List of works by Lawrence J Mandarino

A sustained increase in plasma free fatty acids impairs insulin secretion in nondiabetic subjects genetically predisposed to develop type 2 diabetes

scientific article published on October 2003

AMASS: a database for investigating protein structures.

scientific article

Abdominal fat distribution and peripheral and hepatic insulin resistance in type 2 diabetes mellitus

scientific article published in December 2002

Abnormal coupling of insulin receptor binding in noninsulin-dependent diabetes

scientific article published on 01 November 1984

Adenine nucleotide translocase is acetylated in vivo in human muscle: Modeling predicts a decreased ADP affinity and altered control of oxidative phosphorylation

scientific article

Adipocyte glycogen synthase and pyruvate dehydrogenase in obese and type II diabetic subjects

scientific article

Adiponectin receptors gene expression and insulin sensitivity in non-diabetic Mexican Americans with or without a family history of Type 2 diabetes

scientific article

Alterations of sorbin and SH3 domain containing 3 (SORBS3) in human skeletal muscle following Roux-en-Y gastric bypass surgery

scientific article published on 2 September 2017

Antisomatostatin Gamma Globulin Augments Secretion of Both Insulin and Glucagon In Vitro: Evidence for a Physiologic Role for Endogenous Somatostatin in the Regulation of Pancreatic A- and B-Cell Function ⬇️

scientific article published on 01 September 1980

Association of common genetic variants with diabetes and metabolic syndrome related traits in the Arizona Insulin Resistance registry: a focus on Mexican American families in the Southwest

scientific article published on 08 July 2014

Association of liprin β-1 with kank proteins in melanoma

scientific article published on 6 January 2016

Brain-Derived Neurotrophic Factor and Its Associations with Metabolism and Physical Activity in a Latino Sample

Calcineurin inhibition and new-onset diabetes mellitus after transplantation

scientific article

Cationized ferritin as a magnetic resonance imaging probe to detect microstructural changes in a rat model of non-alcoholic steatohepatitis

scientific article

Ceramide content is increased in skeletal muscle from obese insulin-resistant humans

scientific article published on January 2004

Changes in Pre- and Post-Exercise Gene Expression among Patients with Chronic Kidney Disease and Kidney Transplant Recipients

scientific article

Characterization of the Human Adipocyte Proteome and Reproducibility of Protein Abundance by One-Dimensional Gel Electrophoresis and HPLC-ESI-MS/MS.

scientific article

Characterization of the human skeletal muscle proteome by one-dimensional gel electrophoresis and HPLC-ESI-MS/MS.

scientific article published on October 2007

Characterization of the novel protein KIAA0564 (Von Willebrand Domain-containing Protein 8).

scientific article published on 13 April 2017

Cloning, chromosome localization, expression, and characterization of an Src homology 2 and pleckstrin homology domain-containing insulin receptor binding protein hGrb10gamma

scientific article

Contribution of impaired muscle glucose clearance to reduced postabsorptive systemic glucose clearance in NIDDM.

scientific article

Coordinated reduction of genes of oxidative metabolism in humans with insulin resistance and diabetes: Potential role of PGC1 and NRF1

scientific article

Cortisol-induced insulin resistance in man: impaired suppression of glucose production and stimulation of glucose utilization due to a postreceptor detect of insulin action.

scientific article

Decreased activation of skeletal muscle glycogen synthase by mixed-meal ingestion in NIDDM.

scientific article

Deletion of the Mitochondrial Protein VWA8 Induces Oxidative Stress and an HNF4α Compensatory Response in Hepatocytes

scientific article published on 20 November 2019

Developing a Process for Returning Medically Actionable Genomic Variants to Latino Patients in a Federally Qualified Health Center

scientific article published on 06 December 2018

Differential regulation of intracellular glucose metabolism by glucose and insulin in human muscle

scientific article published on 01 December 1993

Discordant effects of a chronic physiological increase in plasma FFA on insulin signaling in healthy subjects with or without a family history of type 2 diabetes

scientific article

Dose-response characteristics for effects of insulin on production and utilization of glucose in man

scientific article published on 01 June 1981

Dose-response effect of elevated plasma free fatty acid on insulin signaling

scientific article published in June 2005

Effect of IGF-I on FFA and glucose metabolism in control and type 2 diabetic subjects

scientific article

Effect of a sustained reduction in plasma free fatty acid concentration on intramuscular long-chain fatty Acyl-CoAs and insulin action in type 2 diabetic patients

scientific article

Effect of acute physiological hyperinsulinemia on gene expression in human skeletal muscle in vivo

scientific article published on 11 March 2008

Effect of exercise on the skeletal muscle proteome in patients with type 2 diabetes

scientific article published on June 2013

Effect of misoprostol (PGE1) on glucose metabolism in type-2-diabetic and control subjects

scientific article published in May 2002

Effect of pioglitazone on abdominal fat distribution and insulin sensitivity in type 2 diabetic patients

scientific article published in June 2002

Effect of pioglitazone on circulating adipocytokine levels and insulin sensitivity in type 2 diabetic patients

scientific article published in September 2004

Effect of rosiglitazone on glucose and non-esterified fatty acid metabolism in Type II diabetic patients

scientific article published in December 2001

Effect of thyroid hormone excess on action, secretion, and metabolism of insulin in humans

scientific article published on 01 May 1985

Effects of acute exposure to increased plasma branched-chain amino acid concentrations on insulin-mediated plasma glucose turnover in healthy young subjects

scientific article

Effects of exercise and insulin on insulin signaling proteins in human skeletal muscle

scientific article published on 01 July 1999

Effects of growth hormone on insulin action in man. Mechanisms of insulin resistance, impaired suppression of glucose production, and impaired stimulation of glucose utilization

scientific article published on August 1982

Effects of insulin infusion on human skeletal muscle pyruvate dehydrogenase, phosphofructokinase, and glycogen synthase. Evidence for their role in oxidative and nonoxidative glucose metabolism

scientific article published on September 1987

Effects of insulin on skeletal muscle glucose storage, oxidation, and glycolysis in humans

scientific article published on 01 June 1990

Effects of insulin on subcellular localization of hexokinase II in human skeletal muscle in vivo

scientific article published on 01 January 1998

Estimation and kinetic analysis of insulin-independent glucose uptake in human subjects ⬇️

scientific article published on 01 June 1983

Exercise increases hexokinase II mRNA, but not activity in obesity and type 2 diabetes

scientific article published in May 2001

Exercise training improves muscle insulin resistance but not insulin receptor signaling in obese Zucker rats

scientific article published in February 2002

Exercise training increases ERK2 activity in skeletal muscle of obese Zucker rats

scientific article

Exercise training increases glycogen synthase activity and GLUT4 expression but not insulin signaling in overweight nondiabetic and type 2 diabetic subjects

scientific article published in September 2004

Exercise-induced improvement in vasodilatory function accompanies increased insulin sensitivity in obesity and type 2 diabetes mellitus

scientific article published on 03 October 2006

Expression of the cereblon binding protein argonaute 2 plays an important role for multiple myeloma cell growth and survival.

scientific article

Familial insulin resistance and acanthosis nigricans. Presence of a postbinding defect.

scientific article published in January 1986

Fasting hyperglycemia normalizes oxidative and nonoxidative pathways of insulin-stimulated glucose metabolism in noninsulin-dependent diabetes mellitus

scientific article published in December 1990

Free fatty acid-induced peripheral insulin resistance augments splanchnic glucose uptake in healthy humans

scientific article

Free fatty acids reduce splanchnic and peripheral glucose uptake in patients with type 2 diabetes

scientific article published in October 2002

Fuel selection in human skeletal muscle in insulin resistance: a reexamination

scientific article

Gene and MicroRNA Expression Responses to Exercise; Relationship with Insulin Sensitivity

scientific article published on 18 May 2015

Genome-wide association study of habitual physical activity in over 377,000 UK Biobank participants identifies multiple variants including CADM2 and APOE

scientific article published on 13 June 2018

Gestational diabetes is characterized by reduced mitochondrial protein expression and altered calcium signaling proteins in skeletal muscle

scientific article

Global Assessment of Regulation of Phosphorylation of Insulin Receptor Substrate-1 by Insulin In Vivo in Human Muscle

scientific article published on 14 March 2007

Global IRS-1 phosphorylation analysis in insulin resistance

scientific article published on 18 August 2011

Global relationship between the proteome and transcriptome of human skeletal muscle

scientific article published on 10 July 2008

Glucose response curve and type 2 diabetes risk in Latino adolescents

scientific article

Glycogen synthase kinetics in isolated human adipocytes: an in vitro model for the effects of insulin on glycogen synthase

scientific article published on 01 December 1987

Glycogen synthase: key effect of exercise on insulin action

scientific article published in July 2004

Hemolysis-induced Lung Vascular Leakage Contributes to the Development of Pulmonary Hypertension.

scientific article published on 13 April 2018

Human ATP synthase beta is phosphorylated at multiple sites and shows abnormal phosphorylation at specific sites in insulin-resistant muscle

scientific article published on 12 December 2009

Hyperglycemia normalizes insulin-stimulated skeletal muscle glucose oxidation and storage in noninsulin-dependent diabetes mellitus

scientific article published in December 1990

Hypoadiponectinemia Is Closely Associated with Impaired Nitric Oxide Synthase Activity in Skeletal Muscle of Type 2 Diabetic Subjects ⬇️

scientific article published on October 1, 2010

IGF-binding protein-1 levels are related to insulin-mediated glucose disposal and are a potential serum marker of insulin resistance

scientific article published in July 2006

Identification of Novel Changes in Human Skeletal Muscle Proteome After Roux-en-Y Gastric Bypass Surgery

scientific article

Identification of a novel phosphorylation site in adipose triglyceride lipase as a regulator of lipid droplet localization

scientific article

Identification of a role for CLASP2 in insulin action

scientific article

Identification of insulin receptor substrate 1 serine/threonine phosphorylation sites using mass spectrometry analysis: regulatory role of serine 1223.

scientific article

Identification of phosphorylation sites in insulin receptor substrate-1 by hypothesis-driven high-performance liquid chromatography-electrospray ionization tandem mass spectrometry

scientific article published in September 2005

Impaired mitochondrial activity and insulin-resistant offspring of patients with type 2 diabetes

scientific article

Improved glycemic control and enhanced insulin sensitivity in type 2 diabetic subjects treated with pioglitazone

scientific article published in April 2001

In response to: 'Information bias in measures of self-reported physical activity'

scientific article published on 21 November 2018

In vivo phosphoproteome of human skeletal muscle revealed by phosphopeptide enrichment and HPLC-ESI-MS/MS.

scientific article published on November 2009

Increased abundance of the adaptor protein containing pleckstrin homology domain, phosphotyrosine binding domain and leucine zipper motif (APPL1) in patients with obesity and type 2 diabetes: evidence for altered adiponectin signalling

scientific article

Increased collagen content in insulin-resistant skeletal muscle

scientific article

Increased insulin receptor signaling and glycogen synthase activity contribute to the synergistic effect of exercise on insulin action

scientific article published on 8 August 2003

Increased plasma availability of L-arginine in the postprandial period decreases the postprandial lipemia in older adults

scientific article

Increased reactive oxygen species production and lower abundance of complex I subunits and carnitine palmitoyltransferase 1B protein despite normal mitochondrial respiration in insulin-resistant human skeletal muscle

scientific article published on 3 August 2010

Increases in insulin sensitivity among obese youth are associated with gene expression changes in whole blood

scientific article

Influence of Changes in Insulin Receptor Binding during Insulin Infusions on the Shape of the Insulin Dose-Response Curve for Glucose Disposal in Man* ⬇️

scientific article published on 01 February 1984

Infusion of insulin impairs human adipocyte glucose metabolism in vitro without decreasing adipocyte insulin receptor binding

scientific article published on September 1984

Insulin increases the maximum velocity for glucose uptake without altering the Michaelis constant in man. Evidence that insulin increases glucose uptake merely by providing additional transport sites

scientific article published on December 1982

Insulin resistance differentially affects the PI 3-kinase- and MAP kinase-mediated signaling in human muscle

scientific article published on February 2000

Insulin-induced hexokinase II expression is reduced in obesity and NIDDM

scientific article published on 01 March 1998

Insulin-resistant muscle is exercise resistant: evidence for reduced response of nuclear-encoded mitochondrial genes to exercise

scientific article published on 8 January 2008

Interaction between glucose and free fatty acid metabolism in human skeletal muscle

scientific article

Interaction of carbohydrate and fat fuels in human skeletal muscle: impact of obesity and NIDDM

scientific article published on 01 March 1996

Intracellular defects in glucose metabolism in obese patients with NIDDM.

scientific article published in June 1992

LKB1-AMPK signaling in muscle from obese insulin-resistant Zucker rats and effects of training

scientific article

Label-free proteomic identification of endogenous, insulin-stimulated interaction partners of insulin receptor substrate-1.

scientific article published on 29 January 2011

Label-free relative quantification of co-eluting isobaric phosphopeptides of insulin receptor substrate-1 by HPLC-ESI-MS/MS.

scientific article

Lipid Infusion Decreases the Expression of Nuclear Encoded Mitochondrial Genes and Increases the Expression of Extracellular Matrix Genes in Human Skeletal Muscle

scientific article published in Journal of Biological Chemistry

Lower Fasted-State but Greater Increase in Muscle Protein Synthesis in Response to Elevated Plasma Amino Acids in Obesity.

scientific article published on 12 June 2018

Mechanism and significance of insulin resistance in non-insulin-dependent diabetes mellitus.

scientific article published in December 1981

Mechanism of hyperglycemia and response to treatment with an inhibitor of fatty acid oxidation in a patient with insulin resistance due to antiinsulin receptor antibodies

scientific article published on 01 October 1984

Mechanisms of insulin resistance in man. Assessment using the insulin dose-response curve in conjunction with insulin-receptor binding

scientific article published on 01 January 1981

Metabolic pathways of glucose in skeletal muscle of lean NIDDM patients

scientific article published on 01 August 1993

Mitochondrial dysfunction and insulin resistance from the outside in: extracellular matrix, the cytoskeleton, and mitochondria

scientific article published on 23 August 2011

Muscle glucose transport and phosphorylation in type 2 diabetic, obese nondiabetic, and genetically predisposed individuals

scientific article published on 08 August 2006

Next-generation sequencing methylation profiling of subjects with obesity identifies novel gene changes

scientific article published on 18 July 2016

Normalization of plasma glucose concentration by insulin therapy improves insulin-stimulated glycogen synthesis in type 2 diabetes

scientific article published in February 2002

Osteocalcin and type 2 diabetes risk in Latinos: a life course approach.

scientific article published on 19 June 2015

Paradoxical changes in muscle gene expression in insulin-resistant subjects after sustained reduction in plasma free fatty acid concentration

scientific article published on 01 March 2007

Pathogenesis of Hypoglycemia in Insulinoma Patients: Suppression of Hepatic Glucose Production by Insulin ⬇️

scientific article published on May 1, 1981

Pathogenesis of Type 2 Diabetes Mellitus

scientific article published on 24 April 2015

Phosphorylation and activation of a transducible recombinant form of human HSP20 in Escherichia coli

scientific article

Phosphorylation of human insulin receptor substrate-1 at Serine 629 plays a positive role in insulin signaling

scientific article published on 19 July 2007

Physical activity and FTO genotype by physical activity interactive influences on obesity

scientific article

Physiological hyperinsulinemia impairs insulin-stimulated glycogen synthase activity and glycogen synthesis.

scientific article published in May 2001

Postprandial lipemia in the elderly involves increased incorporation of ingested fat in plasma free fatty acids and small (Sf 20-400) triglyceride-rich lipoproteins

scientific article

Postprandial spillover of dietary lipid into plasma is increased with moderate amounts of ingested fat and is inversely related to adiposity in healthy older men.

scientific article

Potential epigenetic biomarkers of obesity-related insulin resistance in human whole-blood.

scientific article published on 20 January 2017

Production of insulin resistance by hyperinsulinaemia in man.

scientific article published on February 1985

Prolonged Exposure of Primary Human Muscle Cells to Plasma Fatty Acids Associated with Obese Phenotype Induces Persistent Suppression of Muscle Mitochondrial ATP Synthase β Subunit

scientific article

Prolonged sulfonylurea administration decreases insulin resistance and increases insulin secretion in non-insulin-dependent diabetes mellitus: evidence for improved insulin action at a postreceptor site in hepatic as well as extrahepatic tissues

scientific article published on May 1, 1984

Protein metabolism in human obesity: a shift in focus from whole-body to skeletal muscle

scientific article published on 16 December 2010

Proteome profile of functional mitochondria from human skeletal muscle using one-dimensional gel electrophoresis and HPLC-ESI-MS/MS.

scientific article published on 28 June 2009

Proteomics analyses of subcutaneous adipocytes reveal novel abnormalities in human insulin resistance.

scientific article published on July 2016

Proteomics analysis of human skeletal muscle reveals novel abnormalities in obesity and type 2 diabetes

scientific article

Pulmonary Arterial Hypertension Induces a Distinct Signature of Circulating Metabolites

scientific article published on 14 January 2020

Quantification of phosphorylation of insulin receptor substrate-1 by HPLC-ESI-MS/MS.

scientific article published on 28 February 2006

Quantification of the relative impairment in actions of insulin on hepatic glucose production and peripheral glucose uptake in non-insulin-dependent diabetes mellitus.

scientific article published in January 1988

Rates of noninsulin-mediated glucose uptake are elevated in type II diabetic subjects

scientific article

Reduced skeletal muscle inhibitor of kappaB beta content is associated with insulin resistance in subjects with type 2 diabetes: reversal by exercise training

scientific article published in March 2006

Reduction in reactive oxygen species production by mitochondria from elderly subjects with normal and impaired glucose tolerance

scientific article

Regulation of MAP kinase pathway activity in vivo in human skeletal muscle

scientific article published on 01 June 2000

Regulation of hexokinase II activity and expression in human muscle by moderate exercise

scientific article published on 01 February 1998

Regulation of hexokinase II and glycogen synthase mRNA, protein, and activity in human muscle

scientific article published on 01 October 1995

Regulation of hexokinase II expression in human skeletal muscle in vivo

scientific article published on 01 June 2000

Regulation of skeletal muscle oxidative capacity and insulin signaling by the mitochondrial rhomboid protease PARL.

scientific article

Reproducibility of an HPLC-ESI-MS/MS method for the measurement of stable-isotope enrichment of in vivo-labeled muscle ATP synthase beta subunit

scientific article

Returning genomic results in a Federally Qualified Health Center: the intersection of precision medicine and social determinants of health

scientific article published on 06 May 2020

Role of adiponectin in human skeletal muscle bioenergetics

scientific article published on July 2006

Role of the adipocyte, free fatty acids, and ectopic fat in pathogenesis of type 2 diabetes mellitus: peroxisomal proliferator-activated receptor agonists provide a rational therapeutic approach

scientific article

Rosiglitazone improves downstream insulin receptor signaling in type 2 diabetic patients

scientific article published in August 2003

Selective effects of somatostatin-14, -25 and -28 on in vitro insulin and glucagon secretion ⬇️

scientific article published on May 7, 1981

Selenium supplementation and insulin resistance in a randomized, clinical trial

scholarly article by Elizabeth Theresa Jacobs et al published 2019 in BMJ open diabetes research & care

Seven days of euglycemic hyperinsulinemia induces insulin resistance for glucose metabolism but not hypertension, elevated catecholamine levels, or increased sodium retention in conscious normal rats

scientific article published on 01 October 1997

Single Mutation in the <i>NFU1</i> Gene Metabolically Reprograms Pulmonary Artery Smooth Muscle Cells

scientific article published on 10 December 2020

Site-specific phosphorylation of protein phosphatase 1 regulatory subunit 12A stimulated or suppressed by insulin

scientific article

Skeletal muscle insulin resistance in normoglycemic subjects with a strong family history of type 2 diabetes is associated with decreased insulin-stimulated insulin receptor substrate-1 tyrosine phosphorylation

scientific article published in November 2001

Skeletal muscle is a major site of lactate uptake and release during hyperinsulinemia ⬇️

scientific article published on 01 February 1992

Somatostatin: its role in health and disease

scientific article published on January 1, 1982

Stimulation of Insulin Release in the Absence of Extracellular Calcium by Isobutylmethylxanthine and Its Inhibition by Somatostatin* ⬇️

scientific article published on February 1, 1980

Sustained reduction in plasma free fatty acid concentration improves insulin action without altering plasma adipocytokine levels in subjects with strong family history of type 2 diabetes

scientific article

Synergistic interaction of magnesium and vanadate on glucose metabolism in diabetic rats

scientific article published on 01 June 1999

The CLASP2 Protein Interaction Network in Adipocytes Links CLIP2 to AGAP3, CLASP2 to G2L1, MARK2, and SOGA1, and Identifies SOGA1 as a Microtubule-Associated Protein.

scientific article published on 26 May 2017

The Sangre Por Salud Biobank: Facilitating Genetic Research in an Underrepresented Latino Community

scientific article published on 5 July 2016

The design and conduct of a community-based registry and biorepository: a focus on cardiometabolic health in Latinos

scientific article

The effect of exercise, training, and inactivity on insulin sensitivity in diabetics and their relatives: what is new?

scientific article published on June 2007

The identification of raptor as a substrate for p44/42 MAPK

scientific article

Time course of insulin action on tissue-specific intracellular glucose metabolism in normal rats

scientific article published on April 1998

Time to Look Back and to Look Forward

scientific article published on 01 April 2014

Tumor necrosis factor alpha and insulin resistance in obese type 2 diabetic patients

scientific article published on 01 January 2003

UDP-N-acetylglucosamine transferase and glutamine: fructose 6-phosphate amidotransferase activities in insulin-sensitive tissues

scientific article published on 01 January 1997

Use of glucose uptake and glucose clearance for the evaluation of insulin action in vivo.

scientific article

Von Willebrand factor A domain-containing protein 8 (VWA8) localizes to the matrix side of the inner mitochondrial membrane

scientific article published on 17 October 2019

Whole blood gene expression profiles in insulin resistant Latinos with the metabolic syndrome

scientific article

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