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List of works by Pavel Strnad

"Toxic memory" via chaperone modification is a potential mechanism for rapid Mallory-Denk body reinduction.

scientific article published in September 2008

A novel monoclonal antibody immunoassay for the detection of human serum hepcidin

scientific article published on 07 December 2010

Alpha-1 antitrypsin (AAT) augmentation therapy and liver phenotype in individuals with homozygous Pi*Z AAT mutation (Pi*ZZ genotype)

scientific article published in 2022

Analysis of keratin polypeptides 8 and 19 variants in inflammatory bowel disease.

scientific article published on 16 May 2007

Assessment of liver phenotype in adults with severe alpha-1 antitrypsin deficiency (Pi*ZZ genotype)

scientific article published on 05 October 2019

Broad spectrum of hepatocyte inclusions in humans, animals, and experimental models

scientific article published on October 2013

CHOP-mediated hepcidin suppression modulates hepatic iron load.

scientific article published on 15 October 2013

Canonical NF-κB signaling in hepatocytes acts as a tumor-suppressor in hepatitis B virus surface antigen-driven hepatocellular carcinoma by controlling the unfolded protein response.

scientific article

Chemistry and biology of dihydroisoxazole derivatives: selective inhibitors of human transglutaminase 2.

scientific article

Cytoskeletal keratin glycosylation protects epithelial tissue from injury.

scientific article published on 22 August 2010

DEFI-ALFA: The French key to the alpha1 mystery?

scientific article published on 01 June 2019

Decrease of renal resistance during hypothermic oxygenated machine perfusion is associated with early allograft function in extended criteria donation kidney transplantation

scientific article published on 20 October 2020

Denaturing temperature selection may underestimate keratin mutation detection by DHPLC.

scientific article published in May 2006

Deregulation of Hepatic Mek1/2⁻Erk1/2 Signaling Module in Iron Overload Conditions

scientific article published on 07 May 2019

Desmoglein 2, but not desmocollin 2, protects intestinal epithelia from injury

scientific article published on 16 August 2018

Diagnosis of hereditary hemochromatosis in the era of genetic testing

scientific article published on 07 June 2012

Endoglin in human liver disease and murine models of liver fibrosis - a protective factor against liver fibrosis

scientific article published on 20 September 2017

Enhanced expression of c-myc in hepatocytes promotes initiation and progression of alcoholic liver disease.

scientific article published on 11 November 2015

Epidermolysis bullosa simplex-type mutations alter the dynamics of the keratin cytoskeleton and reveal a contribution of actin to the transport of keratin subunits.

scientific article

Epiplakin attenuates experimental mouse liver injury by chaperoning keratin reorganization

scientific journal article

Epiplakin deficiency aggravates murine caerulein-induced acute pancreatitis and favors the formation of acinar keratin granules

scientific journal article

Extracellular transglutaminase 2 is catalytically inactive, but is transiently activated upon tissue injury

scientific article

From Mallory to Mallory-Denk bodies: what, how and why?

scientific article published on 27 April 2007

Hepatic activation of IKK/NFκB signaling induces liver fibrosis via macrophage-mediated chronic inflammation.

scientific article

Hepcidin as a predictor of treatment response in chronic hepatitis C infection

scientific article published on 18 February 2014

Hepcidin is an antibacterial, stress-inducible peptide of the biliary system

scientific article

Hepcidin knockout mice fed with iron-rich diet develop chronic liver injury and liver fibrosis due to lysosomal iron overload

scientific article published on 06 May 2014

Hepcidin knockout mice spontaneously develop chronic pancreatitis owing to cytoplasmic iron overload in acinar cells.

scientific article published on 14 October 2016

Heterozygous carriage of the alpha1-antitrypsin Pi*Z variant increases the risk to develop liver cirrhosis

scientific article published on 01 August 2018

High Keratin 8/18 Ratio Predicts Aggressive Hepatocellular Cancer Phenotype

scientific article published on 12 November 2018

High-fat diet triggers Mallory-Denk body formation through misfolding and crosslinking of excess keratin 8.

scientific article published on 27 May 2014

Hsp72 overexpression accelerates the recovery from caerulein-induced pancreatitis

scientific article

Hsp72 protects from liver injury via attenuation of hepatocellular death, oxidative stress and JNK-signaling.

scientific article published on 10 January 2018

Human Ran cysteine 112 oxidation by pervanadate regulates its binding to keratins.

scientific article published on 3 February 2005

Human keratin 8 variants promote mouse acetaminophen hepatotoxicity coupled with c-jun amino-terminal kinase activation and protein adduct formation.

scientific article

Identification of Keratin 23 as a Hepatitis C Virus-Induced Host Factor in the Human Liver

scientific article published on 18 June 2019

Identification of novel principles of keratin filament network turnover in living cells

scientific article

Identification, sequencing, and cellular localization of hepcidin in guinea pig (Cavia porcellus).

scientific article

Impact of Angiogenesis- and Hypoxia-Associated Polymorphisms on Tumor Recurrence in Patients with Hepatocellular Carcinoma Undergoing Surgical Resection

scientific article published on 18 December 2020

In alcoholic cirrhosis, low-serum hepcidin levels associate with poor long-term survival

scientific article published on 12 November 2015

Induction of rapid and reversible cytokeratin filament network remodeling by inhibition of tyrosine phosphatases.

scientific article published in November 2002

Iron Parameters Determine the Prognosis of Critically Ill Patients

scientific article

Ischemia-Reperfusion Injury in Marginal Liver Grafts and the Role of Hypothermic Machine Perfusion: Molecular Mechanisms and Clinical Implications

scientific article published on 20 March 2020

Keratin 18 overexpression but not phosphorylation or filament organization blocks mouse Mallory body formation

scientific article published on 01 January 2007

Keratin 23 is a stress-inducible marker of mouse and human ductular reaction in liver disease

scientific article

Keratin 8 overexpression promotes mouse Mallory body formation

scientific article

Keratin 8 phosphorylation regulates its transamidation and hepatocyte Mallory‐Denk body formation ⬇️

scientific article published on February 23, 2012

Keratin 8 variants are infrequent in patients with alcohol-related liver cirrhosis and do not associate with development of hepatocellular carcinoma

scientific article

Keratin mutation predisposes to mouse liver fibrosis and unmasks differential effects of the carbon tetrachloride and thioacetamide models.

scientific article published on 18 January 2008

Keratin overexpression levels correlate with the extent of spontaneous pancreatic injury.

scientific article published on 18 March 2008

Keratin variants are overrepresented in primary biliary cirrhosis and associate with disease severity

scientific article published on August 2009

Keratin variants associate with progression of fibrosis during chronic hepatitis C infection

scientific article published on 01 June 2006

Keratin variants predispose to acute liver failure and adverse outcome: race and ethnic associations.

scientific article published on 9 June 2010

Keratins 8 and 18 are type II acute-phase responsive genes overexpressed in human liver disease

article

Keratins are novel markers of renal epithelial cell injury

scientific article published on 6 February 2016

Keratins in health and disease

scientific article

Keratins let liver live: Mutations predispose to liver disease and crosslinking generates Mallory-Denk bodies.

scientific article published on November 2007

Keratins modulate the shape and function of hepatocyte mitochondria: a mechanism for protection from apoptosis

scientific article published on 13 October 2009

Keratins: Biomarkers and modulators of apoptotic and necrotic cell death in the liver.

scientific article published on 8 February 2016

Left- versus right-sided hepatectomy with hilar en-bloc resection in perihilar cholangiocarcinoma

scientific article published on 02 August 2019

Light-induced resistance of the keratin network to the filament-disrupting tyrosine phosphatase inhibitor orthovanadate.

scientific article published in February 2003

Liver - guardian, modifier and target of sepsis

scientific article published on 7 December 2016

Liver Fibrosis and Metabolic Alterations in Adults With alpha-1-antitrypsin Deficiency Caused by the Pi*ZZ Mutation

scientific article published on 20 May 2019

Liver Phenotypes of European Adults Heterozygous or Homozygous for Pi*Z Variant of AAT (Pi*MZ vs Pi*ZZ genotype) and Non-carriers

scientific article published on 03 May 2020

Loss of keratin 19 favours the development of cholestatic liver disease through decreased ductular reaction.

scientific article

Low Serum Hepcidin Is Associated With Reduced Short-Term Survival in Adults With Acute Liver Failure

scientific article published on 15 March 2019

Mild Iron Overload as Seen in Individuals Homozygous for the Alpha-1 Antitrypsin Pi*Z Variant Does Not Promote Liver Fibrogenesis in HFE Knockout Mice

scientific article published on 09 November 2019

Non-Invasive Assessment and Management of Liver Involvement in Adults With Alpha-1 Antitrypsin Deficiency

scientific article published on 08 July 2020

Non-coding keratin variants associate with liver fibrosis progression in patients with hemochromatosis

scientific article

Oblique Bile Duct Predisposes to the Recurrence of Bile Duct Stones ⬇️

scientific article published on January 24, 2013

Pharmacologic transglutaminase inhibition attenuates drug-primed liver hypertrophy but not Mallory body formation

scientific article published on 01 April 2006

Phenome-wide association study in adult coeliac disease: role of HLA subtype

scientific article published on 05 December 2020

Prevalence of genetic variants of keratins 8 and 18 in patients with drug-induced liver injury

scientific article published on 19 August 2015

Prognostic and Predictive Value of DAMPs and DAMP-Associated Processes in Cancer

scientific article

Protein phosphatase-2A associates with and dephosphorylates keratin 8 after hyposmotic stress in a site- and cell-specific manner.

scientific article published in April 2006

Reg-II is an exocrine pancreas injury-response product that is up-regulated by keratin absence or mutation

scientific article

Reply to: "Hepatic hepcidin expression is decreased in cirrhosis and HCC"

scientific article published on 21 November 2014

Response to: The Pi*MZ Allele in Alpha-1 Antitrypsin Increases Liver-Related Outcomes in a Population-Based Study

scientific article published on 05 January 2021

Serum keratin 19 (CYFRA21-1) links ductular reaction with portal hypertension and outcome of various advanced liver diseases

scientific article published on 12 November 2020

Simple Epithelial Keratins

scientific article

Telomerase gene mutations are associated with cirrhosis formation

scientific article published in May 2011

The Medium-Chain Fatty Acid Receptor GPR84 Mediates Myeloid Cell Infiltration Promoting Steatohepatitis and Fibrosis

scientific article published on 16 April 2020

The authors reply

The authors reply

The cytoskeleton in nonalcoholic steatohepatitis: 100 years old but still youthful ⬇️

scientific article published on April 1, 2011

The genetic background modulates susceptibility to mouse liver Mallory-Denk body formation and liver injury.

scientific article published in September 2008

The role of telomeres in liver disease

scientific article published on January 2014

Toward unraveling the complexity of simple epithelial keratins in human disease

scientific article

Transglutaminase 2 regulates mallory body inclusion formation and injury-associated liver enlargement

scientific article published on 07 February 2007

Transglutaminase cross-links Sp1-mediated transcription to ethanol-induced liver injury.

scientific article published on 21 March 2009

Unique amino acid signatures that are evolutionarily conserved distinguish simple-type, epidermal and hair keratins

scientific article

p62/Sequestosome-1 Is Indispensable for Maturation and Stabilization of Mallory-Denk Bodies

scientific article (publication date: 2016)

rs641738C>T near MBOAT7 is associated with liver fat, ALT, and fibrosis in NAFLD: a meta-analysis

scientific article published on 31 August 2020

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