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List of works by Tony Kettle

2-Thioxanthines Are Mechanism-based Inactivators of Myeloperoxidase That Block Oxidative Stress during Inflammation

scientific article

3-Chlorotyrosine as a marker of protein damage by myeloperoxidase in tracheal aspirates from preterm infants: association with adverse respiratory outcome

scientific article published in March 2003

A kinetic analysis of the catalase activity of myeloperoxidase

scientific article published in August 2001

A multi-substrate assay for finding physiologically effective inhibitors of myeloperoxidase

scientific article

A myeloperoxidase precursor, pro-myeloperoxidase, is present in human plasma and elevated in cardiovascular disease patients.

scientific article published on 28 March 2018

A novel quinone derived from 5-hydroxyindoleacetic acid reacts with protein: Possible participation of oxidation of serotonin and its metabolite in the development of atherosclerosis.

scientific article published on 14 November 2016

A pulse radiolysis investigation of the reactions of myeloperoxidase with superoxide and hydrogen peroxide

scientific article published on 01 August 1988

A sensitive and selective assay for chloramine production by myeloperoxidase

scientific article published on 8 August 2005

Acetaminophen (Paracetamol) Inhibits Myeloperoxidase-Catalyzed Oxidant Production And Biological Damage at Therapeutically-Achievable Doses in Humans

Acetaminophen (paracetamol) inhibits myeloperoxidase-catalyzed oxidant production and biological damage at therapeutically achievable concentrations

scientific article published on 5 December 2009

Antiinflammatory and Antimicrobial Effects of Thiocyanate in a Cystic Fibrosis Mouse Model

scientific article

Assays for the chlorination activity of myeloperoxidase

scientific article published on 01 January 1994

Assays using horseradish peroxidase and phenolic substrates require superoxide dismutase for accurate determination of hydrogen peroxide production by neutrophils

scientific article published on 01 August 1994

Assessment of myeloperoxidase activity by the conversion of hydroethidine to 2-chloroethidium

scientific article published on 16 January 2014

Biomarkers of myeloperoxidase-derived hypochlorous acid

scientific article

Bromination and chlorination reactions of myeloperoxidase at physiological concentrations of bromide and chloride

scientific article published on 3 August 2005

Bromotyrosines in sputum proteins and treatment effects of terbutaline and budesonide in asthma

scientific article published in October 2009

Ceruloplasmin is an endogenous inhibitor of myeloperoxidase

scientific article published on 10 January 2013

Characterisation of peroxidasin activity in isolated extracellular matrix and direct detection of hypobromous acid formation

scientific article published on 4 April 2018

Characterization of non-covalent oligomers of proteins treated with hypochlorous acid

scientific article published on October 2003

Chemical Characterization of Urate Hydroperoxide, A Pro-oxidant Intermediate Generated by Urate Oxidation in Inflammatory and Photoinduced Processes.

scientific article published on 24 July 2015

Chlorination of bacterial and neutrophil proteins during phagocytosis and killing of Staphylococcus aureus

scientific article published on 3 December 2001

Chlorination of tyrosyl residues in peptides by myeloperoxidase and human neutrophils

scientific article published on 01 July 1995

Circulating myeloperoxidase is elevated in septic shock and is associated with systemic organ failure and mortality in critically ill patients

scientific article published on 05 November 2019

Comparison of mono- and dichlorinated tyrosines with carbonyls for detection of hypochlorous acid modified proteins

scientific article published in May 2000

Conjugation of urate-derived electrophiles to proteins during normal metabolism and inflammation

scientific article published in Journal of Biological Chemistry

Correction: High performing AgNW transparent conducting electrodes with a sheet resistance of 2.5 Ω Sq-1 based upon a roll-to-roll compatible post-processing technique

scientific article published on 01 March 2019

Covalent modification of cytoskeletal proteins in neuronal cells by tryptamine-4,5-dione.

scientific article published on 22 August 2014

Cross-linking methionine and amine residues with reactive halogen species.

scientific article published on 28 January 2014

Detection of allantoin in clinical samples using hydrophilic liquid chromatography with stable isotope dilution negative ion tandem mass spectrometry

scientific article published on 13 February 2012

Detection of monobromamine, monochloramine and dichloramine using selected ion flow tube mass spectrometry and their relevance as breath markers

scientific article published on 01 January 2008

Disease stage-dependent accumulation of lipid and protein oxidation products in human atherosclerosis

scientific article published on February 2002

Do neutrophils produce ozone? An appraisal of current evidence

scientific article published in January 2005

Effect of activated human polymorphonuclear leucocytes on T lymphocyte proliferation and viability

scientific article published in November 2012

Elevated seminal plasma myeloperoxidase is associated with a decreased sperm concentration in young men.

scientific article

Eosinophil peroxidase produces hypobromous acid in the airways of stable asthmatics

scientific article

Evaluating the bactericidal action of hypochlorous acid in culture media

scientific article published on 30 July 2020

Exposure of Pseudomonas aeruginosa to bactericidal hypochlorous acid during neutrophil phagocytosis is compromised in cystic fibrosis

scientific article published on 24 July 2019

Factors influencing local and systemic levels of plasma myeloperoxidase in ST-segment elevation acute myocardial infarction

scientific article published on August 2010

Heterogeneity of hypochlorous acid production in individual neutrophil phagosomes revealed by a rhodamine-based probe

scientific article published in Journal of Biological Chemistry

Hypobromous acid and bromamine production by neutrophils and modulation by superoxide

scientific article published in February 2009

Hypochlorous Acid Activates the Tumor Suppressor Protein p53 in Cultured Human Skin Fibroblasts ⬇️

scientific article published on 01 November 1998

Identifying peroxidases and their oxidants in the early pathology of cystic fibrosis

scientific article published on 18 July 2010

Inactivation of human myeloperoxidase by hydrogen peroxide

scientific article

Influence of superoxide on myeloperoxidase kinetics measured with a hydrogen peroxide electrode

scientific article published on November 1989

Inhibition of MPO (Myeloperoxidase) Attenuates Endothelial Dysfunction in Mouse Models of Vascular Inflammation and Atherosclerosis

scientific article published on 02 May 2019

Inhibition of myeloperoxidase by benzoic acid hydrazides

scientific article

Inside the neutrophil phagosome: oxidants, myeloperoxidase, and bacterial killing.

scientific article

Interactions of staphyloxanthin and enterobactin with myeloperoxidase and reactive chlorine species.

scientific article

Intestinal helminth infection promotes IL-5- and CD4 T cell-dependent immunity in the lung against migrating parasites

scientific article published on 06 November 2018

Involvement of superoxide and myeloperoxidase in oxygen-dependent killing of Staphylococcus aureus by neutrophils

scientific article

Isoniazid as a substrate and inhibitor of myeloperoxidase: Identification of amine adducts and the influence of superoxide dismutase on their formation

scientific article published on 27 July 2012

Levels of inflammation and oxidative stress, and a role for taurine in dystropathology of the Golden Retriever Muscular Dystrophy dog model for Duchenne Muscular Dystrophy

scientific article published on 30 August 2016

Macrophage migration inhibitory factor (MIF) is rendered enzymatically inactive by myeloperoxidase-derived oxidants but retains its immunomodulatory function

scientific article published on 7 October 2015

Measurements for Sulfide-Mediated Inhibition of Myeloperoxidase Activity

scientific article published on 01 January 2019

Measuring chlorine bleach in biology and medicine

scientific article published on 18 July 2013

Mechanism and regulation of peroxidase-catalyzed nitric oxide consumption in physiological fluids: critical protective actions of ascorbate and thiocyanate

scientific article published on 04 April 2014

Mechanism of inactivation of myeloperoxidase by 4-aminobenzoic acid hydrazide

scientific article

Mechanism of inhibition of myeloperoxidase by anti-inflammatory drugs ⬇️

scientific article published on May 15, 1991

Mechanism of nitrite oxidation by eosinophil peroxidase: implications for oxidant production and nitration by eosinophils

scientific article

Mechanism of reaction of myeloperoxidase with nitrite

scientific journal article

Modeling the reactions of superoxide and myeloperoxidase in the neutrophil phagosome: implications for microbial killing

scientific article published on 30 October 2006

Molecular structure and dynamic properties of a sulfonamide derivative of glutathione that is produced under conditions of oxidative stress by hypochlorous acid

scientific article published in May 2008

Myeloperoxidase

scientific article published on 01 January 2000

Myeloperoxidase and oxidation of uric acid in gout: implications for the clinical consequences of hyperuricaemia

scientific article published on 4 June 2014

Myeloperoxidase and oxidative stress in rheumatoid arthritis

scientific article published on 19 July 2012

Myeloperoxidase and protein oxidation in the airways of young children with cystic fibrosis

scientific article published in October 2004

Myeloperoxidase associated with neutrophil extracellular traps is active and mediates bacterial killing in the presence of hydrogen peroxide.

scientific article

Myeloperoxidase catalyzes the conjugation of serotonin to thiols via free radicals and tryptamine-4,5-dione

scientific article

Myeloperoxidase inhibition decreases morbidity and oxidative stress in mice with cystic fibrosis-like lung inflammation

scientific article published on 04 March 2020

Myeloperoxidase-dependent generation of a tyrosine peroxide by neutrophils

scientific article published on 01 February 1997

Myeloperoxidase-dependent lipid peroxidation promotes the oxidative modification of cytosolic proteins in phagocytic neutrophils

scientific article

Myeloperoxidase: a front-line defender against phagocytosed microorganisms

scientific article

Myeloperoxidase: a key regulator of neutrophil oxidant production

scientific article published on 01 February 1997

Myricitrin as a substrate and inhibitor of myeloperoxidase: implications for the pharmacological effects of flavonoids

scientific article published on 6 October 2007

Neutrophil granule proteins generate bactericidal ammonia chloramine on reaction with hydrogen peroxide

scientific article published on 18 October 2017

Neutrophil-mediated oxidation of enkephalins via myeloperoxidase-dependent addition of superoxide

scientific article published on 10 June 2010

Neutrophil-vascular interactions drive myeloperoxidase accumulation in the brain in Alzheimer's disease

scientific article published on 24 March 2022

Neutrophils suppress mucosal-associated invariant T cells in humans

scientific article published on 16 January 2020

Nitrite as a substrate and inhibitor of myeloperoxidase. Implications for nitration and hypochlorous acid production at sites of inflammation

scientific article

Optimising hydrogen peroxide measurement in exhaled breath condensate

scientific article published on 01 January 2006

Oxidation contributes to low glutathione in the airways of children with cystic fibrosis

scientific article published on 23 March 2014

Oxidation of bacillithiol by myeloperoxidase-derived oxidants

scientific article published on 03 July 2020

Oxidation of calprotectin by hypochlorous acid prevents chelation of essential metal ions and allows bacterial growth: Relevance to infections in cystic fibrosis

scientific article

Oxidation of hydroquinone by myeloperoxidase. Mechanism of stimulation by benzoquinone ⬇️

scientific article published on April 25, 1992

Oxidation of methionine to dehydromethionine by reactive halogen species generated by neutrophils

scientific article published in October 2009

Oxidative cross-linking of calprotectin occurs in vivo, altering its structure and susceptibility to proteolysis

scientific article published on 13 April 2019

Oxidative metabolism of amsacrine by the neutrophil enzyme myeloperoxidase

scientific article published on 01 November 1992

Oxidative stress in early cystic fibrosis lung disease is exacerbated by airway glutathione deficiency

scientific article

Oxidized glutathione and uric acid as biomarkers of early cystic fibrosis lung disease

scientific article

Pathways for the decay of organic dichloramines and liberation of antimicrobial chloramine gases.

scientific article published in December 2008

Peroxidasin mediates bromination of tyrosine residues in the extracellular matrix

scientific article published on 16 July 2020

Peroxynitrite and myeloperoxidase leave the same footprint in protein nitration

scientific article published on 01 October 1997

Potent Reversible Inhibition of Myeloperoxidase by Aromatic Hydroxamates

scientific article

Potent inhibition of macrophage migration inhibitory factor (MIF) by myeloperoxidase-dependent oxidation of epicatechins

scientific article published on 01 September 2014

Production of glutathione sulfonamide and dehydroglutathione from GSH by myeloperoxidase-derived oxidants and detection using a novel LC-MS/MS method

scientific article published in October 2006

Protein chlorination in neutrophil phagosomes and correlation with bacterial killing

scientific article published on 16 September 2014

Radical-radical reactions of superoxide: a potential route to toxicity

scientific article

Rapid reaction of superoxide with insulin-tyrosyl radicals to generate a hydroperoxide with subsequent glutathione addition

scientific article published on 20 February 2014

Reactions of myeloperoxidase with superoxide and hydrogen peroxide: significance for its function in the neutrophil.

scientific article published in January 1988

Reactions of superoxide with myeloperoxidase

scientific article published on 24 March 2007

Reactions of superoxide with myeloperoxidase and its products.

scientific article published in October 2004

Reactions of superoxide with the myoglobin tyrosyl radical.

scientific article

Reactive Oxygen Species and Neutrophil Function

scientific article published on 6 April 2016

Redox reactions and microbial killing in the neutrophil phagosome

scientific article published on 09 October 2012

Requirements for NADPH oxidase and myeloperoxidase in neutrophil extracellular trap formation differ depending on the stimulus

scientific article published on 16 July 2012

Rust never sleeps: The continuing story of the Iron Bolt

scientific article published on 18 June 2018

Serotonin as a physiological substrate for myeloperoxidase and its superoxide-dependent oxidation to cytotoxic tryptamine-4,5-dione.

scientific article published on 14 December 2009

Simultaneous determination of reduced glutathione, glutathione disulphide and glutathione sulphonamide in cells and physiological fluids by isotope dilution liquid chromatography-tandem mass spectrometry.

scientific article published on 15 April 2009

Spectral and kinetic evidence for reaction of superoxide with compound I of myeloperoxidase

scientific article published on 25 September 2011

Studies in neuro-endocrinology

1983 master's thesis by Anthony Kettle at Massey University

Substrates and products of eosinophil peroxidase

scientific article published on 15 August 2001

Superoxide converts indigo carmine to isatin sulfonic acid: implications for the hypothesis that neutrophils produce ozone

scientific article (publication date: 30 April 2004)

Superoxide dismutase protects ribonucleotide reductase from inactivation in yeast

scientific article published on 3 January 2018

Superoxide enhances hypochlorous acid production by stimulated human neutrophils

scientific article published on 01 May 1990

Superoxide is an antagonist of antiinflammatory drugs that inhibit hypochlorous acid production by myeloperoxidase

scientific article

Superoxide modulates the activity of myeloperoxidase and optimizes the production of hypochlorous acid

scientific article published on June 1988

Superoxide-dependent hydroxylation by myeloperoxidase

scientific article published on 01 June 1994

Superoxide-dependent oxidation of melatonin by myeloperoxidase.

scientific article

Superoxide-mediated formation of tyrosine hydroperoxides and methionine sulfoxide in peptides through radical addition and intramolecular oxygen transfer

scientific article published on 18 March 2009

Suppression of Autoimmunity and Renal Disease in Pristane-Induced Lupus by Myeloperoxidase

scientific article published on 01 July 2015

The influence of superoxide on the production of hypochlorous acid by human neutrophils

scientific article published on 01 January 1991

The lipocalin alpha1-microglobulin has radical scavenging activity

scientific article published on 31 August 2007

The mechanism of myeloperoxidase-dependent chlorination of monochlorodimedon

scientific article published on 01 November 1988

Thiocyanate and chloride as competing substrates for myeloperoxidase.

scientific article published on October 1997

Transient and Steady-state Kinetics of the Oxidation of Substituted Benzoic Acid Hydrazides by Myeloperoxidase

scientific article published in Journal of Biological Chemistry

Urate as a physiological substrate for myeloperoxidase: implications for hyperuricemia and inflammation

scientific article

Uric acid and thiocyanate as competing substrates of lactoperoxidase

scientific article published on 13 June 2014

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