List of works - Tao Yang

A structural requirement for processing the cardiac K+ channel KCNQ1.

scientific article

Ablation of triadin causes loss of cardiac Ca2+ release units, impaired excitation-contraction coupling, and cardiac arrhythmias

scientific journal article

Allelic variants in long-QT disease genes in patients with drug-associated torsades de pointes

scientific article

Androgenic Effects on Ventricular Repolarization: A Translational Study From the International Pharmacovigilance Database to iPSC-Cardiomyocytes

scientific article published on 05 August 2019

Atrial fibrillation in KCNE1-null mice

scientific article

Augmented potassium current is a shared phenotype for two genetic defects associated with familial atrial fibrillation

scientific article

Azithromycin Causes a Novel Proarrhythmic Syndrome

scientific article published in April 2017

Bidirectional ventricular tachycardia and channelopathy ⬇️

scientific article published on October 15, 2003

Biophysical properties of 9 KCNQ1 mutations associated with long-QT syndrome.

scientific article published on 22 May 2009

Blocking Scn10a Channels in Heart Reduces Late Sodium Current and Is Antiarrhythmic ⬇️

scientific article published on June 20, 2012

Cardiac-enriched LIM domain protein fhl2 is required to generate I(Ks) in a heterologous system

scientific article published in October 2002

Cardiovascular Toxicities Associated With Ibrutinib

scientific article published on 01 October 2019

Casq2 deletion causes sarcoplasmic reticulum volume increase, premature Ca2+ release, and catecholaminergic polymorphic ventricular tachycardia

scientific journal article

Clinical, genetic, and biophysical characterization of a homozygous HERG mutation causing severe neonatal long QT syndrome

scientific article published on 5 March 2003

Coinheritance of long QT syndrome and Kearns-Sayre syndrome

scientific article published on 15 August 2007

Contrasting Nav1.8 Activity in Scn10a-/- Ventricular Myocytes and the Intact Heart

scientific article

Coordinated regulation of murine cardiomyocyte contractility by nanomolar (-)-epigallocatechin-3-gallate, the major green tea catechin

scientific article

Deep Mutational Scan of an SCN5A Voltage Sensor

scientific article published on 12 January 2020

Defective human Ether-à-go-go-related gene trafficking linked to an endoplasmic reticulum retention signal in the C terminus

scientific article published on 20 May 2002

Exploiting ion channel structure to assess rare variant pathogenicity

scientific article published on 9 January 2018

Images in cardiovascular medicine. Himalayan T waves in the congenital long-QT syndrome.

scientific article published in March 2005

Increased late sodium current contributes to long QT-related arrhythmia susceptibility in female mice ⬇️

scientific article published on May 4, 2012

Informatic and functional approaches to identifying a regulatory region for the cardiac sodium channel

scientific article

KCNE1 induces fenestration in the Kv7.1/KCNE1 channel complex that allows for highly specific pharmacological targeting

scientific article (publication date: 12 October 2016)

KCNQ1 and Long QT Syndrome in 1/45 Amish: The Road from Identification to Implementation of Culturally Appropriate Precision Medicine

scientific article published on 03 November 2020

Modest reductions of cardiac calsequestrin increase sarcoplasmic reticulum Ca2+ leak independent of luminal Ca2+ and trigger ventricular arrhythmias in mice

scientific article published on 26 July 2007

Modification of proteins by isoketal-containing oxidized phospholipids

scientific article

Modulation of drug block of the cardiac potassium channel KCNA5 by the drug transporters OCTN1 and MDR1 ⬇️

scientific article published on November 1, 2010

Multiple mechanisms underlie increased cardiac late sodium current

scientific article published on 21 January 2019

Multiplex ligation-dependent probe amplification copy number variant analysis in patients with acquired long QT syndrome

scientific article published on 06 January 2015

New mechanism contributing to drug-induced arrhythmia: rescue of a misprocessed LQT3 mutant

scientific article

Novel KCNA5 mutation implicates tyrosine kinase signaling in human atrial fibrillation

scientific article

Personalized structural biology reveals the molecular mechanisms underlying heterogeneous epileptic phenotypes caused by de novo KCNC2 variants

scientific article published in 2022

Phosphorylation of the IKs channel complex inhibits drug block: novel mechanism underlying variable antiarrhythmic drug actions

scientific article published on 30 June 2003

Probing the mechanisms underlying modulation of quinidine sensitivity to cardiac I(Ks) block by protein kinase A-mediated I(Ks) phosphorylation

scientific article published on 12 June 2009

Prospective, population-based long QT molecular autopsy study of postmortem negative sudden death in 1 to 40 year olds

scientific article published on 9 November 2010

Protecting the heart against arrhythmias: potassium current physiology and repolarization reserve

scientific article published on 01 September 2005

Recombinase-mediated cassette exchange to rapidly and efficiently generate mice with human cardiac sodium channels.

scientific article

Risperidone prolongs cardiac repolarization by blocking the rapid component of the delayed rectifier potassium current

scientific article published in June 2003

Role of common and rare variants in SCN10A: results from the Brugada syndrome QRS locus gene discovery collaborative study.

scientific article published on 17 February 2015

SCN10A/Nav1.8 modulation of peak and late sodium currents in patients with early onset atrial fibrillation

scientific article published on 22 July 2014

SCN5A variant R222Q generated abnormal changes in cardiac sodium current and action potentials in murine myocytes and Purkinje cells

scientific article published on 21 May 2019

Screening for acute IKr block is insufficient to detect torsades de pointes liability: role of late sodium current.

scientific article

Sodium channel β1 subunit mutations associated with Brugada syndrome and cardiac conduction disease in humans

scientific article

Striking In vivo phenotype of a disease-associated human SCN5A mutation producing minimal changes in vitro

scientific article published on 8 August 2011

The organic cation transporter, OCTN1, expressed in the human heart, potentiates antagonism of the HERG potassium channel

scientific article published on July 2009

Unmasking of brugada syndrome by lithium

scientific article

Voltage-gated sodium channels are required for heart development in zebrafish

scientific article

List of works by Tao Yang

A structural requirement for processing the cardiac K+ channel KCNQ1.

Ablation of triadin causes loss of cardiac Ca2+ release units, impaired excitation-contraction coupling, and cardiac arrhythmias

Allelic variants in long-QT disease genes in patients with drug-associated torsades de pointes

Androgenic Effects on Ventricular Repolarization: A Translational Study From the International Pharmacovigilance Database to iPSC-Cardiomyocytes

Atrial fibrillation in KCNE1-null mice

Augmented potassium current is a shared phenotype for two genetic defects associated with familial atrial fibrillation

Azithromycin Causes a Novel Proarrhythmic Syndrome

Bidirectional ventricular tachycardia and channelopathy ⬇️

Biophysical properties of 9 KCNQ1 mutations associated with long-QT syndrome.

Blocking Scn10a Channels in Heart Reduces Late Sodium Current and Is Antiarrhythmic ⬇️

Cardiac-enriched LIM domain protein fhl2 is required to generate I(Ks) in a heterologous system

Cardiovascular Toxicities Associated With Ibrutinib

Casq2 deletion causes sarcoplasmic reticulum volume increase, premature Ca2+ release, and catecholaminergic polymorphic ventricular tachycardia

Clinical, genetic, and biophysical characterization of a homozygous HERG mutation causing severe neonatal long QT syndrome

Coinheritance of long QT syndrome and Kearns-Sayre syndrome

Contrasting Nav1.8 Activity in Scn10a-/- Ventricular Myocytes and the Intact Heart

Coordinated regulation of murine cardiomyocyte contractility by nanomolar (-)-epigallocatechin-3-gallate, the major green tea catechin

Deep Mutational Scan of an SCN5A Voltage Sensor

Defective human Ether-à-go-go-related gene trafficking linked to an endoplasmic reticulum retention signal in the C terminus

Exploiting ion channel structure to assess rare variant pathogenicity

Images in cardiovascular medicine. Himalayan T waves in the congenital long-QT syndrome.

Increased late sodium current contributes to long QT-related arrhythmia susceptibility in female mice ⬇️

Informatic and functional approaches to identifying a regulatory region for the cardiac sodium channel

KCNE1 induces fenestration in the Kv7.1/KCNE1 channel complex that allows for highly specific pharmacological targeting

KCNQ1 and Long QT Syndrome in 1/45 Amish: The Road from Identification to Implementation of Culturally Appropriate Precision Medicine

Modest reductions of cardiac calsequestrin increase sarcoplasmic reticulum Ca2+ leak independent of luminal Ca2+ and trigger ventricular arrhythmias in mice

Modification of proteins by isoketal-containing oxidized phospholipids

Modulation of drug block of the cardiac potassium channel KCNA5 by the drug transporters OCTN1 and MDR1 ⬇️

Multiple mechanisms underlie increased cardiac late sodium current

Multiplex ligation-dependent probe amplification copy number variant analysis in patients with acquired long QT syndrome

New mechanism contributing to drug-induced arrhythmia: rescue of a misprocessed LQT3 mutant

Novel KCNA5 mutation implicates tyrosine kinase signaling in human atrial fibrillation

Personalized structural biology reveals the molecular mechanisms underlying heterogeneous epileptic phenotypes caused by de novo KCNC2 variants

Phosphorylation of the IKs channel complex inhibits drug block: novel mechanism underlying variable antiarrhythmic drug actions

Probing the mechanisms underlying modulation of quinidine sensitivity to cardiac I(Ks) block by protein kinase A-mediated I(Ks) phosphorylation

Prospective, population-based long QT molecular autopsy study of postmortem negative sudden death in 1 to 40 year olds

Protecting the heart against arrhythmias: potassium current physiology and repolarization reserve

Recombinase-mediated cassette exchange to rapidly and efficiently generate mice with human cardiac sodium channels.

Risperidone prolongs cardiac repolarization by blocking the rapid component of the delayed rectifier potassium current

Role of common and rare variants in SCN10A: results from the Brugada syndrome QRS locus gene discovery collaborative study.

SCN10A/Nav1.8 modulation of peak and late sodium currents in patients with early onset atrial fibrillation

SCN5A variant R222Q generated abnormal changes in cardiac sodium current and action potentials in murine myocytes and Purkinje cells

Screening for acute IKr block is insufficient to detect torsades de pointes liability: role of late sodium current.

Sodium channel β1 subunit mutations associated with Brugada syndrome and cardiac conduction disease in humans

Striking In vivo phenotype of a disease-associated human SCN5A mutation producing minimal changes in vitro

The organic cation transporter, OCTN1, expressed in the human heart, potentiates antagonism of the HERG potassium channel

Unmasking of brugada syndrome by lithium

Voltage-gated sodium channels are required for heart development in zebrafish