List of works by Bořivoj Vojtěšek

8-Azapurines as new inhibitors of cyclin-dependent kinases

scientific article published on September 2005

A Casein kinase 1/Checkpoint kinase 1 pyrazolo-pyridine protein kinase inhibitor as novel activator of the p53 pathway

scientific article published on 16 August 2013

A Cyclic Pentamethinium Salt Induces Cancer Cell Cytotoxicity through Mitochondrial Disintegration and Metabolic Collapse ⬇️

scientific article published on 28 August 2019

A DHODH inhibitor increases p53 synthesis and enhances tumor cell killing by p53 degradation blockage.

scientific article published on 16 March 2018

A global analysis of the complex landscape of isoforms and regulatory networks of p63 in human cells and tissues.

scientific article published on 7 August 2015

A multiprotein binding interface in an intrinsically disordered region of the tumor suppressor protein interferon regulatory factor-1

scientific article

A novel ataxia-telangiectasia mutated autoregulatory feedback mechanism in murine embryonic stem cells

scientific article

A novel p53 phosphorylation site within the MDM2 ubiquitination signal: I. phosphorylation at SER269 in vivo is linked to inactivation of p53 function

scientific article

AGR2 associates with HER2 expression predicting poor outcome in subset of estrogen receptor negative breast cancer patients.

scientific article published on 23 February 2017

AGR2 oncoprotein inhibits p38 MAPK and p53 activation through a DUSP10-mediated regulatory pathway

scientific article published on 17 December 2015

AGR2 predicts tamoxifen resistance in postmenopausal breast cancer patients

scientific article

AGR2 silencing contributes to metformin-dependent sensitization of colorectal cancer cells to chemotherapy

scientific article published on 04 September 2019

Acetylsalicylic Acid and its Potential for Chemoprevention of Colorectal Carcinoma

scientific article published on 01 January 2018

Activation of the DNA-binding ability of latent p53 protein by protein kinase C is abolished by protein kinase CK2.

scientific article published on March 2004

Allosteric changes in HDM2 by the ATM phosphomimetic S395D mutation: implications on HDM2 function

scientific article published on 01 November 2019

Alterations of the Hsp70/Hsp90 chaperone and the HOP/CHIP co-chaperone system in cancer.

scientific article published on 5 June 2012

An Ultrasensitive Biosensor for Detection of Femtogram Levels of the Cancer Antigen AGR2 Using Monoclonal Antibody Modified Screen-Printed Gold Electrodes

scientific article published on 7 June 2021

Analysis of venom sac constituents from the solitary, aculeate wasp Cerceris rybyensis

scientific article published on 25 July 2019

Anterior gradient 2 and mucin 4 expression mirrors tumor cell differentiation in pancreatic adenocarcinomas, but aberrant anterior gradient 2 expression predicts worse patient outcome in poorly differentiated tumors

scientific article

Anterior gradient 2: a novel player in tumor cell biology

scientific article published on 02 March 2011

Anterior gradient protein 3 is associated with less aggressive tumors and better outcome of breast cancer patients

scientific article published on 24 June 2015

Anticancer pentamethinium salt is a potent photosensitizer inducing mitochondrial disintegration and apoptosis upon red light illumination

scientific article published on 23 June 2020

Autophagic degradation of the inhibitory p53 isoform Δ133p53α as a regulatory mechanism for p53-mediated senescence.

scientific article published on 21 August 2014

Biomarker discovery in low-grade breast cancer using isobaric stable isotope tags and two-dimensional liquid chromatography-tandem mass spectrometry (iTRAQ-2DLC-MS/MS) based quantitative proteomic analysis

scientific article published in January 2009

CHIP-dependent regulation of the actin cytoskeleton is linked to neuronal cell membrane integrity

scientific article published on 17 July 2021

Cancer-associated S100P protein binds and inactivates p53, permits therapy-induced senescence and supports chemoresistance

scientific article published on 9 March 2016

Characterization of specific p63 and p63-N-terminal isoform antibodies and their application for immunohistochemistry

scientific article published on 26 July 2013

Combined Proteomics and Transcriptomics Identifies Carboxypeptidase B1 and Nuclear Factor κB (NF-κB) Associated Proteins as Putative Biomarkers of Metastasis in Low Grade Breast Cancer

scientific article

Corrigendum: The histone H2B-specific ubiquitin ligase RNF20/hBRE1 acts as a putative tumor suppressor through selective regulation of gene expression

scientific article published in September 2017

DeltaNp63 transcriptionally regulates ATM to control p53 Serine-15 phosphorylation

scientific article published on 21 July 2010

Deregulation of cell proliferation by polycyclic aromatic hydrocarbons in human breast carcinoma MCF-7 cells reflects both genotoxic and nongenotoxic events

scientific article

Differential expression of anterior gradient protein 3 in intrahepatic cholangiocarcinoma and hepatocellular carcinoma.

scientific article published on 18 April 2014

Downregulation of natural killer cell-activating ligand CD155 by human cytomegalovirus UL141

scientific article

Electrochemical chip-based genomagnetic assay for detection of high-risk human papillomavirus DNA.

scientific article published on 14 April 2016

Emergent Role of IFITM1/3 towards Splicing Factor (SRSF1) and Antigen-Presenting Molecule (HLA-B) in Cervical Cancer

scientific article published in 2022

Endoplasmic reticulum stress and apoptosis.

scientific article published on 5 September 2006

Erratum to: ΔNp63 regulates cell proliferation, differentiation, adhesion, and migration in the BL2 subtype of basal-like breast cancer.

scientific article

Evaluation of cytotoxic activity of titanocene difluorides and determination of their mechanism of action in ovarian cancer cells

scientific article published on 24 July 2015

Evidence for allosteric effects on p53 oligomerization induced by phosphorylation.

scientific article published on 10 November 2017

Expression and Functional Characterization of miR-34c in Cervical Cancer

scientific article published on 01 January 2018

Genomagnetic LAMP-based electrochemical test for determination of high-risk HPV16 and HPV18 in clinical samples

scientific article published on 11 August 2018

HCMV pUL135 remodels the actin cytoskeleton to impair immune recognition of infected cells

scientific article

HDM2 and HDMX Proteins in Human Cancer

scientific article published on 01 January 2018

Hammock: a hidden Markov model-based peptide clustering algorithm to identify protein-interaction consensus motifs in large datasets.

scientific article published on 5 September 2015

Homocysteine: exploring its potential as a pharmacodynamic biomarker of antifolate chemotherapy

scientific article

Human Stress-inducible Hsp70 Has a High Propensity to Form ATP-dependent Antiparallel Dimers That Are Differentially Regulated by Cochaperone Binding

scientific article published on 20 November 2018

Hydrogen Deuterium Exchange Mass Spectrometry identifies the dominant paratope in CD20 antigen binding to the NCD1.2 monoclonal antibody

scientific article published on 07 December 2020

IFI16 Preferentially Binds to DNA with Quadruplex Structure and Enhances DNA Quadruplex Formation

scientific article

Identification of an AKT-dependent signalling pathway that mediates tamoxifen-dependent induction of the pro-metastatic protein anterior gradient-2.

scientific article published on 24 January 2013

Immunoassays of chemically modified polysaccharides, glycans in glycoproteins and ribose in nucleic acids

scientific article published on 26 December 2016

Impaired pre-mRNA processing and altered architecture of 3' untranslated regions contribute to the development of human disorders

scientific article published on 26 July 2013

Impairment of carbonic anhydrase IX ectodomain cleavage reinforces tumorigenic and metastatic phenotype of cancer cells

scientific article published on 25 March 2020

Importance of Membrane Proteins in the Treatment of Tumor Diseases and the Possibilities of Their Further Study

scientific article published on 01 January 2018

Influence of mutation type on prognostic and predictive values of TP53 status in primary breast cancer patients.

scientific article

Inhibition of post-transcriptional RNA processing by CDK inhibitors and its implication in anti-viral therapy

scientific article

Intact protein profiling in breast cancer biomarker discovery: protein identification issue and the solutions based on 3D protein separation, bottom-up and top-down mass spectrometry

scientific article

Intracellular distribution of the ΔNp73 protein isoform in medulloblastoma cells: a study with newly generated rabbit polyclonal antibodies

scientific article published on 22 January 2013

Intrinsic proteotoxic stress levels vary and act as a predictive marker for sensitivity of cancer cells to Hsp90 inhibition

scientific article published in PLoS ONE

Intronic polymorphisms in TP53 indicate lymph node metastasis in breast cancer.

scientific article

Investigations of the supercoil-selective DNA binding of wild type p53 suggest a novel mechanism for controlling p53 function

scientific article

Keratin 36, a specific marker of tongue filiform papillae, is downregulated in squamous cell carcinoma of the mobile tongue

scientific article published on 26 February 2020

MB-88QUANTITATIVE PROTEOMIC PROFILING IN MEDULLOBLASTOMA RECAPITULATES SUBGROUPING BASED ON TRANSCRIPTIONAL PROFILES.

scientific article published on 30 May 2016

MDM2SNP309 does not associate with elevated MDM2 protein expression or breast cancer risk

scientific article

Magnetic bead-based hybridization assay for electrochemical detection of microRNA

scientific article published on 16 January 2014

Magnetic poly(glycidyl methacrylate) microspheres for protein capture.

scientific article

Mechanisms of anterior gradient-2 regulation and function in cancer

scientific article published on 30 April 2015

Microgradient separation technique for purification and fractionation of permethylated N-glycans before mass spectrometric analyses

scientific article

Mitochondrial Processes in Targeted Cancer Therapy

scientific article published on 01 January 2018

Mutant p53 accumulation in human breast cancer is not an intrinsic property or dependent on structural or functional disruption but is regulated by exogenous stress and receptor status.

scientific article published on 21 May 2014

Mutations in the TP53 gene affected recruitment of 53BP1 protein to DNA lesions, but level of 53BP1 was stable after γ-irradiation that depleted MDC1 protein in specific TP53 mutants

scientific article published on 10 April 2017

N-Glycome changes reflecting resistance to platinum-based chemotherapy in ovarian cancer

scientific article published on 05 September 2020

New ELISA technique for analysis of p53 protein/DNA binding properties.

scientific article

Novel Entropically Driven Conformation-specific Interactions with Tomm34 Protein Modulate Hsp70 Protein Folding and ATPase Activities ⬇️

scientific article published on 4 March 2016

Polycyclic aromatic hydrocarbons modulate cell proliferation in rat hepatic epithelial stem-like WB-F344 cells.

scientific article published in April 2004

Polymorphisms in p53 and the p53 pathway: roles in cancer susceptibility and response to treatment

scientific article published on March 2009

Positive feedback between p53 and TRF2 during telomere-damage signalling and cellular senescence.

scientific article

Possible Usage of p63 in Bioptic Diagnostics

scientific article published on 01 January 2018

Prediction of human papillomavirus 16 e6 gene expression and cervical intraepithelial neoplasia progression by methylation status

scientific article published in April 2009

Preferential binding of hot spot mutant p53 proteins to supercoiled DNA in vitro and in cells.

scientific article

Prima-1 and APR-246 in Cancer Therapy

scientific article published on 01 January 2018

Proteogenomic Platform for Identification of Tumor Specific Antigens

scientific article published on 01 January 2018

Publisher Correction: A DHODH inhibitor increases p53 synthesis and enhances tumor cell killing by p53 degradation blockage.

scientific article published on 22 May 2018

Quantitative Shotgun Proteomics Unveils Candidate Novel Esophageal Adenocarcinoma (EAC)-specific Proteins.

scientific article

Quantitative proteomic profiling of pleomorphic human sarcoma identifies CLIC1 as a dominant pro-oncogenic receptor expressed in diverse sarcoma types

scientific article published on 9 April 2014

Radiation-induced astrocyte senescence is rescued by Δ133p53

scientific article published on 01 March 2019

Recognition of DNA modified by antitumor cisplatin by “latent” and “active” protein p53 ⬇️

scientific article published on April 15, 2003

Regulation of AGR2 expression via 3'UTR shortening

scientific article published on 10 April 2017

Restoring wild-type conformation and DNA-binding activity of mutant p53 is insufficient for restoration of transcriptional activity

scientific article published on 19 October 2006

Role of p53 in regulating constitutive and X-radiation-inducible CD95 expression and function in carcinoma cells ⬇️

scientific article published on November 1, 2003

Role of tumor suppressor p53 domains in selective binding to supercoiled DNA.

scientific article published on November 2002

STAT3, stem cells, cancer stem cells and p63.

scientific article published on 22 March 2018

Simian virus-40 infection inhibits DNA damage-induced enhancement of CD95 expression and function.

scientific article published in January 2002

Small molecular weight variants of p53 are expressed in human melanoma cells and are induced by the DNA-damaging agent cisplatin.

scientific article

Stat3 Tyrosine 705 and Serine 727 Phosphorylation Associate With Clinicopathological Characteristics and Distinct Tumor Cell Phenotypes in Triple-Negative Breast Cancer

scientific article published in 2022

Suppression of AGR2 in a TGF-β-induced Smad regulatory pathway mediates epithelial-mesenchymal transition

scientific article published on 15 August 2017

Suppression of costimulation by human cytomegalovirus promotes evasion of cellular immune defenses.

scientific article published on 24 April 2018

Surface-enhanced laser desorption ionization/time-of-flight mass spectrometry reveals significant artifacts in serum obtained from clot activator-containing collection devices

scientific article published on 01 November 2006

Surface-enhanced laser desorption/ionization time-of-flight proteomic profiling of breast carcinomas identifies clinicopathologically relevant groups of patients similar to previously defined clusters from cDNA expression.

scientific article

Switching p53-dependent growth arrest to apoptosis via the inhibition of DNA damage-activated kinases

scientific article published on 4 June 2010

TAp63 and ΔNp63 (p40) in prostate adenocarcinomas: ΔNp63 associates with a basal-like cancer stem cell population but not with metastasis

scientific article published on 10 October 2020

Tamoxifen-Dependent Induction of AGR2 Is Associated with Increased Aggressiveness of Endometrial Cancer Cells

scientific article published on 12 April 2017

Targeting Oncogenic Pathways in the Era of Personalized Oncology: A Systemic Analysis Reveals Highly Mutated Signaling Pathways in Cancer Patients and Potential Therapeutic Targets

scientific article published in 2022

The MDM2 ligand Nutlin-3 differentially alters expression of the immune blockade receptors PD-L1 and CD276

scientific article published on 31 August 2020

The Novel Anti-cMet Antibody seeMet 12 Potentiates Sorafenib Therapy and Radiotherapy in a Colorectal Cancer Model

scientific article published on 11 September 2020

The Role of HSF1 Protein in Malignant Transformation

scientific article published on 01 January 2018

The Role of HSP70 in Cancer and its Exploitation as a Therapeutic Target

scientific article published on 01 January 2018

The assembly and intermolecular properties of the Hsp70-Tomm34-Hsp90 molecular chaperone complex

scientific article published on 24 February 2014

The cell type-specific effect of TAp73 isoforms on the cell cycle and apoptosis.

scientific article

The diverse oncogenic and tumour suppressor roles of p63 and p73 in cancer: a review by cancer site

scientific article

The effect of cellular environment and p53 status on the mode of action of the platinum derivative LA-12.

scientific article

The effects of IFITM1 and IFITM3 gene deletion on IFNγ stimulated protein synthesis

scientific article published on 02 April 2019

The histone H2B-specific ubiquitin ligase RNF20/hBRE1 acts as a putative tumor suppressor through selective regulation of gene expression

scientific article

The inhibitor of cyclin-dependent kinases, olomoucine II, exhibits potent antiviral properties.

scientific article published on 5 January 2010

The interaction of the mitochondrial protein importer TOMM34 with HSP70 is regulated by TOMM34 phosphorylation and binding to 14-3-3 adaptors

scientific article published on 05 May 2020

The new platinum(IV) derivative LA-12 shows stronger inhibitory effect on Hsp90 function compared to cisplatin.

scientific article published on 15 June 2010

The new platinum-based anticancer agent LA-12 induces retinol binding protein 4 in vivo

scientific article

The role of AGR2 and AGR3 in cancer: similar but not identical.

scientific article published on 21 January 2015

The role of MAPK signal pathways during Francisella tularensis LVS infection-induced apoptosis in murine macrophages.

scientific article

The role of miR-409-3p in regulation of HPV16/18-E6 mRNA in human cervical high-grade squamous intraepithelial lesions

scientific article published on 31 January 2019

The role of p63 in cancer, stem cells and cancer stem cells.

scientific article published on 20 March 2011

The role of the 3' untranslated region in post-transcriptional regulation of protein expression in mammalian cells

scientific article published on May 2012

Tomm34 is commonly expressed in epithelial ovarian cancer and associates with tumour type and high FIGO stage

scientific article published on 27 March 2019

Tooth agenesis: What do we know and is there a connection to cancer?

scientific article published on 29 November 2020

Variability in the Solid Cancer Cell Population and Its Consequences for Cancer Diagnostics and Treatment

scientific article published on 01 January 2018

p53 isoforms Delta133p53 and p53beta are endogenous regulators of replicative cellular senescence

scientific article

p53 isoforms regulate aging- and tumor-associated replicative senescence in T lymphocytes

scientific article

p63 isoforms in triple-negative breast cancer: ΔNp63 associates with the basal phenotype whereas TAp63 associates with androgen receptor, lack of BRCA mutation, PTEN and improved survival

scientific article published on 27 February 2018

ΔNp63 activates EGFR signaling to induce loss of adhesion in triple-negative basal-like breast cancer cells.

scientific article published on 27 March 2017

ΔNp63α expression induces loss of cell adhesion in triple-negative breast cancer cells

scientific article

∆Np63/p40 correlates with the location and phenotype of basal/mesenchymal cancer stem-like cells in human ER+ and HER2+ breast cancers

scientific article published on 06 December 2019

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