List of works - Michelle R Arkin

14‐3‐3 Protein‐Protein Interactions: From Mechanistic Understanding to Their Small‐Molecule Stabilization

scientific article published on 24 June 2024

A High-Throughput Turbidometric Assay for Screening Inhibitors of Leishmania major Protein Disulfide Isomerase ⬇️

scientific article published on March 25, 2011

A New Data Analysis Method to Determine Binding Constants of Small Molecules to Proteins Using Equilibrium Analytical Ultracentrifugation with Absorption Optics ⬇️

scientific article published on December 1, 2001

A multi-dimensional, time-lapse, high content screening platform applied to schistosomiasis drug discovery

scientific article published on 21 December 2020

Analysis of high‐throughput screening assays using cluster enrichment ⬇️

scientific article published on July 5, 2012

Author Correction: Transcriptional profiling and therapeutic targeting of oxidative stress in neuroinflammation

scientific article published on 13 July 2020

Diverse Inhibitor Chemotypes Targeting Trypanosoma cruzi CYP51 ⬇️

scientific article published on July 31, 2012

Exploration of a 14-3-3 PPI Pocket by Covalent Fragments as Stabilizers

scientific article published in 2021

Fluorescence Anisotropy-Based Tethering for Discovery of Protein-Protein Interaction Stabilizers

scientific article published on 16 November 2020

Genetically Encoded, pH-Sensitive mTFP1 Biosensor for Probing Lysosomal pH

scientific article published on 08 June 2021

Inhibition and Crystal Structure of the Human DHTKD1-Thiamin Diphosphate Complex

scientific article published on 09 July 2020

Mechanistic and Structural Understanding of Uncompetitive Inhibitors of Caspase-6 ⬇️

scientific article published on December 5, 2012

Modulating protein-protein interaction networks in protein homeostasis

scientific article published on 23 March 2019

Phenotypic Screening Using High-Content Imaging to Identify Lysosomal pH Modulators in a Neuronal Cell Model

scientific article published on 06 May 2022

Screening for noise in gene expression identifies drug synergies

scientific article

Site-Directed Fragment-Based Screening for the Discovery of Protein-Protein Interaction Stabilizers

scientific article published on 19 February 2019

Small molecule inhibitors of Smoothened ciliary localization and ciliogenesis ⬇️

scientific article published on August 3, 2012

Structural and Enzymatic Insights into Caspase-2 Protein Substrate Recognition and Catalysis ⬇️

scientific article published on August 2, 2011

Structure-Based Optimization of Covalent, Small-Molecule Stabilizers of the 14-3-3σ/ERα Protein–Protein Interaction from Nonselective Fragments

scientific article published on 7 September 2023

Structure–activity relationship (SAR) of the α-amino acid residue of potent tetrahydroisoquinoline (THIQ)-derived LFA-1/ICAM-1 antagonists ⬇️

scientific article published on 05 November 2010

Tackling reproducibility in academic preclinical drug discovery

scientific article published on 21 September 2015

Transcriptional profiling and therapeutic targeting of oxidative stress in neuroinflammation

scientific article published on 13 April 2020

USP7 small-molecule inhibitors interfere with ubiquitin binding

scientific article published on 18 October 2017

List of works by Michelle R Arkin