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List of works by Gordon R. Bernard

A Data-Driven Method of Discovering Misspellings of Medication Names on Twitter.

scientific article

A case series of drotrecogin alfa (activated) in lung transplant recipients.

scientific article

A collaborative, academic approach to optimizing the national clinical research infrastructure: The first year of the Trial Innovation Network

scientific article published on 01 August 2018

A double-blind placebo-controlled study to evaluate the safety and efficacy of L-2-oxothiazolidine-4-carboxylic acid in the treatment of patients with acute respiratory distress syndrome

scientific article published in March 2008

A placebo-controlled, double-blind, dose-escalation study to assess the safety, tolerability and pharmacokinetics/pharmacodynamics of single and multiple intravenous infusions of AZD9773 in patients with severe sepsis and septic shock.

scientific article

A randomized, controlled trial of furosemide with or without albumin in hypoproteinemic patients with acute lung injury

scientific article

A randomized, double-blind, placebo-controlled trial of TAK-242 for the treatment of severe sepsis

scientific article published in August 2010

A randomized, double-blind, placebo-controlled, Phase 2b study to evaluate the safety and efficacy of recombinant human soluble thrombomodulin, ART-123, in patients with sepsis and suspected disseminated intravascular coagulation.

scientific article

A replicable method for blood glucose control in critically Ill patients

scientific article published in June 2008

ARDS Network (NHLBI) Studies: Successes and Challenges in ARDS Clinical Research ⬇️

scientific article published on July 1, 2011

Accelerating Precision Drug Development and Drug Repurposing by Leveraging Human Genetics

scientific article published on 5 April 2017

Activated Protein C for Severe Sepsis

scientific article published on 01 September 2002

Acute Lung Failure - Our Evolving Understanding of ARDS.

scientific article published on August 2017

Acute kidney injury risk-based screening in pediatric inpatients: a pragmatic randomized trial

scientific article published on 27 August 2019

Acute lung injury and the acute respiratory distress syndrome: a clinical review

scientific article published on May 2007

Acute lung injury and the acute respiratory distress syndrome: challenges in clinical trial design

scientific article published on December 2006

Acute lung injury in patients with traumatic injuries: utility of a panel of biomarkers for diagnosis and pathogenesis

scientific article

Acute respiratory distress syndrome: a historical perspective

scientific article published on 14 July 2005

Advances in sepsis treatment

scientific article published on 01 October 2004

Advancing donor management research: design and implementation of a large, randomized, placebo-controlled trial

scientific article published on 14 June 2011

Advocating for mutually beneficial access to shelved compounds

scientific article published on 23 May 2018

Albumin and furosemide therapy in hypoproteinemic patients with acute lung injury

scientific article published in October 2002

Albumin influences total plasma antioxidant capacity favorably in patients with acute lung injury.

scientific article

An Electronic Tool for the Evaluation and Treatment of Sepsis in the ICU: A Randomized Controlled Trial

scientific article

An informatics-based tool to assist researchers in initiating research at an academic medical center: Vanderbilt Customized Action Plan

scientific article published on January 2010

Are Central Institutional Review Boards the Solution? The National Heart, Lung, and Blood Institute Working Group’s Report on Optimizing the IRB Process ⬇️

scientific article published on December 1, 2012

Association between haptoglobin, hemopexin and mortality in adults with sepsis

scientific article

Associations of markers of inflammation and coagulation with delirium during critical illness

scientific article published on 18 August 2012

Atrial Fibrillation Is an Independent Predictor of Mortality in Critically Ill Patients

scientific article

Attitudes and perceptions of patients towards methods of establishing a DNA biobank

scientific article published on 25 October 2007

Atypical Sleep in Ventilated Patients: Empirical Electroencephalography Findings and the Path Toward Revised ICU Sleep Scoring Criteria

scientific article published on 12 June 2013

Atypical sleep in ventilated patients: empirical electroencephalography findings and the path toward revised ICU sleep scoring criteria

scientific article published on August 2013

Balanced Crystalloids versus Saline in Critically Ill Adults.

scientific article published on 27 February 2018

Balanced Crystalloids versus Saline in Noncritically Ill Adults.

scientific article published on 27 February 2018

Balanced Crystalloids versus Saline in Sepsis. A Secondary Analysis of the SMART Clinical Trial

scientific article published on 01 December 2019

Balanced Crystalloids versus Saline in the Intensive Care Unit. The SALT Randomized Trial

scientific article published on 17 October 2016

Balanced crystalloids versus saline in the intensive care unit: study protocol for a cluster-randomized, multiple-crossover trial

scientific article published on 16 March 2017

Beyond mortality: future clinical research in acute lung injury

scientific article

Biomarkers of lung epithelial injury and inflammation distinguish severe sepsis patients with acute respiratory distress syndrome

scientific article

COMPASS: A Pilot Trial of an Early Palliative Care Intervention for Patients With End-Stage Liver Disease

scientific article published on 02 July 2019

Challenges in translating plasma proteomics from bench to bedside: update from the NHLBI Clinical Proteomics Programs.

scientific article published on 2 May 2008

Chlorhexidine bathing and health care-associated infections: a randomized clinical trial

scientific article

Cigarette Smoke Exposure and the Acute Respiratory Distress Syndrome

scientific article published on 22 May 2015

Clinical Characteristics and Outcomes Are Similar in ARDS Diagnosed by Oxygen Saturation/Fio2 Ratio Compared With Pao2/Fio2 Ratio

scientific article

Clinical and translational research studios: a multidisciplinary internal support program

scientific article

Clinical issues and research in respiratory failure from severe acute respiratory syndrome

scientific article published on 10 December 2004

Clinical phenotypes of delirium during critical illness and severity of subsequent long-term cognitive impairment: a prospective cohort study.

scientific article published in March 2018

Closing the Evidence Gap in Interstitial Lung Disease. The Promise of Real-World Data

scientific article published on 01 May 2019

CommLog: a communication log system for clinical trials

scientific article published on 01 December 2003

Community Engagement Studios: A Structured Approach to Obtaining Meaningful Input From Stakeholders to Inform Research

scientific article

Comparison of the SpO2/FIO2 ratio and the PaO2/FIO2 ratio in patients with acute lung injury or ARDS.

scientific article published on 15 June 2007

Comparison of two fluid-management strategies in acute lung injury

scientific article

Connecting the public with clinical trial options: The ResearchMatch Trials Today tool

scientific article published on 01 August 2018

Consciousness monitoring in ventilated patients: bispectral EEG monitors arousal not delirium

scientific article published on 4 May 2004

Controversies in sepsis clinical trials: proceedings of a meeting of the International Sepsis Forum, Lausanne, Switzerland, September 29, 2001

article

Corticosteroids: the "terminator" of all untreatable serious pulmonary illness

scientific article published in December 2003

Cost-effectiveness of drotrecogin alfa (activated) in the treatment of severe sepsis

scientific article

Costs associated with delirium in mechanically ventilated patients

scientific article published on April 2004

Current opinions regarding the importance, diagnosis, and management of delirium in the intensive care unit: a survey of 912 healthcare professionals

scientific article published on January 2004

Delirium and sedation in the intensive care unit: survey of behaviors and attitudes of 1384 healthcare professionals.

scientific article

Delirium as a predictor of long-term cognitive impairment in survivors of critical illness.

scientific article published on July 2010

Delirium as a predictor of mortality in mechanically ventilated patients in the intensive care unit

scientific article

Delirium in mechanically ventilated patients: validity and reliability of the confusion assessment method for the intensive care unit (CAM-ICU).

scientific article

Delirium in the ICU and subsequent long-term disability among survivors of mechanical ventilation

scientific article published on February 2014

Depression, post-traumatic stress disorder, and functional disability in survivors of critical illness in the BRAIN-ICU study: a longitudinal cohort study.

scientific article

Derivation and validation of Spo2/Fio2 ratio to impute for Pao2/Fio2 ratio in the respiratory component of the Sequential Organ Failure Assessment score

scientific article published on April 2009

Diabetes does not alter mortality or hemostatic and inflammatory responses in patients with severe sepsis

scientific article published in February 2010

Distinct molecular phenotypes of direct vs indirect ARDS in single-center and multicenter studies

scientific article published on June 2015

Drotrecogin alfa (activated) (recombinant human activated protein C) for the treatment of severe sepsis

scientific article

Drotrecogin alfa (activated) administration across clinically important subgroups of patients with severe sepsis

scientific article published on 01 January 2003

Drotrecogin alfa (activated) for the treatment of severe sepsis and septic shock

scientific article published in October 2004

Drotrecogin alfa (activated) in the treatment of severe sepsis patients with multiple-organ dysfunction: data from the PROWESS trial

scientific article

Drotrecogin alfa (activated) treatment in severe sepsis from the global open-label trial ENHANCE: Further evidence for survival and safety and implications for early treatment*

scientific article published on 01 October 2005

Drotrecogin alfa (activated) treatment of older patients with severe sepsis

scientific article

Early Resuscitation for Adults With Sepsis in a Low-income Country-Reply

scientific article published in February 2018

Early exposure to hyperoxia and mortality in critically ill patients with severe traumatic injuries

scientific article

Effect of active temperature management on mortality in intensive care unit patients

scholarly article

Effect of an Early Resuscitation Protocol on In-hospital Mortality Among Adults With Sepsis and Hypotension: A Randomized Clinical Trial.

scientific article published on October 2017

Effect of sedation with dexmedetomidine vs lorazepam on acute brain dysfunction in mechanically ventilated patients: the MENDS randomized controlled trial

scientific article published on December 2007

Effects of drotrecogin alfa (activated) on organ dysfunction in the PROWESS trial

scientific article published in March 2003

Efficacy and safety of a paired sedation and ventilator weaning protocol for mechanically ventilated patients in intensive care (Awakening and Breathing Controlled trial): a randomised controlled trial

scientific article published on 01 January 2008

Ethics and standard of care in clinical trials

scientific article published in July 2004

Evaluating the efficacy and safety of two doses of the polyclonal anti-tumor necrosis factor-α fragment antibody AZD9773 in adult patients with severe sepsis and/or septic shock: randomized, double-blind, placebo-controlled phase IIb study*.

scientific article published on March 2014

Evaluation of delirium in critically ill patients: validation of the Confusion Assessment Method for the Intensive Care Unit (CAM-ICU).

scientific article published in July 2001

Evaluation of the effectiveness of posters to provide information to patients about a DNA database and their opportunity to opt out.

scientific article published on 2 February 2007

Extended evaluation of recombinant human activated protein C United States Trial (ENHANCE US): a single-arm, phase 3B, multicenter study of drotrecogin alfa (activated) in severe sepsis

scientific article published in June 2004

External validation of a biomarker and clinical prediction model for hospital mortality in acute respiratory distress syndrome

scientific article published on 7 June 2017

Feasibility, efficacy, and safety of antipsychotics for intensive care unit delirium: the MIND randomized, placebo-controlled trial

scientific article published on February 2010

Fever control in critically ill adults. An individual patient data meta-analysis of randomised controlled trials

scientific article published on 11 February 2019

Findings on the portable chest radiograph correlate with fluid balance in critically ill patients

scientific article published on 01 December 2002

Frailty and Subsequent Disability and Mortality among Patients with Critical Illness

scientific article published on 06 December 2016

Giants in Chest Medicine: Arthur P. Wheeler, MD, FCCP

scientific article published on 01 May 2016

Haloperidol and Ziprasidone for Treatment of Delirium in Critical Illness

scientific article published on 22 October 2018

Identifying Clinical Research Priorities in Adult Pulmonary and Critical Care: NHLBI Working Group Report

scientific article published on 09 March 2020

Identifying Consumer Health Terms of Side Effects in Twitter Posts.

scientific article published in January 2018

Identifying personal health experience tweets with deep neural networks

scientific article published on July 2017

Identifying tweets of personal health experience through word embedding and LSTM neural network.

scientific article published on 13 June 2018

Identifying unpredicted drug benefit through query of patient experiential knowledge: a proof of concept web-based system

scientific article

Impact of Initial Central Venous Pressure on Outcomes of Conservative Versus Liberal Fluid Management in Acute Respiratory Distress Syndrome

scientific article published on 6 January 2016

Impact of a Follow-up Telephone Call Program on 30-Day Readmissions (FUTR-30): A Pragmatic Randomized Controlled Real-world Effectiveness Trial

scientific article published on 23 July 2020

In response: Letter on update to the Vitamin C, Thiamine and Steroids in Sepsis (VICTAS) protocol

scientific article published on 22 April 2020

Informed consent in research to improve the number and quality of deceased donor organs

scientific article published on February 2011

Large-scale implementation of sedation and delirium monitoring in the intensive care unit: a report from two medical centers

scientific article

Leveraging Human Genetics to Identify Safety Signals Prior to Drug Marketing Approval and Clinical Use

scientific article published on 28 February 2020

Long-term cognitive and psychological outcomes in the awakening and breathing controlled trial

scientific article

Long-term cognitive impairment after critical illness

scientific article

Longer storage duration of red blood cells is associated with an increased risk of acute lung injury in patients with sepsis

scientific article published on 24 September 2013

Lorazepam is an independent risk factor for transitioning to delirium in intensive care unit patients

scientific article published in January 2006

Low plasma citrulline levels are associated with acute respiratory distress syndrome in patients with severe sepsis

scientific article

Lower tidal volume ventilation and plasma cytokine markers of inflammation in patients with acute lung injury

scientific article published in January 2005

Making Sepsis Molecular - Is There Enough Time for New Tests?

scientific article published on 20 April 2018

Measuring outcome differences associated with STEMI screening and diagnostic performance: a multicentred retrospective cohort study protocol.

scientific article published on 3 May 2018

Mechanical ventilation in ARDS: a state-of-the-art review.

scientific article published on March 2007

Mining Potential Effects of HUMIRA in Twitter Posts Through Relational Similarity

scientific article published on 01 June 2020

Models of interinstitutional partnerships between research intensive universities and minority serving institutions (MSI) across the Clinical Translational Science Award (CTSA) consortium

scientific article

Monitoring sedation status over time in ICU patients: reliability and validity of the Richmond Agitation-Sedation Scale (RASS).

scientific article

Motivation for Launching a Cancer Metastasis Inhibition (CMI) Program

scientific article published on 7 December 2017

Multicenter validation of a computer-based clinical decision support tool for glucose control in adult and pediatric intensive care units

scientific article

Neutrophil elastase inhibition in acute lung injury: results of the STRIVE study

scientific article

New additions to the intensive care armamentarium.

scientific article published on February 2004

Noninvasive ventilation--don't push too hard

scientific article published in June 2004

O-glycoside biomarker of apolipoprotein C3: responsiveness to obesity, bariatric surgery, and therapy with metformin, to chronic or severe liver disease and to mortality in severe sepsis and graft vs host disease

scientific article published in February 2009

One-year mortality and predictors of death among hospital survivors of acute respiratory distress syndrome

scientific article published on 17 January 2014

Outcome measures for clinical research in sepsis: a report of the 2nd Cambridge Colloquium of the International Sepsis Forum

scientific article

PD-1 up-regulation on CD4 T cells promotes pulmonary fibrosis through STAT3-mediated IL-17A and TGF-β1 production

scientific article published on 01 September 2018

PEEP guided by esophageal pressure--any added value?

scientific article published on 11 November 2008

Predicting Major Adverse Kidney Events among Critically Ill Adults Using the Electronic Health Record

scientific article published on 31 August 2017

Prediction of Personal Experience Tweets of Medication Use via Contextual Word Representations

scientific article published on 01 July 2019

Prehospital aspirin use is associated with reduced risk of acute respiratory distress syndrome in critically ill patients: a propensity-adjusted analysis

scientific article

Prehospital statin and aspirin use and the prevalence of severe sepsis and acute lung injury/acute respiratory distress syndrome

scientific article

Preparedness of the CTSA's structural and scientific assets to support the mission of the National Center for Advancing Translational Sciences (NCATS)

scientific article

Principles of human subjects protections applied in an opt-out, de-identified biobank

scientific article

Prognostic and pathogenetic value of combining clinical and biochemical indices in patients with acute lung injury

scientific article

Protein C concentrations in severe sepsis: an early directional change in plasma levels predicts outcome

scientific article published on 15 June 2006

Protocolized Post-Extubation Respiratory Support to prevent reintubation: protocol and statistical analysis plan for a clinical trial

scientific article published on 02 August 2019

Proven processes: The Vanderbilt Institute for clinical and translational research

scientific article published on June 2009

Pulmonary-artery versus central venous catheter to guide treatment of acute lung injury.

scientific article

Randomised controlled pragmatic clinical trial evaluating the effectiveness of a discharge follow-up phone call on 30-day hospital readmissions: balancing pragmatic and explanatory design considerations

scientific article published on 14 February 2018

Randomized trial of automated, electronic monitoring to facilitate early detection of sepsis in the intensive care unit*.

scientific article published on July 2012

Randomized trial of initial trophic versus full-energy enteral nutrition in mechanically ventilated patients with acute respiratory failure

scientific article

Randomized, placebo-controlled trial of acetaminophen for the reduction of oxidative injury in severe sepsis: the Acetaminophen for the Reduction of Oxidative Injury in Severe Sepsis trial

scientific article

Recombinant Activated Factor VII Safety in Trauma Patients: Results From the CONTROL Trial

scientific article published on 01 July 2011

Recommendations for informed consent forms for critical care clinical trials

scientific article

Recommendations to Facilitate Expanded Access to Investigational Therapies for Seriously Ill Patients

scientific article published on 5 October 2015

Recovery Rate and Prognosis in Older Persons Who Develop Acute Lung Injury and the Acute Respiratory Distress Syndrome ⬇️

scientific article published on 01 January 2002

Reducing mortality in sepsis: new directions

scientific article (publication date: December 2002)

Reengineering the national clinical and translational research enterprise: the strategic plan of the National Clinical and Translational Science Awards Consortium

scientific article

Relationship between Race and the Effect of Fluids on Long-term Mortality after Acute Respiratory Distress Syndrome. Secondary Analysis of the National Heart, Lung, and Blood Institute Fluid and Catheter Treatment Trial

scientific article published on 14 July 2017

Reply to Vincent and De Backer: We Do Not Appreciate SALT

scientific article published on 01 May 2018

Reply to Ward and Colleagues' Comment on "Using Human Experiments of Nature to Predict Drug Safety Issues: An Example with PCSK9 Inhibitors"

scientific article published on 01 November 2018

Results of the CONTROL trial: efficacy and safety of recombinant activated Factor VII in the management of refractory traumatic hemorrhage

scientific article

Risk factors for post-traumatic stress disorder symptoms following critical illness requiring mechanical ventilation: a prospective cohort study

scientific article

Rosuvastatin for sepsis-associated acute respiratory distress syndrome

scientific article

Safety and efficacy of affinity-purified, anti–tumor necrosis factor-α, ovine fab for injection (CytoFab) in severe sepsis*

scientific article published on 01 September 2006

Safety assessment of drotrecogin alfa (activated) in the treatment of adult patients with severe sepsis

scientific article

Saline versus balanced crystalloids for intravenous fluid therapy in the emergency department: study protocol for a cluster-randomized, multiple-crossover trial.

scientific article

Scientific and logistical challenges in designing the CONTROL trial: recombinant factor VIIa in severe trauma patients with refractory bleeding

scientific article published on 8 September 2009

Severe sepsis

scientific article published on 01 December 2002

Simplified severe sepsis protocol: a randomized controlled trial of modified early goal-directed therapy in Zambia

scientific article

Sources of variability on the estimate of treatment effect in the PROWESS trial: implications for the design and conduct of future studies in severe sepsis.

scientific article published on December 2004

StarBRITE: the Vanderbilt University Biomedical Research Integration, Translation and Education portal

scientific article

Statins and delirium during critical illness: a multicenter, prospective cohort study

scientific article

Statins for acutely hospitalized patients: randomized controlled trials are long overdue

scientific article

Statistical evaluation of ventilator-free days as an efficacy measure in clinical trials of treatments for acute respiratory distress syndrome

scientific article published in August 2002

Steroid treatment for persistent ARDS: a word of caution

scientific article published in January 2007

Subsyndromal Delirium and Institutionalization Among Patients With Critical Illness

scientific article published in November 2017

Surviving Sepsis Campaign: International Guidelines for Management of Sepsis and Septic Shock: 2016.

scientific article published on 18 January 2017

Surviving Sepsis Campaign: International Guidelines for Management of Sepsis and Septic Shock: 2016.

scientific article published on 17 January 2017

Systemic host responses in severe sepsis analyzed by causative microorganism and treatment effects of drotrecogin alfa (activated).

scientific article

Tackling the "so what" problem in scientific research: a systems-based approach to resource and publication tracking

scientific article published in August 2015

The Connors et al PAC Study, with expert commentary by Dr Gordon Bernard.

scientific article published in June 2005

The Effect of Pulmonary Artery Catheter Use on Costs and Long-Term Outcomes of Acute Lung Injury ⬇️

scientific article published on July 21, 2011

The Immune Response: Targets for the Treatment of Severe Sepsis ⬇️

scientific article published on 03 December 2012

The International Sepsis Forum's controversies in sepsis: corticosteroids should not be routinely used to treat septic shock

scientific article

The Third International Consensus Definitions for Sepsis and Septic Shock (Sepsis-3)

scientific article

The Vitamin C, Thiamine and Steroids in Sepsis (VICTAS) Protocol: a prospective, multi-center, double-blind, adaptive sample size, randomized, placebo-controlled, clinical trial

scientific article published on 05 April 2019

The definition of ARDS revisited: 20 years later

scientific article published on 4 March 2016

The effect of drotrecogin alfa (activated) on long-term survival after severe sepsis

scientific article

The impact of delirium in the intensive care unit on hospital length of stay

scientific article published on 8 November 2001

The role of the coagulation cascade in the continuum of sepsis and acute lung injury and acute respiratory distress syndrome

scientific article published on August 2006

Therapeutic Targets in Sepsis: Past, Present, and Future

scientific article published on 18 March 2016

Therapeutic intervention and targets for sepsis

scientific article

To end disease tomorrow, begin with trials today: Digital strategies for increased awareness of a clinical trials finder

scientific article published on 20 August 2019

Top‐down proteomic analysis by MALDI‐TOF profiling: Concentration‐independent biomarkers ⬇️

scientific article published on January 15, 2008

Update to the Vitamin C, Thiamine and Steroids in Sepsis (VICTAS) protocol: statistical analysis plan for a prospective, multicenter, double-blind, adaptive sample size, randomized, placebo-controlled, clinical trial

scientific article published on 04 December 2019

Using Human 'Experiments of Nature' to Predict Drug Safety Issues: An Example with PCSK9 Inhibitors

scientific article published on 28 November 2017

Vascular pedicle width in acute lung injury: correlation with intravascular pressures and ability to discriminate fluid status

scientific article published on 7 March 2011

Vitamin D deficiency and risk of acute lung injury in severe sepsis and severe trauma: a case-control study

scientific article published on 24 February 2014

We're not all cut from the same cloth: TAILORing treatments for children with chronic conditions

scientific article published on 29 April 2019

When Enough Is Enough: Decision Criteria for Moving a Known Drug into Clinical Testing for a New Indication in the Absence of Preclinical Efficacy Data

scientific article published in December 2017

ePrescribing: Reducing Costs through In-Class Therapeutic Interchange

scientific article published on 14 December 2016

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