Search filters

List of works by Debra K. Newman

A newly identified complex of spinophilin and the tyrosine phosphatase, SHP-1, modulates platelet activation by regulating G protein-dependent signaling.

scientific article published on 30 December 2011

An alternatively spliced isoform of PECAM-1 is expressed at high levels in human and murine tissues, and suggests a novel role for the C-terminus of PECAM-1 in cytoprotective signaling

scientific article published on April 2008

An important role of phospholipase Cgamma1 in pre-B-cell development and allelic exclusion

scientific article published on 16 September 2004

Anti-GPVI-associated ITP: an acquired platelet disorder caused by autoantibody-mediated clearance of the GPVI/FcRgamma-chain complex from the human platelet surface.

scientific article

B-cell tolerance regulates production of antibodies causing heparin-induced thrombocytopenia

scientific article

CD39 target practice

scientific article published in April 2013

CLEC-2: the inside story

scientific article published on June 2015

CRISPR-mediated deletion of the PECAM-1 cytoplasmic domain increases receptor lateral mobility and strengthens endothelial cell junctional integrity

scientific article published on 6 November 2017

Cadherin 6 has a functional role in platelet aggregation and thrombus formation

scientific article published on 26 April 2012

Cooperative integrin/ITAM signaling in platelets enhances thrombus formation in vitro and in vivo

scientific article

Critical amino acid residues involved in the electrogenic sodium-bicarbonate cotransporter kNBC1-mediated transport

scientific article

Critical role for mouse marginal zone B cells in PF4/heparin antibody production

scientific article

CryoEM structure of the human SLC4A4 sodium-coupled acid-base transporter NBCe1.

scientific article published on 2 March 2018

Diacylglycerol kinase ζ (DGKζ) and Casitas b-lineage proto-oncogene b-deficient mice have similar functional outcomes in T cells but DGKζ-deficient mice have increased T cell activation and tumor clearance

scientific article published on 01 April 2018

Diacylglycerol kinase ζ is a negative regulator of GPVI-mediated platelet activation

scientific article published on 01 April 2019

Effect of 22q11.2 deletion on bleeding and transfusion utilization in children with congenital heart disease undergoing cardiac surgery

scientific article published on 22 October 2015

Endothelial cell PECAM-1 confers protection against endotoxic shock

scientific article published on 19 August 2004

Eptifibatide-induced thrombocytopenia and thrombosis in humans require FcgammaRIIa and the integrin beta3 cytoplasmic domain

scientific article

Expression and localization of rat NBC4c in liver and renal uroepithelium

scientific journal article

Frontline Science: PECAM-1 (CD31) expression in naïve and memory, but not acutely activated, CD8+ T cells

scientific article published on 31 July 2018

G418-mediated ribosomal read-through of a nonsense mutation causing autosomal recessive proximal renal tubular acidosis.

scientific article published on 09 July 2008

G6b-B: the "Y's" and wherefores

scientific article published on 01 September 2018

Generation of PECAM-1 (CD31) conditional knockout mice

scientific article published on 15 November 2019

Heparin promotes platelet responsiveness by potentiating αIIbβ3-mediated outside-in signaling ⬇️

scientific article published on March 2, 2011

High-throughput phosphotyrosine profiling using SH2 domains

scientific article

Human SLC4A11-C functions as a DIDS-stimulatable H⁺(OH⁻) permeation pathway: partial correction of R109H mutant transport

scientific article

Identification of FcgammaRIIa as the ITAM-bearing receptor mediating alphaIIbbeta3 outside-in integrin signaling in human platelets

scientific article published on 18 July 2008

Identification of membrane topography of the electrogenic sodium bicarbonate cotransporter pNBC1 by in vitro transcription/translation

scientific article (publication date: 28 January 2003)

Immunoreceptor tyrosine-based inhibitory motif (ITIM)-mediated inhibitory signaling is regulated by sequential phosphorylation mediated by distinct nonreceptor tyrosine kinases: a case study involving PECAM-1

scientific article published on 3 April 2013

Integrin αIIbβ3 inside-out activation: an in situ conformational analysis reveals a new mechanism

scientific article published on 21 May 2012

Interplay between disulfide bonding and N-glycosylation defines SLC4 Na+-coupled transporter extracellular topography

scientific article

Lyn and PECAM-1 function as interdependent inhibitors of platelet aggregation ⬇️

scientific article published on February 4, 2011

Mechanism of outside-in {alpha}IIb{beta}3-mediated activation of human platelets by the colonizing Bacterium, Streptococcus gordonii

scientific article published on 11 November 2010

Missense mutation T485S alters NBCe1-A electrogenicity causing proximal renal tubular acidosis

scientific article published on May 2013

Molecular mechanism of kNBC1-carbonic anhydrase II interaction in proximal tubule cells

scientific article

Mouse aminoacylase 3: a metalloenzyme activated by cobalt and nickel

scientific article published on 09 April 2009

Multifunctional ion transport properties of human SLC4A11: comparison of the SLC4A11-B and SLC4A11-C variants

scientific article published on 31 August 2016

NBCe1-A Transmembrane Segment 1 Lines the Ion Translocation Pathway

scientific article

Neutrophil transmigration mediated by the neutrophil-specific antigen CD177 is influenced by the endothelial S536N dimorphism of platelet endothelial cell adhesion molecule-1.

scientific article

Nitration of PECAM-1 ITIM tyrosines abrogates phosphorylation and SHP-2 binding.

scientific article

Novel role of platelet endothelial cell adhesion molecule-1 (PECAM-1) in facilitating TGF-beta-mediated inhibition of T cell function.

scientific article published on 4 November 2015

Oligomeric structure and minimal functional unit of the electrogenic sodium bicarbonate cotransporter NBCe1-A.

scientific article published on 25 July 2008

PECAM-1 dampens cytokine levels during LPS-induced endotoxemia by regulating leukocyte trafficking ⬇️

scientific article published on November 18, 2011

PECAM-1 functions as a specific and potent inhibitor of mitochondrial-dependent apoptosis

scientific article published on 20 March 2003

PECAM-1 negatively regulates GPIb/V/IX signaling in murine platelets

scientific article published on 31 July 2003

PECAM-1: conflicts of interest in inflammation

scientific article

PI3Kbeta goes to the head of its class

scientific article published on 01 September 2009

Paxillin family members function as Csk-binding proteins that regulate Lyn activity in human and murine platelets

scientific article

Peroxynitrite reduces the endothelium-derived hyperpolarizing factor component of coronary flow-mediated dilation in PECAM-1-knockout mice

scientific article published on 15 September 2005

Phospholipase Cgamma2 contributes to stable thrombus formation on VWF

scientific article published on 01 August 2004

Phospholipase Cγ1 is required for pre-TCR signal transduction and pre-T cell development

scientific article published on 19 October 2016

Platelet Activation and Thrombus Formation over IgG Immune Complexes Requires Integrin αIIbβ3 and Lyn Kinase

scientific article

Platelet Function Changes during Neonatal Cardiopulmonary Bypass Surgery: Mechanistic Basis and Lack of Correlation with Excessive Bleeding

scientific article published on 21 November 2019

Platelet PECAM-1 inhibits thrombus formation in vivo.

scientific article published on 15 September 2005

Platelet signaling

scientific article

Platelet-Endothelial Cell Adhesion Molecule-1 Regulates Endothelial NO Synthase Activity and Localization Through Signal Transducers and Activators of Transcription 3–Dependent NOSTRIN Expression ⬇️

scientific article published on December 23, 2010

Reactive oxygen species induce reversible PECAM-1 tyrosine phosphorylation and SHP-2 binding.

scientific article published on 31 July 2003

Relative contribution of PECAM-1 adhesion and signaling to the maintenance of vascular integrity.

scientific article

Residues within a lipid-associated segment of the PECAM-1 cytoplasmic domain are susceptible to inducible, sequential phosphorylation ⬇️

scientific article published on April 4, 2011

Restoration of responsiveness of phospholipase Cγ2-deficient platelets by enforced expression of phospholipase Cγ1

scientific article published on 20 March 2015

Rotational Thromboelastometry Rapidly Predicts Thrombocytopenia and Hypofibrinogenemia During Neonatal Cardiopulmonary Bypass

scientific article published on 01 July 2018

SLC4A11 function: evidence for H+(OH-) and NH3-H+ transport

scientific article published on 27 November 2019

Severe neurologic impairment in mice with targeted disruption of the electrogenic sodium bicarbonate cotransporter NBCe2 (Slc4a5 gene)

scientific journal article

Signal transduction pathways mediated by PECAM-1: new roles for an old molecule in platelet and vascular cell biology

scientific article (publication date: June 2003)

Site-specific effects of PECAM-1 on atherosclerosis in LDL receptor-deficient mice

scientific article

Slc4a11 gene disruption in mice: cellular targets of sensorineuronal abnormalities

scientific article

Specificity of aminoacylase III-mediated deacetylation of mercapturic acids.

scientific article

Structural and Functional Characterization of the C-terminal Transmembrane Region of NBCe1-A ⬇️

scientific article published on September 13, 2010

Structural characterization of dimeric murine aminoacylase III

scientific journal article

Structural characterization, tissue distribution, and functional expression of murine aminoacylase III

scientific journal article

TCR stimulation drives cleavage and shedding of the ITIM receptor CD31.

scientific article published on 16 April 2010

The COOH termini of NBC3 and the 56-kDa H+-ATPase subunit are PDZ motifs involved in their interaction

scientific article (publication date: March 2003)

The Role of Sialylated Glycans in Human Platelet Endothelial Cell Adhesion Molecule 1 (PECAM-1)-mediated Trans Homophilic Interactions and Endothelial Cell Barrier Function

scientific article published on 28 October 2016

The adhesion molecule PECAM-1 enhances the TGF-β-mediated inhibition of T cell function

scientific article published on 8 March 2016

The alleles of PECAM-1.

scientific article

The anti-inflammatory actions of platelet endothelial cell adhesion molecule-1 do not involve regulation of endothelial cell NF-kappa B.

scientific article published on 19 February 2010

The cell-adhesion and signaling molecule PECAM-1 is a molecular mediator of resistance to genotoxic chemotherapy.

scientific article published on 30 December 2006

The proinflammatory phenotype of PECAM-1-deficient mice results in atherogenic diet-induced steatohepatitis

scientific article published on 11 October 2007

Topological location and structural importance of the NBCe1-A residues mutated in proximal renal tubular acidosis

scientific article

Topology of NBCe1 protein transmembrane segment 1 and structural effect of proximal renal tubular acidosis (pRTA) S427L mutation

scientific article published on 28 January 2013

Transport of N-acetyl-S-(1,2-dichlorovinyl)-L-cysteine, a metabolite of trichloroethylene, by mouse multidrug resistance associated protein 2 (Mrp2).

scientific article

Upholding the T cell immune-regulatory function of CD31 inhibits the formation of T/B immunological synapses in vitro and attenuates the development of experimental autoimmune arthritis in vivo

scientific article published on 30 September 2014

Validation of a definition of excessive postoperative bleeding in infants undergoing cardiac surgery with cardiopulmonary bypass

scientific article published on 13 December 2017

Paulina is supported by:

About Paulina

Help