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List of works by Rosemary J Akhurst

A sweet link between TGFbeta and vascular disease?

scientific article published on 01 April 2006

BMP-9 balances endothelial cell fate

scientific article

Cancer: dangerous liaisons

scientific article published in March 2004

Chronic TGF-β exposure drives stabilized EMT, tumor stemness, and cancer drug resistance with vulnerability to bitopic mTOR inhibition

scientific article published on 26 February 2019

Defective haematopoiesis and vasculogenesis in transforming growth factor-β1 knock out mice ⬇️

scientific article published on June 1, 1995

Defective retinal vascular endothelial cell development as a consequence of impaired integrin αVβ8-mediated activation of transforming growth factor-β.

scientific article published on January 2012

Differentiation plasticity regulated by TGF-beta family proteins in development and disease

scientific article published in September 2007

Elevated cutaneous Smad activation associates with enhanced skin tumor susceptibility in organ transplant recipients

scientific article

Embryonic gene expression patterns of TGF beta 1, beta 2 and beta 3 suggest different developmental functions in vivo ⬇️

scientific article published on January 1, 1991

Enhanced TGF-β Signaling Contributes to the Insulin-Induced Angiogenic Responses of Endothelial Cells

article

Epistatic interactions between Tgfb1 and genetic loci, Tgfbm2 and Tgfbm3, determine susceptibility to an asthmatic stimulus

scientific article

Epistatic interactions between modifier genes confer strain-specific redundancy for Tgfb1 in developmental angiogenesis

scientific article

Epithelial carcinogenesis in the mouse: correlating the genetics and the biology ⬇️

scientific article published on June 29, 1998

Erratum: Mouse and human strategies identify PTPN14 as a modifier of angiogenesis and hereditary haemorrhagic telangiectasia

scientific article published in Nature Communications

Excessive vascular sprouting underlies cerebral hemorrhage in mice lacking αVβ8-TGFβ signaling in the brain

scientific article

From prevention to cure, repurposing anti-viral vaccines for cancer immunotherapy

scientific article published on 01 December 2018

Functional loss of tumour suppressor genes in multistage chemical carcinogenesis

scientific article published on 01 January 1991

Genetic modifiers interact with maternal determinants in vascular development of Tgfb1(-/-) mice

scientific article published on 01 July 2003

Genetic variants of Adam17 differentially regulate TGFβ signaling to modify vascular pathology in mice and humans.

scientific article

Genetic variants of Tgfb1 act as context-dependent modifiers of mouse skin tumor susceptibility.

scholarly article

Genetic variation in the functional ENG allele inherited from the non-affected parent associates with presence of pulmonary arteriovenous malformation in hereditary hemorrhagic telangiectasia 1 (HHT1) and may influence expression of PTPN14

scientific article

Integrin αvβ8 on T cells suppresses anti-tumor immunity in multiple models and is a promising target for tumor immunotherapy

scientific article published on 01 July 2021

Large- and small-molecule inhibitors of transforming growth factor-beta signaling.

scientific article published on June 2006

Latent transforming growth factor-beta activation in mammary gland: regulation by ovarian hormones affects ductal and alveolar proliferation

scientific article published on June 2002

Matters of context guide future research in TGFβ superfamily signaling

scientific article

Metastasis is driven by sequential elevation of H-ras and Smad2 levels.

scientific article

Mouse and human strategies identify PTPN14 as a modifier of angiogenesis and hereditary haemorrhagic telangiectasia

scientific article

Mouse strain-dependent heterogeneity of resting limbal vasculature

scientific article

Multiple self-healing squamous epithelioma (MSSE): rare variants in an adjacent region of chromosome 9q22.3 to known TGFBR1 mutations suggest a digenic or multilocus etiology

scientific article published on 28 January 2013

Mutations of TGFbeta signaling molecules in human disease

scientific article published on January 2006

Outgrowth of drug-resistant carcinomas expressing markers of tumor aggression after long-term TβRI/II kinase inhibition with LY2109761.

scientific article

RNA and protein localisations of TGFβ2 in the early mouse embryo suggest an involvement in cardiac development ⬇️

scientific article published on 01 February 1993

ShcA Protects against Epithelial-Mesenchymal Transition through Compartmentalized Inhibition of TGF-β-Induced Smad Activation

scientific article published on 17 December 2015

Smad3-mediated recruitment of the methyltransferase SETDB1/ESET controls Snail1 expression and epithelial-mesenchymal transition.

scientific article published on 12 December 2017

TGF beta in murine morphogenetic processes: the early embryo and cardiogenesis ⬇️

scientific article published on April 1, 1990

TGF beta inhibition for cancer therapy

scientific article published on November 2006

TGF beta signaling in health and disease

scientific article published on 01 August 2004

TGF-beta antagonists: why suppress a tumor suppressor?

scientific article

TGF-β-induced activation of mTOR complex 2 drives epithelial-mesenchymal transition and cell invasion

scientific article published on 7 March 2012

TGFbeta inhibition of yolk-sac-like differentiation of human embryonic stem-cell-derived embryoid bodies illustrates differences between early mouse and human development

scientific article published on 31 January 2006

TGFβ biology in cancer progression and immunotherapy

scientific article published on 24 July 2020

TGFβ1 inhibition increases the radiosensitivity of breast cancer cells in vitro and promotes tumor control by radiation in vivo.

scientific article published on 25 October 2011

Taking thalidomide out of rehab

scientific article published on April 2010

Targeting TGF-β Signaling for Therapeutic Gain

scientific article published on 28 February 2017

Targeting the TGFβ signalling pathway in disease

scientific article

The Role of TGF? in Mouse Development ⬇️

scientific article published on January 1, 1990

The complexities of TGF-β action during mammary and squamous cell carcinogenesis

scientific article

The paradoxical TGF-β vasculopathies ⬇️

scientific article published on July 27, 2012

The type I TGF-beta receptor is covalently modified and regulated by sumoylation

scientific article published on 11 May 2008

Transforming growth factor beta is essential for spindle cell conversion of mouse skin carcinoma in vivo: implications for tumor invasion ⬇️

scientific article published on May 1, 1998

Transforming growth factor-beta in breast cancer: too much, too late

scientific article published on 26 February 2009

Transforming growth factor-beta receptor inhibition enhances adenoviral infectability of carcinoma cells via up-regulation of Coxsackie and Adenovirus Receptor in conjunction with reversal of epithelial-mesenchymal transition.

scientific article published in February 2006

Transforming growth factor-beta1 mediates cellular response to DNA damage in situ.

scientific article published in October 2002

α-PD-1 therapy elevates Treg/Th balance and increases tumor cell pSmad3 that are both targeted by α-TGFβ antibody to promote durable rejection and immunity in squamous cell carcinomas

scientific article published on 04 March 2019

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