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List of works by Todd E Fox

AP-1 binding transcriptionally regulates human neutral ceramidase

scientific article

Acid ceramidase is upregulated in AML and represents a novel therapeutic target

scientific article

Acid ceramidase promotes drug resistance in acute myeloid leukemia through NF-κB-dependent P-glycoprotein upregulation

scientific article published on 08 April 2019

Altered sphingolipid metabolism in patients with metastatic pancreatic cancer

scientific article published on 25 July 2013

Bif-1 regulates Atg9 trafficking by mediating the fission of Golgi membranes during autophagy

scientific article

C(6)-Ceramide-Coated Catheters Promote Re-Endothelialization of Stretch-Injured Arteries

scientific article published in August 2008

C6-ceramide nanoliposomes target the Warburg effect in chronic lymphocytic leukemia

scientific article

Calcium phosphate nanocomposite particles for in vitro imaging and encapsulated chemotherapeutic drug delivery to cancer cells

scientific article published on December 2008

Ceramide 1-Phosphate Mediates Endothelial Cell Invasion via the Annexin a2-p11 Heterotetrameric Protein Complex ⬇️

scientific article published on May 21, 2013

Ceramide 1-phosphate regulates cell migration and invasion of human pancreatic cancer cells

scientific article

Ceramide Analogue SACLAC Modulates Sphingolipid Levels and MCL-1 Splicing to Induce Apoptosis in Acute Myeloid Leukemia

scientific article published on 19 November 2019

Ceramide modulates HERG potassium channel gating by translocation into lipid rafts

scientific article

Ceramide nanoliposomes as a MLKL-dependent, necroptosis-inducing, chemotherapeutic reagent in ovarian cancer

scientific article published on 27 October 2017

Ceramide recruits and activates protein kinase C zeta (PKC zeta) within structured membrane microdomains

scientific journal article

Ceramide-tamoxifen regimen targets bioenergetic elements in acute myelogenous leukemia

scientific article

Chemotherapy selection pressure alters sphingolipid composition and mitochondrial bioenergetics in resistant HL-60 cells

scientific article published on 30 July 2019

Circulating sphingolipid biomarkers in models of type 1 diabetes

scientific article

Combinatorial therapies improve the therapeutic efficacy of nanoliposomal ceramide for pancreatic cancer ⬇️

scientific article published on October 1, 2011

Conductance-Based Biophysical Distinction and Microfluidic Enrichment of Nanovesicles Derived from Pancreatic Tumor Cells of Varying Invasiveness

scientific article published on 01 August 2019

Diabetes alters sphingolipid metabolism in the retina: a potential mechanism of cell death in diabetic retinopathy

scientific article

Diabetes diminishes phosphatidic acid in the retina: a putative mediator for reduced mTOR signaling and increased neuronal cell death

scientific article

Dysregulation of sphingolipid metabolism in cancer ⬇️

scientific article published on January 15, 2011

Effective encapsulation and biological activity of phosphorylated chemotherapeutics in calcium phosphosilicate nanoparticles for the treatment of pancreatic cancer

scientific article published on 30 June 2017

Ether-linked diglycerides inhibit vascular smooth muscle cell growth via decreased MAPK and PI3K/Akt signaling

scientific article published on 22 August 2008

Exogenous Liposomal Ceramide-C6 Ameliorates Lipidomic Profile, Energy Homeostasis, and Anti-Oxidant Systems in NASH

scientific article published on 16 May 2020

Exogenous ceramide-1-phosphate reduces lipopolysaccharide (LPS)-mediated cytokine expression

scientific article published on 7 November 2011

Inhibition of Lysosomal Function Mitigates Protective Mitophagy and Augments Ceramide Nanoliposome-Induced Cell Death in Head and Neck Squamous Cell Carcinoma

scientific article published on 21 October 2020

Inhibition of NADPH oxidase by glucosylceramide confers chemoresistance ⬇️

scientific article published on December 1, 2010

Inhibition of corneal inflammation by liposomal delivery of short-chain, C-6 ceramide

scientific article published on 17 April 2008

Insulin signaling in retinal neurons is regulated within cholesterol-enriched membrane microdomains.

scientific article published on 4 January 2011

Liposomal Delivery of Diacylglycerol Lipase-Beta Inhibitors to Macrophages Dramatically Enhances Selectivity and Efficacy in Vivo

scientific article published on 13 September 2017

Lysosomal degradation of CD44 mediates ceramide nanoliposome-induced anoikis and diminished extravasation in metastatic carcinoma cells

scientific article

Modification of sphingolipid metabolism by tamoxifen and N-desmethyltamoxifen in acute myelogenous leukemia--Impact on enzyme activity and response to cytotoxics

scientific article

Nanoliposomal minocycline for ocular drug delivery

scientific article published on 28 March 2012

Nanoliposome C6-Ceramide Increases the Anti-tumor Immune Response and Slows Growth of Liver Tumors in Mice

scientific article published on 30 January 2018

Neurotensin receptor-1 inducible palmitoylation is required for efficient receptor-mediated mitogenic-signaling within structured membrane microdomains

scientific article

Novel off-target effect of tamoxifen — Inhibition of acid ceramidase activity in cancer cells ⬇️

scientific article published on August 9, 2013

Optimized expression and purification of myristoylated human neuronal calcium sensor 1 in E. coli.

scientific article

Phosphatidic acid mediates activation of mTORC1 through the ERK signaling pathway

scientific article

PhotoImmunoNanoTherapy reveals an anticancer role for sphingosine kinase 2 and dihydrosphingosine-1-phosphate

scientific article published on 14 February 2013

Preclinical development of a C6-ceramide NanoLiposome, a novel sphingolipid therapeutic

scientific article published on June 2015

Propagation of Undifferentiated Human Embryonic Stem Cells with Nano-Liposomal Ceramide

scientific article published in January 2009

SKI-178: A Multitargeted Inhibitor of Sphingosine Kinase and Microtubule Dynamics Demonstrating Therapeutic Efficacy in Acute Myeloid Leukemia Models

scientific article published on July 2017

STAT3 mediates C6-ceramide-induced cell death in chronic lymphocytic leukemia

Sphingolipid metabolism determines the therapeutic efficacy of nanoliposomal ceramide in acute myeloid leukemia

scientific article published on 01 September 2019

Sphingosine Kinase 1 Cooperates with Autophagy to Maintain Endocytic Membrane Trafficking

scientific article

Sphingosine kinase 1 localized to the plasma membrane lipid raft microdomain overcomes serum deprivation induced growth inhibition

scientific article published on 24 September 2009

Sphingosine kinase inhibitors decrease viability and induce cell death in natural killer-large granular lymphocyte leukemia

scientific article

Targeting glucosylceramide synthase synergizes with C6-ceramide nanoliposomes to induce apoptosis in natural killer cell leukemia

scientific article

Targeting sphingosine kinase-1 to inhibit melanoma.

scientific article published on March 2012

The apoptotic mechanism of action of the sphingosine kinase 1 selective inhibitor SKI-178 in human acute myeloid leukemia cell lines

scientific article

Therapeutic efficacy of FTY720 in a rat model of NK-cell leukemia

scientific article

Therapeutic strategies for diabetes and complications: a role for sphingolipids?

scientific article published on January 2010

Toll-like receptors at the ocular surface

scientific article published on July 2008

Transcriptional regulation of the human neutral ceramidase gene

scientific article

Tumor-promoting effects of pancreatic cancer cell exosomes on THP-1-derived macrophages

scientific article published in PLoS ONE

Use of high performance liquid chromatography-electrospray ionization-tandem mass spectrometry for the analysis of ceramide-1-phosphate levels

scientific article

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