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List of works by Craig J. Thomas

2-Oxo-N-aryl-1,2,3,4-tetrahydroquinoline-6-sulfonamides as activators of the tumor cell specific M2 isoform of pyruvate kinase

scientific article

A 1536-well quantitative high-throughput screen to identify compounds targeting cancer stem cells.

scientific article

A Druggable TCF4- and BRD4-Dependent Transcriptional Network Sustains Malignancy in Blastic Plasmacytoid Dendritic Cell Neoplasm

scientific article

A basis for reduced chemical library inhibition of firefly luciferase obtained from directed evolution

scientific article

A comparison of the ability of rilpivirine (TMC278) and selected analogues to inhibit clinically relevant HIV-1 reverse transcriptase mutants

scientific article

A highly potent and selective caspase 1 inhibitor that utilizes a key 3-cyanopropanoic acid moiety

scientific article

A multiprotein supercomplex controlling oncogenic signalling in lymphoma

scientific article published in Nature

A novel class of ion displacement ligands as antagonists of the αIIbβ3 receptor that limit conformational reorganization of the receptor

scientific article published on 08 January 2014

A small molecule inverse agonist for the human thyroid-stimulating hormone receptor

scientific article

A small molecule that inhibits OGT activity in cells

scientific article published on 18 March 2015

ATF4 Gene Network Mediates Cellular Response to the Anticancer PAD Inhibitor YW3-56 in Triple-Negative Breast Cancer Cells.

scientific article

Alteration of the selectivity of DNA cleavage by a deglycobleomycin analogue containing a trithiazole moiety

scientific article

Aurora B kinase is a potent and selective target in MYCN-driven neuroblastoma

scientific article published on 21 October 2015

Blockade of oncogenic IκB kinase activity in diffuse large B-cell lymphoma by bromodomain and extraterminal domain protein inhibitors

scientific article

Brigatinib causes tumor shrinkage in both NF2-deficient meningioma and schwannoma through inhibition of multiple tyrosine kinases but not ALK

scientific article published on 15 July 2021

CD28 and ITK signals regulate autoreactive T cell trafficking.

scientific article

CP-690,550, a therapeutic agent, inhibits cytokine-mediated Jak3 activation and proliferation of T cells from patients with ATL and HAM/TSP

scientific article

Calcium-sensing receptor is a physiologic multimodal chemosensor regulating gastric G-cell growth and gastrin secretion

scientific article

Cancer network activity associated with therapeutic response and synergism

scientific article published on 24 August 2016

Chemical Screens Identify Drugs that Enhance or Mitigate Cellular Responses to Antibody-Toxin Fusion Proteins

scientific article

Chiral kinase inhibitors

scientific article

Chronic active B-cell-receptor signalling in diffuse large B-cell lymphoma

scientific article

Comparison of bioluminescent kinase assays using substrate depletion and product formation

scientific article

Comprehensive Mechanistic Analysis of Hits from High-Throughput and Docking Screens against β-Lactamase

scientific article

Comprehensive survey of chemical libraries for drug discovery and chemical biology: 2008.

scientific article published in September 2009

Comprehensive survey of chemical libraries for drug discovery and chemical biology: 2009.

scientific article

Conformationally constrained analogues of bleomycin A5.

scientific article

Cooperative epigenetic modulation by cancer amplicon genes

scientific article

Design and synthesis of new bicyclic diketopiperazines as scaffolds for receptor probes of structurally diverse functionality.

scientific article

Diversity-Oriented Synthesis Yields a Novel Lead for the Treatment of Malaria

scientific article

Drug repurposing screen identifies lestaurtinib amplifies the ability of the poly (ADP-ribose) polymerase 1 inhibitor AG14361 to kill breast cancer associated gene-1 mutant and wild type breast cancer cells

scientific article

Enhanced efficacy of JAK1 inhibitor with mTORC1/C2 targeting in smoldering/chronic adult T cell leukemia

scientific article published on 22 October 2020

Environment Dictates Dependence on Mitochondrial Complex I for NAD+ and Aspartate Production and Determines Cancer Cell Sensitivity to Metformin

scientific article published on 12 October 2016

Erratum: Pyruvate kinase M2 activators promote tetramer formation and suppress tumorigenesis

article

Evaluation of substituted N,N'-diarylsulfonamides as activators of the tumor cell specific M2 isoform of pyruvate kinase

scientific article

Evaluation of the Activity of Lamivudine and Zidovudine against Ebola Virus

scientific article published on 30 November 2016

Evaluation of thieno[3,2-b]pyrrole[3,2-d]pyridazinones as activators of the tumor cell specific M2 isoform of pyruvate kinase

scientific article

Exploiting synthetic lethality for the therapy of ABC diffuse large B cell lymphoma

scientific article

Exploration and optimization of substituted triazolothiadiazines and triazolopyridazines as PDE4 inhibitors

scientific article

Exploratory analysis of kinetic solubility measurements of a small molecule library

scientific article

Exploring the cellular activity of camptothecin-triple-helix-forming oligonucleotide conjugates

scientific article

Fluorescence spectroscopic profiling of compound libraries

scientific article

Functional screening of FGFR4-driven tumorigenesis identifies PI3K/mTOR inhibition as a therapeutic strategy in rhabdomyosarcoma

scientific article published on 28 February 2018

Genome-wide Screens Identify Lineage- and Tumor-Specific Genes Modulating MHC-I- and MHC-II-Restricted Immunosurveillance of Human Lymphomas

scientific article published on 02 December 2020

High-throughput combinatorial screening identifies drugs that cooperate with ibrutinib to kill activated B-cell-like diffuse large B-cell lymphoma cells

scientific article

High-throughput matrix screening identifies synergistic and antagonistic antimalarial drug combinations

scientific article

Hydroxylated tropolones inhibit hepatitis B virus replication by blocking viral ribonuclease H activity

scientific article

Identification and Optimization of Inhibitors of Trypanosomal Cysteine Proteases: Cruzain, Rhodesain, and TbCatB

scientific article

Identification of N-(quinolin-8-yl)benzenesulfonamides as agents capable of down-regulating NFkappaB activity within two separate high-throughput screens of NFkappaB activation

scientific article

Identification of a potent new chemotype for the selective inhibition of PDE4

scientific article

Identification of oxadiazoles as new drug leads for the control of schistosomiasis

scientific article

Identification of potent Yes1 kinase inhibitors using a library screening approach

scientific article

Inhibition of B Cell Receptor Signaling by Ibrutinib in Primary CNS Lymphoma

scientific article published on 10 May 2017

Inhibition of pyruvate kinase M2 by reactive oxygen species contributes to cellular antioxidant responses

scientific article

KIF11 and KIF15 mitotic kinesins are potential therapeutic vulnerabilities for malignant peripheral nerve sheath tumors

scientific article published on 04 January 2020

Large-scale pharmacological profiling of 3D tumor models of cancer cells.

scientific article

Matrix Drug Screen Identifies Synergistic Drug Combinations to Augment SMAC Mimetic Activity in Ovarian Cancer

scientific article published on 15 December 2020

Modulation of innate and adaptive immune responses by tofacitinib (CP-690,550).

scientific article

Molecular basis for the high-affinity binding and stabilization of firefly luciferase by PTC124

scientific article

Multi-Tissue Acceleration of the Mitochondrial Phosphoenolpyruvate Cycle Improves Whole-Body Metabolic Health

scientific article published on 01 November 2020

Multiple A2E treatments lead to melanization of rod outer segment-challenged ARPE-19 cells

scientific article published on 14 March 2014

Multiplexing high-content flow (HCF) and quantitative high-throughput screening (qHTS) to identify compounds capable of decreasing cell viability, activating caspase 3/7, expressing annexin V, and changing mitochondrial membrane integrity.

scientific article published in January 2013

N4-phenyl modifications of N2-(2-hydroxyl)ethyl-6-(pyrrolidin-1-yl)-1,3,5-triazine-2,4-diamines enhance glucocerebrosidase inhibition by small molecules with potential as chemical chaperones for Gaucher disease

scientific article

NMDAR inhibition-independent antidepressant actions of ketamine metabolites.

scientific article

Novel Phenotypic Outcomes Identified for a Public Collection of Approved Drugs from a Publicly Accessible Panel of Assays

scientific article

Overcoming Acquired Epigenetic Resistance to BTK Inhibitors

scientific article published on 14 September 2021

Overcoming adaptive therapy resistance in AML by targeting immune response pathways

scientific article published on 01 September 2019

PfCRT and PfMDR1 modulate interactions of artemisinin derivatives and ion channel blockers

scientific article (publication date: 5 May 2016)

Phosphodiesterase 4 inhibitors enhance sexual pleasure-seeking activity in rodents

scientific article

Playing well with others! Initiating and sustaining successful collaborations between industry, academia and government

scientific article

Pyruvate kinase M2 activators promote tetramer formation and suppress tumorigenesis

scientific article

Pyruvate kinase M2 regulates Hif-1α activity and IL-1β induction and is a critical determinant of the warburg effect in LPS-activated macrophages

scientific article published on January 2015

Quantitative analyses of aggregation, autofluorescence, and reactivity artifacts in a screen for inhibitors of a thiol protease

scientific article

Quantitative high-throughput screen identifies inhibitors of the Schistosoma mansoni redox cascade

scientific article

Quantitative high-throughput screening identifies inhibitors of anthrax-induced cell death

scientific article

Quantitative high-throughput screening using a live-cell cAMP assay identifies small-molecule agonists of the TSH receptor

scientific article

RNA Polymerase II Regulates Topoisomerase 1 Activity to Favor Efficient Transcription

scientific article

RUC-4: a novel αIIbβ3 antagonist for prehospital therapy of myocardial infarction

scientific article

Rigosertib induces mitotic arrest and apoptosis in RAS-driven rhabdomyosarcoma and neuroblastoma

scientific article published on 06 November 2020

Rilpivirine analogs potently inhibit drug-resistant HIV-1 mutants

scientific article published on 16 February 2016

Selective small molecule inhibitor of the Mycobacterium tuberculosis fumarate hydratase reveals an allosteric regulatory site

scientific journal article

Selective targeting of JAK/STAT signaling is potentiated by Bcl-xL blockade in IL-2-dependent adult T-cell leukemia

scientific article

Small-molecule agonists for the thyrotropin receptor stimulate thyroid function in human thyrocytes and mice

scientific article published on 10 July 2009

Solid-phase synthesis of bleomycin A(5) and three monosaccharide analogues: exploring the role of the carbohydrate moiety in RNA cleavage

scientific article

Solid-phase synthesis of bleomycin group antibiotics. Construction of a 108-member deglycobleomycin library

scientific article

Structure-Guided Design of a High-Affinity Platelet Integrin  IIb 3 Receptor Antagonist That Disrupts Mg2+ Binding to the MIDAS

scientific article

Synthesis and characterization of a BODIPY conjugate of the BCR-ABL kinase inhibitor Tasigna (nilotinib): evidence for transport of Tasigna and its fluorescent derivative by ABC drug transporters

scientific article

Synthesis, Activity, and Structural Analysis of Novel α-Hydroxytropolone Inhibitors of Human Immunodeficiency Virus Reverse Transcriptase-Associated Ribonuclease H

scientific article

The Synthesis and Evaluation of Dihydroquinazolin-4-ones and Quinazolin-4-ones as Thyroid Stimulating Hormone Receptor Agonists

scientific article published on October 2011

The extracellular calcium-sensing receptor is required for cholecystokinin secretion in response to L-phenylalanine in acutely isolated intestinal I cells

scientific article

The inhibition and treatment of breast cancer with poly (ADP-ribose) polymerase (PARP-1) inhibitors

scientific article

The phosphatidylinositol-3-phosphate 5-kinase inhibitor apilimod blocks filoviral entry and infection

scientific article published on 12 April 2017

The pilot phase of the NIH Chemical Genomics Center

scientific article

Therapeutic strategies for diffuse midline glioma from high-throughput combination drug screening

scientific article published on 01 November 2019

Transcriptomic profiling and quantitative high-throughput (qHTS) drug screening of CDH1 deficient hereditary diffuse gastric cancer (HDGC) cells identify treatment leads for familial gastric cancer.

scientific article

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