List of works - Thomas M Frimurer

6-Acylamino-2-amino-4-methylquinolines as potent melanin-concentrating hormone 1 receptor antagonists: structure-activity exploration of eastern and western parts

scientific article

6-Acylamino-2-aminoquinolines as potent melanin-concentrating hormone 1 receptor antagonists. Identification, structure-activity relationship, and investigation of binding mode

scientific article published in September 2005

A conserved aromatic lock for the tryptophan rotameric switch in TM-VI of seven-transmembrane receptors

scientific article published on 17 November 2009

A physicogenetic method to assign ligand-binding relationships between 7TM receptors

scientific article published in August 2005

Allosteric and orthosteric sites in CC chemokine receptor (CCR5), a chimeric receptor approach

scientific article published on 30 August 2011

Assessment and challenges of ligand docking into comparative models of G-protein coupled receptors

scientific article (publication date: 2013)

Biased Gs versus Gq proteins and β-arrestin signaling in the NK1 receptor determined by interactions in the water hydrogen bond network

scientific article published on 12 August 2015

Biased and constitutive signaling in the CC-chemokine receptor CCR5 by manipulating the interface between transmembrane helices 6 and 7.

scientific article published on 14 March 2013

Conserved water-mediated hydrogen bond network between TM-I, -II, -VI, and -VII in 7TM receptor activation

scientific article published on 15 April 2010

Discovery of novel, orally available benzimidazoles as melanin concentrating hormone receptor 1 (MCHR1) antagonists

scientific article published on 29 July 2010

Drug Design of GPCR Ligands Using Physicogenetics and Chemogenomics - Principles and Case Studies ⬇️

scientific article published on January 1, 2011

Exploration of SAR features by modifications of thiazoleacetic acids as CRTH2 antagonists

scientific article

GPR40 (FFAR1) - Combined Gs and Gq signaling in vitro is associated with robust incretin secretagogue action ex vivo and in vivo

scientific article

Human substance P receptor binding mode of the antagonist drug aprepitant by NMR and crystallography

scientific article published in Nature Communications

Identification of a novel site within G protein alpha subunits important for specificity of receptor-G protein interaction

scientific article

In Silico Investigation of the Neurotensin Receptor 1 Binding Site: Overlapping Binding Modes for Small Molecule Antagonists and the Endogenous Peptide Agonist

scientific article published on 16 September 2015

Inhibiting RHOA Signaling in Mice Increases Glucose Tolerance and Numbers of Enteroendocrine and Other Secretory Cells in the Intestine

scientific article published on 20 June 2018

Ligand binding and micro-switches in 7TM receptor structures

scientific article published on 16 April 2009

Ligand-induced conformational changes: improved predictions of ligand binding conformations and affinities.

scientific article

Ligand-selective small molecule modulators of the constitutively active vGPCR US28

scientific article published on 31 May 2018

Melanin concentrating hormone receptor 1 (MCHR1) antagonists—Still a viable approach for obesity treatment? ⬇️

scientific article published on August 19, 2012

Metal ion site engineering indicates a global toggle switch model for seven-transmembrane receptor activation

scientific article published on 27 March 2006

Model-Based Discovery of Synthetic Agonists for the Zn2+-Sensing G-Protein-Coupled Receptor 39 (GPR39) Reveals Novel Biological Functions

scientific article

Modulation of constitutive activity and signaling bias of the ghrelin receptor by conformational constraint in the second extracellular loop

scientific article published on 30 July 2012

Molecular dynamics-guided discovery of an ago-allosteric modulator for GPR40/FFAR1

scientific article published on 14 March 2019

Molecular mechanism of 7TM receptor activation--a global toggle switch model

scientific article

Mutation-Guided Unbiased Modeling of the Fat Sensor GPR119 for High-Yield Agonist Screening

scientific article published on 29 October 2015

Novel selective orally active CRTH2 antagonists for allergic inflammation developed from in silico derived hits

scientific article published on 01 November 2006

Novel selective thiazoleacetic acids as CRTH2 antagonists developed from in silico derived hits. Part 1.

scientific article

Novel selective thiazoleacetic acids as CRTH2 antagonists developed from in silico derived hits. Part 2.

scientific article

Optimisation of in silico derived 2-aminobenzimidazole hits as unprecedented selective kappa opioid receptor agonists.

scientific article published on 6 January 2015

Overlapping binding site for the endogenous agonist, small-molecule agonists, and ago-allosteric modulators on the ghrelin receptor

scientific article

PheVI:09 (Phe6.44) as a sliding microswitch in seven-transmembrane (7TM) G protein-coupled receptor activation

scientific article published on 7 November 2012

Receptor structure-based discovery of non-metabolite agonists for the succinate receptor GPR91.

scientific article published on 30 September 2017

Role of Conserved Disulfide Bridges and Aromatic Residues in Extracellular Loop 2 of Chemokine Receptor CCR8 for Chemokine and Small Molecule Binding

scientific article

Structural changes at the myrtenol backbone reverse its positive allosteric potential into inhibitory GABAA receptor modulation.

scientific article published on 27 November 2017

Structure-Activity Investigations and Optimisations of Non-metabolite Agonists for the Succinate Receptor 1.

scientific article published on 3 July 2018

Structure-activity relationships and identification of optmized CC-chemokine receptor CCR1, 5, and 8 metal-ion chelators

scientific article published on 22 October 2013

Structure-based discovery of novel US28 small molecule ligands with different modes of action

scientific article published on 29 August 2016

The HETE Is on FFAR1 and Pancreatic Islet Cells

scientific article published in February 2018

The arginine of the DRY motif in transmembrane segment III functions as a balancing micro-switch in the activation of the β2-adrenergic receptor

scientific article published on 26 July 2012

The minor binding pocket: a major player in 7TM receptor activation

scientific article published on 25 September 2010

Unique interaction pattern for a functionally biased ghrelin receptor agonist

scientific article published on 14 March 2011

List of works by Thomas M Frimurer

6-Acylamino-2-amino-4-methylquinolines as potent melanin-concentrating hormone 1 receptor antagonists: structure-activity exploration of eastern and western parts

6-Acylamino-2-aminoquinolines as potent melanin-concentrating hormone 1 receptor antagonists. Identification, structure-activity relationship, and investigation of binding mode

A conserved aromatic lock for the tryptophan rotameric switch in TM-VI of seven-transmembrane receptors

A physicogenetic method to assign ligand-binding relationships between 7TM receptors

Allosteric and orthosteric sites in CC chemokine receptor (CCR5), a chimeric receptor approach

Assessment and challenges of ligand docking into comparative models of G-protein coupled receptors

Biased Gs versus Gq proteins and β-arrestin signaling in the NK1 receptor determined by interactions in the water hydrogen bond network

Biased and constitutive signaling in the CC-chemokine receptor CCR5 by manipulating the interface between transmembrane helices 6 and 7.

Conserved water-mediated hydrogen bond network between TM-I, -II, -VI, and -VII in 7TM receptor activation

Discovery of novel, orally available benzimidazoles as melanin concentrating hormone receptor 1 (MCHR1) antagonists

Drug Design of GPCR Ligands Using Physicogenetics and Chemogenomics - Principles and Case Studies ⬇️

Exploration of SAR features by modifications of thiazoleacetic acids as CRTH2 antagonists

GPR40 (FFAR1) - Combined Gs and Gq signaling in vitro is associated with robust incretin secretagogue action ex vivo and in vivo

Human substance P receptor binding mode of the antagonist drug aprepitant by NMR and crystallography

Identification of a novel site within G protein alpha subunits important for specificity of receptor-G protein interaction

In Silico Investigation of the Neurotensin Receptor 1 Binding Site: Overlapping Binding Modes for Small Molecule Antagonists and the Endogenous Peptide Agonist

Inhibiting RHOA Signaling in Mice Increases Glucose Tolerance and Numbers of Enteroendocrine and Other Secretory Cells in the Intestine

Ligand binding and micro-switches in 7TM receptor structures

Ligand-induced conformational changes: improved predictions of ligand binding conformations and affinities.

Ligand-selective small molecule modulators of the constitutively active vGPCR US28

Melanin concentrating hormone receptor 1 (MCHR1) antagonists—Still a viable approach for obesity treatment? ⬇️

Metal ion site engineering indicates a global toggle switch model for seven-transmembrane receptor activation

Model-Based Discovery of Synthetic Agonists for the Zn2+-Sensing G-Protein-Coupled Receptor 39 (GPR39) Reveals Novel Biological Functions

Modulation of constitutive activity and signaling bias of the ghrelin receptor by conformational constraint in the second extracellular loop

Molecular dynamics-guided discovery of an ago-allosteric modulator for GPR40/FFAR1

Molecular mechanism of 7TM receptor activation--a global toggle switch model

Mutation-Guided Unbiased Modeling of the Fat Sensor GPR119 for High-Yield Agonist Screening

Novel selective orally active CRTH2 antagonists for allergic inflammation developed from in silico derived hits

Novel selective thiazoleacetic acids as CRTH2 antagonists developed from in silico derived hits. Part 1.

Novel selective thiazoleacetic acids as CRTH2 antagonists developed from in silico derived hits. Part 2.

Optimisation of in silico derived 2-aminobenzimidazole hits as unprecedented selective kappa opioid receptor agonists.

Overlapping binding site for the endogenous agonist, small-molecule agonists, and ago-allosteric modulators on the ghrelin receptor

PheVI:09 (Phe6.44) as a sliding microswitch in seven-transmembrane (7TM) G protein-coupled receptor activation

Receptor structure-based discovery of non-metabolite agonists for the succinate receptor GPR91.

Role of Conserved Disulfide Bridges and Aromatic Residues in Extracellular Loop 2 of Chemokine Receptor CCR8 for Chemokine and Small Molecule Binding

Structural changes at the myrtenol backbone reverse its positive allosteric potential into inhibitory GABAA receptor modulation.

Structure-Activity Investigations and Optimisations of Non-metabolite Agonists for the Succinate Receptor 1.

Structure-activity relationships and identification of optmized CC-chemokine receptor CCR1, 5, and 8 metal-ion chelators

Structure-based discovery of novel US28 small molecule ligands with different modes of action

The HETE Is on FFAR1 and Pancreatic Islet Cells

The arginine of the DRY motif in transmembrane segment III functions as a balancing micro-switch in the activation of the β2-adrenergic receptor

The minor binding pocket: a major player in 7TM receptor activation

Unique interaction pattern for a functionally biased ghrelin receptor agonist