List of works - Mamoun Alhamadsheh

A biomimetic approach for enhancing the in vivo half-life of peptides.

scientific article

AG10 inhibits amyloidogenesis and cellular toxicity of the familial amyloid cardiomyopathy-associated V122I transthyretin

scientific article

Alkyl-CoA disulfides as inhibitors and mechanistic probes for FabH enzymes

scientific article

Antimalarial activity of natural and synthetic prodiginines

scientific article published on 8 July 2011

Biosynthesis of the salinosporamide A polyketide synthase substrate chloroethylmalonyl-coenzyme A from S-adenosyl-L-methionine

scholarly article

Design, total synthesis, and evaluation of novel open-chain epothilone analogues

scientific article published on February 2006

Elucidation of the Streptomyces coelicolor pathway to 2-undecylpyrrole, a key intermediate in undecylprodiginine and streptorubin B biosynthesis

scientific article

Enthalpy-Driven Stabilization of Transthyretin by AG10 Mimics a Naturally Occurring Genetic Variant That Protects from Transthyretin Amyloidosis

scientific article published on 22 August 2018

Hydrophilic Small Molecules That Harness Transthyretin To Enhance the Safety and Efficacy of Targeted Chemotherapeutic Agents

scientific article published on 13 June 2019

Modular polyketide synthases and cis double bond formation: establishment of activated cis-3-cyclohexylpropenoic acid as the diketide intermediate in phoslactomycin biosynthesis

scientific article published on 27 January 2007

Potent Kinetic Stabilizers That Prevent Transthyretin-Mediated Cardiomyocyte Proteotoxicity

scientific article

Probing reactivity and substrate specificity of both subunits of the dimeric Mycobacterium tuberculosis FabH using alkyl-CoA disulfide inhibitors and acyl-CoA substrates

scientific article

Separate entrance and exit portals for ligand traffic in Mycobacterium tuberculosis FabH

scientific article

Structure and Function of the RedJ Protein, a Thioesterase from the Prodiginine Biosynthetic Pathway in Streptomyces coelicolor

scientific article

Synthesis and biological evaluation of novel sulfonyl-naphthalene-1,4-diols as FabH inhibitors

scientific article

Synthesis and biological evaluation of thiazolidine-2-one 1,1-dioxide as inhibitors of Escherichia coli beta-ketoacyl-ACP-synthase III (FabH).

scientific article published on December 2006

Total synthesis and selective activity of a new class of conformationally restrained epothilones

scientific article published on January 2008

Unsymmetric aryl-alkyl disulfide growth inhibitors of methicillin-resistant Staphylococcus aureus and Bacillus anthracis

scientific article published on 17 May 2008

cis-Delta(2,3)-double bond of phoslactomycins is generated by a post-PKS tailoring enzyme

scientific article published on 21 August 2008

List of works by Mamoun Alhamadsheh

A biomimetic approach for enhancing the in vivo half-life of peptides.

AG10 inhibits amyloidogenesis and cellular toxicity of the familial amyloid cardiomyopathy-associated V122I transthyretin

Alkyl-CoA disulfides as inhibitors and mechanistic probes for FabH enzymes

Antimalarial activity of natural and synthetic prodiginines

Biosynthesis of the salinosporamide A polyketide synthase substrate chloroethylmalonyl-coenzyme A from S-adenosyl-L-methionine

Design, total synthesis, and evaluation of novel open-chain epothilone analogues

Elucidation of the Streptomyces coelicolor pathway to 2-undecylpyrrole, a key intermediate in undecylprodiginine and streptorubin B biosynthesis

Enthalpy-Driven Stabilization of Transthyretin by AG10 Mimics a Naturally Occurring Genetic Variant That Protects from Transthyretin Amyloidosis

Hydrophilic Small Molecules That Harness Transthyretin To Enhance the Safety and Efficacy of Targeted Chemotherapeutic Agents

Modular polyketide synthases and cis double bond formation: establishment of activated cis-3-cyclohexylpropenoic acid as the diketide intermediate in phoslactomycin biosynthesis

Potent Kinetic Stabilizers That Prevent Transthyretin-Mediated Cardiomyocyte Proteotoxicity

Probing reactivity and substrate specificity of both subunits of the dimeric Mycobacterium tuberculosis FabH using alkyl-CoA disulfide inhibitors and acyl-CoA substrates

Separate entrance and exit portals for ligand traffic in Mycobacterium tuberculosis FabH

Structure and Function of the RedJ Protein, a Thioesterase from the Prodiginine Biosynthetic Pathway in Streptomyces coelicolor

Synthesis and biological evaluation of novel sulfonyl-naphthalene-1,4-diols as FabH inhibitors

Synthesis and biological evaluation of thiazolidine-2-one 1,1-dioxide as inhibitors of Escherichia coli beta-ketoacyl-ACP-synthase III (FabH).

Total synthesis and selective activity of a new class of conformationally restrained epothilones

Unsymmetric aryl-alkyl disulfide growth inhibitors of methicillin-resistant Staphylococcus aureus and Bacillus anthracis

cis-Delta(2,3)-double bond of phoslactomycins is generated by a post-PKS tailoring enzyme