List of works - Gerald A Dienel

A glycogen phosphorylase inhibitor selectively enhances local rates of glucose utilization in brain during sensory stimulation of conscious rats: implications for glycogen turnover

scientific article

Activation of astrocytes in brain of conscious rats during acoustic stimulation: acetate utilization in working brain

scientific article

Aerobic glycolysis during brain activation: adrenergic regulation and influence of norepinephrine on astrocytic metabolism

scientific article published on 10 May 2016

Astrocyte activation in working brain: energy supplied by minor substrates

scientific article

Astrocytes are poised for lactate trafficking and release from activated brain and for supply of glucose to neurons

scientific article

Astrocytes are ‘Good Scouts’: Being Prepared Also Helps Neighboring Neurons ⬇️

scientific article published on September 8, 2010

Astrocytic connexin distributions and rapid, extensive dye transfer via gap junctions in the inferior colliculus: implications for [(14)C]glucose metabolite trafficking

scientific article

Astrocytic contributions to bioenergetics of cerebral ischemia

scientific article

Astrocytic energetics during excitatory neurotransmission: What are contributions of glutamate oxidation and glycolysis? ⬇️

scientific article published on July 6, 2013

Astrocytic gap junctional communication is reduced in amyloid-β-treated cultured astrocytes, but not in Alzheimer's disease transgenic mice

scientific article

Behavioral training increases local astrocytic metabolic activity but does not alter outcome of mild transient ischemia

scientific article published in January 2003

Biochemical, Metabolic, and Behavioral Characteristics of Immature Chronic Hyperphenylalanemic Rats

scientific article published on 30 July 2015

Brain Lactate Metabolism: The Discoveries and the Controversies ⬇️

scientific article published on December 21, 2011

CD117 expression in glial tumors

scientific article published in November 2005

Cellular Origin of [18F]FDG-PET Imaging Signals During Ceftriaxone-Stimulated Glutamate Uptake: Astrocytes and Neurons

scientific article published in December 2017

Contributions of glycogen to astrocytic energetics during brain activation

scientific article

Determination of Glucose Utilization Rates in Cultured Astrocytes and Neurons with [14C]deoxyglucose: Progress, Pitfalls, and Discovery of Intracellular Glucose Compartmentation

scientific article

Does shuttling of glycogen-derived lactate from astrocytes to neurons take place during neurotransmission and memory consolidation?

scientific article published on 22 January 2019

Effect of reactive cell density on net [2-14C]acetate uptake into rat brain: labeling of clusters containing GFAP+- and lectin+-immunoreactive cells

scientific article

Energy metabolism in astrocytes: high rate of oxidative metabolism and spatiotemporal dependence on glycolysis/glycogenolysis

scientific article

Energy metabolism in the brain

scientific article

Exchange-mediated dilution of brain lactate specific activity: implications for the origin of glutamate dilution and the contributions of glutamine dilution and other pathways

scientific article

Fluxes of lactate into, from, and among gap junction-coupled astrocytes and their interaction with noradrenaline

scientific article

Fueling and Imaging Brain Activation ⬇️

scientific article published on July 20, 2012

Generalized sensory stimulation of conscious rats increases labeling of oxidative pathways of glucose metabolism when the brain glucose-oxygen uptake ratio rises

scientific article published in December 2002

High glycogen levels in brains of rats with minimal environmental stimuli: implications for metabolic contributions of working astrocytes

scientific article published in December 2002

Hyperglycaemia and diabetes impair gap junctional communication among astrocytes

scientific article

Hypothesis: A Novel Neuroprotective Role for Glucose-6-phosphatase (G6PC3) in Brain-To Maintain Energy-Dependent Functions Including Cognitive Processes

scientific article published on 19 August 2020

Imaging brain activation: simple pictures of complex biology

scientific article

In memoriam Louis Sokoloff, M.D. 1921-2015.

scientific article published on 23 October 2015

Lack of appropriate stoichiometry: Strong evidence against an energetically important astrocyte-neuron lactate shuttle in brain

scientific article published on 2 February 2017

Lactate muscles its way into consciousness: fueling brain activation

scientific article

Lactate shuttling and lactate use as fuel after traumatic brain injury: metabolic considerations

scientific article

Lactate transport and transporters: general principles and functional roles in brain cells

scientific article

Metabolomic and Imaging Mass Spectrometric Assays of Labile Brain Metabolites: Critical Importance of Brain Harvest Procedures

scientific article published on 19 September 2020

Microdialysate concentration changes do not provide sufficient information to evaluate metabolic effects of lactate supplementation in brain-injured patients

scientific article published on 7 September 2016

Neighborly interactions of metabolically-activated astrocytes in vivo ⬇️

scientific article published on September 1, 2003

Nutrition during brain activation: does cell-to-cell lactate shuttling contribute significantly to sweet and sour food for thought?

scientific article published on July 2004

Rapid manifestation of reactive astrogliosis in acute hippocampal brain slices

scientific article

Receptor-mediated glutamate release from volume sensitive channels in astrocytes

scientific article

Reduced clearance of proteins labeled with diisopropylfluorophosphate in portacaval-shunted rats

scientific article published on 25 October 2013

Reduced gap junctional communication among astrocytes in experimental diabetes: contributions of altered connexin protein levels and oxidative-nitrosative modifications

scientific article

Reevaluation of Astrocyte-Neuron Energy Metabolism with Astrocyte Volume Fraction Correction: Impact on Cellular Glucose Oxidation Rates, Glutamate-Glutamine Cycle Energetics, Glycogen Levels and Utilization Rates vs. Exercising Muscle, and Na+/K+ P

scientific article published on 18 September 2020

Regional registration of [6‐14C]glucose metabolism during brain activation of α‐syntrophin knockout mice ⬇️

scientific article published on March 6, 2013

Selective astrocytic gap junctional trafficking of molecules involved in the glycolytic pathway: impact on cellular brain imaging

scientific article

Sugar for the brain: the role of glucose in physiological and pathological brain function

scientific article published on 20 August 2013

The "protected" glucose transport through the astrocytic endoplasmic reticulum is too slow to serve as a quantitatively-important highway for nutrient delivery

scientific article published on 03 May 2019

The unfolded protein response to endoplasmic reticulum stress in cultured astrocytes and rat brain during experimental diabetes ⬇️

scientific article published on February 11, 2013

Trafficking of glucose, lactate, and amyloid-beta from the inferior colliculus through perivascular routes

scientific article

beta-Adrenergics enhance brain extraction of levodopa

scientific article published on January 2002

List of works by Gerald A Dienel

A glycogen phosphorylase inhibitor selectively enhances local rates of glucose utilization in brain during sensory stimulation of conscious rats: implications for glycogen turnover

Activation of astrocytes in brain of conscious rats during acoustic stimulation: acetate utilization in working brain

Aerobic glycolysis during brain activation: adrenergic regulation and influence of norepinephrine on astrocytic metabolism

Astrocyte activation in working brain: energy supplied by minor substrates

Astrocytes are poised for lactate trafficking and release from activated brain and for supply of glucose to neurons

Astrocytes are ‘Good Scouts’: Being Prepared Also Helps Neighboring Neurons ⬇️

Astrocytic connexin distributions and rapid, extensive dye transfer via gap junctions in the inferior colliculus: implications for [(14)C]glucose metabolite trafficking

Astrocytic contributions to bioenergetics of cerebral ischemia

Astrocytic energetics during excitatory neurotransmission: What are contributions of glutamate oxidation and glycolysis? ⬇️

Astrocytic gap junctional communication is reduced in amyloid-β-treated cultured astrocytes, but not in Alzheimer's disease transgenic mice

Behavioral training increases local astrocytic metabolic activity but does not alter outcome of mild transient ischemia

Biochemical, Metabolic, and Behavioral Characteristics of Immature Chronic Hyperphenylalanemic Rats

Brain Lactate Metabolism: The Discoveries and the Controversies ⬇️

CD117 expression in glial tumors

Cellular Origin of [18F]FDG-PET Imaging Signals During Ceftriaxone-Stimulated Glutamate Uptake: Astrocytes and Neurons

Contributions of glycogen to astrocytic energetics during brain activation

Determination of Glucose Utilization Rates in Cultured Astrocytes and Neurons with [14C]deoxyglucose: Progress, Pitfalls, and Discovery of Intracellular Glucose Compartmentation

Does shuttling of glycogen-derived lactate from astrocytes to neurons take place during neurotransmission and memory consolidation?

Effect of reactive cell density on net [2-14C]acetate uptake into rat brain: labeling of clusters containing GFAP+- and lectin+-immunoreactive cells

Energy metabolism in astrocytes: high rate of oxidative metabolism and spatiotemporal dependence on glycolysis/glycogenolysis

Energy metabolism in the brain

Exchange-mediated dilution of brain lactate specific activity: implications for the origin of glutamate dilution and the contributions of glutamine dilution and other pathways

Fluxes of lactate into, from, and among gap junction-coupled astrocytes and their interaction with noradrenaline

Fueling and Imaging Brain Activation ⬇️

Generalized sensory stimulation of conscious rats increases labeling of oxidative pathways of glucose metabolism when the brain glucose-oxygen uptake ratio rises

High glycogen levels in brains of rats with minimal environmental stimuli: implications for metabolic contributions of working astrocytes

Hyperglycaemia and diabetes impair gap junctional communication among astrocytes

Hypothesis: A Novel Neuroprotective Role for Glucose-6-phosphatase (G6PC3) in Brain-To Maintain Energy-Dependent Functions Including Cognitive Processes

Imaging brain activation: simple pictures of complex biology

In memoriam Louis Sokoloff, M.D. 1921-2015.

Lack of appropriate stoichiometry: Strong evidence against an energetically important astrocyte-neuron lactate shuttle in brain

Lactate muscles its way into consciousness: fueling brain activation

Lactate shuttling and lactate use as fuel after traumatic brain injury: metabolic considerations

Lactate transport and transporters: general principles and functional roles in brain cells

Metabolomic and Imaging Mass Spectrometric Assays of Labile Brain Metabolites: Critical Importance of Brain Harvest Procedures

Microdialysate concentration changes do not provide sufficient information to evaluate metabolic effects of lactate supplementation in brain-injured patients

Neighborly interactions of metabolically-activated astrocytes in vivo ⬇️

Nutrition during brain activation: does cell-to-cell lactate shuttling contribute significantly to sweet and sour food for thought?

Rapid manifestation of reactive astrogliosis in acute hippocampal brain slices

Receptor-mediated glutamate release from volume sensitive channels in astrocytes

Reduced clearance of proteins labeled with diisopropylfluorophosphate in portacaval-shunted rats

Reduced gap junctional communication among astrocytes in experimental diabetes: contributions of altered connexin protein levels and oxidative-nitrosative modifications

Reevaluation of Astrocyte-Neuron Energy Metabolism with Astrocyte Volume Fraction Correction: Impact on Cellular Glucose Oxidation Rates, Glutamate-Glutamine Cycle Energetics, Glycogen Levels and Utilization Rates vs. Exercising Muscle, and Na+/K+ P

Regional registration of [6‐14C]glucose metabolism during brain activation of α‐syntrophin knockout mice ⬇️

Selective astrocytic gap junctional trafficking of molecules involved in the glycolytic pathway: impact on cellular brain imaging

Sugar for the brain: the role of glucose in physiological and pathological brain function

The "protected" glucose transport through the astrocytic endoplasmic reticulum is too slow to serve as a quantitatively-important highway for nutrient delivery

The unfolded protein response to endoplasmic reticulum stress in cultured astrocytes and rat brain during experimental diabetes ⬇️

Trafficking of glucose, lactate, and amyloid-beta from the inferior colliculus through perivascular routes

beta-Adrenergics enhance brain extraction of levodopa