List of works by Sarah R Leist

27th International Mammalian Genome Conference meeting report.

scientific article

A Mouse-Adapted SARS-CoV-2 Induces Acute Lung Injury and Mortality in Standard Laboratory Mice

scientific article published on 23 September 2020

A Newcastle Disease Virus (NDV) Expressing a Membrane-Anchored Spike as a Cost-Effective Inactivated SARS-CoV-2 Vaccine

scientific article published on 17 December 2020

A Newcastle disease virus (NDV) expressing membrane-anchored spike as a cost-effective inactivated SARS-CoV-2 vaccine

scientific article published on 31 July 2020

A mouse-adapted SARS-CoV-2 model for the evaluation of COVID-19 medical countermeasures

scientific article published on 08 May 2020

A mouse-adapted model of SARS-CoV-2 to test COVID-19 countermeasures

scientific article published on 27 August 2020

Acute SARS-CoV-2 Infection is Highly Cytopathic, Elicits a Robust Innate Immune Response and is Efficiently Prevented by EIDD-2801

scientific article published on 24 September 2020

An orally bioavailable broad-spectrum antiviral inhibits SARS-CoV-2 and multiple endemic, epidemic and bat coronavirus

scientific article (preprint)

An orally bioavailable broad-spectrum antiviral inhibits SARS-CoV-2 in human airway epithelial cell cultures and multiple coronaviruses in mice

scientific article published on 06 April 2020

Antibody potency, effector function and combinations in protection from SARS-CoV-2 infection in vivo

scientific article published on 15 September 2020

Antibody potency, effector function, and combinations in protection and therapy for SARS-CoV-2 infection in vivo

scientific article published on 01 March 2021

Baseline T cell immune phenotypes predict virologic and disease control upon SARS-CoV infection

scientific article published on 21 September 2020

Broad-spectrum antiviral GS-5734 inhibits both epidemic and zoonotic coronaviruses.

scientific article

Cell and animal models of SARS-CoV-2 pathogenesis and immunity

scientific article published on 01 September 2020

Combination Attenuation Offers Strategy for Live Attenuated Coronavirus Vaccines

scholarly article by Vineet D. Menachery published in September 2018

Combination attenuation offers strategy for live-attenuated coronavirus vaccines

scholarly article published 28 April 2018

Comparative therapeutic efficacy of remdesivir and combination lopinavir, ritonavir, and interferon beta against MERS-CoV

scientific article published on 10 January 2020

Complement Activation Contributes to Severe Acute Respiratory Syndrome Coronavirus Pathogenesis

article

Complex Genetic Architecture Underlies Regulation of Influenza-A-Virus-Specific Antibody Responses in the Collaborative Cross

scientific article published on 01 April 2020

Dissecting strategies to tune the therapeutic potential of SARS-CoV-2–specific monoclonal antibody CR3022

scientific article published in 2021

Elicitation of Potent Neutralizing Antibody Responses by Designed Protein Nanoparticle Vaccines for SARS-CoV-2

scientific article published on 31 October 2020

Elicitation of potent neutralizing antibody responses by designed protein nanoparticle vaccines for SARS-CoV-2

scientific article published on 12 August 2020

Ex vivo and in vivo suppression of SARS-CoV-2 with combinatorial AAV/RNAi expression vectors

scientific article published in 2022

Genetically Engineering a Susceptible Mouse Model for MERS-CoV-Induced Acute Respiratory Distress Syndrome

scientific article published on 01 January 2020

Giving the Genes a Shuffle: Using Natural Variation to Understand Host Genetic Contributions to Viral Infections

article

High Potency of a Bivalent Human VH Domain in SARS-CoV-2 Animal Models

scientific article published on 04 September 2020

In vivo knockdown of Piccolino disrupts presynaptic ribbon morphology in mouse photoreceptor synapses

scientific article

Increased virulence of a PB2/HA mutant of an avian H9N2 influenza strain after three passages in porcine differentiated airway epithelial cells

scientific article published on 16 October 2017

Increasing the translation of mouse models of MERS coronavirus pathogenesis through kinetic hematological analysis

scientific article published in 2019

Influenza H3N2 infection of the collaborative cross founder strains reveals highly divergent host responses and identifies a unique phenotype in CAST/EiJ mice

scientific article

Lst1 deficiency has a minor impact on course and outcome of the host response to influenza A H1N1 infections in mice

scientific article published on 27 January 2016

MERS-CoV NSP16 necessary for IFN resistance and viral pathogenesis

Middle East Respiratory Syndrome Coronavirus Nonstructural Protein 16 Is Necessary for Interferon Resistance and Viral Pathogenesis

scientific article published on 15 November 2017

Modeling pathogenesis of emergent and pre-emergent human coronaviruses in mice

Mutations during the Adaptation of H9N2 Avian Influenza Virus to the Respiratory Epithelium of Pigs Enhance Sialic Acid Binding Activity and Virulence in Mice.

scientific article published on February 2017

Newcastle disease virus (NDV) expressing the spike protein of SARS-CoV-2 as a live virus vaccine candidate

scientific article published on 21 November 2020

Newcastle disease virus (NDV) expressing the spike protein of SARS-CoV-2 as vaccine candidate

scientific article published on 26 July 2020

Of mice and men: the host response to influenza virus infection

scientific article published on 15 June 2018

Remdesivir Inhibits SARS-CoV-2 in Human Lung Cells and Chimeric SARS-CoV Expressing the SARS-CoV-2 RNA Polymerase in Mice

scientific article published on 07 July 2020

Remdesivir potently inhibits SARS-CoV-2 in human lung cells and chimeric SARS-CoV expressing the SARS-CoV-2 RNA polymerase in mice

scientific article published on 28 April 2020

SARS-CoV-2 D614G Variant Exhibits Enhanced Replication ex vivo and Earlier Transmission in vivo

scientific article published on 29 September 2020

SARS-CoV-2 D614G variant exhibits efficient replication ex vivo and transmission in vivo

scientific article

SARS-CoV-2 Reverse Genetics Reveals a Variable Infection Gradient in the Respiratory Tract

scientific article published on 27 May 2020

SARS-CoV-2 infection is effectively treated and prevented by EIDD-2801

scientific article

SARS-CoV-2 mRNA Vaccine Development Enabled by Prototype Pathogen Preparedness

scientific article published on 11 June 2020

SARS-CoV-2 mRNA vaccine design enabled by prototype pathogen preparedness

scientific article published on 05 August 2020

Tmprss2 knock-out mice are resistant to H10 influenza A virus pathogenesis

scientific article published on 17 May 2019

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