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List of works by Thomas J Gardella

A Homozygous [Cys25]PTH(1-84) Mutation That Impairs PTH/PTHrP Receptor Activation Defines a Novel Form of Hypoparathyroidism

scientific article

A new multi-system disorder caused by the Gαs mutation p.F376V

article

Actions of the small molecule ligands SW106 and AH-3960 on the type-1 parathyroid hormone receptor

scientific article

Acute Down-regulation of Sodium-dependent Phosphate Transporter NPT2a Involves Predominantly the cAMP/PKA Pathway as Revealed by Signaling-selective Parathyroid Hormone Analogs ⬇️

scientific article published on November 3, 2010

Allosteric interactions in the parathyroid hormone GPCR-arrestin complex formation

scientific article published on 06 July 2020

Amino-terminal parathyroid hormone fragment analogs containing alpha,alpha-di-alkyl amino acids at positions 1 and 3.

scientific article

An Inverse Agonist Ligand of the PTH Receptor Partially Rescues Skeletal Defects in a Mouse Model of Jansen's Metaphyseal Chondrodysplasia

scientific article published on 04 December 2019

Backbone Modification of a Parathyroid Hormone Receptor-1 Antagonist/Inverse Agonist

scientific article published on 17 August 2016

Backbone modification of a polypeptide drug alters duration of action in vivo

scientific article

Backbone-methylated analogues of the principle receptor binding region of human parathyroid hormone. Evidence for binding to both the N-terminal extracellular domain and extracellular loop region

scientific article

Chemistry as an expanding resource in protein science: fully synthetic and fully active human parathyroid hormone-related protein (1-141).

scientific article published on 4 November 2012

Cooperative interaction of arginine-19 and the N-terminal signaling domain in the affinity and potency of parathyroid hormone

scientific article published in March 2004

Corrigendum: SIKs control osteocyte responses to parathyroid hormone

scientific article published on 22 February 2017

Critical role of parathyroid hormone (PTH) receptor-1 phosphorylation in regulating acute responses to PTH ⬇️

scientific article published on March 26, 2013

Engineering of Therapeutic Polypeptides through Chemical Synthesis: Early Lessons from Human Parathyroid Hormone and Analogues ⬇️

scientific article published on August 29, 2012

Functional evidence for an intramolecular side chain interaction between residues 6 and 10 of receptor-bound parathyroid hormone analogues

scientific article published in March 2003

Identification of a contact site for residue 19 of parathyroid hormone (PTH) and PTH-related protein analogs in transmembrane domain two of the type 1 PTH receptor

scientific article published on 28 August 2003

Jansen Metaphyseal Chondrodysplasia due to Heterozygous H223R-PTH1R Mutations With or Without Overt Hypercalcemia

scientific article published on 13 July 2016

Mechanisms of ligand binding to the parathyroid hormone (PTH)/PTH-related protein receptor: selectivity of a modified PTH(1-15) radioligand for GalphaS-coupled receptor conformations

scientific article published on 8 December 2005

Non-canonical signaling of the PTH receptor ⬇️

scientific article published on June 16, 2012

Novel parathyroid hormone (PTH) antagonists that bind to the juxtamembrane portion of the PTH/PTH-related protein receptor

scientific article

Optimization of PTH/PTHrP Hybrid Peptides to Derive a Long-Acting PTH Analog (LA-PTH)

scientific article published on 30 May 2020

Parathyroid hormone and parathyroid hormone-related peptide, and their receptors

scientific article

Pharmacodynamic Actions of a Long-Acting PTH Analog (LA-PTH) in Thyroparathyroidectomized (TPTX) Rats and Normal Monkeys.

scientific article published on 10 February 2016

Precise druggability of the PTH type 1 receptor

scientific article published on 23 December 2021

Progression of Mineral Ion Abnormalities in Patients With Jansen Metaphyseal Chondrodysplasia

scientific article published on 01 July 2018

Prolonged Pharmacokinetic and Pharmacodynamic Actions of a Pegylated Parathyroid Hormone (1-34) Peptide Fragment

scientific article published on 18 July 2016

Prolonged signaling at the parathyroid hormone receptor by peptide ligands targeted to a specific receptor conformation

scholarly article

Residue 19 of the parathyroid hormone (PTH) modulates ligand interaction with the juxtamembrane region of the PTH-1 receptor

scientific article published in November 2002

Retromer terminates the generation of cAMP by internalized PTH receptors ⬇️

scientific article published on March 27, 2011

Role of amino acid side chains in region 17-31 of parathyroid hormone (PTH) in binding to the PTH receptor

scientific article published on 21 August 2006

SIKs control osteocyte responses to parathyroid hormone

scientific article published on 19 October 2016

Salt-inducible kinases dictate parathyroid hormone 1 receptor action in bone development and remodeling

scientific article published on 01 December 2019

Toward Parathyroid Hormone Minimization: Conformational Studies of Cyclic PTH(1−14) Analogues

scientific article published on 01 January 2004

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