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List of works by Dawn C. Newcomb

A chimeric A2 strain of respiratory syncytial virus (RSV) with the fusion protein of RSV strain line 19 exhibits enhanced viral load, mucus, and airway dysfunction

scientific article published on 11 February 2009

A functional IL-13 receptor is expressed on polarized murine CD4+ Th17 cells and IL-13 signaling attenuates Th17 cytokine production

scientific article published on May 2009

Allergic airway inflammation decreases lung bacterial burden following acute Klebsiella pneumoniae infection in a neutrophil- and CCL8-dependent manner

scientific article

Association of estrogen receptor α polymorphism rs1999805 with asthma

scientific article published on 16 November 2018

Attenuation of chronic pulmonary inflammation in A2B adenosine receptor knockout mice

scientific article

Bugs and asthma: a different disease?

scientific article published on May 2009

COX Inhibition Increases Alternaria-Induced Pulmonary Group 2 Innate Lymphoid Cell Responses and IL-33 Release in Mice

scientific article published on 20 July 2020

Cellular and systemic energy metabolic dysregulation in asthma development—a hypothesis-generating approach

scientific article published in 2022

Cooperative effects of rhinovirus and TNF-{alpha} on airway epithelial cell chemokine expression.

scientific article

Cyclooxygenase inhibition abrogates aeroallergen-induced immune tolerance by suppressing prostaglandin I2 receptor signaling

scientific article

Cyclooxygenase inhibition during allergic sensitization increases STAT6-independent primary and memory Th2 responses

scientific article published in October 2008

Deficiency of gp91phox inhibits allergic airway inflammation

scientific article published on September 2013

Differential pathogenesis of respiratory syncytial virus clinical isolates in BALB/c mice

scientific article

Distinct Regulation of Th17 and Th1 Cell Differentiation by Glutaminase-Dependent Metabolism

scientific article published on 01 November 2018

ERα Signaling Increased IL-17A Production in Th17 Cells by Upregulating IL-23R Expression, Mitochondrial Respiration, and Proliferation

scientific article published on 27 November 2019

Effect of Infant RSV Infection on Memory T Cell Responses at Age 2-3 Years

scientific article published on 17 March 2022

Endogenous PGI2 signaling through IP inhibits neutrophilic lung inflammation in LPS-induced acute lung injury mice model.

scientific article published on 13 April 2018

Endoplasmic reticulum stress enhances fibrotic remodeling in the lungs ⬇️

scientific article published on June 13, 2011

Estrogen and progesterone decrease let-7f microRNA expression and increase IL-23/IL-23 receptor signaling and IL-17A production in patients with severe asthma

scientific article

Estrogen receptor-α signaling increases allergen-induced IL-33 release and airway inflammation

scientific article published on 10 July 2020

Glucagon-like peptide 1 signaling inhibits allergen-induced lung IL-33 release and reduces group 2 innate lymphoid cell (ILC2) cytokine production in vivo.

scientific article

Glucagon-like peptide-1 receptor signaling attenuates RSV-induced type 2 responses and immunopathology.

scientific article published on 17 April 2018

H. influenzae potentiates airway epithelial cell responses to rhinovirus by increasing ICAM-1 and TLR3 expression

scientific article published on 16 August 2006

Heat Shock-Related Protein 20 Peptide Decreases Human Airway Constriction Downstream of β2-Adrenergic Receptor

scientific article published on 24 February 2016

Human TH17 cells express a functional IL-13 receptor and IL-13 attenuates IL-17A production

scientific article published on 13 January 2011

Human bronchial smooth muscle cell lines show a hypertrophic phenotype typical of severe asthma

scientific article published on 23 December 2003

Human rhinovirus 1B exposure induces phosphatidylinositol 3-kinase-dependent airway inflammation in mice

scientific article published on 14 February 2008

IL-13 Regulates Th17 Secretion of IL-17A in an IL-10–Dependent Manner ⬇️

scientific article published on December 30, 2011

IL-17A induces signal transducers and activators of transcription-6-independent airway mucous cell metaplasia

scientific article published on June 2013

IL-33 Is a Cell-Intrinsic Regulator of Fitness during Early B Cell Development

scientific article published on 07 August 2019

IL-33 promotes the egress of group 2 innate lymphoid cells from the bone marrow.

scientific article published on 8 December 2017

Identification of residues in the human respiratory syncytial virus fusion protein that modulate fusion activity and pathogenesis

scientific article

Intratracheal bleomycin causes airway remodeling and airflow obstruction in mice

scientific article

Mechanisms Driving Gender Differences in Asthma

scientific article published on March 2017

Monocyte-derived dendritic cells link localized secretory IgA deficiency to adaptive immune activation in COPD

scientific article published on 23 September 2020

Neutrophilic inflammation during lung development disrupts elastin assembly and predisposes adult mice to COPD

scientific article published on 27 October 2020

PD-1 up-regulation on CD4 T cells promotes pulmonary fibrosis through STAT3-mediated IL-17A and TGF-β1 production

scientific article published on 01 September 2018

PGI synthase overexpression protects against bleomycin-induced mortality and is associated with increased Nqo 1 expression

scientific article published on 15 July 2011

PGI2 as a regulator of CD4+ subset differentiation and function ⬇️

scientific article published on August 12, 2011

PGI₂ signaling inhibits antigen uptake and increases migration of immature dendritic cells

scientific article published on 26 April 2013

Phosphatidylinositol 3-kinase is required for rhinovirus-induced airway epithelial cell interleukin-8 expression.

scientific article published on 24 August 2005

Proliferation of the airway epithelium in asthma: are inflammatory cells required?

scientific article

Prostaglandin I2 Signaling Drives Th17 Differentiation and Exacerbates Experimental Autoimmune Encephalomyelitis ⬇️

scientific article published on May 10, 2012

Prostaglandin I2 Signaling and Inhibition of Group 2 Innate Lymphoid Cell Responses.

scientific article published on 17 September 2015

Prostaglandin I2 Suppresses Proinflammatory Chemokine Expression, CD4 T Cell Activation, and STAT6-Independent Allergic Lung Inflammation

scientific article published on 25 July 2016

Prostaglandin I2 inhibits IL-33-induced IL-5 and IL-13 production by human type 2 innate lymphoid cells

scientific article

Respiratory syncytial virus infection activates IL-13-producing group 2 innate lymphoid cells through thymic stromal lymphopoietin

scientific article published on 09 April 2016

Rhinovirus activates interleukin-8 expression via a Src/p110beta phosphatidylinositol 3-kinase/Akt pathway in human airway epithelial cells.

scientific article published on 22 November 2006

STAT1 Represses Cytokine-Producing Group 2 and Group 3 Innate Lymphoid Cells during Viral Infection

scientific article published on 2 June 2017

STAT1 negatively regulates lung basophil IL-4 expression induced by respiratory syncytial virus infection

scientific article published on 08 July 2009

STAT4 deficiency fails to induce lung Th2 or Th17 immunity following primary or secondary respiratory syncytial virus (RSV) challenge but enhances the lung RSV-specific CD8+ T cell immune response to secondary challenge

scientific article

STAT6 Signaling Attenuates Interleukin-17-Producing γδ T Cells during Acute Klebsiella pneumoniae Infection

scientific article published on 7 March 2016

Sex Bias in Asthma Prevalence and Pathogenesis

article

Sex hormones, gender and asthma

scientific article published in February 2018

Sex-specific association between prenatal life stress exposure and infant pro-inflammatory cytokine levels during acute respiratory infection

scientific article published on 11 December 2018

TLR4 genotype and environmental LPS mediate RSV bronchiolitis through Th2 polarization

scientific article

TSLP and IL-33 reciprocally promote each other's lung protein expression and ILC2 receptor expression to enhance innate type-2 airway inflammation

scientific article published on 23 January 2020

Targeting In Vivo Metabolic Vulnerabilities of Th2 and Th17 Cells Reduces Airway Inflammation

scientific article published on 08 February 2021

Testosterone Attenuates Group 2 Innate Lymphoid Cell-Mediated Airway Inflammation

scientific article published in November 2017

Testosterone Decreases House Dust Mite-Induced Type 2 and IL-17A-Mediated Airway Inflammation

scientific article published on 20 August 2018

Th17-mediated inflammation in asthma

scientific article

The Innate Immune Protein S100A9 Protects from T-Helper Cell Type 2-mediated Allergic Airway Inflammation

scientific article published on 01 October 2019

The PGI2 Analog Cicaprost Inhibits IL-33-Induced Th2 Responses, IL-2 Production, and CD25 Expression in Mouse CD4+ T Cells

scientific article published on 20 August 2018

The histone deacetylase inhibitor trichostatin A suppresses murine innate allergic inflammation by blocking group 2 innate lymphoid cell (ILC2) activation

scientific article published on 12 April 2016

β-catenin in the alveolar epithelium protects from lung fibrosis after intratracheal bleomycin

scientific article published on 10 January 2013

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