List of works - Konstantinos Konstantopoulos

A 3-D computational model predicts that cell deformation affects selectin-mediated leukocyte rolling

scientific article

A Direct Podocalyxin-Dynamin-2 Interaction Regulates Cytoskeletal Dynamics to Promote Migration and Metastasis in Pancreatic Cancer Cells

scientific article published on 11 April 2019

A microfluidic assay for the quantification of the metastatic propensity of breast cancer specimens

scientific article published on 06 May 2019

A microfluidic cell-migration assay for the prediction of progression-free survival and recurrence time of patients with glioblastoma

scientific article published on 28 September 2020

A physical sciences network characterization of non-tumorigenic and metastatic cells

scientific article published on January 2013

A pro-carcinogenic colon microbe promotes breast tumorigenesis and metastatic progression and concomitantly activates Notch and βcatenin axes

scientific article published on 06 January 2021

An analytical model for determining two-dimensional receptor-ligand kinetics

scientific article

Bioengineering paradigms for cell migration in confined microenvironments

scientific article

Biomechanics of leukocyte rolling

scientific article

Biomolecular characterization of CD44-fibrin(ogen) binding: distinct molecular requirements mediate binding of standard and variant isoforms of CD44 to immobilized fibrin(ogen) ⬇️

scientific article

Biophysics of selectin-ligand interactions in inflammation and cancer

scientific article

By suppressing the expression of anterior pharynx-defective-1α and -1β and inhibiting the aggregation of β-amyloid protein, magnesium ions inhibit the cognitive decline of amyloid precursor protein/presenilin 1 transgenic mice

scientific article published on 20 August 2015

Cancer cells in transit: the vascular interactions of tumor cells

scientific article (publication date: 2009)

Cell sensing and decision-making in confinement: The role of TRPM7 in a tug of war between hydraulic pressure and cross-sectional area

scientific article published on 24 July 2019

Chapter 15: Live-cell single-molecule force spectroscopy

scientific article

Characteristics of new Staphylococcus aureus-RBC adhesion mechanism independent of fibrinogen and IgG under hydrodynamic shear conditions

scientific article published on 11 May 2005

Class 3 semaphorins induce F-actin reorganization in human dendritic cells: Role in cell migration

scientific article published on 12 July 2016

Confinement Sensing and Signal Optimization via Piezo1/PKA and Myosin II Pathways.

scientific article published on 4 May 2016

Confinement hinders motility by inducing RhoA-mediated nuclear influx, volume expansion, and blebbing

scientific article published on 05 November 2019

Dimensional control of cancer cell migration

scientific article published on January 2013

Distinct kinetic and mechanical properties govern mucin 16- and podocalyxin-mediated tumor cell adhesion to E- and L-selectin in shear flow

scientific article

Distinct kinetic and mechanical properties govern selectin-leukocyte interactions

scientific article

Distinct kinetic and molecular requirements govern CD44 binding to hyaluronan versus fibrin(ogen)

scientific article

Distinct signaling mechanisms regulate migration in unconfined versus confined spaces

scientific article

Divergent roles of CD44 and carcinoembryonic antigen in colon cancer metastasis

scientific article

Dorsoventral polarity directs cell responses to migration track geometries

scientific article published on 31 July 2020

E-selectin-mediated rolling facilitates pancreatic cancer cell adhesion to hyaluronic acid

scientific article published in August 2017

Engineered Models of Confined Cell Migration

scientific article published on July 2016

Fluid shear- and time-dependent modulation of molecular interactions between PMNs and colon carcinomas

scientific article

Functional interplay between the cell cycle and cell phenotypes

scientific article published on March 2013

Giant obscurins regulate the PI3K cascade in breast epithelial cells via direct binding to the PI3K/p85 regulatory subunit

scientific article published on 13 June 2016

HER2 missense mutations have distinct effects on oncogenic signaling and migration.

scientific article in 2015

Identification, characterization and utilization of tumor cell selectin ligands in the design of colon cancer diagnostics

scientific article

Interleukin-1β and cyclic AMP mediate the invasion of sheared chondrosarcoma cells via a matrix metalloproteinase-1-dependent mechanism

scientific article published on 25 January 2014

Interplay of the physical microenvironment, contact guidance, and intracellular signaling in cell decision making.

scientific article published on 22 February 2016

Intrinsic epigenetic control of angiogenesis in induced pluripotent stem cell-derived endothelium regulates vascular regeneration

scientific article published on 12 May 2022

Local 3D matrix confinement determines division axis through cell shape

scientific article published on 15 October 2015

Loss of giant obscurins alters breast epithelial cell mechanosensing of matrix stiffness

scientific article published on August 2016

Mathematical modeling of cell adhesion in shear flow: application to targeted drug delivery in inflammation and cancer metastasis

scientific article published on January 2007

Mesothelin binding to CA125/MUC16 promotes pancreatic cancer cell motility and invasion via MMP-7 activation

scientific article published on January 2013

Metabolic flux increases glycoprotein sialylation: implications for cell adhesion and cancer metastasis

scientific article

Mucin 16 is a functional selectin ligand on pancreatic cancer cells

scientific article published on 9 December 2011

Multifunctional surfaces with discrete functionalized regions for biological applications

scientific article published on 27 June 2008

PDGF suppresses the sulfation of CD44v and potentiates CD44v-mediated binding of colon carcinoma cells to fibrin under flow

scientific article

Piezo2 channel regulates RhoA and actin cytoskeleton to promote cell mechanobiological responses.

scientific article published on 5 February 2018

Platelet-induced enhancement of LS174T colon carcinoma and THP-1 monocytoid cell adhesion to vascular endothelium under flow

scientific article published on 14 April 2004

Preferential binding of platelets to monocytes over neutrophils under flow

scientific article

Probing cell traction forces in confined microenvironments

scientific article

Receptor-ligand binding: 'catch' bonds finally caught

scientific article

Roles of cell and microvillus deformation and receptor-ligand binding kinetics in cell rolling

scientific article published on 25 July 2008

Shear modulation of intercellular contact area between two deformable cells colliding under flow

scientific article

Single molecule characterization of P-selectin/ligand binding

scientific article published on 08 January 2003

Single-molecule analysis of cadherin-mediated cell-cell adhesion

scientific article published in January 2006

Single-molecule binding of CD44 to fibrin versus P-selectin predicts their distinct shear-dependent interactions in cancer

scientific article published on 10 May 2011

The dual role of CD44 as a functional P-selectin ligand and fibrin receptor in colon carcinoma cell adhesion

scientific article

The physics of cancer: the role of physical interactions and mechanical forces in metastasis

scientific article published on 24 June 2011

The role of cyclooxygenase-2, interleukin-1β and fibroblast growth factor-2 in the activation of matrix metalloproteinase-1 in sheared-chondrocytes and articular cartilage

scientific article

Time-lapse lens-free imaging of cell migration in diverse physical microenvironments

scientific article

TrkA overexpression in non-tumorigenic human breast cell lines confers oncogenic and metastatic properties

scientific article in 2019

Water permeation drives tumor cell migration in confined microenvironments

scientific article

alpha4 beta1-Integrin regulates directionally persistent cell migration in response to shear flow stimulation

scientific article

List of works by Konstantinos Konstantopoulos

A 3-D computational model predicts that cell deformation affects selectin-mediated leukocyte rolling

A Direct Podocalyxin-Dynamin-2 Interaction Regulates Cytoskeletal Dynamics to Promote Migration and Metastasis in Pancreatic Cancer Cells

A microfluidic assay for the quantification of the metastatic propensity of breast cancer specimens

A microfluidic cell-migration assay for the prediction of progression-free survival and recurrence time of patients with glioblastoma

A physical sciences network characterization of non-tumorigenic and metastatic cells

A pro-carcinogenic colon microbe promotes breast tumorigenesis and metastatic progression and concomitantly activates Notch and βcatenin axes

An analytical model for determining two-dimensional receptor-ligand kinetics

Bioengineering paradigms for cell migration in confined microenvironments

Biomechanics of leukocyte rolling

Biomolecular characterization of CD44-fibrin(ogen) binding: distinct molecular requirements mediate binding of standard and variant isoforms of CD44 to immobilized fibrin(ogen) ⬇️

Biophysics of selectin-ligand interactions in inflammation and cancer

By suppressing the expression of anterior pharynx-defective-1α and -1β and inhibiting the aggregation of β-amyloid protein, magnesium ions inhibit the cognitive decline of amyloid precursor protein/presenilin 1 transgenic mice

Cancer cells in transit: the vascular interactions of tumor cells

Cell sensing and decision-making in confinement: The role of TRPM7 in a tug of war between hydraulic pressure and cross-sectional area

Chapter 15: Live-cell single-molecule force spectroscopy

Characteristics of new Staphylococcus aureus-RBC adhesion mechanism independent of fibrinogen and IgG under hydrodynamic shear conditions

Class 3 semaphorins induce F-actin reorganization in human dendritic cells: Role in cell migration

Confinement Sensing and Signal Optimization via Piezo1/PKA and Myosin II Pathways.

Confinement hinders motility by inducing RhoA-mediated nuclear influx, volume expansion, and blebbing

Dimensional control of cancer cell migration

Distinct kinetic and mechanical properties govern mucin 16- and podocalyxin-mediated tumor cell adhesion to E- and L-selectin in shear flow

Distinct kinetic and mechanical properties govern selectin-leukocyte interactions

Distinct kinetic and molecular requirements govern CD44 binding to hyaluronan versus fibrin(ogen)

Distinct signaling mechanisms regulate migration in unconfined versus confined spaces

Divergent roles of CD44 and carcinoembryonic antigen in colon cancer metastasis

Dorsoventral polarity directs cell responses to migration track geometries

E-selectin-mediated rolling facilitates pancreatic cancer cell adhesion to hyaluronic acid

Engineered Models of Confined Cell Migration

Fluid shear- and time-dependent modulation of molecular interactions between PMNs and colon carcinomas

Functional interplay between the cell cycle and cell phenotypes

Giant obscurins regulate the PI3K cascade in breast epithelial cells via direct binding to the PI3K/p85 regulatory subunit

HER2 missense mutations have distinct effects on oncogenic signaling and migration.

Identification, characterization and utilization of tumor cell selectin ligands in the design of colon cancer diagnostics

Interleukin-1β and cyclic AMP mediate the invasion of sheared chondrosarcoma cells via a matrix metalloproteinase-1-dependent mechanism

Interplay of the physical microenvironment, contact guidance, and intracellular signaling in cell decision making.

Intrinsic epigenetic control of angiogenesis in induced pluripotent stem cell-derived endothelium regulates vascular regeneration

Local 3D matrix confinement determines division axis through cell shape

Loss of giant obscurins alters breast epithelial cell mechanosensing of matrix stiffness

Mathematical modeling of cell adhesion in shear flow: application to targeted drug delivery in inflammation and cancer metastasis

Mesothelin binding to CA125/MUC16 promotes pancreatic cancer cell motility and invasion via MMP-7 activation

Metabolic flux increases glycoprotein sialylation: implications for cell adhesion and cancer metastasis

Mucin 16 is a functional selectin ligand on pancreatic cancer cells

Multifunctional surfaces with discrete functionalized regions for biological applications

PDGF suppresses the sulfation of CD44v and potentiates CD44v-mediated binding of colon carcinoma cells to fibrin under flow

Piezo2 channel regulates RhoA and actin cytoskeleton to promote cell mechanobiological responses.

Platelet-induced enhancement of LS174T colon carcinoma and THP-1 monocytoid cell adhesion to vascular endothelium under flow

Preferential binding of platelets to monocytes over neutrophils under flow

Probing cell traction forces in confined microenvironments

Receptor-ligand binding: 'catch' bonds finally caught

Roles of cell and microvillus deformation and receptor-ligand binding kinetics in cell rolling

Shear modulation of intercellular contact area between two deformable cells colliding under flow

Single molecule characterization of P-selectin/ligand binding

Single-molecule analysis of cadherin-mediated cell-cell adhesion

Single-molecule binding of CD44 to fibrin versus P-selectin predicts their distinct shear-dependent interactions in cancer

The dual role of CD44 as a functional P-selectin ligand and fibrin receptor in colon carcinoma cell adhesion

The physics of cancer: the role of physical interactions and mechanical forces in metastasis

The role of cyclooxygenase-2, interleukin-1β and fibroblast growth factor-2 in the activation of matrix metalloproteinase-1 in sheared-chondrocytes and articular cartilage

Time-lapse lens-free imaging of cell migration in diverse physical microenvironments

TrkA overexpression in non-tumorigenic human breast cell lines confers oncogenic and metastatic properties

Water permeation drives tumor cell migration in confined microenvironments

alpha4 beta1-Integrin regulates directionally persistent cell migration in response to shear flow stimulation