List of works - Sabine Specht

A histochemical study of the Nras/let-60 activity in filarial nematodes

scientific article published in July 2015

An Integrated Multiomics Approach to Identify Candidate Antigens for Serodiagnosis of Human Onchocerciasis

scientific article published on 15 October 2015

Analysis of nematode motion using an improved light-scatter based system

scientific article (publication date: February 2015)

CCL17 controls mast cells for the defense against filarial larval entry

scientific article

Chronic filarial infection provides protection against bacterial sepsis by functionally reprogramming macrophages

scientific article

Combinations of registered drugs reduce treatment times required to deplete Wolbachia in the Litomosoides sigmodontis mouse model.

scientific article

Comparison of Doxycycline, Minocycline, Doxycycline plus Albendazole and Albendazole Alone in Their Efficacy against Onchocerciasis in a Randomized, Open-Label, Pilot Trial

scientific article

Corallopyronin A Specifically Targets and Depletes Essential Obligate Wolbachia Endobacteria From Filarial Nematodes In Vivo ⬇️

scientific article published on May 14, 2012

Criteria for the differentiation between young and old Onchocerca volvulus filariae

scientific article published on 26 September 2009

Doxycycline Leads to Sterility and Enhanced Killing of Female Onchocerca volvulus Worms in an Area With Persistent Microfilaridermia After Repeated Ivermectin Treatment: A Randomized, Placebo-Controlled, Double-Blind Trial

scientific article published on 6 May 2015

Doxycycline improves filarial lymphedema independent of active filarial infection: a randomized controlled trial.

scientific article

Doxycycline reduces plasma VEGF-C/sVEGFR-3 and improves pathology in lymphatic filariasis

scientific article

Efficacy of 2- and 4-week rifampicin treatment on the Wolbachia of Onchocerca volvulus

scientific article

Efficacy of 5-week doxycycline treatment on adult Onchocerca volvulus

scientific article

Elevated adaptive immune responses are associated with latent infections of Wuchereria bancrofti

scientific article

Epithelial cell lines of the cotton rat (Sigmodon hispidus) are highly susceptible in vitro models to zoonotic Bunya-, Rhabdo-, and Flaviviruses

scientific article published on 4 May 2016

Ex vivo responses of Plasmodium falciparum clinical isolates to conventional and new antimalarial drugs in Niger

scientific article published on 22 April 2013

Filaria-induced IL-10 suppresses murine cerebral malaria

scientific article published on 24 April 2010

Filarial infection induces protection against P. berghei liver stages in mice

scientific article published on 19 November 2008

Filarial nematode phenotypic screening cascade to identify compounds with anti-parasitic activity for drug discovery optimization

scientific article published in 2022

Helminth infection with Litomosoides sigmodontis induces regulatory T cells and inhibits allergic sensitization, airway inflammation, and hyperreactivity in a murine asthma model

scientific article

Helpful or a hindrance: co-infections with helminths during malaria

scientific article published on January 2014

Human coronavirus EMC does not require the SARS-coronavirus receptor and maintains broad replicative capability in mammalian cell lines

scientific article

Hyperreactive onchocerciasis is characterized by a combination of Th17-Th2 immune responses and reduced regulatory T cells.

scientific article

Immunization with L. sigmodontis microfilariae reduces peripheral microfilaraemia after challenge infection by inhibition of filarial embryogenesis

scientific article (publication date: 2012)

Immunoepidemiological profiling of onchocerciasis patients reveals associations with microfilaria loads and ivermectin intake on both individual and community levels

scientific article (publication date: February 2014)

In Vitro and In Vivo Antimalarial Activity Assays of Seeds from Balanites aegyptiaca: Compounds of the Extract Show Growth Inhibition and Activity against Plasmodial Aminopeptidase

scientific article

Increased early local immune responses and altered worm development in high-dose infections of mice susceptible to the filaria Litomosoides sigmodontis

scientific article

Induction of pro-inflammatory mediators in Plasmodium berghei infected BALB/c mice breaks blood-brain-barrier and leads to cerebral malaria in an IL-12 dependent manner ⬇️

scientific article published on May 12, 2011

Interleukin-10 (IL-10) counterregulates IL-4-dependent effector mechanisms in Murine Filariasis

scientific article

Lack of eosinophil peroxidase or major basic protein impairs defense against murine filarial infection

scientific journal article

Lymphatic vascularisation and involvement of Lyve-1+ macrophages in the human onchocerca nodule

scientific article

Macrofilaricidal Activity in Wuchereria bancrofti after 2 Weeks Treatment with a Combination of Rifampicin plus Doxycycline

scientific article

Macrofilaricidal activity after doxycycline only treatment of Onchocerca volvulus in an area of Loa loa co-endemicity: a randomized controlled trial

scientific article

Macrofilaricidal efficacy of single and repeated oral and subcutaneous doses of flubendazole in Litomosoides sigmodontis infected jirds

scientific article published on 16 January 2019

Migratory phase of Litomosoides sigmodontis filarial infective larvae is associated with pathology and transient increase of S100A9 expressing neutrophils in the lung.

scientific article

Murine filariasis: interleukin 4 and interleukin 5 lead to containment of different worm developmental stages

scientific article published on 10 December 2002

NOD2 dependent neutrophil recruitment is required for early protective immune responses against infectious Litomosoides sigmodontis L3 larvae

scientific article published on 22 December 2016

Newly acquired Onchocerca volvulus filariae after doxycycline treatment

scientific article published on 16 September 2009

Onchocerca volvulus-neurotransmitter tyramine is a biomarker for river blindness

scientific article published on 25 February 2013

Oxfendazole mediates macrofilaricidal efficacy against the filarial nematode Litomosoides sigmodontis in vivo and inhibits Onchocerca spec. motility in vitro

scientific article published on 06 July 2020

Pleural cellular reaction to the filarial infection Litomosoides sigmodontis is determined by the moulting process, the worm alteration, and the host strain

scientific article

Reductions in microfilaridermia by repeated ivermectin treatment are associated with lower Plasmodium-specific Th17 immune responses in Onchocerca volvulus-infected individuals

scientific article

Renal dendritic cells stimulate IL-10 production and attenuate nephrotoxic nephritis

scientific article published on 30 January 2008

Repurposing of approved drugs from the human pharmacopoeia to target Wolbachia endosymbionts of onchocerciasis and lymphatic filariasis

scientific article

ST2 deficiency does not impair type 2 immune responses during chronic filarial infection but leads to an increased microfilaremia due to an impaired splenic microfilarial clearance

scientific article

Synergism of gamma interferon and interleukin-5 in the control of murine filariasis

scientific article

The IFN-γ-inducible GTPase, Irga6, protects mice against Toxoplasma gondii but not against Plasmodium berghei and some other intracellular pathogens

scientific article

The guanylhydrazone CNI-1493: an inhibitor with dual activity against malaria-inhibition of host cell pro-inflammatory cytokine release and parasitic deoxyhypusine synthase

scientific article

The human parasite Loa loa in cytokine and cytokine receptor gene knock out BALB/c mice: survival, development and localization ⬇️

scientific article published on February 21, 2012

Therapeutic efficacy and macrofilaricidal activity of doxycycline for the treatment of river blindness

scientific article published on 23 December 2014

Wolbachia endobacteria depletion by doxycycline as antifilarial therapy has macrofilaricidal activity in onchocerciasis: a randomized placebo-controlled study

scientific article

Wolbachia endobacteria depletion by doxycycline as antifilarial therapy has macrofilaricidal activity in onchocerciasis: a randomized placebo-controlled study

scientific article published in 2008

List of works by Sabine Specht

A histochemical study of the Nras/let-60 activity in filarial nematodes

An Integrated Multiomics Approach to Identify Candidate Antigens for Serodiagnosis of Human Onchocerciasis

Analysis of nematode motion using an improved light-scatter based system

CCL17 controls mast cells for the defense against filarial larval entry

Chronic filarial infection provides protection against bacterial sepsis by functionally reprogramming macrophages

Combinations of registered drugs reduce treatment times required to deplete Wolbachia in the Litomosoides sigmodontis mouse model.

Comparison of Doxycycline, Minocycline, Doxycycline plus Albendazole and Albendazole Alone in Their Efficacy against Onchocerciasis in a Randomized, Open-Label, Pilot Trial

Corallopyronin A Specifically Targets and Depletes Essential Obligate Wolbachia Endobacteria From Filarial Nematodes In Vivo ⬇️

Criteria for the differentiation between young and old Onchocerca volvulus filariae

Doxycycline Leads to Sterility and Enhanced Killing of Female Onchocerca volvulus Worms in an Area With Persistent Microfilaridermia After Repeated Ivermectin Treatment: A Randomized, Placebo-Controlled, Double-Blind Trial

Doxycycline improves filarial lymphedema independent of active filarial infection: a randomized controlled trial.

Doxycycline reduces plasma VEGF-C/sVEGFR-3 and improves pathology in lymphatic filariasis

Efficacy of 2- and 4-week rifampicin treatment on the Wolbachia of Onchocerca volvulus

Efficacy of 5-week doxycycline treatment on adult Onchocerca volvulus

Elevated adaptive immune responses are associated with latent infections of Wuchereria bancrofti

Epithelial cell lines of the cotton rat (Sigmodon hispidus) are highly susceptible in vitro models to zoonotic Bunya-, Rhabdo-, and Flaviviruses

Ex vivo responses of Plasmodium falciparum clinical isolates to conventional and new antimalarial drugs in Niger

Filaria-induced IL-10 suppresses murine cerebral malaria

Filarial infection induces protection against P. berghei liver stages in mice

Filarial nematode phenotypic screening cascade to identify compounds with anti-parasitic activity for drug discovery optimization

Helminth infection with Litomosoides sigmodontis induces regulatory T cells and inhibits allergic sensitization, airway inflammation, and hyperreactivity in a murine asthma model

Helpful or a hindrance: co-infections with helminths during malaria

Human coronavirus EMC does not require the SARS-coronavirus receptor and maintains broad replicative capability in mammalian cell lines

Hyperreactive onchocerciasis is characterized by a combination of Th17-Th2 immune responses and reduced regulatory T cells.

Immunization with L. sigmodontis microfilariae reduces peripheral microfilaraemia after challenge infection by inhibition of filarial embryogenesis

Immunoepidemiological profiling of onchocerciasis patients reveals associations with microfilaria loads and ivermectin intake on both individual and community levels

In Vitro and In Vivo Antimalarial Activity Assays of Seeds from Balanites aegyptiaca: Compounds of the Extract Show Growth Inhibition and Activity against Plasmodial Aminopeptidase

Increased early local immune responses and altered worm development in high-dose infections of mice susceptible to the filaria Litomosoides sigmodontis

Induction of pro-inflammatory mediators in Plasmodium berghei infected BALB/c mice breaks blood-brain-barrier and leads to cerebral malaria in an IL-12 dependent manner ⬇️

Interleukin-10 (IL-10) counterregulates IL-4-dependent effector mechanisms in Murine Filariasis

Lack of eosinophil peroxidase or major basic protein impairs defense against murine filarial infection

Lymphatic vascularisation and involvement of Lyve-1+ macrophages in the human onchocerca nodule

Macrofilaricidal Activity in Wuchereria bancrofti after 2 Weeks Treatment with a Combination of Rifampicin plus Doxycycline

Macrofilaricidal activity after doxycycline only treatment of Onchocerca volvulus in an area of Loa loa co-endemicity: a randomized controlled trial

Macrofilaricidal efficacy of single and repeated oral and subcutaneous doses of flubendazole in Litomosoides sigmodontis infected jirds

Migratory phase of Litomosoides sigmodontis filarial infective larvae is associated with pathology and transient increase of S100A9 expressing neutrophils in the lung.

Murine filariasis: interleukin 4 and interleukin 5 lead to containment of different worm developmental stages

NOD2 dependent neutrophil recruitment is required for early protective immune responses against infectious Litomosoides sigmodontis L3 larvae

Newly acquired Onchocerca volvulus filariae after doxycycline treatment

Onchocerca volvulus-neurotransmitter tyramine is a biomarker for river blindness

Oxfendazole mediates macrofilaricidal efficacy against the filarial nematode Litomosoides sigmodontis in vivo and inhibits Onchocerca spec. motility in vitro

Pleural cellular reaction to the filarial infection Litomosoides sigmodontis is determined by the moulting process, the worm alteration, and the host strain

Reductions in microfilaridermia by repeated ivermectin treatment are associated with lower Plasmodium-specific Th17 immune responses in Onchocerca volvulus-infected individuals

Renal dendritic cells stimulate IL-10 production and attenuate nephrotoxic nephritis

Repurposing of approved drugs from the human pharmacopoeia to target Wolbachia endosymbionts of onchocerciasis and lymphatic filariasis

ST2 deficiency does not impair type 2 immune responses during chronic filarial infection but leads to an increased microfilaremia due to an impaired splenic microfilarial clearance

Synergism of gamma interferon and interleukin-5 in the control of murine filariasis

The IFN-γ-inducible GTPase, Irga6, protects mice against Toxoplasma gondii but not against Plasmodium berghei and some other intracellular pathogens

The guanylhydrazone CNI-1493: an inhibitor with dual activity against malaria-inhibition of host cell pro-inflammatory cytokine release and parasitic deoxyhypusine synthase

The human parasite Loa loa in cytokine and cytokine receptor gene knock out BALB/c mice: survival, development and localization ⬇️

Therapeutic efficacy and macrofilaricidal activity of doxycycline for the treatment of river blindness

Wolbachia endobacteria depletion by doxycycline as antifilarial therapy has macrofilaricidal activity in onchocerciasis: a randomized placebo-controlled study

Wolbachia endobacteria depletion by doxycycline as antifilarial therapy has macrofilaricidal activity in onchocerciasis: a randomized placebo-controlled study