List of works - Sabine Specht

Human coronavirus EMC does not require the SARS-coronavirus receptor and maintains broad replicative capability in mammalian cell lines

scientific article

Wolbachia endobacteria depletion by doxycycline as antifilarial therapy has macrofilaricidal activity in onchocerciasis: a randomized placebo-controlled study

scientific article

Doxycycline reduces plasma VEGF-C/sVEGFR-3 and improves pathology in lymphatic filariasis

scientific article

Helminth infection with Litomosoides sigmodontis induces regulatory T cells and inhibits allergic sensitization, airway inflammation, and hyperreactivity in a murine asthma model

scientific article

Macrofilaricidal activity after doxycycline only treatment of Onchocerca volvulus in an area of Loa loa co-endemicity: a randomized controlled trial

scientific article

Renal dendritic cells stimulate IL-10 production and attenuate nephrotoxic nephritis

scientific article published on 30 January 2008

Efficacy of 5-week doxycycline treatment on adult Onchocerca volvulus

scientific article

Lack of eosinophil peroxidase or major basic protein impairs defense against murine filarial infection

scientific journal article

Therapeutic efficacy and macrofilaricidal activity of doxycycline for the treatment of river blindness

scientific article published on 23 December 2014

Murine filariasis: interleukin 4 and interleukin 5 lead to containment of different worm developmental stages

scientific article published on 10 December 2002

The IFN-γ-inducible GTPase, Irga6, protects mice against Toxoplasma gondii but not against Plasmodium berghei and some other intracellular pathogens

scientific article

Repurposing of approved drugs from the human pharmacopoeia to target Wolbachia endosymbionts of onchocerciasis and lymphatic filariasis

scientific article

Doxycycline improves filarial lymphedema independent of active filarial infection: a randomized controlled trial.

scientific article

Doxycycline Leads to Sterility and Enhanced Killing of Female Onchocerca volvulus Worms in an Area With Persistent Microfilaridermia After Repeated Ivermectin Treatment: A Randomized, Placebo-Controlled, Double-Blind Trial

scientific article published on 6 May 2015

Efficacy of 2- and 4-week rifampicin treatment on the Wolbachia of Onchocerca volvulus

scientific article

Synergism of gamma interferon and interleukin-5 in the control of murine filariasis

scientific article

Corallopyronin A Specifically Targets and Depletes Essential Obligate Wolbachia Endobacteria From Filarial Nematodes In Vivo

scientific article published on May 14, 2012

Filaria-induced IL-10 suppresses murine cerebral malaria

scientific article published on 24 April 2010

Elevated adaptive immune responses are associated with latent infections of Wuchereria bancrofti

scientific article

Chronic filarial infection provides protection against bacterial sepsis by functionally reprogramming macrophages

scientific article

Interleukin-10 (IL-10) counterregulates IL-4-dependent effector mechanisms in Murine Filariasis

scientific article

Hyperreactive onchocerciasis is characterized by a combination of Th17-Th2 immune responses and reduced regulatory T cells.

scientific article

Onchocerca volvulus-neurotransmitter tyramine is a biomarker for river blindness

scientific article published on 25 February 2013

Lymphatic vascularisation and involvement of Lyve-1+ macrophages in the human onchocerca nodule

scientific article

Comparison of Doxycycline, Minocycline, Doxycycline plus Albendazole and Albendazole Alone in Their Efficacy against Onchocerciasis in a Randomized, Open-Label, Pilot Trial

scientific article

Newly acquired Onchocerca volvulus filariae after doxycycline treatment

scientific article published on 16 September 2009

CCL17 controls mast cells for the defense against filarial larval entry

scientific article

Macrofilaricidal Activity in Wuchereria bancrofti after 2 Weeks Treatment with a Combination of Rifampicin plus Doxycycline

scientific article

Immunization with L. sigmodontis microfilariae reduces peripheral microfilaraemia after challenge infection by inhibition of filarial embryogenesis

scientific article (publication date: 2012)

ST2 deficiency does not impair type 2 immune responses during chronic filarial infection but leads to an increased microfilaremia due to an impaired splenic microfilarial clearance

scientific article

Increased early local immune responses and altered worm development in high-dose infections of mice susceptible to the filaria Litomosoides sigmodontis

scientific article

Induction of pro-inflammatory mediators in Plasmodium berghei infected BALB/c mice breaks blood-brain-barrier and leads to cerebral malaria in an IL-12 dependent manner

scientific article published on May 12, 2011

Migratory phase of Litomosoides sigmodontis filarial infective larvae is associated with pathology and transient increase of S100A9 expressing neutrophils in the lung.

scientific article

Criteria for the differentiation between young and old Onchocerca volvulus filariae

scientific article published on 26 September 2009

The human parasite Loa loa in cytokine and cytokine receptor gene knock out BALB/c mice: survival, development and localization

scientific article published on February 21, 2012

Filarial infection induces protection against P. berghei liver stages in mice

scientific article published on 19 November 2008

NOD2 dependent neutrophil recruitment is required for early protective immune responses against infectious Litomosoides sigmodontis L3 larvae

scientific article published on 22 December 2016

Immunoepidemiological profiling of onchocerciasis patients reveals associations with microfilaria loads and ivermectin intake on both individual and community levels

scientific article (publication date: February 2014)

Pleural cellular reaction to the filarial infection Litomosoides sigmodontis is determined by the moulting process, the worm alteration, and the host strain

scientific article

Ex Vivo Responses of Plasmodium falciparum Clinical Isolates to Conventional and New Antimalarial Drugs in Niger

scientific article published on April 22, 2013

The guanylhydrazone CNI-1493: an inhibitor with dual activity against malaria-inhibition of host cell pro-inflammatory cytokine release and parasitic deoxyhypusine synthase

scientific article

Combinations of registered drugs reduce treatment times required to deplete Wolbachia in the Litomosoides sigmodontis mouse model.

scientific article

An Integrated Multiomics Approach to Identify Candidate Antigens for Serodiagnosis of Human Onchocerciasis

scientific article published on 15 October 2015

In Vitro and In Vivo Antimalarial Activity Assays of Seeds from Balanites aegyptiaca: Compounds of the Extract Show Growth Inhibition and Activity against Plasmodial Aminopeptidase

scientific article

Helpful or a hindrance: co-infections with helminths during malaria

scientific article published on January 2014

Macrofilaricidal efficacy of single and repeated oral and subcutaneous doses of flubendazole in Litomosoides sigmodontis infected jirds

scientific article published on 16 January 2019

Reductions in microfilaridermia by repeated ivermectin treatment are associated with lower Plasmodium-specific Th17 immune responses in Onchocerca volvulus-infected individuals

scientific article published on March 28, 2015

Epithelial cell lines of the cotton rat (Sigmodon hispidus) are highly susceptible in vitro models to zoonotic Bunya-, Rhabdo-, and Flaviviruses

scientific article published on 4 May 2016

Wolbachia endobacteria depletion by doxycycline as antifilarial therapy has macrofilaricidal activity in onchocerciasis: a randomized placebo-controlled study

scientific article published in 2008

Analysis of nematode motion using an improved light-scatter based system

scientific article (publication date: February 2015)

List of works by Sabine Specht

Human coronavirus EMC does not require the SARS-coronavirus receptor and maintains broad replicative capability in mammalian cell lines

Wolbachia endobacteria depletion by doxycycline as antifilarial therapy has macrofilaricidal activity in onchocerciasis: a randomized placebo-controlled study

Doxycycline reduces plasma VEGF-C/sVEGFR-3 and improves pathology in lymphatic filariasis

Helminth infection with Litomosoides sigmodontis induces regulatory T cells and inhibits allergic sensitization, airway inflammation, and hyperreactivity in a murine asthma model

Macrofilaricidal activity after doxycycline only treatment of Onchocerca volvulus in an area of Loa loa co-endemicity: a randomized controlled trial

Renal dendritic cells stimulate IL-10 production and attenuate nephrotoxic nephritis

Efficacy of 5-week doxycycline treatment on adult Onchocerca volvulus

Lack of eosinophil peroxidase or major basic protein impairs defense against murine filarial infection

Therapeutic efficacy and macrofilaricidal activity of doxycycline for the treatment of river blindness

Murine filariasis: interleukin 4 and interleukin 5 lead to containment of different worm developmental stages

The IFN-γ-inducible GTPase, Irga6, protects mice against Toxoplasma gondii but not against Plasmodium berghei and some other intracellular pathogens

Repurposing of approved drugs from the human pharmacopoeia to target Wolbachia endosymbionts of onchocerciasis and lymphatic filariasis

Doxycycline improves filarial lymphedema independent of active filarial infection: a randomized controlled trial.

Doxycycline Leads to Sterility and Enhanced Killing of Female Onchocerca volvulus Worms in an Area With Persistent Microfilaridermia After Repeated Ivermectin Treatment: A Randomized, Placebo-Controlled, Double-Blind Trial

Efficacy of 2- and 4-week rifampicin treatment on the Wolbachia of Onchocerca volvulus

Synergism of gamma interferon and interleukin-5 in the control of murine filariasis

Corallopyronin A Specifically Targets and Depletes Essential Obligate Wolbachia Endobacteria From Filarial Nematodes In Vivo

Filaria-induced IL-10 suppresses murine cerebral malaria

Elevated adaptive immune responses are associated with latent infections of Wuchereria bancrofti

Chronic filarial infection provides protection against bacterial sepsis by functionally reprogramming macrophages

Interleukin-10 (IL-10) counterregulates IL-4-dependent effector mechanisms in Murine Filariasis

Hyperreactive onchocerciasis is characterized by a combination of Th17-Th2 immune responses and reduced regulatory T cells.

Onchocerca volvulus-neurotransmitter tyramine is a biomarker for river blindness

Lymphatic vascularisation and involvement of Lyve-1+ macrophages in the human onchocerca nodule

Comparison of Doxycycline, Minocycline, Doxycycline plus Albendazole and Albendazole Alone in Their Efficacy against Onchocerciasis in a Randomized, Open-Label, Pilot Trial

Newly acquired Onchocerca volvulus filariae after doxycycline treatment

CCL17 controls mast cells for the defense against filarial larval entry

Macrofilaricidal Activity in Wuchereria bancrofti after 2 Weeks Treatment with a Combination of Rifampicin plus Doxycycline

Immunization with L. sigmodontis microfilariae reduces peripheral microfilaraemia after challenge infection by inhibition of filarial embryogenesis

ST2 deficiency does not impair type 2 immune responses during chronic filarial infection but leads to an increased microfilaremia due to an impaired splenic microfilarial clearance

Increased early local immune responses and altered worm development in high-dose infections of mice susceptible to the filaria Litomosoides sigmodontis

Induction of pro-inflammatory mediators in Plasmodium berghei infected BALB/c mice breaks blood-brain-barrier and leads to cerebral malaria in an IL-12 dependent manner

Migratory phase of Litomosoides sigmodontis filarial infective larvae is associated with pathology and transient increase of S100A9 expressing neutrophils in the lung.

Criteria for the differentiation between young and old Onchocerca volvulus filariae

The human parasite Loa loa in cytokine and cytokine receptor gene knock out BALB/c mice: survival, development and localization

Filarial infection induces protection against P. berghei liver stages in mice

NOD2 dependent neutrophil recruitment is required for early protective immune responses against infectious Litomosoides sigmodontis L3 larvae

Immunoepidemiological profiling of onchocerciasis patients reveals associations with microfilaria loads and ivermectin intake on both individual and community levels

Pleural cellular reaction to the filarial infection Litomosoides sigmodontis is determined by the moulting process, the worm alteration, and the host strain

Ex Vivo Responses of Plasmodium falciparum Clinical Isolates to Conventional and New Antimalarial Drugs in Niger

The guanylhydrazone CNI-1493: an inhibitor with dual activity against malaria-inhibition of host cell pro-inflammatory cytokine release and parasitic deoxyhypusine synthase

Combinations of registered drugs reduce treatment times required to deplete Wolbachia in the Litomosoides sigmodontis mouse model.

An Integrated Multiomics Approach to Identify Candidate Antigens for Serodiagnosis of Human Onchocerciasis

In Vitro and In Vivo Antimalarial Activity Assays of Seeds from Balanites aegyptiaca: Compounds of the Extract Show Growth Inhibition and Activity against Plasmodial Aminopeptidase

Helpful or a hindrance: co-infections with helminths during malaria

Macrofilaricidal efficacy of single and repeated oral and subcutaneous doses of flubendazole in Litomosoides sigmodontis infected jirds

Reductions in microfilaridermia by repeated ivermectin treatment are associated with lower Plasmodium-specific Th17 immune responses in Onchocerca volvulus-infected individuals

Epithelial cell lines of the cotton rat (Sigmodon hispidus) are highly susceptible in vitro models to zoonotic Bunya-, Rhabdo-, and Flaviviruses

Wolbachia endobacteria depletion by doxycycline as antifilarial therapy has macrofilaricidal activity in onchocerciasis: a randomized placebo-controlled study

Analysis of nematode motion using an improved light-scatter based system