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List of works by Takahiko Nakagawa

A breakthrough in diabetic nephropathy: the role of endothelial dysfunction

scientific article published on 25 June 2007

A novel role for uric acid in acute kidney injury associated with tumour lysis syndrome

scientific article published on 06 July 2009

A role for bone marrow-derived cells in diabetic nephropathy

scientific article published on 29 November 2018

A role for uric acid in the progression of renal disease

scientific article published in December 2002

A single pathway for the development of essential hypertension

scientific article

ACE2 and Ang-(1-7) confer protection against development of diabetic retinopathy.

scientific article published on 26 July 2011

Abnormal angiogenesis in diabetic nephropathy.

scientific article published on July 2009

Activation of Src kinase in platelet-derived growth factor-B-dependent tubular regeneration after acute ischemic renal injury

scientific article

Adverse effects of the classic antioxidant uric acid in adipocytes: NADPH oxidase-mediated oxidative/nitrosative stress

scientific article published on 11 April 2007

Aging-associated renal disease in mice is fructokinase dependent.

scientific article published on 27 July 2016

Angiostatin overexpression is associated with an improvement in chronic kidney injury by an anti-inflammatory mechanism.

scientific article published on 29 October 2008

Asymptomatic Hyperuricemia Without Comorbidities Predicts Cardiometabolic Diseases: Five-Year Japanese Cohort Study

scientific article published on 10 April 2017

Basigin deficiency prevents anaplerosis and ameliorates insulin resistance and hepatosteatosis

scientific article published in 2021

Blockade of NADPH Oxidase Restores Vasoreparative Function in Diabetic CD34+Cells ⬇️

scientific article published on July 7, 2011

Carbon monoxide and nitric oxide mediate cytoskeletal reorganization in microvascular cells via vasodilator-stimulated phosphoprotein phosphorylation: evidence for blunted responsiveness in diabetes

scientific article published on 16 June 2008

Cerebral Fructose Metabolism as a Potential Mechanism Driving Alzheimer's Disease

scientific article published on 11 September 2020

Combination of ACE inhibitor with nicorandil provides further protection in chronic kidney disease

scientific article published on 15 October 2014

Combination of captopril and allopurinol retards fructose-induced metabolic syndrome

scientific article published on 21 August 2009

Could uric acid have a role in acute renal failure?

scientific article published on 6 December 2006

Deletion of Fructokinase in the Liver or in the Intestine Reveals Differential Effects on Sugar-Induced Metabolic Dysfunction

scientific article published on 28 May 2020

Diabetic eNOS-knockout mice develop accelerated retinopathy.

scientific article

Diabetic endothelial nitric oxide synthase knockout mice develop advanced diabetic nephropathy

scientific article published on 3 January 2007

Diabetic retinopathy is associated with bone marrow neuropathy and a depressed peripheral clock

scientific article

Dietary fructose causes tubulointerstitial injury in the normal rat kidney

scientific article

Do thiazides worsen metabolic syndrome and renal disease? The pivotal roles for hyperuricemia and hypokalemia

scientific article

Effect of lowering uric acid on renal disease in the type 2 diabetic db/db mice

scientific article published on 20 May 2009

Effects of acute and chronic L-arginine treatment in experimental hyperuricemia

scientific article published on 26 December 2006

Effects of febuxostat on metabolic and renal alterations in rats with fructose-induced metabolic syndrome.

scientific article published on 23 January 2008

Endogenous fructose production and fructokinase activation mediate renal injury in diabetic nephropathy

scientific article

Endothelial Nitric Oxide Synthase ⬇️

scientific article published on 09 June 2011

Endothelial dysfunction as a potential contributor in diabetic nephropathy ⬇️

scientific article published on November 2, 2010

Endothelial injury due to eNOS deficiency accelerates the progression of chronic renal disease in the mouse

scientific article

Endothelial von Willebrand factor release due to eNOS deficiency predisposes to thrombotic microangiopathy in mouse aging kidney

scientific article

Epicatechin limits renal injury by mitochondrial protection in cisplatin nephropathy ⬇️

scientific article published on August 29, 2012

Epidermis-dermis junction as a novel location for bone marrow-derived cells to reside in response to ionizing radiation

scientific article published on 25 April 2015

Fructokinase activity mediates dehydration-induced renal injury

scientific article

Fructose Production and Metabolism in the Kidney

scientific article published on 06 April 2020

Fructose and sugar: A major mediator of non-alcoholic fatty liver disease.

scientific article published on 31 January 2018

Fructose contributes to the Warburg effect for cancer growth

scientific article published on 10 July 2020

Fructose induces the inflammatory molecule ICAM-1 in endothelial cells ⬇️

scientific article published on 28 May 2008

Fructose, but not dextrose, accelerates the progression of chronic kidney disease

scientific article published in August 2007

Fructose-induced metabolic syndrome is associated with glomerular hypertension and renal microvascular damage in rats

scientific article published on 29 August 2006

High salt intake causes leptin resistance and obesity in mice by stimulating endogenous fructose production and metabolism.

scientific article published on 5 March 2018

Hormonal and cytokine effects of uric acid

scientific article

Hyperglycemia Induces Skin Barrier Dysfunctions with Impairment of Epidermal Integrity in Non-Wounded Skin of Type 1 Diabetic Mice

scientific article

Hyperosmolarity drives hypertension and CKD--water and salt revisited.

scientific article

Hyperuricemia causes glomerular hypertrophy in the rat.

scientific article published in January 2003

Hyperuricemia induces endothelial dysfunction

scientific article published on May 2005

Hypokalemic nephropathy is associated with impaired angiogenesis

scientific article published on January 2008

Hypothesis: fructose-induced hyperuricemia as a causal mechanism for the epidemic of the metabolic syndrome

scientific article published on December 2005

Inhibition of p38 mitogen-activated protein kinase augments progression of remnant kidney model by activating the ERK pathway

scientific article

Intensive uric acid-lowering therapy in CKD patients: the protocol for a randomized controlled trial

scientific article published on 15 November 2019

Is there a dark side to thiazide therapy for hypertension? ⬇️

scientific article published on October 1, 2010

Lead, at low levels, accelerates arteriolopathy and tubulointerstitial injury in chronic kidney disease

scientific article published on 22 August 2007

Lessons from comparative physiology: could uric acid represent a physiologic alarm signal gone awry in western society?

scientific article

Lowering blood pressure blocks mesangiolysis and mesangial nodules, but not tubulointerstitial injury, in diabetic eNOS knockout mice.

scientific article published on 26 February 2009

Microarray and bioinformatic detection of novel and established genes expressed in experimental anti-Thy1 nephritis

scientific article published on 01 December 2005

Mild hyperuricemia induces glomerular hypertension in normal rats

scientific article published in November 2002

Nicorandil as a novel therapy for advanced diabetic nephropathy in the eNOS-deficient mouse

scientific article

Nicorandil, a Katp channel opener, alleviates chronic renal injury by targeting podocytes and macrophages ⬇️

scientific article published on May 23, 2012

Nitric oxide modulates vascular disease in the remnant kidney model

scientific article published on July 2002

Opposing activity changes in AMP deaminase and AMP-activated protein kinase in the hibernating ground squirrel

scientific article

Overexpression of calmodulin in pancreatic beta cells induces diabetic nephropathy

scientific article published on 4 June 2008

Pathogenesis of essential hypertension: historical paradigms and modern insights

scientific article published on March 2008

Protective role of fructokinase blockade in the pathogenesis of acute kidney injury in mice

scientific article published on 13 February 2017

Renoprotective effect of topiroxostat via antioxidant activity in puromycin aminonucleoside nephrosis rats

scientific article published on August 2017

Role of oxidative stress in the renal abnormalities induced by experimental hyperuricemia.

scientific article published on 13 August 2008

Selective stimulation of VEGFR2 accelerates progressive renal disease

scientific article

Soluble Flt-1 gene therapy ameliorates albuminuria but accelerates tubulointerstitial injury in diabetic mice

scientific article published on 16 December 2009

Sucrose induces fatty liver and pancreatic inflammation in male breeder rats independent of excess energy intake

scientific article

Sugar, uric acid, and the etiology of diabetes and obesity.

scientific article

Systemic inflammation, metabolic syndrome and progressive renal disease

scientific article published on 10 February 2009

TGF-beta induces proangiogenic and antiangiogenic factors via parallel but distinct Smad pathways

scientific article published on August 2004

The conundrum of hyperuricemia, metabolic syndrome, and renal disease.

scientific article

The effect of fructose on renal biology and disease

scientific article

The effects of fruit consumption in patients with hyperuricaemia or gout

scientific article published on 01 July 2019

The pivotal role of VEGF on glomerular macrophage infiltration in advanced diabetic nephropathy

scientific article published on 7 July 2008

The role of endothelial cell injury in thrombotic microangiopathy

scientific article

Thiazide diuretics exacerbate fructose-induced metabolic syndrome

scientific article published on 12 September 2007

Tubulointerstitial disease: role of ischemia and microvascular disease

scientific article

Umami: the taste that drives purine intake.

scientific article

Uncoupling of VEGF with endothelial NO as a potential mechanism for abnormal angiogenesis in the diabetic nephropathy

scientific article published on 09 December 2013

Uncoupling of vascular endothelial growth factor with nitric oxide as a mechanism for diabetic vasculopathy

scientific article published on 25 January 2006

Uric Acid Is a Strong Risk Marker for Developing Hypertension From Prehypertension: A 5-Year Japanese Cohort Study.

scientific article published on 4 December 2017

Uric acid and chronic kidney disease: which is chasing which?

scientific article

Uric acid and chronic renal disease: possible implication of hyperuricemia on progression of renal disease

scientific article

Uric acid causes vascular smooth muscle cell proliferation by entering cells via a functional urate transporter

scientific article

Uric acid in metabolic syndrome: From an innocent bystander to a central player

scientific article

Uric acid induces hepatic steatosis by generation of mitochondrial oxidative stress: potential role in fructose-dependent and -independent fatty liver.

scientific article

Uric acid, hominoid evolution, and the pathogenesis of salt-sensitivity

scientific article

Uric acid, the metabolic syndrome, and renal disease

scientific article

Uric acid--a uremic toxin?

scientific article

Uric acid-induced endothelial dysfunction is associated with mitochondrial alterations and decreased intracellular ATP concentrations

scientific article published on 07 December 2012

Uric acid: more to learn, more experiments to do.

scientific article published in September 2009

Vasopressin mediates fructose-induced metabolic syndrome by activating the V1b receptor

scientific article published on 15 December 2020

eNOS knockout mice with advanced diabetic nephropathy have less benefit from renin-angiotensin blockade than from aldosterone receptor antagonists

scientific article

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