List of works - David Palmer

A missense mutation (c.184C>T) in ovine CLN6 causes neuronal ceroid lipofuscinosis in Merino sheep whereas affected South Hampshire sheep have reduced levels of CLN6 mRNA.

scientific article published on 12 September 2006

A new large animal model of CLN5 neuronal ceroid lipofuscinosis in Borderdale sheep is caused by a nucleotide substitution at a consensus splice site (c.571+1G>A) leading to excision of exon 3.

scientific article

A triad of highly divergent polymeric immunoglobulin receptor (PIGR) haplotypes with major effect on IgA concentration in bovine milk

scientific article (publication date: 2013)

Accumulation of sphingolipid activator proteins (SAPs) A and D in granular osmiophilic deposits in miniature Schnauzer dogs with ceroid-lipofuscinosis

scientific article

Activation of non-neuronal cells within the prenatal developing brain of sheep with neuronal ceroid lipofuscinosis

scientific article published in April 2006

An EEG Investigation of Sleep Homeostasis in Healthy and CLN5 Batten Disease Affected Sheep.

scientific article published in August 2016

Batten disease and the ATP synthase subunit c turnover pathway: raising antibodies to subunit c.

scientific article

Biochemical studies on ovine ceroid-lipofuscinosis

1987 doctoral thesis by David Norris Palmer at Massey University

Ceroid lipofuscinosis in sheep. I. Bis(monoacylglycero)phosphate, dolichol, ubiquinone, phospholipids, fatty acids, and fluorescence in liver lipopigment lipids

scientific article published on 01 February 1986

Ceroid lipofuscinosis in sheep. II. The major component of the lipopigment in liver, kidney, pancreas, and brain is low molecular weight protein.

scientific article published in February 1986

Ceroid-lipofuscinosis (Batten's disease): pathogenesis and sequential neuropathological changes in the ovine model

scientific article

Ceroid-lipofuscinosis in miniature Schnauzer dogs

scientific article published in January 1997

Changes in GABAergic neuron distribution in situ and in neuron cultures in ovine (OCL6) Batten disease

scientific article

Chronic oral administration of minocycline to sheep with ovine CLN6 neuronal ceroid lipofuscinosis maintains pharmacological concentrations in the brain but does not suppress neuroinflammation or disease progression

scientific article published on 30 July 2013

Computed tomography provides enhanced techniques for longitudinal monitoring of progressive intracranial volume loss associated with regional neurodegeneration in ovine neuronal ceroid lipofuscinoses

scientific article published on 23 August 2018

Defective endoplasmic reticulum-resident membrane protein CLN6 affects lysosomal degradation of endocytosed arylsulfatase A

scientific article published on 21 May 2004

Different patterns of hydrophobic protein storage in different forms of neuronal ceroid lipofuscinosis (NCL, Batten disease)

scientific article published on 01 February 1997

Disease-specific pathology in neurons cultured from sheep affected with ceroid lipofuscinosis

scientific article

Enhanced expression of manganese-dependent superoxide dismutase in human and sheep CLN6 tissues

scientific article published on December 2003

Glial activation spreads from specific cerebral foci and precedes neurodegeneration in presymptomatic ovine neuronal ceroid lipofuscinosis (CLN6).

scientific article

Immunocytochemical studies in the ceroid-lipofuscinoses (Batten disease) using antibodies to subunit c of mitochondrial ATP synthase

scientific article published on 01 June 1995

In vitro culture of neurons from sheep with Batten disease

scientific article

Inhibition of storage pathology in prenatal CLN5-deficient sheep neural cultures by lentiviral gene therapy.

scientific article published on 19 November 2013

Ion pores made of mitochondrial ATP synthase subunit c in the neuronal plasma membrane and Batten disease

scientific article published in April 1999

Lentiviral-mediated gene transfer to the sheep brain: implications for gene therapy in Batten disease.

scientific article

Location and connectivity determine GABAergic interneuron survival in the brains of South Hampshire sheep with CLN6 neuronal ceroid lipofuscinosis

scientific article published on 25 June 2008

Longitudinal In Vivo Monitoring of the CNS Demonstrates the Efficacy of Gene Therapy in a Sheep Model of CLN5 Batten Disease

article

Lysine 43 is trimethylated in subunit C from bovine mitochondrial ATP synthase and in storage bodies associated with batten disease

scientific article published on 9 March 2004

Mapping quantitative trait loci (QTL) in sheep. I. A new male framework linkage map and QTL for growth rate and body weight

scientific article published on 24 April 2009

Metabolomic investigation of CLN6 neuronal ceroid lipofuscinosis in affected South Hampshire sheep

scientific article

Mitochondrial ATP synthase subunit c storage in the ceroid-lipofuscinoses (Batten disease)

scientific article published on 01 February 1992

Molecular neuropathology of the synapse in sheep with CLN5 Batten disease

scientific article

NCL disease mechanisms

scientific article published on 23 May 2013

Neuronal ceroid lipofuscinosis in Devon cattle is caused by a single base duplication (c.662dupG) in the bovine CLN5 gene

scientific article published on 25 July 2006

Neuronal ceroid lipofuscinosis in Merino sheep

scientific article

Neuronal ceroid-lipofuscinosis in Borderdale sheep

scientific article published in October 2002

Neuropeptide changes and neuroactive amino acids in CSF from humans and sheep with neuronal ceroid lipofuscinoses (NCLs, Batten disease).

scientific article published on 05 August 2009

Ovine ceroid lipofuscinosis. The major lipopigment protein and the lipid-binding subunit of mitochondrial ATP synthase have the same NH2-terminal sequence

scientific article published on 01 April 1989

Ovine ceroid-lipofuscinosis II: Pathologic changes interpreted in light of biochemical observations

scientific article

Ovine ceroid-lipofuscinosis. I: Lipopigment composition is indicative of a lysosomal proteinosis.

scientific article published on January 1988

Practical implications of motion correction with motion insensitive radial k-space acquisitions in MRI.

scientific article published on 14 March 2018

Rapid and Progressive Regional Brain Atrophy in CLN6 Batten Disease Affected Sheep Measured with Longitudinal Magnetic Resonance Imaging

scientific article published on 10 July 2015

Rapid, quantitative analysis of 3'- and 6'-sialyllactose in milk by flow-injection analysis-mass spectrometry: screening of milks for naturally elevated sialyllactose concentration

scientific article published on 17 October 2013

Recent studies of ovine neuronal ceroid lipofuscinoses from BARN, the Batten Animal Research Network

scientific article

Sheep and other animals with ceroid-lipofuscinoses: their relevance to Batten disease.

scientific article published in February 1992

Splicing variants in sheep CLN3, the gene underlying juvenile neuronal ceroid lipofuscinosis

scientific article published in June 1999

The development and characterisation of complex ovine neuron cultures from fresh and frozen foetal neurons

scientific article

The development of brain magnetic resonance approaches in large animal models for preclinical research

scientific article published on 25 June 2019

The neuronal ceroid-lipofuscinoses (Batten disease): comparative aspects

scientific article published on February 1995

The origin of fluorescence in the neuronal ceroid lipofuscinoses (Batten disease) and neuron cultures from affected sheep for studies of neurodegeneration

scientific article published in May 2002

The specific loss of GnRH-positive neurons from the hypothalamus of sheep with CLN6 neuronal ceroid lipofuscinosis occurs without glial activation and has only minor effects on reproduction ⬇️

scientific article published on November 24, 2010

Translational neurophysiology in sheep: measuring sleep and neurological dysfunction in CLN5 Batten disease affected sheep.

scientific article

Variant proteins in ovine ceroid-lipofuscinosis

scientific article published on 01 June 1995

List of works by David Palmer

A missense mutation (c.184C>T) in ovine CLN6 causes neuronal ceroid lipofuscinosis in Merino sheep whereas affected South Hampshire sheep have reduced levels of CLN6 mRNA.

A new large animal model of CLN5 neuronal ceroid lipofuscinosis in Borderdale sheep is caused by a nucleotide substitution at a consensus splice site (c.571+1G>A) leading to excision of exon 3.

A triad of highly divergent polymeric immunoglobulin receptor (PIGR) haplotypes with major effect on IgA concentration in bovine milk

Accumulation of sphingolipid activator proteins (SAPs) A and D in granular osmiophilic deposits in miniature Schnauzer dogs with ceroid-lipofuscinosis

Activation of non-neuronal cells within the prenatal developing brain of sheep with neuronal ceroid lipofuscinosis

An EEG Investigation of Sleep Homeostasis in Healthy and CLN5 Batten Disease Affected Sheep.

Batten disease and the ATP synthase subunit c turnover pathway: raising antibodies to subunit c.

Biochemical studies on ovine ceroid-lipofuscinosis

Ceroid lipofuscinosis in sheep. I. Bis(monoacylglycero)phosphate, dolichol, ubiquinone, phospholipids, fatty acids, and fluorescence in liver lipopigment lipids

Ceroid lipofuscinosis in sheep. II. The major component of the lipopigment in liver, kidney, pancreas, and brain is low molecular weight protein.

Ceroid-lipofuscinosis (Batten's disease): pathogenesis and sequential neuropathological changes in the ovine model

Ceroid-lipofuscinosis in miniature Schnauzer dogs

Changes in GABAergic neuron distribution in situ and in neuron cultures in ovine (OCL6) Batten disease

Chronic oral administration of minocycline to sheep with ovine CLN6 neuronal ceroid lipofuscinosis maintains pharmacological concentrations in the brain but does not suppress neuroinflammation or disease progression

Computed tomography provides enhanced techniques for longitudinal monitoring of progressive intracranial volume loss associated with regional neurodegeneration in ovine neuronal ceroid lipofuscinoses

Defective endoplasmic reticulum-resident membrane protein CLN6 affects lysosomal degradation of endocytosed arylsulfatase A

Different patterns of hydrophobic protein storage in different forms of neuronal ceroid lipofuscinosis (NCL, Batten disease)

Disease-specific pathology in neurons cultured from sheep affected with ceroid lipofuscinosis

Enhanced expression of manganese-dependent superoxide dismutase in human and sheep CLN6 tissues

Glial activation spreads from specific cerebral foci and precedes neurodegeneration in presymptomatic ovine neuronal ceroid lipofuscinosis (CLN6).

Immunocytochemical studies in the ceroid-lipofuscinoses (Batten disease) using antibodies to subunit c of mitochondrial ATP synthase

In vitro culture of neurons from sheep with Batten disease

Inhibition of storage pathology in prenatal CLN5-deficient sheep neural cultures by lentiviral gene therapy.

Ion pores made of mitochondrial ATP synthase subunit c in the neuronal plasma membrane and Batten disease

Lentiviral-mediated gene transfer to the sheep brain: implications for gene therapy in Batten disease.

Location and connectivity determine GABAergic interneuron survival in the brains of South Hampshire sheep with CLN6 neuronal ceroid lipofuscinosis

Longitudinal In Vivo Monitoring of the CNS Demonstrates the Efficacy of Gene Therapy in a Sheep Model of CLN5 Batten Disease

Lysine 43 is trimethylated in subunit C from bovine mitochondrial ATP synthase and in storage bodies associated with batten disease

Mapping quantitative trait loci (QTL) in sheep. I. A new male framework linkage map and QTL for growth rate and body weight

Metabolomic investigation of CLN6 neuronal ceroid lipofuscinosis in affected South Hampshire sheep

Mitochondrial ATP synthase subunit c storage in the ceroid-lipofuscinoses (Batten disease)

Molecular neuropathology of the synapse in sheep with CLN5 Batten disease

NCL disease mechanisms

Neuronal ceroid lipofuscinosis in Devon cattle is caused by a single base duplication (c.662dupG) in the bovine CLN5 gene

Neuronal ceroid lipofuscinosis in Merino sheep

Neuronal ceroid-lipofuscinosis in Borderdale sheep

Neuropeptide changes and neuroactive amino acids in CSF from humans and sheep with neuronal ceroid lipofuscinoses (NCLs, Batten disease).

Ovine ceroid lipofuscinosis. The major lipopigment protein and the lipid-binding subunit of mitochondrial ATP synthase have the same NH2-terminal sequence

Ovine ceroid-lipofuscinosis II: Pathologic changes interpreted in light of biochemical observations

Ovine ceroid-lipofuscinosis. I: Lipopigment composition is indicative of a lysosomal proteinosis.

Practical implications of motion correction with motion insensitive radial k-space acquisitions in MRI.

Rapid and Progressive Regional Brain Atrophy in CLN6 Batten Disease Affected Sheep Measured with Longitudinal Magnetic Resonance Imaging

Rapid, quantitative analysis of 3'- and 6'-sialyllactose in milk by flow-injection analysis-mass spectrometry: screening of milks for naturally elevated sialyllactose concentration

Recent studies of ovine neuronal ceroid lipofuscinoses from BARN, the Batten Animal Research Network

Sheep and other animals with ceroid-lipofuscinoses: their relevance to Batten disease.

Splicing variants in sheep CLN3, the gene underlying juvenile neuronal ceroid lipofuscinosis

The development and characterisation of complex ovine neuron cultures from fresh and frozen foetal neurons

The development of brain magnetic resonance approaches in large animal models for preclinical research

The neuronal ceroid-lipofuscinoses (Batten disease): comparative aspects

The origin of fluorescence in the neuronal ceroid lipofuscinoses (Batten disease) and neuron cultures from affected sheep for studies of neurodegeneration

The specific loss of GnRH-positive neurons from the hypothalamus of sheep with CLN6 neuronal ceroid lipofuscinosis occurs without glial activation and has only minor effects on reproduction ⬇️

Translational neurophysiology in sheep: measuring sleep and neurological dysfunction in CLN5 Batten disease affected sheep.

Variant proteins in ovine ceroid-lipofuscinosis