates programmed cell death 4 and tissue inhibitor of metalloproteinase 3.

scientific article

MicroRNAs: key modulators of posttranscriptional gene expression.

scientific article published on 03 December 2008

Mitochondrial injury and caspase activation by the local anesthetic lidocaine

scientific article

Mixed lineage kinase 3 deficient mice are protected against the high fat high carbohydrate diet-induced steatohepatitis.

scientific article

Mixed lineage kinase 3 mediates release of C-X-C motif ligand 10-bearing chemotactic extracellular vesicles from lipotoxic hepatocytes

scientific article published on 25 September 2015

Mo1368 A Targeted Multicolor FISH Probe Set Increases the Diagnostic Sensitivity for Detecting Malignancy in Pancreatobiliary Brushings

Mo1469 Fibroblast Growth Factor Receptor (FGFR) Signaling Activation Culminates in a Mcl-1 Regulated Tumor Survival Pathway in CC

Model for end-stage liver disease (MELD) exception for bacterial cholangitis

scientific article published on 01 December 2006

Model for end-stage liver disease (MELD) exception for cholangiocarcinoma or biliary dysplasia

scientific article published on 01 December 2006

Model to estimate survival in ambulatory patients with hepatocellular carcinoma.

scientific article published on 2 July 2012

Molecular Profiling and Research of Therapeutic Targets

scientific article published on 6 July 2015

Molecular mechanisms of lipotoxicity in nonalcoholic fatty liver disease

scientific article published on 27 October 2008

Molecular pathogenesis of cholangiocarcinoma

scientific article

Molecular profiling of cholangiocarcinoma shows potential for targeted therapy treatment decisions

scientific article published on February 4, 2013

Mortality and hospital utilization for hepatocellular carcinoma in the United States

scientific article published in August 2005

Myofibroblast-derived PDGF-BB promotes Hedgehog survival signaling in cholangiocarcinoma cells

scientific article

Neoadjuvant therapy and liver transplantation for hilar cholangiocarcinoma: is pretreatment pathological confirmation of diagnosis necessary?

scientific article published on 22 May 2012

Neuroimaging in hepatic encephalopathy

scientific article

New staging system and a registry for perihilar cholangiocarcinoma

scientific article published on April 1, 2011

Nitric oxide (NO) inhibits apoptosis in cholangiocarcinoma cells by blocking caspase 9 activation

Nitric oxide inhibits apoptosis downstream of cytochrome C release by nitrosylating caspase 9

scientific article published on 01 March 2002

Nitric oxide promotes caspase-independent hepatic stellate cell apoptosis through the generation of reactive oxygen species

scientific article published on June 2008

Non-alcoholic steatohepatitis pathogenesis: sublethal hepatocyte injury as a driver of liver inflammation

scientific article published on 24 January 2018

Non-canonical Hedgehog signaling contributes to chemotaxis in cholangiocarcinoma

scientific article published on 14 November 2013

Notch-driven carcinogenesis: The merging of hepatocellular cancer and cholangiocarcinoma into a common molecular liver cancer subtype

scientific article published on January 23, 2013

Noxa mediates hepatic stellate cell apoptosis by proteasome inhibition.

scientific article

Octreotide therapy for advanced hepatocellular carcinoma

scientific article

Open access journals: why are we not there yet? (!)

scientific article published on October 26, 2010

Our new president--Nicholas F. LaRusso, MD.

scientific article published in May 2007

Outcome of Transplant-fallout Patients With Unresectable Cholangiocarcinoma

scientific article published on 11 June 2014

Overexpression of mcl-1 attenuates liver injury and fibrosis in the bile duct-ligated mouse.

scientific article

Oxysterols induce cyclooxygenase-2 expression in cholangiocytes: implications for biliary tract carcinogenesis

scientific article published on March 2004

PPAR agonists for primary biliary cholangitis

scientific article published on 14 August 2017

Palmitoleate attenuates palmitate-induced Bim and PUMA up-regulation and hepatocyte lipoapoptosis

scientific article

Pathobiology of biliary epithelia and cholangiocarcinoma: proceedings of the Henry M. and Lillian Stratton Basic Research Single-Topic Conference

scientific article published on December 2008

Pathogenesis of primary sclerosing cholangitis and advances in diagnosis and management

scientific article

Pathogenesis, diagnosis, and management of cholangiocarcinoma

scientific article

Paving the TRAIL to anti-fibrotic therapy

scientific article published on 29 February 2016

Performance of magnetic resonance elastography in primary sclerosing cholangitis

scientific article

Piercing the armor of hepatobiliary cancer: Bcl-2 homology domain 3 (BH3) mimetics and cell death.

scientific article published on September 2007

Pilot study to assess patient outcomes following endoscopic application of photodynamic therapy for advanced cholangiocarcinoma

scientific article

Placenta-derived CD95 ligand causes liver damage in hemolysis, elevated liver enzymes, and low platelet count syndrome

scientific article published in March 2004

Platelet-derived growth factor primes cancer-associated fibroblasts for apoptosis.

scientific article

Platelet-derived growth factor regulates YAP transcriptional activity via Src family kinase dependent tyrosine phosphorylation.

scientific article

Polo-like kinase 2 is a mediator of hedgehog survival signaling in cholangiocarcinoma.

scientific article published on 06 August 2013

Portal vein encasement predicts neoadjuvant therapy response in liver transplantation for perihilar cholangiocarcinoma protocol

scientific article published on 16 July 2015

Positron emission tomography scan for a hepatic mass

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Predictors of disease recurrence following neoadjuvant chemoradiotherapy and liver transplantation for unresectable perihilar cholangiocarcinoma

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Predictors of pretransplant dropout and posttransplant recurrence in patients with perihilar cholangiocarcinoma

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Predisposed to toxins: association of gallbladder cancer with N-acetyl transferase SNPs

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Preliminary experience comparing routine cytology results with the composite results of digital image analysis and fluorescence in situ hybridization in patients undergoing EUS-guided FNA.

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Preliminary experience with liver transplantation in selected patients with unresectable hilar cholangiocarcinoma

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Presentation of the Julius M. Friedenwald Medal to Nicholas F. LaRusso, MD.

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Pretransplant Psychiatric and Substance Use Comorbidity in Patients with Cholangiocarcinoma Who Received a Liver Transplant

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Primary Sclerosing Cholangitis Patients With Serial Polysomy Fluorescence In Situ Hybridization Results Are at Increased Risk of Cholangiocarcinoma

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Primary Sclerosing Cholangitis Risk Estimate Tool (PREsTo) Predicts Outcomes of the Disease: A Derivation and Validation Study Using Machine Learning

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Primary Sclerosing Cholangitis as a Premalignant Biliary Tract Disease: Surveillance and Management

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Primary Sclerosing Cholangitis: What the Gastroenterologist and Hepatologist Needs to Know

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Primary sclerosing cholangitis and cholangiocarcinoma

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Primary sclerosing cholangitis with equivocal cytology: fluorescence in situ hybridization and serum CA 19-9 predict risk of malignancy.

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Primary sclerosing cholangitis: summary of a workshop

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Proapoptotic signaling induced by deletion of receptor-interacting kinase 1 and TNF receptor-associated factor 2 results in liver carcinogenesis

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Prognostic Significance of the Histologic Response of Perihilar Cholangiocarcinoma to Preoperative Neoadjuvant Chemoradiation in Liver Explants

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Prospective evaluation of advanced molecular markers and imaging techniques in patients with indeterminate bile duct strictures

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Proteasome inhibition attenuates hepatic injury in the bile duct-ligated mouse

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Proteasome inhibition induces hepatic stellate cell apoptosis

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Proteasome inhibition-induces endoplasmic reticulum dysfunction and cell death of human cholangiocarcinoma cells

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Re: Design and Endpoints of Clinical Trials in Hepatocellular Carcinoma

Real-world effectiveness of Ad26.COV2.S adenoviral vector vaccine for COVID-19

Recent Trends in the Epidemiology of Hepatocellular Carcinoma in Olmsted County, Minnesota: A US Population-based Study.

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Recommendations for liver transplantation for hepatocellular carcinoma: an international consensus conference report

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Recurrent hepatocellular carcinoma: it's the virus!

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Regenerative Medicine Build-Out

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Regenerative medicine blueprint

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Reply

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Report of the Multisociety Task Force on GI training

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Report of the Multisociety Task Force on GI training

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Report of the multisociety task force on GI training

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Risk Factors for Intrahepatic Cholangiocarcinoma: Association Between Metformin Use and Reduced Cancer Risk

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Role for Krüppel-like transcription factor 11 in mesenchymal cell function and fibrosis

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SOX17 regulates cholangiocyte differentiation and acts as a tumor suppressor in cholangiocarcinoma.

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Sa1704 Myofibroblast Derived Extracellular Vesicles Induce Migration in Human Cholangiocarcinoma Cells via Fibroblast Growth Factor Receptor Signaling

Selected Patients with Unresectable Perihilar Cholangiocarcinoma (pCCA) Derive Long-Term Benefit from Liver Transplantation

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Selectively targeting Mcl-1 for the treatment of acute myelogenous leukemia and solid tumors

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Serine 64 phosphorylation enhances the antiapoptotic function of Mcl-1.

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Serum extracellular vesicles contain protein biomarkers for primary sclerosing cholangitis and cholangiocarcinoma.

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Silencing of miR-370 in human cholangiocarcinoma by allelic loss and interleukin-6 induced maternal to paternal epigenotype switch

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Sorafenib for HCC: a pragmatic perspective

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Sorafenib inhibits signal transducer and activator of transcription-3 signaling in cholangiocarcinoma cells by activating the phosphatase shatterproof 2.

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Steatohepatitis and apoptosis: therapeutic implications

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Strategies for hepatocellular carcinoma therapy and diagnostics: lessons learned from high throughput and profiling approaches.

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Surgical resection versus transplantation for early hepatocellular carcinoma: clues for the best strategy

Surrogate endpoints for clinical trials in primary sclerosing cholangitis: Review and results from an International PSC Study Group consensus process

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Surveillance for Cholangiocarcinoma in Patients with Primary Sclerosing Cholangitis: Effective and Justified?

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Sustained IL-6/STAT-3 signaling in cholangiocarcinoma cells due to SOCS-3 epigenetic silencing

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Synthetic Smac/DIABLO peptides enhance the effects of chemotherapeutic agents by binding XIAP and cIAP1 in situ

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Systemic therapies for intrahepatic cholangiocarcinoma

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T cell targeting and phagocytosis of apoptotic biliary epithelial cells in primary biliary cirrhosis

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TNF-alpha-mediated lysosomal permeabilization is FAN and caspase 8/Bid dependent

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TRAIL Deletion Prevents Liver, but Not Adipose Tissue, Inflammation during Murine Diet-Induced Obesity

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TRAIL Receptor Deficiency Promotes the Ductular Reaction, Macrophage Accumulation and Hepatic Fibrosis in the Mdr2-/- Mouse

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TRAIL mediates liver injury by the innate immune system in the bile duct-ligated mouse

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TRAIL receptor deletion in mice suppresses the inflammation of nutrient excess

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Targeted Apoptosis Of Ductular Reactive Cells Reduces Hepatic Fibrosis In A Mouse Model of Cholestasis

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Targeted use of siRNA in animal models of hepatic damage: an innovative therapy for acute liver failure

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Targeting IL-6 in cholangiocarcinoma therapy

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Targeting PDGFR-β in Cholangiocarcinoma

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Targeting cholangiocarcinoma

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Targeting senescent cholangiocytes and activated fibroblasts with B-cell lymphoma-extra large inhibitors ameliorates fibrosis in multidrug resistance 2 gene knockout (Mdr2-/- ) mice.

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Targeting tumor stroma: exploiting apoptotic priming

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The Caspase Inhibitor IDN-6556 Attenuates Hepatic Injury and Fibrosis in the Bile Duct Ligated Mouse

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The Two Faces of Relaxin in Cancer: Antitumor or Protumor?

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The anti-apoptotic protein Mcl-1 inhibits mitochondrial Ca2+ signals

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The caspase inhibitor IDN-6556 prevents caspase activation and apoptosis in sinusoidal endothelial cells during liver preservation injury

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The circulating microbiome signature and inferred functional metagenomics in alcoholic hepatitis.

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The emergence of a new discipline, hepatobiliary oncology

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The human immunodeficiency virus type 1 tat protein enhances Cryptosporidium parvum-induced apoptosis in cholangiocytes via a Fas ligand-dependent mechanism

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The liver's dance with death: two Bcl-2 guardian proteins from the abyss

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The lysosomal-mitochondrial axis in free fatty acid-induced hepatic lipotoxicity

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The mTOR pathway in hepatic malignancies

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The pan-caspase inhibitor Emricasan (IDN-6556) decreases liver injury and fibrosis in a murine model of non-alcoholic steatohepatitis

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The role of Mcl-1 downregulation in the proapoptotic activity of the multikinase inhibitor BAY 43-9006.

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The transcription factor ETS1 promotes apoptosis resistance of senescent cholangiocytes by epigenetically up-regulating the apoptosis suppressor BCL2L1

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The utility of Lens culinaris agglutinin-reactive alpha-fetoprotein in the diagnosis of hepatocellular carcinoma: evaluation in a United States referral population

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The value of serum CA 19-9 in predicting cholangiocarcinomas in patients with primary sclerosing cholangitis

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Therapeutic effects of deleting cancer-associated fibroblasts in cholangiocarcinoma

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Therapeutic opportunities for alcoholic steatohepatitis and nonalcoholic steatohepatitis: exploiting similarities and differences in pathogenesis

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Therapeutic targeting of bile acids

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Trail induces cell migration and invasion in apoptosis-resistant cholangiocarcinoma cells

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Trains, tracks, and promotion in an academic medical center

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Trans-peritoneal fine needle aspiration biopsy of hilar cholangiocarcinoma is associated with disease dissemination

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Transcriptional regulation of Bim by FoxO3A mediates hepatocyte lipoapoptosis

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Transforming the practice of medicine through team science

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Translation to Practice: Accelerating the Cycle of Innovation to Impact

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Transplantation for cholangiocarcinoma: when and for whom?

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Transplantation for hilar cholangiocarcinoma

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Treatment endpoints for advanced cholangiocarcinoma

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Treatment of hepatocellular carcinoma

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Treatment options for hepatobiliary and pancreatic cancer

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Triple modality testing by endoscopic retrograde cholangiopancreatography for the diagnosis of cholangiocarcinoma

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Tumor Necrosis Factor-related Apoptosis-inducing Ligand (TRAIL) Protein-induced Lysosomal Translocation of Proapoptotic Effectors Is Mediated by Phosphofurin Acidic Cluster Sorting Protein-2 (PACS-2)

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Tumor necrosis factor-alpha-associated lysosomal permeabilization is cathepsin B dependent

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Tumor necrosis factor-related apoptosis-inducing ligand activates a lysosomal pathway of apoptosis that is regulated by Bcl-2 proteins

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Tumor seeding complicating radiofrequency ablation of hepatocellular carcinoma

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Tumor-specific marker genes for intrahepatic cholangiocarcinoma: utility and mechanistic insight

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Unshackling caspase-7 for cancer therapy

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Ursodeoxycholic acid cytoprotection: dancing with death receptors and survival pathways

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Value of determining carbohydrate-deficient transferrin isoforms in the diagnosis of alcoholic liver disease

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Vascular complications after orthotopic liver transplantation after neoadjuvant therapy for hilar cholangiocarcinoma

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Vismodegib suppresses TRAIL-mediated liver injury in a mouse model of nonalcoholic steatohepatitis.

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What surgeons should know about viral hepatitis and hepatocellular carcinoma

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Who pulls the trigger: JNK activation in liver lipotoxicity?

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YAP Tyrosine Phosphorylation and Nuclear Localization in Cholangiocarcinoma Cells Are Regulated by LCK and Independent of LATS Activity

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YAP and the Hippo pathway in cholangiocarcinoma.

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YAP-associated chromosomal instability and cholangiocarcinoma in mice.

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Yes, hepatocellular cancer does occur in primary biliary cirrhosis

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cFLIP-L inhibits p38 MAPK activation: an additional anti-apoptotic mechanism in bile acid-mediated apoptosis

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cFLIPL prevents TRAIL-induced apoptosis of hepatocellular carcinoma cells by inhibiting the lysosomal pathway of apoptosis

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cHCC-CCA: Consensus terminology for primary liver carcinomas with both hepatocytic and cholangiocytic differentation.

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miRNA in liver pathobiology, diagnosis, and therapy

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p16INK4a promoter mutations are frequent in primary sclerosing cholangitis (PSC) and PSC-associated cholangiocarcinoma

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“Pardon the Interruption”: Comments on the International Liver Cancer Association Fourth Annual Conference, 2010. Is There Really No Role for Liver Biopsy Interpretation in Liver Cancer? σ

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