List of works - Bert L Semler

A 21st century perspective of poliovirus replication

scientific article published on 4 June 2015

A novel Bcr-Abl-mTOR-eIF4A axis regulates IRES-mediated translation of LEF-1

scientific article

A nucleo-cytoplasmic SR protein functions in viral IRES-mediated translation initiation

scientific article

Allosteric effects of ligands and mutations on poliovirus RNA-dependent RNA polymerase

scientific article

Alphacoronavirus transmissible gastroenteritis virus nsp1 protein suppresses protein translation in mammalian cells and in cell-free HeLa cell extracts but not in rabbit reticulocyte lysate

scientific article

Altered interactions between stem-loop IV within the 5' noncoding region of coxsackievirus RNA and poly(rC) binding protein 2: effects on IRES-mediated translation and viral infectivity

scientific article published on 14 May 2009

Alternative polyadenylation signals in the 3' non-coding region of a voltage-gated potassium channel gene are major determinants of mRNA isoform expression

scientific article

An RNA virus hijacks an incognito function of a DNA repair enzyme

scientific article

An authentic 3' noncoding region is necessary for efficient poliovirus replication

scientific article

An internal ribosome entry site mediates translation of lymphoid enhancer factor-1

scientific article

Bridging IRES elements in mRNAs to the eukaryotic translation apparatus

scientific article (publication date: 2009)

Cell-dependent role for the poliovirus 3' noncoding region in positive-strand RNA synthesis

scientific article published on February 2004

Cellular mRNA decay protein AUF1 negatively regulates enterovirus and human rhinovirus infections

scientific article published on 31 July 2013

Cellular protein modification by poliovirus: the two faces of poly(rC)-binding protein ⬇️

scientific article

Construction of a subgenomic CV-B3 replicon expressing emerald green fluorescent protein to assess viral replication of a cardiotropic enterovirus strain in cultured human cells

scientific article published on 19 January 2016

Delayed kinetics of poliovirus RNA synthesis in a human cell line with reduced levels of hnRNP C proteins

scientific article

Differential cleavage of IRES trans-acting factors (ITAFs) in cells infected by human rhinovirus

scientific article

Differential rescue of poliovirus RNA replication functions by genetically modified RNA polymerase precursors

scientific article published on December 2004

Differential restriction patterns of mRNA decay factor AUF1 during picornavirus infections.

scientific article

Distinct poly(rC) binding protein KH domain determinants for poliovirus translation initiation and viral RNA replication

scientific article

Divergent Requirement for a DNA Repair Enzyme during Enterovirus Infections

scientific article

Diverse Strategies Used by Picornaviruses to Escape Host RNA Decay Pathways

scientific article

Engineered picornavirus VPg-RNA substrates: analysis of a tyrosyl-RNA phosphodiesterase activity

scientific article

Exploitation of nuclear functions by human rhinovirus, a cytoplasmic RNA virus

scientific article published on 24 August 2018

Functional Consequences of RNA 5'-Terminal Deletions on Coxsackievirus B3 RNA Replication and Ribonucleoprotein Complex Formation

scientific article published on 24 May 2017

Generation of Recombinant Polioviruses Harboring RNA Affinity Tags in the 5' and 3' Noncoding Regions of Genomic RNAs

scientific article published on 4 February 2016

Genotoxic stress and viral infection induce transient expression of APOBEC3A and pro-inflammatory genes through two distinct pathways

scientific article published on 13 August 2021

Inhibition of poliovirus-induced cleavage of cellular protein PCBP2 reduces the levels of viral RNA replication

scientific article published on 26 December 2013

MDA5 detects the double-stranded RNA replicative form in picornavirus-infected cells.

scientific article

Mammalian Polycistronic mRNAs and Disease

scientific article published on 21 December 2016

Mechanistic Intersections Between Picornavirus Translation and RNA Replication ⬇️

scientific article published on January 1, 2011

Mechanistic consequences of hnRNP C binding to both RNA termini of poliovirus negative-strand RNA intermediates

scientific article

Modification of picornavirus genomic RNA using 'click' chemistry shows that unlinking of the VPg peptide is dispensable for translation and replication of the incoming viral RNA.

scientific article

Multimerization of poly(rC) binding protein 2 is required for translation initiation mediated by a viral IRES

scientific article

Picornavirus modification of a host mRNA decay protein

scientific article

Picornaviruses and nuclear functions: targeting a cellular compartment distinct from the replication site of a positive-strand RNA virus

scientific article

Poliovirus infection induces the co-localization of cellular protein SRp20 with TIA-1, a cytoplasmic stress granule protein

scientific article published on 02 July 2013

Re-localization of Cellular Protein SRp20 during Poliovirus Infection: Bridging a Viral IRES to the Host Cell Translation Apparatus ⬇️

scientific article (publication date: July 2011)

Regulation of picornavirus gene expression

scientific article published on June 2004

SARS coronavirus nsp1 protein induces template-dependent endonucleolytic cleavage of mRNAs: viral mRNAs are resistant to nsp1-induced RNA cleavage

scientific article

Strand-specific RNA synthesis determinants in the RNA-dependent RNA polymerase of poliovirus

scientific article published on May 2004

Stress-inducible alternative translation initiation of human cytomegalovirus latency protein pUL138.

scientific article

Structurally distinct elements mediate internal ribosome entry within the 5'-noncoding region of a voltage-gated potassium channel mRNA

scientific article

The harms of promoting the lab leak hypothesis for SARS-CoV-2 origins without evidence

The linker domain of poly(rC) binding protein 2 is a major determinant in poliovirus cap-independent translation

scientific article published on 25 July 2008

Viral Determinants of miR-122-Independent Hepatitis C Virus Replication.

scientific article published on 25 November 2015

Viral proteinase requirements for the nucleocytoplasmic relocalization of cellular splicing factor SRp20 during picornavirus infections

scientific article published on 19 December 2012

Viral subversion of host functions for picornavirus translation and RNA replication

scientific article published on February 2012

List of works by Bert L Semler

A 21st century perspective of poliovirus replication

A novel Bcr-Abl-mTOR-eIF4A axis regulates IRES-mediated translation of LEF-1

A nucleo-cytoplasmic SR protein functions in viral IRES-mediated translation initiation

Allosteric effects of ligands and mutations on poliovirus RNA-dependent RNA polymerase

Alphacoronavirus transmissible gastroenteritis virus nsp1 protein suppresses protein translation in mammalian cells and in cell-free HeLa cell extracts but not in rabbit reticulocyte lysate

Altered interactions between stem-loop IV within the 5' noncoding region of coxsackievirus RNA and poly(rC) binding protein 2: effects on IRES-mediated translation and viral infectivity

Alternative polyadenylation signals in the 3' non-coding region of a voltage-gated potassium channel gene are major determinants of mRNA isoform expression

An RNA virus hijacks an incognito function of a DNA repair enzyme

An authentic 3' noncoding region is necessary for efficient poliovirus replication

An internal ribosome entry site mediates translation of lymphoid enhancer factor-1

Bridging IRES elements in mRNAs to the eukaryotic translation apparatus

Cell-dependent role for the poliovirus 3' noncoding region in positive-strand RNA synthesis

Cellular mRNA decay protein AUF1 negatively regulates enterovirus and human rhinovirus infections

Cellular protein modification by poliovirus: the two faces of poly(rC)-binding protein ⬇️

Construction of a subgenomic CV-B3 replicon expressing emerald green fluorescent protein to assess viral replication of a cardiotropic enterovirus strain in cultured human cells

Delayed kinetics of poliovirus RNA synthesis in a human cell line with reduced levels of hnRNP C proteins

Differential cleavage of IRES trans-acting factors (ITAFs) in cells infected by human rhinovirus

Differential rescue of poliovirus RNA replication functions by genetically modified RNA polymerase precursors

Differential restriction patterns of mRNA decay factor AUF1 during picornavirus infections.

Distinct poly(rC) binding protein KH domain determinants for poliovirus translation initiation and viral RNA replication

Divergent Requirement for a DNA Repair Enzyme during Enterovirus Infections

Diverse Strategies Used by Picornaviruses to Escape Host RNA Decay Pathways

Engineered picornavirus VPg-RNA substrates: analysis of a tyrosyl-RNA phosphodiesterase activity

Exploitation of nuclear functions by human rhinovirus, a cytoplasmic RNA virus

Functional Consequences of RNA 5'-Terminal Deletions on Coxsackievirus B3 RNA Replication and Ribonucleoprotein Complex Formation

Generation of Recombinant Polioviruses Harboring RNA Affinity Tags in the 5' and 3' Noncoding Regions of Genomic RNAs

Genotoxic stress and viral infection induce transient expression of APOBEC3A and pro-inflammatory genes through two distinct pathways

Inhibition of poliovirus-induced cleavage of cellular protein PCBP2 reduces the levels of viral RNA replication

MDA5 detects the double-stranded RNA replicative form in picornavirus-infected cells.

Mammalian Polycistronic mRNAs and Disease

Mechanistic Intersections Between Picornavirus Translation and RNA Replication ⬇️

Mechanistic consequences of hnRNP C binding to both RNA termini of poliovirus negative-strand RNA intermediates

Modification of picornavirus genomic RNA using 'click' chemistry shows that unlinking of the VPg peptide is dispensable for translation and replication of the incoming viral RNA.

Multimerization of poly(rC) binding protein 2 is required for translation initiation mediated by a viral IRES

Picornavirus modification of a host mRNA decay protein

Picornaviruses and nuclear functions: targeting a cellular compartment distinct from the replication site of a positive-strand RNA virus

Poliovirus infection induces the co-localization of cellular protein SRp20 with TIA-1, a cytoplasmic stress granule protein

Re-localization of Cellular Protein SRp20 during Poliovirus Infection: Bridging a Viral IRES to the Host Cell Translation Apparatus ⬇️

Regulation of picornavirus gene expression

SARS coronavirus nsp1 protein induces template-dependent endonucleolytic cleavage of mRNAs: viral mRNAs are resistant to nsp1-induced RNA cleavage

Strand-specific RNA synthesis determinants in the RNA-dependent RNA polymerase of poliovirus

Stress-inducible alternative translation initiation of human cytomegalovirus latency protein pUL138.

Structurally distinct elements mediate internal ribosome entry within the 5'-noncoding region of a voltage-gated potassium channel mRNA

The harms of promoting the lab leak hypothesis for SARS-CoV-2 origins without evidence

The linker domain of poly(rC) binding protein 2 is a major determinant in poliovirus cap-independent translation

Viral Determinants of miR-122-Independent Hepatitis C Virus Replication.

Viral proteinase requirements for the nucleocytoplasmic relocalization of cellular splicing factor SRp20 during picornavirus infections

Viral subversion of host functions for picornavirus translation and RNA replication