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List of works by Alwin D R Huitema

A Phase 1 Dose-Escalation Study of Low-Dose Metronomic Treatment With Novel Oral Paclitaxel Formulations in Combination With Ritonavir in Patients With Advanced Solid Tumors

scientific article published on 05 October 2020

A Phase I Dose Escalation Study of Once-Weekly Oral Administration of Docetaxel as ModraDoc001 Capsule or ModraDoc006 Tablet in Combination with Ritonavir

scientific article published on 19 June 2019

A Population Pharmacokinetic Model of Oral Docetaxel Coadministered With Ritonavir to Support Early Clinical Development

scientific article published on 09 October 2019

A Semi-Physiological Population Model to Quantify the Effect of Hematocrit on Everolimus Pharmacokinetics and Pharmacodynamics in Cancer Patients.

scientific article published on 14 June 2016

A dose-escalation study of bi-daily once weekly oral docetaxel either as ModraDoc001 or ModraDoc006 combined with ritonavir

scientific article published on 11 October 2017

A less sensitive detector does not necessarily result in a less sensitive method: fast quantification of 13 antiretroviral analytes in plasma with liquid chromatography coupled with tandem mass spectrometry

scientific article published in August 2010

A model of hypertension and proteinuria in cancer patients treated with the anti-angiogenic drug E7080

scientific article

A phase 0 clinical trial of novel candidate extended-release formulations of capecitabine

scientific article

A randomized phase II pharmacokinetic and pharmacodynamic study of indisulam as second-line therapy in patients with advanced non-small cell lung cancer

scientific article published on 01 March 2007

A semi-mechanistic model based on glutathione depletion to describe intra-individual reduction in busulfan clearance

scientific article published on 18 February 2020

A semi-physiological population pharmacokinetic model describing the non-linear disposition of indisulam

scientific article published in September 2006

A simple and safe method for 131I radiolabeling of rituximab for myeloablative high-dose radioimmunotherapy

scientific article published in February 2009

Accuracy, feasibility, and clinical impact of prospective Bayesian pharmacokinetically guided dosing of cyclophosphamide, thiotepa, and carboplatin in high-dose chemotherapy

scientific article published in January 2005

Age-Associated Hematological Toxicity in Patients with Metastatic Castration-Resistant Prostate Cancer Treated with Docetaxel in Clinical Practice

scientific article published on 01 April 2019

Altered cyclophosphamide and thiotepa pharmacokinetics in a patient with moderate renal insufficiency

scientific article published on 23 April 2008

An Integrated Pharmacokinetic Model for the Influence of CYP3A4 Expression on the In Vivo Disposition of Lopinavir and Its Modulation by Ritonavir ⬇️

scientific article published on December 29, 2010

An overview of the relations between polymorphisms in drug metabolising enzymes and drug transporters and survival after cancer drug treatment

scientific article published on 03 September 2008

Anticonvulsant effectiveness and hemodynamic safety of midazolam in full-term infants treated with hypothermia

scientific article

Anticonvulsant treatment of asphyxiated newborns under hypothermia with lidocaine: efficacy, safety and dosing

scientific article

Antiviral activity of HIV type 1 protease inhibitors nelfinavir and indinavir in vivo is not influenced by P-glycoprotein activity on CD4+ T cells.

scientific article published in January 2007

Application of population pharmacokinetic modeling in early clinical development of the anticancer agent E7820.

scientific article published on 20 August 2008

Aprepitant inhibits cyclophosphamide bioactivation and thiotepa metabolism

scientific article

Are adverse events of nevirapine and efavirenz related to plasma concentrations?

scientific article published in January 2005

Baclofen overdose treated with continuous venovenous hemofiltration

scientific article published on 9 January 2015

Bayesian pharmacokinetically guided dosing of paclitaxel in patients with non-small cell lung cancer.

scientific article published in April 2004

CD4+ T-cell reconstitution predicts Survival Outcomes after acute Graft-versus-Host-Disease; a dual center validation

scientific article published on 04 November 2020

CYP2C9 and CYP2C19 polymorphic forms are related to increased indisulam exposure and higher risk of severe hematologic toxicity

scientific article published on 01 May 2007

Carbamazepine induces bioactivation of cyclophosphamide and thiotepa

scientific article published on 24 April 2008

Carboplatin dosing in overweight and obese patients with normal renal function, does weight matter?

scientific article

Cisplatin and carboplatin pharmacokinetics in a pediatric patient with hepatoblastoma receiving peritoneal dialysis

scientific article published on 20 August 2020

Clinical Pharmacokinetics and Pharmacodynamics of Pazopanib: Towards Optimized Dosing

scientific article

Clinical Trial Simulation To Optimize Trial Design for Fludarabine Dosing Strategies in Allogeneic Hematopoietic Cell Transplantation

scientific article published on 19 January 2020

Clinical pharmacokinetics of an amorphous solid dispersion tablet of elacridar

scientific article published on 18 November 2016

Clinical pharmacokinetics of cyclophosphamide

scientific article

Clinical pharmacokinetics of therapeutic monoclonal antibodies

scientific article published on August 2010

Clinical trial simulations in paediatric oncology: A feasibility study from the Innovative Therapies for Children with Cancer Consortium.

scientific article published on 8 September 2017

Coadministration of ritonavir strongly enhances the apparent oral bioavailability of docetaxel in patients with solid tumors.

scientific article

Concentrations of Erlotinib in Tumor Tissue and Plasma in Non-Small-Cell Lung Cancer Patients After Neoadjuvant Therapy.

scientific article

Concomitant intake of abiraterone acetate and food to increase pharmacokinetic exposure: real life data from a therapeutic drug monitoring programme

scientific article published on 12 March 2020

Correction to: Influence of Malnutrition on the Pharmacokinetics of Drugs Used in the Treatment of Poverty-Related Diseases: A Systematic Review

scientific article

Corrigendum to "Semiphysiological versus Empirical Modelling of the Population Pharmacokinetics of Free and Total Cefazolin during Pregnancy".

scientific article published on 30 March 2015

Covariate-based dose individualization of the cytotoxic drug indisulam to reduce the risk of severe myelosuppression

scientific article

Crizotinib-induced fatal fulminant liver failure

scientific article published on 30 December 2015

Cytochrome P450 3A4, 3A5, and 2C8 expression in breast, prostate, lung, endometrial, and ovarian tumors: relevance for resistance to taxanes

scientific article published on 15 July 2019

Cytosine arabinoside and daunorubicin induction therapy in a patient with acute myeloid leukemia on chronic hemodialysis

scientific article published on 31 May 2016

Design of a drug-drug interaction study of vincristine with azole antifungals in pediatric cancer patients using clinical trial simulation.

scientific article published on 30 August 2014

Design of informative renal impairment studies: evaluation of the impact of design stratification on bias, precision and dose adjustment error

scientific article published on 02 May 2014

Determination of Sunitinib and Its Active Metabolite N-Desethylsunitinib in Sweat of a Patient ⬇️

scientific article published on 01 October 2011

Determination of the absolute bioavailability of oral imatinib using a stable isotopically labeled intravenous imatinib-d8 microdose

scientific article published on 19 May 2020

Development and clinical validation of an LC-MS/MS method for the quantification of pazopanib in DBS

scientific article published on 10 December 2015

Development and validation of a liquid chromatography-tandem mass spectrometry assay for nine oral anticancer drugs in human plasma

scientific article published on 24 June 2019

Development and validation of a population pharmacokinetic model for ritonavir used as a booster or as an antiviral agent in HIV-1-infected patients

scientific article published in February 2005

Development of a Pharmacokinetic Model to Describe the Complex Pharmacokinetics of Pazopanib in Cancer Patients

scientific article

Development of a Tumour Growth Inhibition Model to Elucidate the Effects of Ritonavir on Intratumoural Metabolism and Anti-tumour Effect of Docetaxel in a Mouse Model for Hereditary Breast Cancer

scientific article published on 24 November 2015

Development of a framework for cohort simulation in cost-effectiveness analyses using a multistep ordinary differential equation solver algorithm in R.

scientific article published on 20 March 2013

Development of an extended-release formulation of capecitabine making use of in vitro-in vivo correlation modelling.

scientific article

Development of an oral solid dispersion formulation for use in low-dose metronomic chemotherapy of paclitaxel

scientific article published on 17 October 2012

Dexrazoxane in anthracycline induced cardiotoxicity and extravasation

scientific article

Does Older Age Lead to Higher Risk for Neutropenia in Patients Treated with Paclitaxel?

scientific article published on 15 October 2019

Dosing algorithm to target a predefined AUC in patients with primary central nervous system lymphoma receiving high dose methotrexate.

scientific article published on February 2012

Drug Interaction of Fluvoxamine and Fluoxetine with Nevirapine in HIV-1-Infected Individuals

scientific article published on 01 January 2003

Drug interactions between antiretroviral drugs and comedicated agents

scientific article

Drug-drug interaction between itraconazole and the antiretroviral drug lopinavir/ritonavir in an HIV-1-infected patient with disseminated histoplasmosis

scientific article published in April 2004

Effect of mycophenolate mofetil on the pharmacokinetics of antiretroviral drugs and on intracellular nucleoside triphosphate pools

scientific article published in January 2004

Effects of Pharmacogenetics on the Pharmacokinetics and Pharmacodynamics of Tamoxifen

scientific article published in August 2015

Effects of co-medicated drugs on cyclophosphamide bioactivation in human liver microsomes

scientific article published in March 2005

Evaluation of a pharmacology-driven dosing algorithm of 3-weekly paclitaxel using therapeutic drug monitoring: a pharmacokinetic-pharmacodynamic simulation study

scientific article published in September 2012

Exploring the intracellular pharmacokinetics of the 5-fluorouracil nucleotides during capecitabine treatment.

scientific article published on 31 December 2015

Exposure and Tumor Fn14 Expression as Determinants of Pharmacodynamics of the Anti-TWEAK Monoclonal Antibody RG7212 in Patients with Fn14-Positive Solid Tumors.

scientific article published on 7 October 2015

Exposure to Docetaxel in the Elderly Patient Population: a Population Pharmacokinetic Study

scientific article published on 15 November 2019

Exposure-Response Assessment of Enzalutamide and Its Major Metabolites in a Real-World Cohort of Patients with Metastatic Castration-Resistant Prostate Cancer

scientific article published on 05 November 2019

Exposure-response analyses of anaplastic lymphoma kinase inhibitors crizotinib and alectinib in non-small-cell lung cancer patients

scientific article published on 19 July 2020

Failure of miltefosine in visceral leishmaniasis is associated with low drug exposure

scientific article

Fast and simultaneous determination of darunavir and eleven other antiretroviral drugs for therapeutic drug monitoring: method development and validation for the determination of all currently approved HIV protease inhibitors and non-nucleoside reve

scientific article published on 01 January 2007

Fast and straightforward method for the quantification of pazopanib in human plasma using LC-MS/MS.

scientific article published on 18 December 2017

Fixed Dosing of Monoclonal Antibodies in Oncology

scientific article published on 28 July 2017

Flat dosing of carboplatin is justified in adult patients with normal renal function

scientific article published in November 2006

Food-effect study on uracil and dihydrouracil plasma levels as marker for dihydropyrimidine dehydrogenase activity in human volunteers

scientific article published on 25 September 2018

Geographical Variability in Paromomycin Pharmacokinetics Does Not Explain Efficacy Differences between Eastern African and Indian Visceral Leishmaniasis Patients

scientific article published on 09 June 2021

Germline polymorphisms in patients with advanced nonsmall cell lung cancer receiving first‐line platinum‐gemcitabine chemotherapy ⬇️

scientific article published on September 28, 2011

Harnessing soft tissue sarcoma with low-dose pazopanib - a matter of blood levels

High Variability of Whole-Blood Tacrolimus Pharmacokinetics Early After Thoracic Organ Transplantation

scientific article published on 01 February 2020

Hot flashes are not predictive for serum concentrations of tamoxifen and its metabolites

scientific article

IHC-based Ki67 as response biomarker to tamoxifen in breast cancer window trials enrolling premenopausal women

scientific article published on 20 October 2021

Imatinib Pharmacokinetics in a Large Observational Cohort of Gastrointestinal Stromal Tumour Patients

scientific article

Impact of CYP3A4*22 on Pazopanib Pharmacokinetics in Cancer Patients

scientific article published on 01 May 2019

Impact of Older Age on the Exposure of Paclitaxel: a Population Pharmacokinetic Study

scientific article published on 07 January 2019

Impact of age on exposure to oral antiandrogen therapies in clinical practice

scientific article published on 02 October 2018

Incidence and risk factors for nevirapine-associated rash

scientific article published on 12 August 2003

Incidence of hematologic toxicity in older adults treated with gemcitabine or a gemcitabine-containing regimen in routine clinical practice: a multicenter retrospective cohort study

scientific article published in October 2014

Incorporation of concentration data below the limit of quantification in population pharmacokinetic analyses

scientific article

Increased Plasma Levels of Chemoresistance-Inducing Fatty Acid 16:4(n-3) After Consumption of Fish and Fish Oil.

scientific article published on June 2015

Individualised cancer chemotherapy: strategies and performance of prospective studies on therapeutic drug monitoring with dose adaptation: a review

scientific article

Individualized Pazopanib Dosing-Response

scientific article published on 01 December 2016

Individualized Pazopanib Dosing: A Prospective Feasibility Study in Cancer Patients

scientific article published on 28 July 2016

Individualized dosing of oral targeted therapies in oncology is crucial in the era of precision medicine

scientific article published on 07 June 2019

Influence of Malnutrition on the Pharmacokinetics of Drugs Used in the Treatment of Poverty-Related Diseases: A Systematic Review

scientific article

Influence of polymorphisms of drug metabolizing enzymes (CYP2B6, CYP2C9, CYP2C19, CYP3A4, CYP3A5, GSTA1, GSTP1, ALDH1A1 and ALDH3A1) on the pharmacokinetics of cyclophosphamide and 4-hydroxycyclophosphamide

scientific article

Innate immune recovery predicts CD4+ T-cell reconstitution after Hematopoietic Cell Transplantation

article

Integrated Population Pharmacokinetic Model of both cyclophosphamide and thiotepa suggesting a mutual drug-drug interaction

scientific article published in April 2004

Integrated semi-physiological pharmacokinetic model for both sunitinib and its active metabolite SU12662.

scientific article published on May 2015

Intracellular and plasma steady-state pharmacokinetics of raltegravir, darunavir, etravirine and ritonavir in heavily pre-treated HIV-infected patients

scientific article

Intracellular pharmacokinetics of gemcitabine, its deaminated metabolite 2',2'-difluorodeoxyuridine and their nucleotides

scientific article published on 16 February 2018

Is Bodyweight-Based Dosing Truly Better Than Flat Dosing for Panitumumab? [Letter]

scientific article published on 30 October 2020

Lethal morphine intoxication in a patient with a sickle cell crisis and renal impairment: case report and a review of the literature

scientific article

Lidocaine (lignocaine) dosing regimen based upon a population pharmacokinetic model for preterm and term neonates with seizures.

scientific article

Lidocaine as treatment for neonatal seizures: Evaluation of previously developed population pharmacokinetic models and dosing regimen

scientific article published on 03 January 2020

Liquid chromatographic assay for the non-peptidic protease inhibitor tipranavir in plasma

scientific article

Liquid chromatographic assay for the protease inhibitor atazanavir in plasma

scientific article published in January 2006

Long-term platinum retention after treatment with cisplatin and oxaliplatin

scientific article

Low nevirapine plasma concentrations predict virological failure in an unselected HIV-1-infected population

scientific article

Mass Balance Study of [14C]Eribulin in Patients with Advanced Solid Tumors ⬇️

scientific article published on October 31, 2011

Mass balance and metabolite profiling of 14C-guadecitabine in patients with advanced cancer

scientific article published on 11 October 2019

Measurement of NLG207 (formerly CRLX101) nanoparticle-bound and released camptothecin in human plasma

scientific article published on 27 December 2019

Model-based evaluation and optimization of cardiac monitoring protocols for adjuvant treatment of breast cancer with trastuzumab

scientific article published on 21 August 2012

Model‐Based Evaluation of Similarity in Pharmacokinetics of Two Formulations of the Blood‐Derived Plasma Product C1 Esterase Inhibitor ⬇️

scientific article published on February 1, 2012

Model‐based treatment optimization of a novel VEGFR inhibitor ⬇️

scientific article published on August 1, 2012

Molecular Imaging of ABCB1/ABCG2 Inhibition at the Human Blood Brain Barrier using Elacridar and 11C-Erlotinib PET.

scientific article

Neutropenia and docetaxel exposure in metastatic castration-resistant prostate cancer patients: A meta-analysis and evaluation of a clinical cohort

scientific article published on 22 February 2019

Nevirapine and efavirenz pharmacokinetics and covariate analysis in the 2NN study.

scientific article published in January 2005

No pharmacokinetic drug-drug interaction between nevirapine and paclitaxel

scientific article published in July 2005

Optimal Dosing of Miltefosine in Children and Adults with Visceral Leishmaniasis ⬇️

scientific article published on May 14, 2012

Optimizing drug development of anti-cancer drugs in children using modelling and simulation

scientific article published on July 2013

Performance of Methods for Handling Missing Categorical Covariate Data in Population Pharmacokinetic Analyses ⬇️

scientific article published on May 31, 2012

Persistent neuropathy after treatment with cisplatin and oxaliplatin

scientific article published in January 2009

Pharmacodynamic biomarkers in model-based drug development in oncology

scientific article published on February 2011

Pharmacodynamic modeling of cardiac biomarkers in breast cancer patients treated with anthracycline and trastuzumab regimens

scientific article published on 10 February 2018

Pharmacodynamics and pharmacokinetics of oral topotecan in patients with advanced solid tumours and impaired renal function

scientific article

Pharmacogenetic screening of CYP3A and ABCB1 in relation to population pharmacokinetics of docetaxel

scientific article published on 01 October 2006

Pharmacokinetic Optimization of Everolimus Dosing in Oncology: A Randomized Crossover Trial

scientific article published on 31 July 2017

Pharmacokinetic Targets for Therapeutic Drug Monitoring of Small Molecule Kinase Inhibitors in Pediatric Oncology

scientific article published on 05 February 2020

Pharmacokinetic comparison of two methods of heroin smoking: 'chasing the dragon' versus the use of a heating device

scientific article published in May 2005

Pharmacokinetic evaluation of three oral formulations of docetaxel boosted with ritonavir: two single-drug formulations vs. a fixed-dose combination tablet

scientific article published on June 2013

Pharmacokinetics and excretion of (14)C-lenvatinib in patients with advanced solid tumors or lymphomas.

scientific article published on 8 November 2014

Pharmacokinetics and excretion of (14)C-omacetaxine in patients with advanced solid tumors

scientific article published on 25 May 2016

Pharmacokinetics and pharmacodynamics of high doses of pharmaceutically prepared heroin, by intravenous or by inhalation route in opioid-dependent patients

scientific article

Pharmacokinetics and pharmacokinetic variability of heroin and its metabolites: review of the literature

scientific article published on January 2006

Pharmacokinetics of Capecitabine and Four Metabolites in a Heterogeneous Population of Cancer Patients: A Comprehensive Analysis

scientific article published on 20 November 2019

Pharmacokinetics of Selected Anticancer Drugs in Elderly Cancer Patients: Focus on Breast Cancer

scientific article published on 2 January 2016

Pharmacokinetics of Sustained-Release Oral Dexamphetamine Sulfate in Cocaine and Heroin-Dependent Patients.

scientific article

Pharmacokinetics of cyclophosphamide and thiotepa in a conventional fractionated high-dose regimen compared with a novel simplified unfractionated regimen

scientific article

Pharmacokinetics of eribulin mesylate in patients with solid tumours receiving repeated oral rifampicin ⬇️

scientific article published on February 1, 2013

Pharmacokinetics of gemcitabine and metabolites in a patient with double-sided nephrectomy: a case report and review of the literature

scientific article

Pharmacokinetics of miltefosine in Old World cutaneous leishmaniasis patients.

scientific article published on 2 June 2008

Pharmacokinetics of morphine in encephalopathic neonates treated with therapeutic hypothermia

scientific article published on 14 February 2019

Pharmacokinetics of nevirapine: once-daily versus twice-daily dosing in the 2NN study.

scientific article published in September 2005

Pharmacological Considerations in Antithymocyte Globulin Exposure Calculation

scientific article published on 27 March 2019

Phase 1 study of the pan-HER inhibitor dacomitinib plus the MEK1/2 inhibitor PD-0325901 in patients with KRAS-mutation-positive colorectal, non-small-cell lung and pancreatic cancer

scientific article published on 09 March 2020

Phase I Study of Afatinib and Selumetinib in Patients with KRAS-Mutated Colorectal, Non-Small Cell Lung, and Pancreatic Cancer

scientific article published on 09 December 2020

Phase I dose-escalation study and population pharmacokinetic analysis of fixed dose rate gemcitabine plus carboplatin as second-line therapy in patients with ovarian cancer.

scientific article

Phase I pharmacological study of continuous chronomodulated capecitabine treatment

scientific article published on 07 May 2020

Phase I study of lapatinib plus trametinib in patients with KRAS-mutant colorectal, non-small cell lung, and pancreatic cancer

scientific article published on 09 April 2020

Phase I study of lonafarnib (SCH66336) in combination with trastuzumab plus paclitaxel in Her2/neu overexpressing breast cancer: EORTC study 16023.

scientific article

Phase II and pharmacological study of oral docetaxel plus cyclosporin A in anthracycline pre-treated metastatic breast cancer

scientific article published on 01 May 2014

Phenobarbital, Midazolam Pharmacokinetics, Effectiveness, and Drug-Drug Interaction in Asphyxiated Neonates Undergoing Therapeutic Hypothermia

scientific article published on 28 June 2019

Photophobia in a patient with high indinavir plasma concentrations

scientific article published in December 2003

Piraña and PCluster: a modeling environment and cluster infrastructure for NONMEM.

scientific article published on 02 June 2010

Plasma Levels of Enzalutamide and Its Main Metabolites in a Patient With Metastatic Castration-resistant Prostate Cancer Undergoing Hemodialysis

scientific article published on 19 December 2018

Plasma concentrations of tyrosine kinase inhibitors imatinib, erlotinib, and sunitinib in routine clinical outpatient cancer care

scientific article

Polymorphisms of drug-metabolizing enzymes (GST, CYP2B6 and CYP3A) affect the pharmacokinetics of thiotepa and tepa

scientific article

Population Pharmacokinetics of Fludarabine in Children and Adults during Conditioning Prior to Allogeneic Hematopoietic Cell Transplantation

scientific article published on 01 May 2019

Population Pharmacokinetics of Intracellular 5-Fluorouridine 5'-Triphosphate and its Relationship with Hand-and-Foot Syndrome in Patients Treated with Capecitabine

scientific article published on 08 January 2021

Population Pharmacokinetics of MCLA-128, a HER2/HER3 Bispecific Monoclonal Antibody, in Patients with Solid Tumors

scientific article published on 31 January 2020

Population pharmacokinetic analysis of nanoparticle-bound and free camptothecin after administration of NLG207 in adults with advanced solid tumors

scientific article published on 08 September 2020

Population pharmacokinetic and pharmacodynamic analysis to support treatment optimization of combination chemotherapy with indisulam and carboplatin

scientific article

Population pharmacokinetic modelling to assess the impact of CYP2D6 and CYP3A metabolic phenotypes on the pharmacokinetics of tamoxifen and endoxifen

scientific article

Population pharmacokinetic-pharmacodynamic analysis for eribulin mesilate-associated neutropenia

scientific article published on September 2013

Population pharmacokinetics and pharmacodynamics for treatment optimization in clinical oncology

scientific article published on January 2008

Population pharmacokinetics and pharmacodynamics of doxorubicin and cyclophosphamide in breast cancer patients: a study by the EORTC-PAMM-NDDG.

scientific article published in January 2007

Population pharmacokinetics and pharmacodynamics of paclitaxel and carboplatin in ovarian cancer patients: a study by the European organization for research and treatment of cancer-pharmacology and molecular mechanisms group and new drug development

scientific article

Population pharmacokinetics of caffeine and its metabolites theobromine, paraxanthine and theophylline after inhalation in combination with diacetylmorphine

scientific article published in January 2005

Population pharmacokinetics of cyclophosphamide and its metabolites 4-hydroxycyclophosphamide, 2-dechloroethylcyclophosphamide, and phosphoramide mustard in a high-dose combination with Thiotepa and Carboplatin

scientific article published in December 2005

Population pharmacokinetics of efavirenz in an unselected cohort of HIV-1-infected individuals

scientific article published in January 2005

Population pharmacokinetics of heroin and its major metabolites

scientific article published in January 2006

Population pharmacokinetics of indinavir alone and in combination with ritonavir in HIV-1-infected patients

scientific article published in September 2005

Population pharmacokinetics of intravenously and orally administered docetaxel with or without co-administration of ritonavir in patients with advanced cancer

scientific article

Population pharmacokinetics of itraconazole in Thai HIV-1-infected persons

scientific article published on April 2003

Population pharmacokinetics of nevirapine in an unselected cohort of HIV-1-infected individuals

scientific article published on October 2002

Population plasma pharmacokinetics of 11C-flumazenil at tracer concentrations

scientific article published in November 2005

Practical Recommendations for Therapeutic Drug Monitoring of Kinase Inhibitors in Oncology

scientific article

Practical guidelines for therapeutic drug monitoring of anticancer tyrosine kinase inhibitors: focus on the pharmacokinetic targets

scientific article published on April 2014

Practical guidelines to interpret plasma concentrations of antiretroviral drugs

scientific article published in January 2004

Prediction of drug exposure in critically ill encephalopathic neonates treated with therapeutic hypothermia based on a pooled population pharmacokinetic analysis of seven drugs and five metabolites

scientific article published on 28 May 2020

Predictive Value of Microdose Pharmacokinetics

scientific article published on 01 October 2019

Predictive ability of a semi-mechanistic model for neutropenia in the development of novel anti-cancer agents: two case studies.

scientific article

Predictive value of CYP3A and ABCB1 phenotyping probes for the pharmacokinetics of sunitinib: the ClearSun study

scientific article published in March 2014

Predictors for Autoimmune Cytopenias after Allogeneic Hematopoietic Cell Transplantation in Children

scientific article published on 22 July 2019

Pronounced between-subject and circadian variability in thymidylate synthase and dihydropyrimidine dehydrogenase enzyme activity in human volunteers

scientific article published on 10 May 2016

PropAngio study protocol: a neoadjuvant trial on the efficacy of propranolol monotherapy in cutaneous angiosarcoma-a proof of principle study

scientific article published on 10 September 2020

Quantification of 11 Therapeutic Kinase Inhibitors in Human Plasma for Therapeutic Drug Monitoring Using Liquid Chromatography Coupled With Tandem Mass Spectrometry

scientific article published on 5 October 2016

Quantification of T Cell Binding Polyclonal Rabbit Anti-thymocyte Globulin in Human Plasma with Liquid Chromatography Tandem-Mass Spectrometry

scientific article published on 06 February 2020

Quantification of neutralizing anti-drug antibodies and their neutralizing capacity using competitive displacement and tandem mass spectrometry: Infliximab as proof of principle

scientific article published on 01 April 2019

Quantification of the pharmacokinetic-toxicodynamic relationship of oral docetaxel co-administered with ritonavir

scientific article published on 19 April 2020

Quantification of total dinutuximab concentrations in neuroblastoma patients with liquid chromatography tandem mass spectrometry

scientific article published on 25 June 2018

Quantitative effect of gender, age, liver function, and body size on the population pharmacokinetics of Paclitaxel in patients with solid tumors

scientific article published in April 2006

Race is not associated with nevirapine pharmacokinetics

scientific article published in August 2004

Relations between polymorphisms in drug-metabolising enzymes and toxicity of chemotherapy with cyclophosphamide, thiotepa and carboplatin

scientific article

Relatively Mild Symptoms After an Olanzapine Intoxication in a 2-Year-Old Girl with Excessively High Serum Levels ⬇️

scientific article published on 02 February 2011

Relevance of Endoxifen Concentrations: Absence of Evidence Is Not Evidence of Absence

scientific article published on 18 June 2019

Renal function, body surface area, and age are associated with risk of early-onset fluoropyrimidine-associated toxicity in patients treated with capecitabine-based anticancer regimens in daily clinical care

scientific article published on 4 January 2016

Saturable binding of indisulam to plasma proteins and distribution to human erythrocytes

scientific article published on 24 March 2006

Screening for illicit heroin use in patients in a heroin-assisted treatment program

scientific article published in July 2006

Semi-physiological model describing the hematological toxicity of the anti-cancer agent indisulam

scientific article

Semiphysiological versus empirical modelling of the population pharmacokinetics of free and total cefazolin during pregnancy

scientific article published on 3 February 2014

Severe cannabinoid intoxication in a patient with non-small-cell lung cancer

scientific article published on 01 January 2012

Severe lactic acidosis in a diabetic patient after ethanol abuse and floor cleaner intake.

scientific article

Severe skin toxicity in pediatric oncology patients treated with voriconazole and concomitant methotrexate.

scientific article published on 09 April 2013

Should non-nucleoside reverse transcriptase inhibitors be combined?

scientific article

Sialic Acid-Engineered IL4-10 Fusion Protein is Bioactive and Rapidly Cleared from the Circulation

scientific article published on 26 December 2019

Significant induction of cyclophosphamide and thiotepa metabolism by phenytoin

scientific article

Simple and rapid method for the simultaneous determination of the non-nucleoside reverse transcriptase inhibitors efavirenz and nevirapine in human plasma using liquid chromatography

scientific article

Simultaneous Quantification of Free Adalimumab and Infliximab in Human Plasma Using a Target-Based Sample Purification and Liquid Chromatography-Tandem Mass Spectrometry

scientific article published on 01 October 2019

Simultaneous quantification of cyclophosphamide and its active metabolite 4-hydroxycyclophosphamide in human plasma by high-performance liquid chromatography coupled with electrospray ionization tandem mass spectrometry (LC-MS/MS)

scientific article published on 25 April 2007

Simultaneous quantification of cyclophosphamide, 4-hydroxycyclophosphamide, N,N',N"-triethylenethiophosphoramide (thiotepa) and N,N',N"-triethylenephosphoramide (tepa) in human plasma by high-performance liquid chromatography coupled with electrospr

scientific article published in March 2004

Six-step workflow for the quantification of therapeutic monoclonal antibodies in biological matrices with liquid chromatography mass spectrometry - A tutorial

scientific article published on 11 June 2019

Solubility and bioavailability improvement of pazopanib hydrochloride

scientific article published on 19 April 2018

Sparse sampling design for therapeutic drug monitoring of sequentially administered cyclophosphamide, thiotepa, and carboplatin (CTC).

scientific article published in June 2005

Subtherapeutic antiretroviral plasma concentrations in routine clinical outpatient HIV care

scientific article

The Use of Dried Blood Spots for Pharmacokinetic Monitoring of Vemurafenib Treatment in Melanoma Patients.

scientific article published on 26 February 2016

The effect of seasonal variation and secretion of sunitinib in sweat on the development of hand-foot syndrome

scientific article published on 31 August 2013

The effects of sulfur-containing compounds and gemcitabine on the binding of cisplatin to plasma proteins and DNA determined by inductively coupled plasma mass spectrometry and high performance liquid chromatography-inductively coupled plasma mass s

scientific article published in July 2008

The impact of structural uncertainty on cost-effectiveness models for adjuvant endocrine breast cancer treatments: the need for disease-specific model standardization and improved guidance

scientific article published on January 2014

The plasma and intracellular steady-state pharmacokinetics of lopinavir/ritonavir in HIV-1-infected patients

scientific article

The preparation of radiolabeled monoclonal antibodies for human use.

scientific article published on January 2009

The use of combinations of monoclonal antibodies in clinical oncology

scientific article published on 30 October 2015

Therapeutic Drug Monitoring of Oral Anti-Hormonal Drugs in Oncology

scientific article published on 01 March 2019

Therapeutic Drug Monitoring of Oral Anticancer Drugs: The Dutch Pharmacology Oncology Group-Therapeutic Drug Monitoring Protocol for a Prospective Study

scientific article published on 01 October 2019

Therapeutic Drug Monitoring of endoxifen as an alternative for CYP2D6 genotyping in individualizing tamoxifen therapy

scientific article published on 22 August 2018

Therapeutic drug monitoring of imatinib in patients with gastrointestinal stromal tumours - Results from daily clinical practice

scientific article published on 17 July 2020

Therapeutic drug monitoring of small molecule kinase inhibitors in oncology in a real-world cohort study: does age matter?

scientific article published on 26 September 2018

Three spectroscopic techniques evaluated as a tool to study the effects of iodination of monoclonal antibodies, exemplified by rituximab ⬇️

scientific article published on May 20, 2011

Translational PK-PD modeling analysis of MCLA-128, a HER2/HER3 bispecific monoclonal antibody, to predict clinical efficacious exposure and dose

scientific article published on 05 May 2018

Translational pharmacokinetic modelling and simulation for the assessment of duration of contraceptive use after treatment with miltefosine.

scientific article published on 10 May 2012

Treatment of HIV infection with the CCR5 antagonist maraviroc

scientific article published on May 2010

Treatment of Peritoneal Dissemination in Stomach Cancer Patients With Cytoreductive Surgery and Hyperthermic Intraperitoneal Chemotherapy (HIPEC): Rationale and Design of the PERISCOPE Study

scientific article

Treatment of older patients with immune checkpoint inhibitors in routine clinical care as compared to inclusion in pivotal registration trials

Treatment with the HIV protease inhibitor nelfinavir triggers the unfolded protein response and may overcome proteasome inhibitor resistance of multiple myeloma in combination with bortezomib: a phase I trial (SAKK 65/08).

scientific article published on 11 December 2015

Two-stage model-based clinical trial design to optimize phase I development of novel anticancer agents

scientific article

Two-stage model-based design of cancer phase I dose escalation trials: evaluation using the phase I program of barasertib (AZD1152) ⬇️

scientific article published on May 28, 2011

Tyrosine kinase inhibitor levels matter in treating chronic GVHD

scientific article published on 16 January 2019

Use of dried blood spots for the determination of plasma concentrations of nevirapine and efavirenz ⬇️

scientific article published on February 1, 2012

[Hyperglycaemia during treatment with everolimus].

scientific article published in January 2014

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