List of works - Moira K B Whyte

-------A type I IFN, prothrombotic hyperinflammatory neutrophil signature is distinct for COVID-19 ARDS--

scientific article published on 20 May 2021

A cardinal role for cathepsin d in co-ordinating the host-mediated apoptosis of macrophages and killing of pneumococci.

scientific article

A decoy receptor 3 analogue reduces localised defects in phagocyte function in pneumococcal pneumonia ⬇️

scientific article published on June 26, 2012

A genome-wide search for linkage to asthma phenotypes in the genetics of asthma international network families: evidence for a major susceptibility locus on chromosome 2p.

scientific article

A local circadian clock calls time on lung inflammation.

scientific article published in August 2014

A method for the in vivo measurement of zebrafish tissue neutrophil lifespan ⬇️

scientific article published on July 16, 2012

A role for caspase-1 in serum withdrawal-induced apoptosis of endothelial cells

scientific article published in October 2003

A therapeutic antibody targeting osteoprotegerin attenuates severe experimental pulmonary arterial hypertension

scientific article published on 15 November 2019

A transgenic zebrafish model of neutrophilic inflammation

scientific article

A zebrafish compound screen reveals modulation of neutrophil reverse migration as an anti-inflammatory mechanism

scientific article

Acceleration of human neutrophil apoptosis by TRAIL.

scientific article

Activation of hypoxia-inducible factor-1α (Hif-1α) delays inflammation resolution by reducing neutrophil apoptosis and reverse migration in a zebrafish inflammation model

scientific article published on 9 May 2011

Agonists of toll-like receptor (TLR)2 and TLR4 are unable to modulate platelet activation by adenosine diphosphate and platelet activating factor

scientific article published on 01 October 2005

Agonists of toll-like receptors 2 and 4 activate airway smooth muscle via mononuclear leukocytes

scientific article published on 18 January 2005

Alveolar Macrophage Apoptosis Contributes to Pneumococcal Clearance in a Resolving Model of Pulmonary Infection ⬇️

scientific article published on November 15, 2003

Alveolar Macrophage Apoptosis-associated Bacterial Killing Helps Prevent Murine Pneumonia

scientific article published on 01 July 2019

CTLA-4 polymorphisms in allergy and asthma and the TH1/ TH2 paradigm

scientific article

Caspase-1-deficient mice have delayed neutrophil apoptosis and a prolonged inflammatory response to lipopolysaccharide-induced acute lung injury

scientific article published in December 2002

Contrasting roles for reactive oxygen species and nitric oxide in the innate response to pulmonary infection with Streptococcus pneumoniae

scientific article published on 20 September 2006

Cooperative molecular and cellular networks regulate Toll-like receptor-dependent inflammatory responses.

scientific article

Decreased alveolar macrophage apoptosis is associated with increased pulmonary inflammation in a murine model of pneumococcal pneumonia

scientific article published on 01 November 2006

Deficiency of tumour necrosis factor-related apoptosis-inducing ligand exacerbates lung injury and fibrosis.

scientific article

Delayed neutrophil apoptosis enhances NET formation in cystic fibrosis

scientific article

Development of a Consensus Statement for the Definition, Diagnosis, and Treatment of Acute Exacerbations of Idiopathic Pulmonary Fibrosis Using the Delphi Technique.

scientific article

Differential Effects of p38, MAPK, PI3K or Rho Kinase Inhibitors on Bacterial Phagocytosis and Efferocytosis by Macrophages in COPD.

scientific article

Distinct cell death programs in monocytes regulate innate responses following challenge with common causes of invasive bacterial disease.

scientific article published on 23 July 2010

Drift-Diffusion Analysis of Neutrophil Migration during Inflammation Resolution in a Zebrafish Model.

scientific article published on 29 July 2012

Dynamic changes in Mcl-1 expression regulate macrophage viability or commitment to apoptosis during bacterial clearance

scientific article

Effect of Co-trimoxazole (Trimethoprim-Sulfamethoxazole) vs Placebo on Death, Lung Transplant, or Hospital Admission in Patients With Moderate and Severe Idiopathic Pulmonary Fibrosis: The EME-TIPAC Randomized Clinical Trial

scientific article published on 01 December 2020

Effective caspase inhibition blocks neutrophil apoptosis and reveals Mcl-1 as both a regulator and a target of neutrophil caspase activation

scientific article

Endotoxin tolerance induces selective alterations in neutrophil function.

scientific article published on 21 October 2005

Erratum: A genome-wide search for linkage to asthma phenotypes in the genetics of asthma international network families: evidence for a major susceptibility locus on chromosome 2p

article

Expression of pro-apoptotic Bfk isoforms reduces during malignant transformation in the human gastrointestinal tract

scientific article published in July 2005

Facilitation of IL-22 production from innate lymphoid cells by prostaglandin E2 prevents experimental lung neutrophilic inflammation

scientific article published on 24 March 2018

Gelsolin in idiopathic pulmonary fibrosis: a new target supports a central role for epithelial injury in disease pathogenesis

scientific article published in June 2009

Genetic factors in idiopathic pulmonary fibrosis: transforming growth factor-beta implicated at last

scientific article published in August 2003

Genetic variants associated with susceptibility to idiopathic pulmonary fibrosis in people of European ancestry: a genome-wide association study.

scientific article published on 20 October 2017

Granulocyte apoptosis in the pathogenesis and resolution of lung disease

scientific article published in March 2006

Hypoxia selectively inhibits respiratory burst activity and killing of Staphylococcus aureus in human neutrophils.

scientific article

Hypoxia shapes the immune landscape in lung injury and promotes the persistence of inflammation

scientific article published on 27 May 2022

Hypoxia, the HIF pathway and neutrophilic inflammatory responses.

scientific article published on April 2013

Hypoxia-inducible factor 2α regulates key neutrophil functions in humans, mice, and zebrafish.

scientific article

Hypoxia. Hypoxia, hypoxia inducible factor and myeloid cell function

scientific article published on 21 April 2009

IL4Rα Signaling Abrogates Hypoxic Neutrophil Survival and Limits Acute Lung Injury Responses In Vivo

scientific article published on 01 July 2019

Identification of benzopyrone as a common structural feature in compounds with anti-inflammatory activity in a zebrafish phenotypic screen

scientific article

Identifying and hurdling obstacles to translational research

scientific article published on January 2007

Idiopathic pulmonary fibrosis

scientific article published on 22 June 2011

Impaired Mitochondrial Microbicidal Responses in Chronic Obstructive Pulmonary Disease Macrophages

scientific article published on 30 May 2017

Impairment of apoptotic cell engulfment by pyocyanin, a toxic metabolite of Pseudomonas aeruginosa.

scientific article published on 4 October 2007

Implications of apoptotic cell death of resident and recruited cells in COPD

scientific article published on 01 June 2008

Incapacitating the immune system in cystic fibrosis

scientific article published in December 2007

Induction of neutrophil apoptosis by the Pseudomonas aeruginosa exotoxin pyocyanin: a potential mechanism of persistent infection

scientific article published in February 2002

Inhibition of neutrophil apoptosis by ATP is mediated by the P2Y11 receptor.

scientific article published in December 2007

Interleukin 18 receptor 1 gene polymorphisms are associated with asthma

article

Interleukin-1β regulates CXCL8 release and influences disease outcome in response to Streptococcus pneumoniae, defining intercellular cooperation between pulmonary epithelial cells and macrophages

scientific article published on 12 December 2011

Loss of the oxygen sensor PHD3 enhances the innate immune response to abdominal sepsis

scientific article

Modeling inflammation in the zebrafish: how a fish can help us understand lung disease

scientific article published on December 2007

Monocytes Regulate the Mechanism of T-cell Death by Inducing Fas-Mediated Apoptosis during Bacterial Infection ⬇️

scientific article published on July 19, 2012

Mutations in succinate dehydrogenase B (SDHB) enhance neutrophil survival independent of HIF-1α expression

scientific article published on 22 March 2016

NR4A orphan nuclear receptor family members, NR4A2 and NR4A3, regulate neutrophil number and survival

scientific article

Neutrophil apoptosis in infectious disease

scientific article published on December 2007

Neutrophil energetics and oxygen sensing

scientific article published on 01 May 2014

Neutrophils Fuel Effective Immune Responses through Gluconeogenesis and Glycogenesis

scientific article published on 01 December 2020

Neutrophils from patients with heterozygous germline mutations in the von Hippel Lindau protein (pVHL) display delayed apoptosis and enhanced bacterial phagocytosis

scientific article published on 29 June 2006

Nitric oxide levels regulate macrophage commitment to apoptosis or necrosis during pneumococcal infection.

scientific article

Opsonic Phagocytosis in Chronic Obstructive Pulmonary Disease is Enhanced by Nrf2 Agonists.

scientific article

PGE production at sites of tissue injury promotes an anti-inflammatory neutrophil phenotype and determines the outcome of inflammation resolution in vivo

scientific article published on 05 September 2018

Pathological networking: a new approach to understanding COPD.

scientific article

Pathways regulating lipopolysaccharide-induced neutrophil survival revealed by lentiviral transduction of primary human neutrophils.

scientific article published on 28 October 2008

Phenotipic analysis of neutrophil population from GBM patients

scientific article published on 31 January 2018

Pivotal Advance: Pharmacological manipulation of inflammation resolution during spontaneously resolving tissue neutrophilia in the zebrafish

scientific article

Pneumococcal pneumonia: mechanisms of infection and resolution.

scientific article published on August 2012

Pneumolysin activates macrophage lysosomal membrane permeabilization and executes apoptosis by distinct mechanisms without membrane pore formation

scientific article published on 7 October 2014

Potentiation of TLR4 signalling by plasmin activity

scientific article published on 10 January 2006

Practical and conceptual models of chronic obstructive pulmonary disease.

scientific article published on December 2007

Prolyl hydroxylase 3 (PHD3) is essential for hypoxic regulation of neutrophilic inflammation in humans and mice

scientific article published on 7 February 2011

Proteomic evaluation and validation of cathepsin D regulated proteins in macrophages exposed to Streptococcus pneumoniae

scientific article

Pseudomonas expression of an oxygen sensing prolyl hydroxylase homologue regulates neutrophil host responses in vitro and in vivo.

scientific article published on 26 October 2017

Pyocyanin production by Pseudomonas aeruginosa induces neutrophil apoptosis and impairs neutrophil-mediated host defenses in vivo

scientific article

Quantitative linkage genome scan for atopy in a large collection of Caucasian families

scientific article

RESPIRE: The National Institute for Health Research's (NIHR) Global Respiratory Health Unit

article

Reactive oxygen species regulate neutrophil recruitment and survival in pneumococcal pneumonia

scientific article published on 17 January 2008

Reducing the toll of inflammatory lung disease.

scientific article published on May 2007

Regulation of human neutrophil chemokine receptor expression and function by activation of Toll-like receptors 2 and 4.

scientific article published in May 2005

Regulation of neutrophil senescence by microRNAs

scientific article

Regulation of phagocyte lifespan in the lung during bacterial infection.

scientific article

Roles of neutrophils in the regulation of the extent of human inflammation through delivery of IL-1 and clearance of chemokines

scientific article

Selective roles for Toll-like receptor (TLR)2 and TLR4 in the regulation of neutrophil activation and life span.

scientific article published in May 2003

Semaphorin 3F signaling actively retains neutrophils at sites of inflammation

scientific article published on 19 March 2020

Serum and glucocorticoid-regulated kinase 1 regulates neutrophil clearance during inflammation resolution.

scientific article

Sir,

article

Staphylococcus aureus induces eosinophil cell death mediated by α-hemolysin

scientific article

Subversion of a lysosomal pathway regulating neutrophil apoptosis by a major bacterial toxin, pyocyanin

scientific article

TNF-related apoptosis-inducing ligand (TRAIL) regulates inflammatory neutrophil apoptosis and enhances resolution of inflammation

scientific article published on 11 May 2011

Targeting the networks that underpin contiguous immunity in asthma and chronic obstructive pulmonary disease.

scientific article published on 30 November 2006

The Anti-Apoptotic Effect of Respiratory Syncytial Virus on Human Peripheral Blood Neutrophils is Mediated by a Monocyte Derived Soluble Factor

scientific article published on 18 October 2011

The Efficacy and Mechanism Evaluation of Treating Idiopathic Pulmonary fibrosis with the Addition of Co-trimoxazole (EME-TIPAC): study protocol for a randomised controlled trial.

scientific article

The HIF/VHL pathway: from oxygen sensing to innate immunity

scientific article published on 11 October 2007

The expression and roles of Toll-like receptors in the biology of the human neutrophil.

scientific article

The identification of markers of macrophage differentiation in PMA-stimulated THP-1 cells and monocyte-derived macrophages

scientific article

The regulation of pulmonary inflammation by the hypoxia-inducible factor-hydroxylase oxygen-sensing pathway.

scientific article published on December 2014

The role of Toll-like receptors in the regulation of neutrophil migration, activation, and apoptosis

scientific article

The role of interleukin-1beta in direct and toll-like receptor 4-mediated neutrophil activation and survival

scientific article

The role of neutrophils in cancer

article

Three novel Bid proteins generated by alternative splicing of the human Bid gene

scientific article published on 28 October 2003

Toll-like receptor (TLR)2 and TLR4 agonists regulate CCR expression in human monocytic cells

scientific article published on April 2004

Toll-like receptor (TLR)2 and TLR4 in human peripheral blood granulocytes: a critical role for monocytes in leukocyte lipopolysaccharide responses

scientific article published on 01 May 2002

Toll-like receptors and chronic lung disease.

scientific article

Toll-like receptors in health and disease: complex questions remain.

scientific article

Zebrafish as a model for the study of neutrophil biology

scientific article published on 05 March 2013

List of works by Moira K B Whyte

-------A type I IFN, prothrombotic hyperinflammatory neutrophil signature is distinct for COVID-19 ARDS--

A cardinal role for cathepsin d in co-ordinating the host-mediated apoptosis of macrophages and killing of pneumococci.

A decoy receptor 3 analogue reduces localised defects in phagocyte function in pneumococcal pneumonia ⬇️

A genome-wide search for linkage to asthma phenotypes in the genetics of asthma international network families: evidence for a major susceptibility locus on chromosome 2p.

A local circadian clock calls time on lung inflammation.

A method for the in vivo measurement of zebrafish tissue neutrophil lifespan ⬇️

A role for caspase-1 in serum withdrawal-induced apoptosis of endothelial cells

A therapeutic antibody targeting osteoprotegerin attenuates severe experimental pulmonary arterial hypertension

A transgenic zebrafish model of neutrophilic inflammation

A zebrafish compound screen reveals modulation of neutrophil reverse migration as an anti-inflammatory mechanism

Acceleration of human neutrophil apoptosis by TRAIL.

Activation of hypoxia-inducible factor-1α (Hif-1α) delays inflammation resolution by reducing neutrophil apoptosis and reverse migration in a zebrafish inflammation model

Agonists of toll-like receptor (TLR)2 and TLR4 are unable to modulate platelet activation by adenosine diphosphate and platelet activating factor

Agonists of toll-like receptor (TLR)2 and TLR4 are unable to modulate platelet activation by adenosine diphosphate and platelet activating factor

Agonists of toll-like receptors 2 and 4 activate airway smooth muscle via mononuclear leukocytes

Alveolar Macrophage Apoptosis Contributes to Pneumococcal Clearance in a Resolving Model of Pulmonary Infection ⬇️

Alveolar Macrophage Apoptosis-associated Bacterial Killing Helps Prevent Murine Pneumonia

CTLA-4 polymorphisms in allergy and asthma and the TH1/ TH2 paradigm

Caspase-1-deficient mice have delayed neutrophil apoptosis and a prolonged inflammatory response to lipopolysaccharide-induced acute lung injury

Contrasting roles for reactive oxygen species and nitric oxide in the innate response to pulmonary infection with Streptococcus pneumoniae

Cooperative molecular and cellular networks regulate Toll-like receptor-dependent inflammatory responses.

Decreased alveolar macrophage apoptosis is associated with increased pulmonary inflammation in a murine model of pneumococcal pneumonia

Deficiency of tumour necrosis factor-related apoptosis-inducing ligand exacerbates lung injury and fibrosis.

Delayed neutrophil apoptosis enhances NET formation in cystic fibrosis

Development of a Consensus Statement for the Definition, Diagnosis, and Treatment of Acute Exacerbations of Idiopathic Pulmonary Fibrosis Using the Delphi Technique.

Differential Effects of p38, MAPK, PI3K or Rho Kinase Inhibitors on Bacterial Phagocytosis and Efferocytosis by Macrophages in COPD.

Distinct cell death programs in monocytes regulate innate responses following challenge with common causes of invasive bacterial disease.

Drift-Diffusion Analysis of Neutrophil Migration during Inflammation Resolution in a Zebrafish Model.

Dynamic changes in Mcl-1 expression regulate macrophage viability or commitment to apoptosis during bacterial clearance

Effect of Co-trimoxazole (Trimethoprim-Sulfamethoxazole) vs Placebo on Death, Lung Transplant, or Hospital Admission in Patients With Moderate and Severe Idiopathic Pulmonary Fibrosis: The EME-TIPAC Randomized Clinical Trial

Effective caspase inhibition blocks neutrophil apoptosis and reveals Mcl-1 as both a regulator and a target of neutrophil caspase activation

Endotoxin tolerance induces selective alterations in neutrophil function.

Erratum: A genome-wide search for linkage to asthma phenotypes in the genetics of asthma international network families: evidence for a major susceptibility locus on chromosome 2p

Expression of pro-apoptotic Bfk isoforms reduces during malignant transformation in the human gastrointestinal tract

Facilitation of IL-22 production from innate lymphoid cells by prostaglandin E2 prevents experimental lung neutrophilic inflammation

Gelsolin in idiopathic pulmonary fibrosis: a new target supports a central role for epithelial injury in disease pathogenesis

Genetic factors in idiopathic pulmonary fibrosis: transforming growth factor-beta implicated at last

Genetic variants associated with susceptibility to idiopathic pulmonary fibrosis in people of European ancestry: a genome-wide association study.

Granulocyte apoptosis in the pathogenesis and resolution of lung disease

Hypoxia selectively inhibits respiratory burst activity and killing of Staphylococcus aureus in human neutrophils.

Hypoxia shapes the immune landscape in lung injury and promotes the persistence of inflammation

Hypoxia, the HIF pathway and neutrophilic inflammatory responses.

Hypoxia-inducible factor 2α regulates key neutrophil functions in humans, mice, and zebrafish.

Hypoxia. Hypoxia, hypoxia inducible factor and myeloid cell function

IL4Rα Signaling Abrogates Hypoxic Neutrophil Survival and Limits Acute Lung Injury Responses In Vivo

Identification of benzopyrone as a common structural feature in compounds with anti-inflammatory activity in a zebrafish phenotypic screen

Identifying and hurdling obstacles to translational research

Idiopathic pulmonary fibrosis

Impaired Mitochondrial Microbicidal Responses in Chronic Obstructive Pulmonary Disease Macrophages

Impairment of apoptotic cell engulfment by pyocyanin, a toxic metabolite of Pseudomonas aeruginosa.

Implications of apoptotic cell death of resident and recruited cells in COPD

Incapacitating the immune system in cystic fibrosis

Induction of neutrophil apoptosis by the Pseudomonas aeruginosa exotoxin pyocyanin: a potential mechanism of persistent infection

Inhibition of neutrophil apoptosis by ATP is mediated by the P2Y11 receptor.

Interleukin 18 receptor 1 gene polymorphisms are associated with asthma

Interleukin-1β regulates CXCL8 release and influences disease outcome in response to Streptococcus pneumoniae, defining intercellular cooperation between pulmonary epithelial cells and macrophages

Loss of the oxygen sensor PHD3 enhances the innate immune response to abdominal sepsis

Modeling inflammation in the zebrafish: how a fish can help us understand lung disease

Monocytes Regulate the Mechanism of T-cell Death by Inducing Fas-Mediated Apoptosis during Bacterial Infection ⬇️

Mutations in succinate dehydrogenase B (SDHB) enhance neutrophil survival independent of HIF-1α expression

NR4A orphan nuclear receptor family members, NR4A2 and NR4A3, regulate neutrophil number and survival

Neutrophil apoptosis in infectious disease

Neutrophil energetics and oxygen sensing

Neutrophils Fuel Effective Immune Responses through Gluconeogenesis and Glycogenesis

Neutrophils from patients with heterozygous germline mutations in the von Hippel Lindau protein (pVHL) display delayed apoptosis and enhanced bacterial phagocytosis

Nitric oxide levels regulate macrophage commitment to apoptosis or necrosis during pneumococcal infection.

Opsonic Phagocytosis in Chronic Obstructive Pulmonary Disease is Enhanced by Nrf2 Agonists.

PGE production at sites of tissue injury promotes an anti-inflammatory neutrophil phenotype and determines the outcome of inflammation resolution in vivo

Pathological networking: a new approach to understanding COPD.

Pathways regulating lipopolysaccharide-induced neutrophil survival revealed by lentiviral transduction of primary human neutrophils.

Phenotipic analysis of neutrophil population from GBM patients

Pivotal Advance: Pharmacological manipulation of inflammation resolution during spontaneously resolving tissue neutrophilia in the zebrafish

Pneumococcal pneumonia: mechanisms of infection and resolution.

Pneumolysin activates macrophage lysosomal membrane permeabilization and executes apoptosis by distinct mechanisms without membrane pore formation

Potentiation of TLR4 signalling by plasmin activity

Practical and conceptual models of chronic obstructive pulmonary disease.

Prolyl hydroxylase 3 (PHD3) is essential for hypoxic regulation of neutrophilic inflammation in humans and mice

Proteomic evaluation and validation of cathepsin D regulated proteins in macrophages exposed to Streptococcus pneumoniae

Pseudomonas expression of an oxygen sensing prolyl hydroxylase homologue regulates neutrophil host responses in vitro and in vivo.