Search filters

List of works by Jaap Kwekkeboom

Aberrant composition of the dendritic cell population in hepatic lymph nodes of patients with hepatocellular carcinoma

scientific article published in March 2006

Antibodies Against Immune Checkpoint Molecules Restore Functions of Tumor-infiltrating T cells in Hepatocellular Carcinomas

scientific article published on 22 June 2017

Blockade of LAG3 enhances responses of tumor-infiltrating T cells in mismatch repair-proficient liver metastases of colorectal cancer.

scientific article published on 25 April 2018

Calcineurin inhibitor tacrolimus does not interfere with the suppression of hepatitis C virus infection by interferon-alpha

scientific article published in April 2010

Characterization of human liver dendritic cells in liver grafts and perfusates

scientific article published on 01 March 2006

Circulating levels of PD-L1 and Galectin-9 are associated with patient survival in surgically treated Hepatocellular Carcinoma independent of their intra-tumoral expression levels

scientific article published on 23 July 2019

Combined antiviral activity of interferon-α and RNA interference directed against hepatitis C without affecting vector delivery and gene silencing

scientific article (publication date: July 2009)

Counter-regulation of rejection activity against human liver grafts by donor PD-L1 and recipient PD-1 interaction

scientific article

Cytomegalovirus-Induced Expression of CD244 after Liver Transplantation Is Associated with CD8+ T Cell Hyporesponsiveness to Alloantigen

scientific article published on 13 July 2015

Defining early human NK cell developmental stages in primary and secondary lymphoid tissues

scientific article

Detailed kinetics of the direct allo-response in human liver transplant recipients: new insights from an optimized assay

scientific article

Detection of spontaneous tumorigenic transformation during culture expansion of human mesenchymal stromal cells.

scientific article published on 13 November 2013

Dexamethasone transforms lipopolysaccharide-stimulated human blood myeloid dendritic cells into myeloid dendritic cells that prime interleukin-10 production in T cells

scientific article published on 27 February 2008

Differences in Anti-Inflammatory Actions of Intravenous Immunoglobulin between Mice and Men: More than Meets the Eye.

scientific article published on 28 April 2015

Differential Sensitivities of Fast- and Slow-cycling Cancer Cells to Inosine Monophosphate Dehydrogenase 2 Inhibition by Mycophenolic Acid.

scientific article published on 13 October 2015

Disturbance of the microRNA pathway by commonly used lentiviral shRNA libraries limits the application for screening host factors involved in hepatitis C virus infection

scientific article

Exosome-mediated transmission of hepatitis C virus between human hepatoma Huh7.5 cells.

scientific article published on 22 July 2013

Functional impairment of myeloid and plasmacytoid dendritic cells of patients with chronic hepatitis B.

scientific article published in September 2004

GITR engagement in combination with CTLA-4 blockade completely abrogates immunosuppression mediated by human liver tumor-derived regulatory T cells ex vivo

scientific article

GITR ligation enhances functionality of tumor-infiltrating T cells in hepatocellular carcinoma

scientific article published on 27 February 2019

HHLA2 is expressed in pancreatic and ampullary cancers and increased expression is associated with better post-surgical prognosis

scientific article published on 19 February 2020

Hepatic cell-to-cell transmission of small silencing RNA can extend the therapeutic reach of RNA interference (RNAi).

scientific article

Hepatocyte-derived microRNAs as serum biomarkers of hepatic injury and rejection after liver transplantation

scientific article published on March 1, 2012

Human graft-derived mesenchymal stromal cells potently suppress alloreactive T-cell responses

scientific article published on 28 April 2015

Human plasmacytoid dendritic cells induce CD8+LAG‐3+Foxp3+CTLA‐4+ regulatory T cells that suppress allo‐reactive memory T cells

scientific article published on May 25, 2011

Identifying genetic risk variants for coronary heart disease in familial hypercholesterolemia: an extreme genetics approach

scientific article

Immunomagnetic selection of functional dendritic cells from human lymph nodes

scientific article published on 27 March 2005

Immunomodulation by hyperimmunoglobulins after solid organ transplantation: Beyond prevention of viral infection

scientific article published on 19 January 2017

Intrahepatic CD8+ T-lymphocyte response is important for therapy-induced viral clearance in chronic hepatitis B infection

scientific article published on 25 April 2005

Intravenous immunoglobulin treatment in humans suppresses dendritic cell function via stimulation of IL-4 and IL-13 production.

scientific article published on 7 May 2014

JAK-inhibitor tofacitinib suppresses interferon alfa production by plasmacytoid dendritic cells and inhibits arthrogenic and antiviral effects of interferon alfa.

scientific article

Kupffer cells interact with hepatitis B surface antigen in vivo and in vitro, leading to proinflammatory cytokine production and natural killer cell function.

scientific article published on 31 October 2014

Liver grafts contain a unique subset of natural killer cells that are transferred into the recipient after liver transplantation

scientific article published on 01 July 2010

Migration of allosensitizing donor myeloid dendritic cells into recipients after liver transplantation

scientific article published on 01 January 2010

Modulation of dendritic cells and regulatory T cells by naturally occurring antibodies

scientific article published on January 2012

Modulation of the cellular immune system by intravenous immunoglobulin

scientific article published on 14 October 2008

PD-L1, Galectin-9 and CD8+ tumor-infiltrating lymphocytes are associated with survival in hepatocellular carcinoma

scientific article published on 03 January 2017

Prognostic value of intra-tumoral CD8 /FoxP3 lymphocyte ratio in patients with resected colorectal cancer liver metastasis

Prominent HLA-G Expression in Liver Disease But Not After Liver Transplantation.

scientific article published on 8 May 2015

Protective Cytomegalovirus (CMV)-Specific T-Cell Immunity Is Frequent in Kidney Transplant Patients without Serum Anti-CMV Antibodies

scientific article published on 12 September 2017

Reduction of immunosuppressive tumor microenvironment in cholangiocarcinoma by ex vivo targeting immune checkpoint molecules

scientific article published on 11 June 2019

Reply to: Comment on 'Tumour antigen expression in hepatocellular carcinoma in a low-endemic western area'.

scientific article published on 14 April 2016

Rotterdam: main port for organ transplantation research in the Netherlands

scientific article published on 18 September 2014

Secreted factors of human liver-derived mesenchymal stem cells promote liver regeneration early after partial hepatectomy.

scientific article

Superior immunomodulatory effects of intravenous immunoglobulins on human T-cells and dendritic cells: comparison to calcineurin inhibitors

scientific article published on 01 June 2006

T-cell inhibitory capacity of hyperimmunoglobulins is influenced by the production process

scientific article published on 22 January 2014

T-cell suppression mediated by regulatory T cells infiltrating hepatic tumors can be overcome by GITRL treatment

scientific article published on January 2013

Tumor cell expression of immune inhibitory molecules and tumor-infiltrating lymphocyte count predict cancer-specific survival in pancreatic and ampullary cancer

scientific article

Tumor-infiltrating plasmacytoid dendritic cells promote immunosuppression by Tr1 cells in human liver tumors.

scientific article published on 19 March 2015

Unphosphorylated ISGF3 drives constitutive expression of interferon-stimulated genes to protect against viral infections.

scientific article published on 25 April 2017

mTOR signaling in liver regeneration: Rapamycin combined with growth factor treatment

scientific article published on September 2013