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List of works by Shivendra V Singh

A Novel Sulforaphane-Regulated Gene Network in Suppression of Breast Cancer-Induced Osteolytic Bone Resorption

scientific article published on 29 November 2019

A comprehensive review and perspective on anticancer mechanisms of withaferin A in breast cancer

scientific article published on 29 July 2020

A novel metabolic function of Myc in regulation of fatty acid synthesis in prostate cancer

scientific article published on 16 November 2020

AKT-dependent sugar addiction by benzyl isothiocyanate in breast cancer cells

scientific article published on 05 March 2019

Activation of a novel ataxia-telangiectasia mutated and Rad3 related/checkpoint kinase 1-dependent prometaphase checkpoint in cancer cells by diallyl trisulfide, a promising cancer chemopreventive constituent of processed garlic

scientific article published on 3 April 2007

Allyl isothiocyanate, a constituent of cruciferous vegetables, inhibits growth of PC-3 human prostate cancer xenografts in vivo

scientific article published in August 2003

Allyl isothiocyanate, a constituent of cruciferous vegetables, inhibits proliferation of human prostate cancer cells by causing G2/M arrest and inducing apoptosis

scientific article published on May 2003

Autophagy Fails to Alter Withaferin A-Mediated Lethality in Human Breast Cancer Cells ⬇️

scientific article published on July 1, 2013

Ayurvedic medicine constituent withaferin a causes G2 and M phase cell cycle arrest in human breast cancer cells

scientific article

Bax and Bak are required for apoptosis induction by sulforaphane, a cruciferous vegetable-derived cancer chemopreventive agent

scientific article

Benzo[a]pyrene-7,8-diol-9,10-epoxide causes caspase-mediated apoptosis in H460 human lung cancer cell line

scientific article published on 14 August 2007

Benzyl Isothiocyanate Causes FoxO1-Mediated Autophagic Death in Human Breast Cancer Cells ⬇️

scientific article published on March 22, 2012

Benzyl Isothiocyanate Inhibits Epithelial-Mesenchymal Transition in Cultured and Xenografted Human Breast Cancer Cells ⬇️

scientific article published on April 4, 2011

Benzyl isothiocyanate inhibits oncogenic actions of leptin in human breast cancer cells by suppressing activation of signal transducer and activator of transcription 3.

scientific article

Benzyl isothiocyanate-induced apoptosis in human breast cancer cells is initiated by reactive oxygen species and regulated by Bax and Bak.

scientific article published on November 2006

Bim contributes to phenethyl isothiocyanate‐induced apoptosis in breast cancer cells ⬇️

scientific article published on July 7, 2011

Biomarkers of Phenethyl Isothiocyanate-Mediated Mammary Cancer Chemoprevention in a Clinically Relevant Mouse Model ⬇️

scientific article published on August 2, 2012

Broccoli-Derived Sulforaphane and Chemoprevention of Prostate Cancer: From Bench to Bedside

scientific article

CXCR4 is a novel target of cancer chemopreventative isothiocyanates in prostate cancer cells

scientific article published on 23 February 2015

Cancer chemoprevention with dietary isothiocyanates mature for clinical translational research

scientific article published on June 27, 2012

Cancer-selective death of human breast cancer cells by leelamine is mediated by bax and bak activation

scientific article published on 5 May 2016

Caspase-dependent apoptosis induction by guggulsterone, a constituent of Ayurvedic medicinal plant Commiphora mukul, in PC-3 human prostate cancer cells is mediated by Bax and Bak.

scientific article published on November 2005

Caspase-dependent apoptosis induction by phenethyl isothiocyanate, a cruciferous vegetable-derived cancer chemopreventive agent, is mediated by Bak and Bax.

scientific article

Cell cycle arrest, apoptosis induction and inhibition of nuclear factor kappa B activation in anti-proliferative activity of benzyl isothiocyanate against human pancreatic cancer cells

scientific article published on 29 April 2004

Cellular responses to cancer chemopreventive agent D,L-sulforaphane in human prostate cancer cells are initiated by mitochondrial reactive oxygen species

scientific article published on 21 April 2009

Checkpoint kinase 1 regulates diallyl trisulfide-induced mitotic arrest in human prostate cancer cells

scientific article published on 16 June 2005

Chemopreventative potential of the cruciferous vegetable constituent phenethyl isothiocyanate in a mouse model of prostate cancer.

scientific article

Chemoprevention of prostate cancer by d,l-sulforaphane is augmented by pharmacological inhibition of autophagy

scientific article

Chemoprevention strategies for pancreatic cancer

scientific article

Cloning and expression of a novel Mu class murine glutathione transferase isoenzyme

scientific journal article

Critical Role of p53 Upregulated Modulator of Apoptosis in Benzyl Isothiocyanate-Induced Apoptotic Cell Death ⬇️

scientific article published on February 16, 2012

Critical role for reactive oxygen species in apoptosis induction and cell migration inhibition by diallyl trisulfide, a cancer chemopreventive component of garlic ⬇️

scientific article published on February 15, 2013

Critical role of allyl groups and disulfide chain in induction of Pi class glutathione transferase in mouse tissues in vivo by diallyl disulfide, a naturally occurring chemopreventive agent in garlic

scientific article published in October 2002

Crystal structure of human glutathione S-transferase A3-3 and mechanistic implications for its high steroid isomerase activity

scientific article

Cytoprotective autophagy induction by withaferin A in prostate cancer cells involves GABARAPL1

scientific article published on 03 August 2020

D,L-Sulforaphane causes transcriptional repression of androgen receptor in human prostate cancer cells

scientific article published on 07 July 2009

D,L‐sulforaphane‐induced apoptosis in human breast cancer cells is regulated by the adapter protein p66Shc ⬇️

scientific article published on February 1, 2012

Diallyl Trisulfide Inhibits Activation of Signal Transducer and Activator of Transcription 3 in Prostate Cancer Cells in Culture and In vivo ⬇️

scientific article published on October 19, 2010

Diallyl Trisulfide Inhibits Leptin-induced Oncogenic Signaling in Human Breast Cancer Cells but Fails to Prevent Chemically-induced Luminal-type Cancer in Rats

scientific article published on 01 March 2020

Diallyl trisulfide inhibits estrogen receptor-α activity in human breast cancer cells

scientific article published on February 2014

Diallyl trisulfide selectively causes Bax- and Bak-mediated apoptosis in human lung cancer cells

scientific article published on April 2009

Diallyl trisulfide suppresses growth of PC-3 human prostate cancer xenograft in vivo in association with Bax and Bak induction

scientific article published in November 2006

Diallyl trisulfide, a constituent of processed garlic, inactivates Akt to trigger mitochondrial translocation of BAD and caspase-mediated apoptosis in human prostate cancer cells

scientific article published on 16 September 2005

Diallyl trisulfide-induced G(2)-M phase cell cycle arrest in human prostate cancer cells is caused by reactive oxygen species-dependent destruction and hyperphosphorylation of Cdc 25 C.

scientific article published on September 2005

Diallyl trisulfide-induced G2/M phase cell cycle arrest in DU145 cells is associated with delayed nuclear translocation of cyclin-dependent kinase 1.

scientific article

Diallyl trisulfide-induced apoptosis in human cancer cells is linked to checkpoint kinase 1-mediated mitotic arrest

scientific article

Diallyl trisulfide-induced apoptosis in human prostate cancer cells involves c-Jun N-terminal kinase and extracellular-signal regulated kinase-mediated phosphorylation of Bcl-2.

scientific article published on July 2004

Dietary Chemopreventative Benzyl Isothiocyanate Inhibits Breast Cancer Stem Cells In Vitro and In Vivo ⬇️

scientific article published on 09 May 2013

Differential Response of Normal (PrEC) and Cancerous Human Prostate Cells (PC-3) to Phenethyl Isothiocyanate-Mediated Changes in Expression of Antioxidant Defense Genes ⬇️

scientific article published on September 25, 2010

Differential effects of phenethyl isothiocyanate and D,L-sulforaphane on TLR3 signaling

scientific article published on 15 March 2013

Differential expression of glutathione S-transferase isoenzymes in murine small intestine and colon

scientific article published in March 2002

Disease Subtype-Independent Biomarkers of Breast Cancer Chemoprevention by the Ayurvedic Medicine Phytochemical Withaferin A.

scientific article

Evaluation of Biodistribution of Sulforaphane after Administration of Oral Broccoli Sprout Extract in Melanoma Patients with Multiple Atypical Nevi

scientific article published on 24 April 2018

Exceptional activity of murine glutathione transferase A1-1 against (7R,8S)-dihydroxy-(9S,10R)-epoxy-7,8,9,10-tetrahydrobenzo[a]pyrene-induced DNA damage in stably transfected cells

scientific article

Fatty Acid Synthesis Intermediates Represent Novel Noninvasive Biomarkers of Prostate Cancer Chemoprevention by Phenethyl Isothiocyanate

scientific article published on 14 March 2017

Forkhead Box Q1 Is a Novel Target of Breast Cancer Stem Cell Inhibition by Diallyl Trisulfide.

scientific article published on 29 April 2016

Functional relevance of D,L-sulforaphane-mediated induction of vimentin and plasminogen activator inhibitor-1 in human prostate cancer cells

scientific article published on 04 October 2013

Garlic Constituent Diallyl Trisulfide Suppresses X-linked Inhibitor of Apoptosis Protein in Prostate Cancer Cells in Culture andIn Vivo ⬇️

scientific article published on March 16, 2011

Gene Expression Changes by Diallyl Trisulfide Administration in Chemically-induced Mammary Tumors in Rats

scientific article published on 01 March 2022

Ginsenoside Rh2-mediated G1 phase cell cycle arrest in human breast cancer cells is caused by p15 Ink4B and p27 Kip1-dependent inhibition of cyclin-dependent kinases

scientific article published on 23 July 2009

Growth arrest by the antitumor steroidal lactone withaferin A in human breast cancer cells is associated with down-regulation and covalent binding at cysteine 303 of β-tubulin

scientific article published on 02 December 2013

Guggulsterone enhances head and neck cancer therapies via inhibition of signal transducer and activator of transcription-3

scientific article published on 16 September 2009

Guggulsterone-induced apoptosis in human prostate cancer cells is caused by reactive oxygen intermediate dependent activation of c-Jun NH2-terminal kinase

scientific article published on August 2007

Honokiol activates reactive oxygen species-mediated cytoprotective autophagy in human prostate cancer cells

scientific article

Honokiol causes G0-G1 phase cell cycle arrest in human prostate cancer cells in association with suppression of retinoblastoma protein level/phosphorylation and inhibition of E2F1 transcriptional activity

scientific article published in October 2007

Honokiol inhibits androgen receptor activity in prostate cancer cells

scientific article published on 11 December 2013

In Vitro and In Vivo Effects of Phenethyl Isothiocyanate Treatment on Vimentin Protein Expression in Cancer Cells ⬇️

scientific article published on January 1, 2013

Induction of p21 protein protects against sulforaphane-induced mitotic arrest in LNCaP human prostate cancer cell line

scientific article published on May 2007

Inhibition of EGFR-STAT3 signaling with erlotinib prevents carcinogenesis in a chemically-induced mouse model of oral squamous cell carcinoma.

scientific article

Inhibition of Glycolysis in Prostate Cancer Chemoprevention by Phenethyl Isothiocyanate

scientific article published on 15 March 2018

Inhibition of human breast cancer xenograft growth by cruciferous vegetable constituent benzyl isothiocyanate

scientific article

Inhibition of mitochondrial fusion is an early and critical event in breast cancer cell apoptosis by dietary chemopreventative benzyl isothiocyanate

scientific article published on 30 June 2016

Irreversible Inhibition of Glutathione S-Transferase by Phenethyl Isothiocyanate (PEITC), a Dietary Cancer Chemopreventive Phytochemical

scientific article published on 29 September 2016

JS-K, a glutathione/glutathione S-transferase-activated nitric oxide donor of the diazeniumdiolate class with potent antineoplastic activity

scientific article published on April 2003

Leelamine Is a Novel Lipogenesis Inhibitor in Prostate Cancer Cells In Vitro and In Vivo

scientific article published on 08 August 2019

Mammary cancer chemoprevention by withaferin A is accompanied by in vivo suppression of self-renewal of cancer stem cells

scientific article

Metabolic alterations in mammary cancer prevention by withaferin A in a clinically relevant mouse model

scientific article published on 02 July 2013

Mitochondria-mediated apoptosis by diallyl trisulfide in human prostate cancer cells is associated with generation of reactive oxygen species and regulated by Bax/Bak

scientific article

Mitochondrial dysfunction in cancer chemoprevention by phytochemicals from dietary and medicinal plants

scientific article published on 17 November 2016

Molecular mechanisms and targets of cancer chemoprevention by garlic-derived bioactive compound diallyl trisulfide ⬇️

scientific article published on November 1, 2011

Molecular targets of cancer chemoprevention by garlic-derived organosulfides

scientific article published on September 2007

Myoglobin induces mitochondrial fusion, thereby inhibiting breast cancer cell proliferation

scientific article published on 14 March 2019

Notch Activation Is Dispensable for D, L-Sulforaphane-Mediated Inhibition of Human Prostate Cancer Cell Migration ⬇️

scientific article published on September 7, 2012

Notch Activation by Phenethyl Isothiocyanate Attenuates Its Inhibitory Effect on Prostate Cancer Cell Migration ⬇️

scientific article published on October 24, 2011

Notch2 activation by benzyl isothiocyanate impedes its inhibitory effect on breast cancer cell migration ⬇️

scientific article published on April 4, 2012

Notch2 activation is protective against anticancer effects of zerumbone in human breast cancer cells

scientific article

Novel mechanistic targets of forkhead box Q1 transcription factor in human breast cancer cells

scientific article published on 05 August 2020

Peptidyl-prolyl cis/trans isomerase Pin1 regulates withaferin A-mediated cell cycle arrest in human breast cancer cells

scientific article published on 30 March 2018

Phenethyl isothiocyanate inhibits angiogenesis in vitro and ex vivo

scientific article published on 01 March 2007

Phenethyl isothiocyanate inhibits oxidative phosphorylation to trigger reactive oxygen species-mediated death of human prostate cancer cells

scientific article

Phenethyl isothiocyanate inhibits proliferation and induces apoptosis in pancreatic cancer cells in vitro and in a MIAPaca2 xenograft animal model

scientific article

Phenethyl isothiocyanate suppresses inhibitor of apoptosis family protein expression in prostate cancer cells in culture and in vivo ⬇️

scientific article published on December 7, 2011

Phenethyl isothiocyanate, a cancer chemopreventive constituent of cruciferous vegetables, inhibits cap-dependent translation by regulating the level and phosphorylation of 4E-BP1.

scientific article published on April 2007

Phenethyl isothiocyanate-induced apoptosis in PC-3 human prostate cancer cells is mediated by reactive oxygen species-dependent disruption of the mitochondrial membrane potential

scientific article published on 13 June 2006

Phenethyl isothiocyanate-induced apoptosis in p53-deficient PC-3 human prostate cancer cell line is mediated by extracellular signal-regulated kinases.

scientific article published on July 2002

Prevention of Prostate Cancer in Transgenic Adenocarcinoma of the Mouse Prostate Mice by Yellow Passion Fruit Extract and Antiproliferative Effects of Its Bioactive Compound Piceatannol

scientific article published on 01 June 2020

Prevention of breast cancer-induced osteolytic bone resorption by benzyl isothiocyanate

scientific article published on 11 October 2017

Prevention of mammary carcinogenesis in MMTV-neu mice by cruciferous vegetable constituent benzyl isothiocyanate

scientific article published on December 2009

Prostate cancer chemoprevention by sulforaphane in a preclinical mouse model is associated with inhibition of fatty acid metabolism

scientific article published on 01 May 2018

Proteasome-mediated degradation of cell division cycle 25C and cyclin-dependent kinase 1 in phenethyl isothiocyanate-induced G2-M-phase cell cycle arrest in PC-3 human prostate cancer cells.

scientific article published on May 2004

RNA-seq reveals novel cancer-selective and disease subtype-independent mechanistic targets of withaferin A in human breast cancer cells

scientific article published on 04 November 2020

RNA-seq reveals novel mechanistic targets of withaferin A in prostate cancer cellss

scientific article published on 31 January 2020

Reactive oxygen species-dependent apoptosis by gugulipid extract of Ayurvedic medicine plant Commiphora mukul in human prostate cancer cells is regulated by c-Jun N-terminal kinase

scientific article

Requirement of a carbon spacer in benzyl isothiocyanate-mediated cytotoxicity and MAPK activation in head and neck squamous cell carcinoma.

scientific article

Residues 207, 216, and 221 and the catalytic activity of mGSTA1-1 and mGSTA2-2 toward benzo[a]pyrene-(7R,8S)-diol-(9S,10R)-epoxide

scientific article

Reversal of the Warburg phenomenon in chemoprevention of prostate cancer by sulforaphane

scientific article published on 01 December 2019

Role of Krüppel-like Factor 4-p21CIP1 Axis in Breast Cancer Stem-like Cell Inhibition by Benzyl Isothiocyanate

scientific article published on 05 February 2019

Role of mitogen-activated protein kinases and Mcl-1 in apoptosis induction by withaferin A in human breast cancer cells

scientific article published on 09 September 2013

Role of mitogen-activated protein kinases in phenethyl isothiocyanate-induced apoptosis in human prostate cancer cells

scientific article

Short-form RON overexpression augments benzyl isothiocyanate-induced apoptosis in human breast cancer cells

scientific article

Sodium butyrate induces DRP1-mediated mitochondrial fusion and apoptosis in human colorectal cancer cells

scientific article published on 29 October 2013

Structural basis for catalytic differences between alpha class human glutathione transferases hGSTA1-1 and hGSTA2-2 for glutathione conjugation of environmental carcinogen benzo[a]pyrene-7,8-diol-9,10-epoxide

scientific article

Sulforaphane Inhibits c-Myc-Mediated Prostate Cancer Stem-Like Traits

scientific article

Sulforaphane causes autophagy to inhibit release of cytochrome C and apoptosis in human prostate cancer cells

scientific article published on June 2006

Sulforaphane inhibits constitutive and interleukin-6-induced activation of signal transducer and activator of transcription 3 in prostate cancer cells

scientific article

Sulforaphane-induced G2/M phase cell cycle arrest involves checkpoint kinase 2-mediated phosphorylation of cell division cycle 25C.

scientific article published on 8 April 2004

Suppression of FOXQ1 in benzyl isothiocyanate-mediated inhibition of epithelial-mesenchymal transition in human breast cancer cells ⬇️

scientific article published on December 30, 2012

The Role of Lysosome-Associated Membrane Protein 2 in Prostate Cancer Chemopreventive Mechanisms of Sulforaphane

scientific article published on 20 May 2020

The carcinogen (7R,8S)-dihydroxy-(9S,10R)-epoxy-7,8,9,10-tetrahydrobenzo[a]pyrene induces Cdc25B expression in human bronchial and lung cancer cells

scientific article published in February 2003

The garlic constituent diallyl trisulfide increases the lifespan of C. elegans via skn-1 activation

scientific article published on 2 February 2011

The role of polycomb group protein Bmi-1 and Notch4 in breast cancer stem cell inhibition by benzyl isothiocyanate

scientific article

Therapeutic Potential of Leelamine, a Novel Inhibitor of Androgen Receptor and Castration-Resistant Prostate Cancer

scientific article published on 20 July 2018

Transcriptional repression and inhibition of nuclear translocation of androgen receptor by diallyl trisulfide in human prostate cancer cells

scientific article published on 21 July 2009

Transport functions and physiological significance of 76 kDa Ral-binding GTPase activating protein (RLIP76).

scientific article

Withaferin A causes activation of Notch2 and Notch4 in human breast cancer cells ⬇️

scientific article published on September 11, 2012

Withaferin A inhibits activation of signal transducer and activator of transcription 3 in human breast cancer cells ⬇️

scientific article published on August 19, 2010

Withaferin A inhibits experimental epithelial-mesenchymal transition in MCF-10A cells and suppresses vimentin protein level in vivo in breast tumors

scientific article

Withaferin A inhibits expression of ataxia telangiectasia and Rad3-related kinase and enhances sensitivity of human breast cancer cells to cisplatin

scientific article published on 22 August 2019

Withaferin A inhibits in vivo growth of breast cancer cells accelerated by Notch2 knockdown

scientific article published on 21 April 2016

Withaferin A-induced apoptosis in human breast cancer cells is associated with suppression of inhibitor of apoptosis family protein expression

scientific article

Withaferin A-induced apoptosis in human breast cancer cells is mediated by reactive oxygen species

scientific article

Withaferin A-mediated apoptosis in breast cancer cells is associated with alterations in mitochondrial dynamics

scientific article published on 24 January 2019

Withaferin a suppresses estrogen receptor‐α expression in human breast cancer cells ⬇️

scientific article published on March 22, 2011

Withania somnifera root extract inhibits fatty acid synthesis in prostate cancer cells

scientific article published on 07 February 2020

Zerumbone causes Bax- and Bak-mediated apoptosis in human breast cancer cells and inhibits orthotopic xenograft growth in vivo ⬇️

scientific article published on October 6, 2012

Zerumbone modulates CD1d expression and lipid antigen presentation pathway in breast cancer cells

scientific article published on 17 June 2017

c-Jun NH(2)-terminal kinase signaling axis regulates diallyl trisulfide-induced generation of reactive oxygen species and cell cycle arrest in human prostate cancer cells

scientific article published on May 2006

c-Myc is a novel target of cell cycle arrest by honokiol in prostate cancer cells

scientific article published on 24 June 2016

p53 regulates cellular responses to environmental carcinogen benzo[a]pyrene-7,8-diol-9,10-epoxide in human lung cancer cells

scientific article

p53-Independent apoptosis by benzyl isothiocyanate in human breast cancer cells is mediated by suppression of XIAP expression

scientific article

p66Shc is indispensable for phenethyl isothiocyanate-induced apoptosis in human prostate cancer cells

scientific article

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