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List of works by Mark R. Boothby

A 'Tsc, Tsc' keeps the kids quie(scen)t and holds down ROS ⬇️

scientific article published on August 18, 2011

A DNA binding protein regulated by IL-4 and by differentiation in B cells

scientific article published in December 1988

A lipopolysaccharide-induced DNA-binding protein for a class II gene in B cells is distinct from NF-kappa B.

scientific article published on August 1989

A minimal IFN-gamma promoter confers Th1 selective expression

scientific article published on 01 October 2002

A new member of the leucine zipper class of proteins that binds to the HLA DR alpha promoter

scientific journal article

AMPKα1 in B Cells Dampens Primary Antibody Responses yet Promotes Mitochondrial Homeostasis and Persistence of B Cell Memory

scientific article published on 04 November 2020

Alterations in lung collectins in an adaptive allergic immune response

scientific article published in March 2002

An IL-4R alpha allelic variant, I50, acts as a gain-of-function variant relative to V50 for Stat6, but not Th2 differentiation

scientific article published in October 2004

An atopy-associated polymorphism in the ectodomain of the IL-4R(alpha) chain (V50) regulates the persistence of STAT6 phosphorylation

scientific article published on 10 July 2009

Antiapoptotic function of NF-kappaB in T lymphocytes is influenced by their differentiation status: roles of Fas, c-FLIP, and Bcl-xL.

scientific article published in September 2003

Assessment of signal transducer and activator of transcription 6 as a target of glucocorticoid action in human airway epithelial cells.

scientific article

B Cell-Intrinsic mTORC1 Promotes Germinal Center-Defining Transcription Factor Gene Expression, Somatic Hypermutation, and Memory B Cell Generation in Humoral Immunity.

scientific article published on 12 March 2018

B cell-intrinsic and -extrinsic regulation of antibody responses by PARP14, an intracellular (ADP-ribosyl)transferase

scientific article published on 16 August 2013

CRACking the code without Rosetta: molecular regulation of calcium-stimulated gene transcription after T cell activation

scientific article

CTLA-4 engagement regulates NF-kappaB activation in vivo

Cancer-associated immunodeficiency and dendritic cell abnormalities mediated by the prostaglandin EP2 receptor

scientific article

Cdc42 promotes host defenses against fatal infection

scientific article published on 20 May 2013

Collaborator of Stat6 (CoaSt6)-associated poly(ADP-ribose) polymerase activity modulates Stat6-dependent gene transcription

scientific article published on 3 May 2007

Complementing T Cells' Functions: Bringing in Metabolism Matters

scientific article

Constitutive expression of BCL-X(L) in the T lineage attenuates collagen-induced arthritis in Bcl-X(L) transgenic mice

scientific article published in February 2002

Control of immunoglobulin heavy chain constant region gene expression

scientific article published on January 1991

Control of transcription at the murine A alpha locus

scientific article published on January 1990

Cooperative signaling between Slit2 and Ephrin-A1 regulates a balance between angiogenesis and angiostasis.

scientific article

Costimulation reverses the defect in IL-2 but not effector cytokine production by T cells with impaired IkappaBalpha degradation.

scientific article

Cross talk between the Akt and p38α pathways in macrophages downstream of Toll-like receptor signaling

scientific article published on 26 August 2013

Cutting edge: influence of Tmevpg1, a long intergenic noncoding RNA, on the expression of Ifng by Th1 cells

scientific article published on 30 July 2012

Cutting edge: the ontogeny and function of Va14Ja18 natural T lymphocytes require signal processing by protein kinase C theta and NF-kappa B.

scientific article published in April 2004

Differences in DNA sequence specificity among MHC class II X box binding proteins

scientific article published on February 1989

Differential Roles of C-terminal Activation Motifs in the Establishment of Stat6 Transcriptional Specificity ⬇️

scientific article published on September 30, 2003

Discovering new lipidomic features using cell type specific fluorophore expression to provide spatial and biological specificity in a multimodal workflow with MALDI IMS

Discovering new lipidomic features using cell type specific fluorophore expression to provide spatial and biological specificity in a multimodal workflow with MALDI Imaging Mass Spectrometry

scientific article published on 16 April 2020

Distinct cloned class II MHC DNA binding proteins recognize the X box transcription element

scientific article published on 01 October 1988

Effects of cancer-associated EPHA3 mutations on lung cancer.

scientific article published on 24 July 2012

Epigenetic regulation of the Ink4a-Arf (Cdkn2a) tumor suppressor locus in the initiation and progression of Notch1-driven T cell acute lymphoblastic leukemia

scientific article published on 23 November 2012

Essential role of T cell NF-kappa B activation in collagen-induced arthritis

scientific article published on 01 August 1999

Flexibility accompanies commitment of memory CD4 lymphocytes derived from IL-4 locus-activated precursors

scholarly article

Germinal centre hypoxia and regulation of antibody qualities by a hypoxia response system

scientific article published on 08 August 2016

Glycolytic rate and lymphomagenesis depend on PARP14, an ADP ribosyltransferase of the B aggressive lymphoma (BAL) family

scientific article

HMG-I(Y) Phosphorylation Status as a Nuclear Target Regulated through Insulin Receptor Substrate-1 and the I4R Motif of the Interleukin-4 Receptor ⬇️

scientific article published on 01 October 1997

Hypoxia-inducible factors in CD4+ T cells promote metabolism, switch cytokine secretion, and T cell help in humoral immunity

scientific article published on 15 April 2019

IL-15 regulates homeostasis and terminal maturation of NKT cells

scientific article (publication date: 15 December 2011)

INK4a/ARF [corrected] inactivation with activation of the NF-κB/IL-6 pathway is sufficient to drive the development and growth of angiosarcoma

scientific article published on 26 July 2012

Identification of a conserved lipopolysaccharide-plus-interleukin-4-responsive element located at the promoter of germ line epsilon transcripts

scientific article

Impaired NF-kappaB Activation in T Cells Permits Tolerance to Primary Heart Allografts and to Secondary Donor Skin Grafts

scientific article published on 01 February 2003

In vivo function of an interleukin 2 receptor beta chain (IL-2Rbeta)/IL-4Ralpha cytokine receptor chimera potentiates allergic airway disease.

scientific article

Inefficient ZAP-70 phosphorylation and decreased thymic selection in vivo result from inhibition of NF-kappaB/Rel

scientific article published on 01 November 2001

Inhibition of NF-kappa B activity in T and NK cells results in defective effector cell expansion and production of IFN-gamma required for resistance to Toxoplasma gondii.

scientific article

Inhibition of NF-kappaB-dependent T cell activation abrogates acute allograft rejection

scientific article published on 01 November 2001

Interferon-gamma inhibits STAT6 signal transduction and gene expression in human airway epithelial cells.

scientific article

Interleukin-4 and interleukin-13 signaling connections maps

scientific article

Mammalian target of rapamycin protein complex 2 regulates differentiation of Th1 and Th2 cell subsets via distinct signaling pathways

scientific article published on June 2010

Metabolic Regulation of the Immune Humoral Response

scientific article

Molecular profiling of the role of the NF-kappaB family of transcription factors during alloimmunity.

scientific article published in November 2002

Molecular regulation of peripheral B cells and their progeny in immunity

scientific article published on 01 January 2019

Murine dendritic cell rapamycin-resistant and rictor-independent mTOR controls IL-10, B7-H1, and regulatory T-cell induction

scientific article published on 26 February 2013

Myeloid IKKβ promotes antitumor immunity by modulating CCL11 and the innate immune response

scientific article published on 21 October 2014

NF-kappa B activation plays an important role in the IL-4-induced protection from apoptosis

scientific article published on 01 December 2001

NF-kappa B controls cell fate specification, survival, and molecular differentiation of immunoregulatory natural T lymphocytes

scientific article

NF-kappa B/Rel participation in the lymphokine-dependent proliferation of T lymphoid cells

scientific article published on 01 February 2001

NF-kappaB couples protein kinase B/Akt signaling to distinct survival pathways and the regulation of lymphocyte homeostasis in vivo

scientific article published on 01 September 2005

NF-κB Protects NKT Cells from Tumor Necrosis Factor Receptor 1-induced Death.

scientific article

NIH Portfolio Allocation, Lemmings, and the Silent Spring: A Time-Capsule Commentary & Its Update

scientific article published on 20 July 2012

New programming of IL-4 receptor signal transduction in activated T cells: Stat6 induction and Th2 differentiation mediated by IL-4Ralpha lacking cytoplasmic tyrosines

scientific article published in August 2003

Non-consensus DNA sequences function in a cell-type-specific enhancer of the mouse class II MHC gene A alpha

scientific article

Opposing roles for RelB and Bcl-3 in regulation of T-box expressed in T cells, GATA-3, and Th effector differentiation

scientific journal article

Over-Generalizing About GC (Hypoxia): Pitfalls of Limiting Breadth of Experimental Systems and Analyses in Framing Informatics Conclusions

publication published on 10 May 2021

Oxidant stress modulates murine allergic airway responses

scientific article published on 09 December 2005

PARP-14 combines with tristetraprolin in the selective posttranscriptional control of macrophage tissue factor expression

scientific article

PARP-14, a member of the B aggressive lymphoma family, transduces survival signals in primary B cells.

scientific article published on 15 January 2009

PARP14 Controls the Nuclear Accumulation of a Subset of Type I IFN–Inducible Proteins

scientific article published on 02 March 2018

PARP9 and PARP14 cross-regulate macrophage activation via STAT1 ADP-ribosylation

scientific article (publication date: 31 October 2016)

PI3K Inhibition Reduces Mammary Tumor Growth and Facilitates Antitumor Immunity and Anti-PD1 Responses

scientific article published on 21 December 2016

Perturbation of the T lymphocyte lineage in transgenic mice expressing a constitutive repressor of nuclear factor (NF)-kappaB.

scientific article

Preferential role for NF-kappa B/Rel signaling in the type 1 but not type 2 T cell-dependent immune response in vivo

scientific article published on 01 November 1999

Progress in the function and regulation of ADP-Ribosylation

scientific article published on 24 May 2011

Prostaglandin I2 Suppresses Proinflammatory Chemokine Expression, CD4 T Cell Activation, and STAT6-Independent Allergic Lung Inflammation

scientific article published on 25 July 2016

Recall helper T cell response: T helper 1 cell-resistant allergic susceptibility without biasing uncommitted CD4 T cells

scientific article published on 14 November 2003

Redirection of T cell effector function in vivo and enhanced collagen-induced arthritis mediated by an IL-2R beta/IL-4R alpha chimeric cytokine receptor transgene

scientific article published in March 2001

Regulation of endothelial cell proliferation and vascular assembly through distinct mTORC2 signaling pathways.

scientific article

Requirement for Rictor in homeostasis and function of mature B lymphoid cells.

scientific article published on 19 August 2013

Role of lipopolysaccharide and IL-4 in control of transcription of the class II A alpha gene

scientific article

STAT4 and T-bet are required for the plasticity of IFN-γ expression across Th2 ontogeny and influence changes in Ifng promoter DNA methylation

scientific article published on 12 June 2013

Selective glutamine metabolism inhibition in tumor cells improves anti-tumor T lymphocyte activity in triple-negative breast cancer

scientific article published on 15 December 2020

Selective inhibition of mTORC1 in tumor vessels increases antitumor immunity

scientific article published on 06 August 2020

Selective potentiation of Stat-dependent gene expression by collaborator of Stat6 (CoaSt6), a transcriptional cofactor

scholarly article

Sequence motifs in IL-4R alpha mediating cell-cycle progression of primary lymphocytes.

scientific article

Signaling advances from immunogenetics to immunogenomics

scientific article

Signaling in T cells - is anything the m(a)TOR with the picture(s)?

scientific article

Stimulus-dependent synergism of the antiapoptotic tumor necrosis factor receptor-associated factor 2 (TRAF2) and nuclear factor kappaB pathways

scientific article

Susceptibility to allergic lung disease regulated by recall responses of dual-receptor memory T cells

scientific article published in December 2004

T cell-intrinsic requirement for NF-kappa B induction in postdifferentiation IFN-gamma production and clonal expansion in a Th1 response

scientific article published on 01 August 2003

T helper type 1-specific Brg1 recruitment and remodeling of nucleosomes positioned at the IFN-gamma promoter are Stat4 dependent

scientific article

T-bet antagonizes mSin3a recruitment and transactivates a fully methylated IFN-gamma promoter via a conserved T-box half-site

scientific article

TCR-independent CD30 signaling selectively induces IL-13 production via a TNF receptor-associated factor/p38 mitogen-activated protein kinase-dependent mechanism

scientific article published on 01 September 2002

TLR4 genotype and environmental LPS mediate RSV bronchiolitis through Th2 polarization

scientific article

The Goldilocks effect

scientific article published in December 2012

The calculus of integrating differentiation: timing control of T-bet

scientific article published in May 2009

The presence of a DNA binding complex correlates with E beta class II MHC gene expression

scientific article

Vital roles of mTOR complex 2 in Notch-driven thymocyte differentiation and leukemia

scientific article published on 2 April 2012

mTORC1 as a cell-intrinsic rheostat that shapes development, preimmune repertoire, and function of B lymphocytes

scientific article published on 18 September 2019

microRNA-mediated regulation of mTOR complex components facilitates discrimination between activation and anergy in CD4 T cells.

scientific article

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