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List of works by Daniel C Douek

A Phase I study evaluating the safety and immunogenicity of MVA85A, a candidate TB vaccine, in HIV-infected adults

scientific article (publication date: 2011)

A high-throughput single-cell analysis of human CD8⁺ T cell functions reveals discordance for cytokine secretion and cytolysis

scientific article

A human memory T cell subset with stem cell-like properties

scientific article

A molecular basis for the control of preimmune escape variants by HIV-specific CD8+ T cells

scientific article

A novel approach to the analysis of specificity, clonality, and frequency of HIV-specific T cell responses reveals a potential mechanism for control of viral escape.

scientific article published in March 2002

Acquisition of direct antiviral effector functions by CMV-specific CD4+ T lymphocytes with cellular maturation

scientific article

Activation Dynamics and Immunoglobulin Evolution of Pre-existing and Newly Generated Human Memory B cell Responses to Influenza Hemagglutinin

scientific article published on 23 July 2019

Altered differentiation is central to HIV-specific CD4+ T cell dysfunction in progressive disease

scientific article published on 15 July 2019

An autoinflammatory disease with deficiency of the interleukin-1-receptor antagonist

scientific article

Analysis of immunoglobulin transcripts and hypermutation following SHIV(AD8) infection and protein-plus-adjuvant immunization

scientific article

Antibody reactivity to SARS-CoV-2 in adults from the Vancouver metropolitan area, Canada

scientific article published on 09 October 2020

Antigen sensitivity is a major determinant of CD8+ T-cell polyfunctionality and HIV-suppressive activity

scientific article published on 23 April 2009

Autocrine production of beta-chemokines protects CMV-Specific CD4 T cells from HIV infection

scientific article

Availability of a diversely avid CD8+ T cell repertoire specific for the subdominant HLA-A2-restricted HIV-1 Gag p2419-27 epitope

scientific article published on June 2007

Avidity for antigen shapes clonal dominance in CD8+ T cell populations specific for persistent DNA viruses

scientific article

CD127 and CD25 expression defines CD4+ T cell subsets that are differentially depleted during HIV infection

scientific article published on April 2008

CD4+ T cell depletion during all stages of HIV disease occurs predominantly in the gastrointestinal tract

scientific article

CMV-specific T cells generated from naïve T cells recognize atypical epitopes and may be protective in vivo

scientific article published on April 2015

Cellular immunity elicited by human immunodeficiency virus type 1/ simian immunodeficiency virus DNA vaccination does not augment the sterile protection afforded by passive infusion of neutralizing antibodies

scientific article published on October 2003

Challenges in detecting HIV persistence during potentially curative interventions: a study of the Berlin patient

scientific article

Characterization of functional and phenotypic changes in anti-Gag vaccine-induced T cell responses and their role in protection after HIV-1 infection

scientific article

Characterization of subsets of CD4+ memory T cells reveals early branched pathways of T cell differentiation in humans

scientific article

Characterization of the Neutralizing Antibody Response in a Case of Genetically Linked HIV Superinfection

article

Cold urticaria, immunodeficiency, and autoimmunity related to PLCG2 deletions

scientific article published on 11 January 2012

Comparative transcriptomics of extreme phenotypes of human HIV-1 infection and SIV infection in sooty mangabey and rhesus macaque

scientific article

Convergent Evolution in Breadth of Two VH6-1-Encoded Influenza Antibody Clonotypes from a Single Donor

scientific article published on 29 June 2020

Damaged intestinal epithelial integrity linked to microbial translocation in pathogenic simian immunodeficiency virus infections

scientific article

Defining the risk of SARS-CoV-2 variants on immune protection

scientific article published on 31 March 2022

Degeneracy and repertoire of the human HIV-1 Gag p17(77-85) CTL response

scientific article published in June 2006

Delay of T cell senescence by caloric restriction in aged long-lived nonhuman primates

scientific article

Design of Nanoparticulate Group 2 Influenza Virus Hemagglutinin Stem Antigens That Activate Unmutated Ancestor B Cell Receptors of Broadly Neutralizing Antibody Lineages

scientific article published on 26 February 2019

Determinants of protection among HIV‐exposed seronegative persons: an overview

scientific article

Different Vaccine Vectors Delivering the Same Antigen Elicit CD8+ T Cell Responses with Distinct Clonotype and Epitope Specificity

scientific article

Differential Th17 CD4 T-cell depletion in pathogenic and nonpathogenic lentiviral infections

scientific article published on 29 July 2008

Differential association of programmed death-1 and CD57 with ex vivo survival of CD8+ T cells in HIV infection

scientific article

Differential selection pressure exerted on HIV by CTL targeting identical epitopes but restricted by distinct HLA alleles from the same HLA supertype

scientific article published in October 2006

Downregulation of robust acute type I interferon responses distinguishes nonpathogenic simian immunodeficiency virus (SIV) infection of natural hosts from pathogenic SIV infection of rhesus macaques

scientific article

Emerging concepts in the immunopathogenesis of AIDS

scientific article

Epitope specificity delimits the functional capabilities of vaccine-induced CD8 T cell populations

scientific article

Escape from highly effective public CD8+ T-cell clonotypes by HIV

scientific article published on 6 July 2011

Evaluation of the pathogenesis of decreasing CD4(+) T cell counts in human immunodeficiency virus type 1-infected patients receiving successfully suppressive antiretroviral therapy

scientific article published on June 2009

Evolution of the donor T-cell repertoire in recipients in the second decade after allogeneic stem cell transplantation.

scientific article

Expression of CD57 defines replicative senescence and antigen-induced apoptotic death of CD8+ T cells

scientific article (publication date: April 2003)

Functional Profiling of Antibody Immune Repertoires in Convalescent Zika Virus Disease Patients

scientific article

Functional interrogation and mining of natively paired human VH:VL antibody repertoires

scientific article published on 8 January 2018

GM-CSF Production Allows the Identification of Immunoprevalent Antigens Recognized by Human CD4+ T Cells Following Smallpox Vaccination ⬇️

scientific article published on September 9, 2011

Generation of robust CD8+ T-cell responses against subdominant epitopes in conserved regions of HIV-1 by repertoire mining with mimotopes

scientific article

Glatiramer acetate (Copaxone) therapy induces CD8(+) T cell responses in patients with multiple sclerosis

scientific article

Gut barrier structure, mucosal immunity and intestinal microbiota in the pathogenesis and treatment of HIV infection

scientific article

HIV disease progression: immune activation, microbes, and a leaky gut.

scientific article

HIV preferentially infects HIV-specific CD4+ T cells

scientific article

HIV reservoir size and persistence are driven by T cell survival and homeostatic proliferation

scientific article (publication date: August 2009)

Hierarchical IL-5 expression defines a subpopulation of highly differentiated human Th2 cells.

scientific article

High production rates sustain in vivo levels of PD-1high simian immunodeficiency virus-specific CD8 T cells in the face of rapid clearance

scientific article published on 03 July 2013

High-functional-avidity cytotoxic T lymphocyte responses to HLA-B-restricted Gag-derived epitopes associated with relative HIV control

scientific article published on 13 July 2011

Human immunodeficiency virus type 1 neutralization measured by flow cytometric quantitation of single-round infection of primary human T cells

scientific article

Identification of a CD4-Binding-Site Antibody to HIV that Evolved Near-Pan Neutralization Breadth.

scientific article published on November 2016

Immune activation and HIV persistence: implications for curative approaches to HIV infection

scientific article

Immune correlates of protection by mRNA-1273 vaccine against SARS-CoV-2 in nonhuman primates

scientific article

Immunologic pressure within class I-restricted cognate human immunodeficiency virus epitopes during highly active antiretroviral therapy

scientific article

Increased tissue factor expression on circulating monocytes in chronic HIV infection: relationship to in vivo coagulation and immune activation

scientific article

Induction of HIV Neutralizing Antibody Lineages in Mice with Diverse Precursor Repertoires

scientific article published on September 2016

Initiation of ART during early acute HIV infection preserves mucosal Th17 function and reverses HIV-related immune activation

scientific article

Intracellular Casp8p41 content is inversely associated with CD4 T cell count

scientific article

Isolation and Structure of an Antibody that Fully Neutralizes Isolate SIVmac239 Reveals Functional Similarity of SIV and HIV Glycan Shields

scientific article published on 02 October 2019

Long peptides induce polyfunctional T cells against conserved regions of HIV-1 with superior breadth to single-gene vaccines in macaques.

scientific article

Longitudinal Analysis Reveals Early Development of Three MPER-Directed Neutralizing Antibody Lineages from an HIV-1-Infected Individual

scientific article published on 12 March 2019

Longitudinal Genetic Characterization Reveals That Cell Proliferation Maintains a Persistent HIV Type 1 DNA Pool During Effective HIV Therapy

scientific article

Loss of a tyrosine-dependent trafficking motif in the simian immunodeficiency virus envelope cytoplasmic tail spares mucosal CD4 cells but does not prevent disease progression

scientific article

Lymphatic tissue fibrosis is associated with reduced numbers of naive CD4+ T cells in human immunodeficiency virus type 1 infection.

scientific article

Maintenance of naïve CD8 T cells in nonagenarians by leptin, IGFBP3 and T3.

scientific article

Manipulating the Interferon Signaling Pathway: Implications for HIV Infection

article

Massive infection and loss of memory CD4+ T cells in multiple tissues during acute SIV infection

scientific article (publication date: 28 April 2005)

Maturation Pathway from Germline to Broad HIV-1 Neutralizer of a CD4-Mimic Antibody

scientific article

Microbial translocation and infectious diseases: what is the link?

scientific article

Microbial translocation is a cause of systemic immune activation in chronic HIV infection

scientific article published on 19 November 2006

Nonprogressive and progressive primate immunodeficiency lentivirus infections

scientific article

Novel recombinant Mycobacterium bovis BCG, ovine atadenovirus, and modified vaccinia virus Ankara vaccines combine to induce robust human immunodeficiency virus-specific CD4 and CD8 T-cell responses in rhesus macaques

scientific article

PD-1 is a regulator of virus-specific CD8+ T cell survival in HIV infection

scientific article

Pathogenic features associated with increased virulence upon Simian immunodeficiency virus cross-species transmission from natural hosts

scientific article

Persistent, Albeit Reduced, Chronic Inflammation in Persons Starting Antiretroviral Therapy in Acute HIV Infection

scientific article

Plasma levels of soluble CD14 independently predict mortality in HIV infection

scientific article

Preexisting influenza-specific CD4+ T cells correlate with disease protection against influenza challenge in humans

scientific article

Preferential infection shortens the life span of human immunodeficiency virus-specific CD4+ T cells in vivo

scientific article

Programmed death-1-induced interleukin-10 production by monocytes impairs CD4+ T cell activation during HIV infection

scientific article

Protective antibodies elicited by SARS-CoV-2 spike protein vaccination are boosted in the lung after challenge in nonhuman primates

Quantification of HTLV-1 clonality and TCR diversity

scientific article

Recapitulation of HIV-1 Env-antibody coevolution in macaques leading to neutralization breadth

scientific article published on 19 November 2020

Reconstitution of CD4 T cells in bronchoalveolar lavage fluid after initiation of highly active antiretroviral therapy

scientific article

Reduction of immune activation with chloroquine therapy during chronic HIV infection

scientific article published on 15 September 2010

Replicative fitness of transmitted HIV-1 drives acute immune activation, proviral load in memory CD4+ T cells, and disease progression

scientific article

Second messenger role for Mg2+ revealed by human T-cell immunodeficiency

scientific article

Severe depletion of mucosal CD4+ T cells in AIDS-free simian immunodeficiency virus-infected sooty mangabeys

scientific article published on September 2007

Somatic reversion in dedicator of cytokinesis 8 immunodeficiency modulates disease phenotype

scientific article

Stochastic principles governing alternative splicing of RNA.

scientific article published on 14 September 2017

Superior control of HIV-1 replication by CD8+ T cells is reflected by their avidity, polyfunctionality, and clonal turnover

scientific article published on 24 September 2007

Systemic effects of inflammation on health during chronic HIV infection

scientific article

Systemic vaccination prevents the total destruction of mucosal CD4 T cells during acute SIV challenge

scientific article published in August 2006

T-cell immune responses to Wilms tumor 1 protein in myelodysplasia responsive to immunosuppressive therapy

scientific article

T-cell receptor sequencing demonstrates persistence of virus-specific T cells after antiviral immunotherapy

scientific article published on 20 June 2019

T-cell subsets that harbor human immunodeficiency virus (HIV) in vivo: implications for HIV pathogenesis

scientific article published on February 2004

TCR clonotypes modulate the protective effect of HLA class I molecules in HIV-1 infection

scientific article published on 10 June 2012

The Effect of Chloroquine on Immune Activation and Interferon Signatures Associated with HIV-1.

scientific article published on 02 March 2016

The HIV-1 reservoir in eight patients on long-term suppressive antiretroviral therapy is stable with few genetic changes over time

scientific article published on 25 November 2013

The clonal composition of human CD4+CD25+Foxp3+ cells determined by a comprehensive DNA-based multiplex PCR for TCRB gene rearrangements

scientific article

The mucosal barrier and immune activation in HIV pathogenesis

scientific article

The transfer of adaptive immunity to CMV during hematopoietic stem cell transplantation is dependent on the specificity and phenotype of CMV-specific T cells in the donor

scientific article published on 23 September 2009

Tissue myeloid cells in SIV-infected primates acquire viral DNA through phagocytosis of infected T cells

scientific article

Toward an AIDS vaccine: lessons from natural simian immunodeficiency virus infections of African nonhuman primate hosts

scientific article

Tryptophan catabolism by indoleamine 2,3-dioxygenase 1 alters the balance of TH17 to regulatory T cells in HIV disease

scientific article

Type I IFN signaling blockade by a PASylated antagonist during chronic SIV infection suppresses specific inflammatory pathways but does not alter T cell activation or virus replication

scientific article published on 24 August 2018

Type I interferon responses in rhesus macaques prevent SIV infection and slow disease progression

scientific article published on 9 July 2014

Universal and specific quantitative detection of botulinum neurotoxin genes

scientific article

Unsung Hero Robert C. Gallo

scientific article

Unusual immunophenotype of CD8+ T cells in familial hemophagocytic lymphohistiocytosis

scientific article

VRC34-Antibody Lineage Development Reveals How a Required Rare Mutation Shapes the Maturation of a Broad HIV-Neutralizing Lineage

scientific article published on 03 March 2020

Vaccination with prefusion-stabilized respiratory syncytial virus fusion protein induces genetically and antigenically diverse antibody responses

scientific article

Vaccine Design for CD8 T Lymphocyte Responses ⬇️

scientific article published on September 1, 2011

Vaccine-Induced Antibodies that Neutralize Group 1 and Group 2 Influenza A Viruses

scientific article

Virologic effects of broadly neutralizing antibody VRC01 administration during chronic HIV-1 infection

scientific article published on December 2015

mRNA-1273 protects against SARS-CoV-2 beta infection in nonhuman primates

scholarly article by Kizzmekia Corbett et al published 20 August 2021 in Nature Immunology

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