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List of works by Atsushi Iwama

3‐Deazaneplanocin A is a promising therapeutic agent for the eradication of tumor‐initiating hepatocellular carcinoma cells ⬇️

scientific article published on August 20, 2011

A New Conditionally Immortalized Human Fetal Brain Pericyte Cell Line: Establishment and Functional Characterization as a Promising Tool for Human Brain Pericyte Studies.

scientific article published on 11 November 2017

A novel zinc finger protein Zfp277 mediates transcriptional repression of the Ink4a/arf locus through polycomb repressive complex 1

scientific journal article

Aging and Clonal Behavior of Hematopoietic Stem Cells

scientific article published in 2022

Aging and leukemic evolution of hematopoietic stem cells under various stress conditions

scientific article published on 05 November 2020

Aging of spermatogonial stem cells by Jnk-mediated glycolysis activation

scientific article published on 29 July 2019

Akt inhibition synergizes with polycomb repressive complex 2 inhibition in the treatment of multiple myeloma

scientific article published on 22 October 2019

Aldehyde dehydrogenase 1 is associated with recurrence‐free survival but not stem cell‐like properties in hepatocellular carcinoma ⬇️

scientific article published on May 14, 2012

An interlaboratory comparison of dosimetry for a multi-institutional radiobiological research project: Observations, problems, solutions and lessons learned

scientific article

Antiproliferative action of metformin in human lung cancer cell lines ⬇️

scientific article published on April 18, 2012

Author Correction: Lineage-specific RUNX2 super-enhancer activates MYC and promotes the development of blastic plasmacytoid dendritic cell neoplasm

scientific article published on 28 August 2019

Bcor insufficiency promotes initiation and progression of myelodysplastic syndrome

scientific article published on 18 September 2018

Biological features and biomarkers in hepatocellular carcinoma

scientific article

Bmal1 regulates inflammatory responses in macrophages by modulating enhancer RNA transcription

scientific article published on August 2017

Bmi1 confers resistance to oxidative stress on hematopoietic stem cells

scientific article

Bmi1 cooperates with Dnmt1-associated protein 1 in gene silencing

scientific article published on 29 December 2006

Bmi1 counteracts hematopoietic stem cell aging by repressing target genes and enforcing the stem cell gene signature

scientific article published on 01 November 2019

Bmi1 promotes hepatic stem cell expansion and tumorigenicity in both Ink4a/Arf-dependent and -independent manners in mice.

scientific article

Bmi1 regulates memory CD4 T cell survival via repression of the Noxa gene

scientific journal article

Bmi1 restricts the adipogenic differentiation of bone marrow stromal cells to maintain the integrity of the hematopoietic stem cell niche

scientific article published on 11 August 2019

CD244 expression represents functional decline of murine hematopoietic stem cells after culture

Cancer stem cells in hepatocellular carcinoma: Recent progress and perspective

scientific article published on 22 May 2009

Cancer stem cells in hepatocellular carcinoma: Therapeutic implications based on stem cell biology

scientific article published on 29 June 2015

Circulating cancer stem cells: a novel prognostic predictor of hepatocellular carcinoma

scientific article published on February 2013

Circulating soluble LR11/SorLA levels are highly increased and ameliorated by chemotherapy in acute leukemias ⬇️

scientific article published on June 29, 2012

Clonal hematopoiesis with JAK2V617F promotes pulmonary hypertension with ALK1 upregulation in lung neutrophils

scientific article published on 26 October 2021

Compromised hematopoiesis and increased DNA damage following non-lethal ionizing radiation of a human hematopoietic system reconstituted in immunodeficient mice

scientific article published on 25 October 2012

Compromised hematopoiesis and increased DNA damage following non-lethal ionizing radiation of a human hematopoietic system reconstituted in immunodeficient mice

scientific article published on 08 June 2015

Concurrent loss of Ezh2 and Tet2 cooperates in the pathogenesis of myelodysplastic disorders

scientific article published on 11 November 2013

Consequence of the loss of Sox2 in the developing brain of the mouse

scientific article

Cytokine signaling, lipid raft clustering, and HSC hibernation

scientific article published on 18 April 2007

Cytokine signals modulated via lipid rafts mimic niche signals and induce hibernation in hematopoietic stem cells

scientific article published on 20 July 2006

DHODH inhibition synergizes with DNA-demethylating agents in the treatment of myelodysplastic syndromes

scientific article published on 01 January 2021

Dependency on the polycomb gene Ezh2 distinguishes fetal from adult hematopoietic stem cells.

scientific article

Depletion of Dnmt1-associated protein 1 triggers DNA damage and compromises the proliferative capacity of hematopoietic stem cells

scientific article published on 14 April 2010

Depletion of Sf3b1 impairs proliferative capacity of hematopoietic stem cells but is not sufficient to induce myelodysplasia

scientific article published on 15 April 2014

Deregulated Polycomb functions in myeloproliferative neoplasms

scientific article published on 31 January 2019

Deregulated polycomb complex function in the pathogenesis of MDS.

scientific article published on January 2017

Differential impact of Ink4a and Arf on hematopoietic stem cells and their bone marrow microenvironment in Bmi1-deficient mice

scientific article published on 5 September 2006

Diploid, not polyploid: new platelet producers

scientific article published on 01 October 2014

Direct activation of STAT5 by ETV6-LYN fusion protein promotes induction of myeloproliferative neoplasm with myelofibrosis.

scientific article

Distinct expression of polycomb group proteins EZH2 and BMI1 in hepatocellular carcinoma

scientific article published on 22 April 2009

Disulfiram eradicates tumor-initiating hepatocellular carcinoma cells in ROS-p38 MAPK pathway-dependent and -independent manners

scientific article published on 13 January 2014

Dmap1 plays an essential role in the maintenance of genome integrity through the DNA repair process.

scientific article

Downregulation of rRNA transcription triggers cell differentiation

scientific article

Drug resistance originating from a TGF-β/FGF-2-driven epithelial-to-mesenchymal transition and its reversion in human lung adenocarcinoma cell lines harboring an EGFR mutation

scientific article published on 4 March 2016

Dual Inhibition of EZH2 and EZH1 Sensitizes PRC2-Dependent Tumors to Proteasome Inhibition

scientific article published on 10 May 2017

Effect of metformin on residual cells after chemotherapy in a human lung adenocarcinoma cell line

scientific article published on 03 October 2013

Efficacy of the Novel Tubulin Polymerization Inhibitor PTC-028 for Myelodysplastic Syndrome

scientific article published on 09 October 2020

Emerging role of noncanonical polycomb repressive complexes in normal and malignant hematopoiesis

scientific article published on 26 October 2018

Endomucin, a CD34-like sialomucin, marks hematopoietic stem cells throughout development

scientific article published on 28 November 2005

Enhanced self-renewal capability in hepatic stem/progenitor cells drives cancer initiation

scientific article published on 20 June 2007

Enhanced self-renewal of hematopoietic stem cells mediated by the polycomb gene product Bmi-1

scientific article published on 01 December 2004

Epigenetic dysregulation in hematological malignancies

scientific article published on 7 November 2016

Epigenetic regulation of hematopoiesis

scientific article published on 29 September 2012

Epigenetic regulation of hematopoietic stem cell self-renewal by polycomb group genes.

scientific article

Epigenetic traits inscribed in chromatin accessibility in aged hematopoietic stem cells

scientific article published on 16 May 2022

Epigenetics of hematopoietic stem cell aging and disease

scientific article published on August 2014

Epigenome in hematopoietic malignancies

scientific article published on 01 October 2011

Erythroid expansion mediated by the Gfi-1B zinc finger protein: role in normal hematopoiesis

scientific article (publication date: 15 October 2002)

Essential and instructive roles of GATA factors in eosinophil development

scientific article

Ex Vivo Expansion of Human Hematopoietic Stem Cells by Garcinol, a Potent Inhibitor of Histone Acetyltransferase ⬇️

scientific article published on September 12, 2011

Ex vivo expansion of human cord blood hematopoietic stem cells using small-molecule compounds

scientific article published on January 2015

Ex vivo expansion of human hematopoietic stem cells by a small-molecule agonist of c-MPL.

scientific article

Ezh1 Targets Bivalent Genes to Maintain Self-Renewing Stem Cells in Ezh2-Insufficient Myelodysplastic Syndrome

article

Ezh2 augments leukemogenicity by reinforcing differentiation blockage in acute myeloid leukemia

scientific article published on 7 June 2012

Ezh2 loss in hematopoietic stem cells predisposes mice to develop heterogeneous malignancies in an Ezh1-dependent manner

scientific article published on 28 July 2015

Ezh2 loss promotes development of myelodysplastic syndrome but attenuates its predisposition to leukaemic transformation

scientific article published on 23 June 2014

Ezh2 loss propagates hypermethylation at T cell differentiation-regulating genes to promote leukemic transformation

scientific article published on 06 August 2018

Ezh2 regulates the Lin28/let-7 pathway to restrict activation of fetal gene signature in adult hematopoietic stem cells.

scientific article published on 7 January 2016

FET family proto-oncogene Fus contributes to self-renewal of hematopoietic stem cells

scientific article published on 20 April 2010

Fbxl10 overexpression in murine hematopoietic stem cells induces leukemia involving metabolic activation and upregulation of Nsg2.

scientific article published on 14 April 2015

Fbxw7 acts as a critical fail-safe against premature loss of hematopoietic stem cells and development of T-ALL.

scientific article published on 26 March 2008

Fibroblasts from different body parts exhibit distinct phenotypes in adult progeria Werner syndrome

scientific article published on 24 February 2021

Forced expression of the histone demethylase Fbxl10 maintains self-renewing hematopoietic stem cells

scientific article

Forkhead box protein A1 confers resistance to transforming growth factor-β-induced apoptosis in breast cancer cells through inhibition of Smad3 nuclear translocation

scientific article published on 11 September 2018

GLI1 Inhibitors Identified by Target Protein Oriented Natural Products Isolation (TPO-NAPI) with Hedgehog Inhibition

scientific article published on 07 September 2018

Gene expression profiling of loss of TET2 and/or JAK2V617F mutant hematopoietic stem cells from mouse models of myeloproliferative neoplasms

scientific article

Genetic and transcriptional landscape of plasma cells in POEMS syndrome

scientific article published on 11 January 2019

Genetic marking of hematopoietic stem and endothelial cells: identification of the Tmtsp gene encoding a novel cell surface protein with the thrombospondin-1 domain

scientific journal article

Genome-Wide Mapping of Bivalent Histone Modifications in Hepatic Stem/Progenitor Cells

scientific article published on 01 April 2019

Genome-wide analysis of target genes regulated by HoxB4 in hematopoietic stem and progenitor cells developing from embryonic stem cells

scientific article published on 22 February 2011

Granulocyte inducer C/EBPalpha inactivates the myeloid master regulator PU.1: possible role in lineage commitment decisions

scientific article published on July 2002

Guest editorial: Epigenetics of hematopoiesis and hematological malignancies ⬇️

scientific article published on September 27, 2012

Gut Microbiota Promotes Obesity-Associated Liver Cancer through PGE2-Mediated Suppression of Antitumor Immunity

scientific article published on 15 February 2017

Haploinsufficiency of the c-myc transcriptional repressor FIR, as a dominant negative-alternative splicing model, promoted p53-dependent T-cell acute lymphoblastic leukemia progression by activating Notch1.

scientific article published on March 2015

Hematopoietic insults damage bone marrow niche by activating p53 in vascular endothelial cells.

scientific article published on 27 April 2018

Hematopoietic stem cell aging and hematopoietic malignancies

scientific article published on 01 September 2016

High levels of morphological variation despite close genetic relatedness between Zoanthus aff. vietnamensis and Zoanthus kuroshio (Anthozoa: Hexacorallia).

scientific article

Histone acetylation mediated by Brd1 is crucial for Cd8 gene activation during early thymocyte development

scientific article published on 18 December 2014

Histone lysine methyltransferase G9a is a novel epigenetic target for the treatment of hepatocellular carcinoma

scientific article

Histone lysine methyltransferase SUV39H1 is a potent target for epigenetic therapy of hepatocellular carcinoma

scientific article

Hmga2 collaborates with JAK2V617F in the development of myeloproliferative neoplasms

scientific article published on 14 June 2017

Identification and investigation of methylated genes in hepatoma

scientific article published in May 2005

Identification of BMI1 Promoter Inhibitors from Beaumontia murtonii and Eugenia operculata.

scientific article

Identification of Transcripts Commonly Expressed in Both Hematopoietic and Germ-Line Stem Cells

scientific article published on 01 February 2008

Impact of the SCF signaling pathway on leukemia stem cell-mediated ATL initiation and progression in an HBZ transgenic mouse model

scientific article published on 21 June 2016

Internal deletion of BCOR reveals a tumor suppressor function for BCOR in T lymphocyte malignancies

scientific article

KDM2B in polycomb repressive complex 1.1 functions as a tumor suppressor in the initiation of T-cell leukemogenesis

scientific article published on 01 September 2019

Lethal myelofibrosis induced by Bmi1-deficient hematopoietic cells unveils a tumor suppressor function of the polycomb group genes

scientific article published on 20 February 2012

Leukemia Inhibitory Factor Enhances Endogenous Cardiomyocyte Regeneration after Myocardial Infarction

scientific article

Life and death in hematopoietic stem cells.

scientific article published on 6 July 2007

Limited rejuvenation of aged hematopoietic stem cells in young bone marrow niche

scientific article published on 01 March 2021

Lineage-specific RUNX2 super-enhancer activates MYC and promotes the development of blastic plasmacytoid dendritic cell neoplasm

article

Loss of Pcgf5 Affects Global H2A Monoubiquitination but Not the Function of Hematopoietic Stem and Progenitor Cells

scientific article

Loss of TET2 has dual roles in murine myeloproliferative neoplasms: disease sustainer and disease accelerator

scientific article

MEK-ERK Activity Regulates the Proliferative Activity of Fetal Hepatoblasts Through Accumulation of p16/19(cdkn2a).

scientific article published on 16 July 2015

MOZ is essential for maintenance of hematopoietic stem cells

scientific journal article

Manipulation of hematopoietic stem cells for regenerative medicine

scientific article published on 02 December 2013

Mastermind-1 is required for Notch signal-dependent steps in lymphocyte development in vivo

scholarly article

Metformin, a diabetes drug, eliminates tumor-initiating hepatocellular carcinoma cells

scientific article (publication date: 2013)

MicroRNA-27 enhances differentiation of myeloblasts into granulocytes by post-transcriptionally downregulating Runx1.

scientific article published on 2 March 2009

Molecular pathogenesis of progression to myeloid leukemia from TET-insufficient status

scientific article published on 01 March 2020

Morphological and molecular revision of Zoanthus (Anthozoa: Hexacorallia) from southwestern Japan, with descriptions of two new species

scientific article published in March 2006

Multifaceted role of the polycomb-group gene EZH2 in hematological malignancies

scientific article published on 9 November 2016

Myelodysplastic syndrome with extramedullary erythroid hyperplasia induced by loss of Tet2 in mice

scientific article published on 17 July 2014

NUP98-HBO1-fusion generates phenotypically and genetically relevant chronic myelomonocytic leukemia pathogenesis

scientific article published on 01 April 2019

New approaches to expand hematopoietic stem and progenitor cells ⬇️

scientific article published on April 23, 2012

Non-Lethal Ionizing Radiation Promotes Aging-Like Phenotypic Changes of Human Hematopoietic Stem and Progenitor Cells in Humanized Mice

scientific article published on 10 July 2015

Nonmyelinating Schwann cells maintain hematopoietic stem cell hibernation in the bone marrow niche

scientific article published on 01 November 2011

Novel 1p tumour suppressor Dnmt1-associated protein 1 regulates MYCN/ataxia telangiectasia mutated/p53 pathway.

scientific article published on 19 February 2014

Novel myocardial markers GADD45G and NDUFS5 identified by RNA-sequencing predicts left ventricular reverse remodeling in advanced non-ischemic heart failure: a retrospective cohort study

scientific article published on 05 March 2020

Nuclear, not cytoplasmic, PKR maneuvers in AML.

scientific article published in September 2015

OGT Regulates Hematopoietic Stem Cell Maintenance via PINK1-Dependent Mitophagy

scientific article published on 01 January 2021

Oncogenic transcription factor Evi1 regulates hematopoietic stem cell proliferation through GATA-2 expression

scientific article

Overexpression of RUNX3 represses RUNX1 to drive transformation of myelodysplastic syndrome

scientific article published on 27 April 2020

PLZF limits enhancer activity during hematopoietic progenitor aging

scientific article published on 01 May 2019

PRC2 insufficiency causes p53-dependent dyserythropoiesis in myelodysplastic syndrome

scientific article published on 21 August 2020

Paired activating and inhibitory immunoglobulin-like receptors, MAIR-I and MAIR-II, regulate mast cell and macrophage activation

scientific journal article

Parvovirus nonstructural proteins induce an epigenetic modification through histone acetylation in host genes and revert tumor malignancy to benignancy

scientific article

Pathogenic Impacts of Dysregulated Polycomb Repressive Complex Function in Hematological Malignancies

scientific article published on 23 December 2020

Plant homeodomain finger protein 6 in the regulation of normal and malignant hematopoiesis

scientific article published on 07 May 2020

Poised lineage specification in multipotential hematopoietic stem and progenitor cells by the polycomb protein Bmi1.

scientific article published in March 2010

Polycomb group gene Bmi1 plays a role in the growth of thymic epithelial cells ⬇️

scientific article published on March 14, 2011

Polycomb repressive complexes in hematological malignancies

scientific article published on 8 May 2017

Possible role of intragenic DNA hypermethylation in gene silencing of the tumor suppressor gene NR4A3 in acute myeloid leukemia.

scientific article

Progerin impairs vascular smooth muscle cell growth via the DNA damage response pathway.

scientific article published on 7 March 2017

Prominin-1/CD133 expression as potential tissue-resident vascular endothelial progenitor cells in the pulmonary circulation.

scientific article published on 8 April 2016

Putative "stemness" gene jam-B is not required for maintenance of stem cell state in embryonic, neural, or hematopoietic stem cells.

scientific article

RUNX1/AML1 mutant collaborates with BMI1 overexpression in the development of human and murine myelodysplastic syndromes

scientific article published on 7 March 2013

Reciprocal roles for CCAAT/enhancer binding protein (C/EBP) and PU.1 transcription factors in Langerhans cell commitment

scientific article

Recurrent SPI1 (PU.1) fusions in high-risk pediatric T cell acute lymphoblastic leukemia.

scientific article

Regulation of tumour related genes by dynamic epigenetic alteration at enhancer regions in gastric epithelial cells infected by Epstein-Barr virus

scientific article published on 11 August 2017

Retroviral expression screening of oncogenes in natural killer cell leukemia

scientific article published on 24 February 2005

Role for growth factors and extracellular matrix in controlling differentiation of prospectively isolated hepatic stem cells ⬇️

scientific article published on June 1, 2003

Role of Dok-1 and Dok-2 in myeloid homeostasis and suppression of leukemia

scientific article published on December 2004

Role of SOX17 in hematopoietic development from human embryonic stem cells

scientific article

Role of the polycomb group proteins in hematopoietic stem cells

scientific article published on August 2010

Role of the polycomb group proteins in the restriction of tumor development in hematological malignancies

scientific article published in July 2013

Selective activation of STAT5 unveils its role in stem cell self-renewal in normal and leukemic hematopoiesis

scientific article published on July 2005

Selective and potent Akt inhibition triggers anti-myeloma activities and enhances fatal endoplasmic reticulum stress induced by proteasome inhibition

scientific article

Setdb1 maintains hematopoietic stem and progenitor cells by restricting the ectopic activation of nonhematopoietic genes

scientific article published on 14 June 2016

Side population purified from hepatocellular carcinoma cells harbors cancer stem cell-like properties

scientific article published on July 2006

Signal transducers and activators of transcription 3 augments the transcriptional activity of CCAAT/enhancer-binding protein alpha in granulocyte colony-stimulating factor signaling pathway

scientific article

Sox17 as a candidate regulator of myeloid restricted differentiation potential.

scientific article

Sox17-mediated expression of adherent molecules is required for the maintenance of undifferentiated hematopoietic cluster formation in midgestation mouse embryos

scientific article published on 16 August 2020

Sox17-mediated maintenance of fetal intra-aortic hematopoietic cell clusters

scientific article published on 24 March 2014

Src family kinases promote silencing of ATR-Chk1 signaling in termination of DNA damage checkpoint

scientific article published on 14 March 2014

Structure and function of MYST family histone acetyltransferases

scientific article published on 01 July 2011

Suppressive effects of anagrelide on cell cycle progression and the maturation of megakaryocyte progenitor cell lines in human induced pluripotent stem cells

scientific article published on 05 September 2019

TGF-beta as a candidate bone marrow niche signal to induce hematopoietic stem cell hibernation.

scientific article published on 22 October 2008

Targeted BMI1 inhibition impairs tumor growth in lung adenocarcinomas with low CEBPα expression

scientific article published on August 2016

The Hbo1-Brd1/Brpf2 complex is responsible for global acetylation of H3K14 and required for fetal liver erythropoiesis.

scientific article

The Sox-2 regulatory regions display their activities in two distinct types of multipotent stem cells.

scientific article published on May 2004

The Sox2 regulatory region 2 functions as a neural stem cell-specific enhancer in the telencephalon

scientific article published on 16 March 2006

The TIF1β-HP1 system maintains transcriptional integrity of hematopoietic stem cells

scientific article published on 23 January 2014

The chromatin-binding protein Phf6 restricts the self-renewal of hematopoietic stem cells

scientific article published on 27 March 2019

The hematopoietic transcription factor AML1 (RUNX1) is negatively regulated by the cell cycle protein cyclin D3.

scientific article

The loss of Ezh2 drives the pathogenesis of myelofibrosis and sensitizes tumor-initiating cells to bromodomain inhibition.

scientific article published on 11 July 2016

The nicotinic acetylcholine receptor α7 subunit is an essential negative regulator of bone mass

scientific article published on 28 March 2017

The polycomb gene product BMI1 contributes to the maintenance of tumor-initiating side population cells in hepatocellular carcinoma

scientific article published on 01 October 2008

The polycomb group gene product Ezh2 regulates proliferation and differentiation of murine hepatic stem/progenitor cells.

scientific article published on 24 March 2010

Transcriptional profiling of hematopoietic stem cells by high-throughput sequencing

scientific article

Transcriptional regulation of spermatogonial stem cell self-renewal

scientific article published in December 2007

Tumor suppression by phospholipase C-beta3 via SHP-1-mediated dephosphorylation of Stat5.

scientific article

Tumor suppressor function of the polycomb group genes.

scientific article

UTX maintains functional integrity of murine hematopoietic system by globally regulating aging-associated genes

scientific article published on 10 November 2020

Unique composition of polycomb repressive complex 1 in hematopoietic stem cells

scientific article published in February 2007

YAP/TAZ Promote Hematopoietic Regeneration Via Accelerating the Recovery of Bone Marrow Niche

scientific article published on 23 November 2021

[Dyserythropoiesis in myelodysplastic syndrome]

scientific article published on 01 January 2018

[Epigenetic dysregulation in myelodysplastic syndrome]

scientific article published on 01 February 2015

[Function of role of polycomb group complexes and possibility of novel molecular target in cancer]

scientific article published on 01 August 2010

[Ineffective erythropoiesis in myelodysplastic syndrome]

scientific article published on 01 January 2018

[Mutations of epigenetic regulator genes and myeloid malignancies]

scientific article published on 01 November 2015

[Overview]

scientific article published on 01 February 2015

[Self-renewal mechanisms of leukemic stem cells]

scientific article published on 01 July 2008

[The cancer stem cell model in hematological malignancies]

scientific article published in May 2015

pDP4, a novel glycoprotein secreted by mature granulocytes, is regulated by transcription factor PU.1

scientific journal article

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