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List of works by Mark A Knepper

A knowledge base of vasopressin actions in the kidney

scientific article

A selective EP4 PGE2 receptor agonist alleviates disease in a new mouse model of X-linked nephrogenic diabetes insipidus

scientific article published on October 2009

AQP3, p-AQP2, and AQP2 expression is reduced in polyuric rats with hypercalcemia: prevention by cAMP-PDE inhibitors

scientific article published on 30 July 2002

AbDesigner3D: a structure-guided tool for peptide-based antibody production

scientific article

Acute endotoxemia in rats induces down-regulation of V2 vasopressin receptors and aquaporin-2 content in the kidney medulla.

scientific article published in January 2004

Acute regulation of aquaporin-2 phosphorylation at Ser-264 by vasopressin

scholarly article

Akt and ERK1/2 pathways are components of the vasopressin signaling network in rat native IMCD

scientific article

Aldosterone increases urine production and decreases apical AQP2 expression in rats with diabetes insipidus

scientific article

Altered expression of epithelial sodium channel in rats with bilateral or unilateral ureteral obstruction

scientific article published on 02 May 2007

Altered expression of major renal Na transporters in rats with bilateral ureteral obstruction and release of obstruction

scientific article published on 15 July 2003

Altered expression of major renal Na transporters in rats with unilateral ureteral obstruction

scientific article published on 21 August 2002

Altered expression of renal NHE3, TSC, BSC-1, and ENaC subunits in potassium-depleted rats

scientific article published on 30 July 2002

Altered expression of urea transporters in response to ureteral obstruction

scientific article published on 24 February 2004

Altered expression profile of transporters in the inner medullary collecting duct of aquaporin-1 knockout mice

scientific article published on 15 February 2005

Altered renal sodium transporter expression in an animal model of type 2 diabetes mellitus

scientific article published on December 2007

An Efficient Algorithm for Clustering of Large-Scale Mass Spectrometry Data

scientific article

An Efficient Dynamic Programming Algorithm for Phosphorylation Site Assignment of Large-Scale Mass Spectrometry Data

scientific article

An automated platform for analysis of phosphoproteomic datasets: application to kidney collecting duct phosphoproteins.

scientific article published on 7 August 2007

An online tool for calculation of free-energy balance for the renal inner medulla

scientific article

Angiotensin II AT1 receptor blockade decreases vasopressin-induced water reabsorption and AQP2 levels in NaCl-restricted rats

scientific article published on 7 December 2004

Angiotensin II mediates downregulation of aquaporin water channels and key renal sodium transporters in response to urinary tract obstruction

scientific article published on 06 June 2006

Antidiuretic effect of hydrochlorothiazide in lithium-induced nephrogenic diabetes insipidus is associated with upregulation of aquaporin-2, Na-Cl co-transporter, and epithelial sodium channel

scientific article published in November 2004

Antigen retrieval reveals widespread basolateral expression of syntaxin 3 in renal epithelia

scientific article published on 01 March 2002

Application of difference gel electrophoresis to the identification of inner medullary collecting duct proteins

scientific article

Application of systems biology principles to protein biomarker discovery: urinary exosomal proteome in renal transplantation

scientific article published on June 2012

Aquaporin-2 in the "-omics" era

scientific article published on 04 February 2009

Aquaporin-2 regulation in health and disease.

scientific article

Aquaporins in the kidney: from molecules to medicine

scientific article

Automated quantification tool for high-throughput proteomics using stable isotope labeling and LC-MSn

scientific article published on 01 August 2006

BIG: a large-scale data integration tool for renal physiology

scientific article

Bayesian identification of candidate transcription factors for the regulation of <i>Aqp2</i> gene expression

scientific article published on 26 July 2021

Bilateral ureteral obstruction induces early downregulation and redistribution of AQP2 and phosphorylated AQP2.

scientific article

Biphasic effects of ANP infusion in conscious, euvolumic rats: roles of AQP2 and ENaC trafficking.

scientific article published on 20 September 2005

CAMS-RS: Clustering Algorithm for Large-Scale Mass Spectrometry Data using Restricted Search Space and Intelligent Random Sampling

scientific article

COX-2 activity transiently contributes to increased water and NaCl excretion in the polyuric phase after release of ureteral obstruction.

scientific article published on 16 January 2007

COX-2 inhibition prevents downregulation of key renal water and sodium transport proteins in response to bilateral ureteral obstruction.

scientific article

CPhos: a program to calculate and visualize evolutionarily conserved functional phosphorylation sites

scientific article

Calmodulin is required for vasopressin-stimulated increase in cyclic AMP production in inner medullary collecting duct.

scientific article

Changes of renal AQP2, ENaC, and NHE3 in experimentally induced heart failure: response to angiotensin II AT1 receptor blockade ⬇️

scientific article

Chronic furosemide or hydrochlorothiazide administration increases H+-ATPase B1 subunit abundance in rat kidney

scientific article published on 20 February 2007

Combined proteomics and pathways analysis of collecting duct reveals a protein regulatory network activated in vasopressin escape

scientific article

Common sense approaches to urinary biomarker study design

scientific article published on 21 May 2009

Comprehensive database of human E3 ubiquitin ligases: application to aquaporin-2 regulation

scientific article published on 13 May 2016

Concentration of solutes in the renal inner medulla: interstitial hyaluronan as a mechano-osmotic transducer

scientific article

Data integration in physiology using Bayes' rule and minimum Bayes' factors: deubiquitylating enzymes in the renal collecting duct

scientific article

Database for renal collecting duct regulatory and transporter proteins

scientific article published on 16 April 2003

Database of osmoregulated proteins in mammalian cells

scientific article

Decreased abundance of collecting duct urea transporters UT-A1 and UT-A3 with ECF volume expansion

scientific article published in April 2002

Deep Sequencing in Microdissected Renal Tubules Identifies Nephron Segment-Specific Transcriptomes ⬇️

scientific article published on 27 March 2015

Deep proteomic profiling of vasopressin-sensitive collecting duct cells. I. Virtual Western blots and molecular weight distributions

scientific article

Deep proteomic profiling of vasopressin-sensitive collecting duct cells. II. Bioinformatic analysis of vasopressin signaling

scientific article

Defective ENaC processing and function in tissue kallikrein-deficient mice.

scientific article

Deubiquitylation of Protein Cargo Is Not an Essential Step in Exosome Formation.

scientific article published on 16 February 2016

Discovery of urinary biomarkers

scientific article published on 12 July 2006

Does SARS-CoV-2 Infect the Kidney?

scientific article published on 13 October 2020

Downregulation of renal aquaporins in response to unilateral ureteral obstruction

scientific article published on 07 January 2003

Dynamic regulation of lysine acetylation: the balance between acetyltransferase and deacetylase activities

scientific article published on 12 July 2017

Dynamics of aquaporin-2 serine-261 phosphorylation in response to short-term vasopressin treatment in collecting duct

scientific article published on 19 September 2006

Dynamics of the G protein-coupled vasopressin V2 receptor signaling network revealed by quantitative phosphoproteomics.

scientific article

Dysregulation of renal salt and water transport proteins in diabetic Zucker rats

scientific article published in June 2002

Early release of neonatal ureteral obstruction preserves renal function

scientific article

Early targets of lithium in rat kidney inner medullary collecting duct include p38 and ERK1/2.

scientific article published on 30 April 2014

Effect of peristaltic contractions of the renal pelvic wall on solute concentrations of the renal inner medulla in the hamster

scientific article

Effect of primary polydipsia on aquaporin and sodium transporter abundance

scientific article published on 22 July 2003

Effects of dietary fat, NaCl, and fructose on renal sodium and water transporter abundances and systemic blood pressure

scientific article

Elevated BSC-1 and ROMK expression in Dahl salt-sensitive rat kidneys

scientific article published on 16 February 2004

Endogenous carbamylation of renal medullary proteins

scientific article

Enrichment of distinct microfilament-associated and GTP-binding-proteins in membrane/microvilli fractions from lymphoid cells

scientific article published on 28 May 2008

Epilepsy, ataxia, sensorineural deafness, tubulopathy, and KCNJ10 mutations

scientific article

Exosomes and the kidney: prospects for diagnosis and therapy of renal diseases

scientific article

Exploiting Thread-Level and Instruction-Level Parallelism to Cluster Mass Spectrometry Data using Multicore Architectures

scientific article

Expression and functional implications of the renal apelinergic system in rodents

scientific article

Expression of urea transporters in potassium-depleted mouse kidney

scientific article (publication date: December 2003)

Expression of urea transporters in the developing rat kidney

scientific article published in March 2002

Four-dimensional MRI of renal function in the developing mouse

scientific article

From 20th century metabolic wall charts to 21st century systems biology: database of mammalian metabolic enzymes

scientific article published on 14 December 2016

Gamble's "economy of water" revisited: studies in urea transporter knockout mice

scientific article published on 14 February 2006

Gene expression databases for kidney epithelial cells

scientific article published on 23 November 2011

Genome-Wide Mapping of DNA Accessibility and Binding Sites for CREB and C/EBPβ in Vasopressin-Sensitive Collecting Duct Cells

scientific article published on 23 March 2018

Global analysis of neuronal phosphoproteome regulation by chondroitin sulfate proteoglycans

scientific article

Global analysis of the effects of the V2 receptor antagonist satavaptan on protein phosphorylation in collecting duct

scientific article (publication date: 15 February 2014)

Glucocorticoid-stimulated lung epithelial Na(+) transport is associated with regulated ENaC and sgk1 expression

scientific article published on April 2002

High-throughput identification of IMCD proteins using LC-MS/MS

scientific article

Hypokalemia in a mouse model of Gitelman's syndrome

scientific article published on 24 January 2006

Hypotension in NKCC1 null mice: role of the kidneys

scientific article

Identification and proteomic profiling of exosomes in human urine

scientific article

Identification and quantification of basic and acidic proteins using solution-based two-dimensional protein fractionation and label-free or 18O-labeling mass spectrometry.

scientific article published on 17 May 2007

Identification of UT-A1- and AQP2-interacting proteins in rat inner medullary collecting duct

scientific article

Identification of phosphorylation-dependent binding partners of aquaporin-2 using protein mass spectrometry

scientific journal article

Identification of β-catenin-interacting proteins in nuclear fractions of native rat collecting duct cells

scientific article published on 15 March 2017

Identifying protein kinase target preferences using mass spectrometry

scientific article published on 20 June 2012

In vacuo isotope coded alkylation technique (IVICAT); an N-terminal stable isotopic label for quantitative liquid chromatography/mass spectrometry proteomics

scientific article

Increased apical targeting of renal ENaC subunits and decreased expression of 11betaHSD2 in HgCl2-induced nephrotic syndrome in rats

scientific article published on 27 September 2005

Increased apical targeting of renal epithelial sodium channel subunits and decreased expression of type 2 11beta-hydroxysteroid dehydrogenase in rats with CCl4-induced decompensated liver cirrhosis

scientific article

Increased collecting duct urea transporter expression in Dahl salt-sensitive rats

scientific article published on 8 April 2003

Increased expression and apical targeting of renal ENaC subunits in puromycin aminonucleoside-induced nephrotic syndrome in rats

scientific journal article

Increased expression of ENaC subunits and increased apical targeting of AQP2 in the kidneys of spontaneously hypertensive rats.

scientific article published on 14 June 2005

Increased renal ENaC subunit and sodium transporter abundances in streptozotocin-induced type 1 diabetes

scientific article published on 5 August 2003

Integrated Design of Antibodies for Systems Biology Using Ab Designer

scientific article

LC-MS/MS analysis of apical and basolateral plasma membranes of rat renal collecting duct cells.

scientific article published on 9 August 2006

LC-MS/MS analysis of differential centrifugation fractions from native inner medullary collecting duct of rat

scientific article published on 15 October 2008

Large scale protein identification in intracellular aquaporin-2 vesicles from renal inner medullary collecting duct

scientific journal article

Large-scale phosphoproteomic analysis of membrane proteins in renal proximal and distal tubule

scientific article

Large-scale phosphotyrosine proteomic profiling of rat renal collecting duct epithelium reveals predominance of proteins involved in cell polarity determination

scientific article published on 21 September 2011

Large-scale proteomics and phosphoproteomics of urinary exosomes

scientific article

Large-scale quantitative LC-MS/MS analysis of detergent-resistant membrane proteins from rat renal collecting duct.

scientific article published on 2 July 2008

Letter to the editor: "Systems biology versus reductionism in cell physiology"

scientific article

Lithium-induced NDI in rats is associated with loss of alpha-ENaC regulation by aldosterone in CCD.

scientific article

Long-term regulation of ENaC expression in kidney by angiotensin II.

scientific article published on 7 April 2003

Long-term treatment with cyclosporine decreases aquaporins and urea transporters in the rat kidney

scientific article published on 10 February 2004

Magnetic resonance imaging of urea transporter knockout mice shows renal pelvic abnormalities

scientific article published on 13 August 2008

Maintained ENaC trafficking in aldosterone-infused rats during mineralocorticoid and glucocorticoid receptor blockade

scientific article published on 15 August 2006

Mechanisms through which ammonia regulates cortical collecting duct net proton secretion

scientific article

Modulation of Cl signaling and ion transport by recruitment of kinases and phosphatases mediated by the regulatory protein IRBIT

scientific article published on 30 October 2018

Molecular physiology of water balance

scientific article published on April 2015

Mouse models and the urinary concentrating mechanism in the new millennium

scientific article published on October 2007

NGS-Integrator: An efficient tool for combining multiple NGS data tracks using minimum Bayes' factors

scientific article published on 19 November 2020

NHLBI-AbDesigner: an online tool for design of peptide-directed antibodies

scientific article published on 28 September 2011

Na+-H+Exchange Activity in Taste Receptor Cells ⬇️

scientific article published on November 5, 2003

Neonatal ureteral obstruction alters expression of renal sodium transporters and aquaporin water channels

scientific article published in July 2004

Oxytocin induces apical and basolateral redistribution of aquaporin-2 in rat kidney

scientific article published on 01 January 2003

Peptide Labeling Using Isobaric Tagging Reagents for Quantitative Phosphoproteomics

scientific article published on January 2016

Peter Agre, 2003 Nobel Prize winner in chemistry

scientific article

PhosSA: Fast and accurate phosphorylation site assignment algorithm for mass spectrometry data

scientific article

PhosphoScore: an open-source phosphorylation site assignment tool for MSn data

scientific article

Phosphoproteomic Identification of Vasopressin-Regulated Protein Kinases in Collecting Duct Cells

scientific article published on 21 December 2020

Phosphoproteomic profiling reveals vasopressin-regulated phosphorylation sites in collecting duct

scientific article

Phosphoproteomics of vasopressin signaling in the kidney

scientific article

Phosphorylation Changes in Response to Kinase Inhibitor H89 in PKA-Null Cells

scientific article published on 26 February 2019

Physiology: Courier service for ammonia

scientific article published in November 2008

Posttranscriptional compensation for heterozygous disruption of the kidney-specific NaK2Cl cotransporter gene

scientific article

Prioritizing Functional Goals as We Rebuild the Kidney

scientific article published on 01 November 2019

Prospects for urinary proteomics: exosomes as a source of urinary biomarkers

scientific article

Proteome-wide measurement of protein half-lives and translation rates in vasopressin-sensitive collecting duct cells

scientific article published on 12 September 2013

Proteomic analysis of V-ATPase-rich cells harvested from the kidney and epididymis by fluorescence-activated cell sorting.

scientific article

Proteomic analysis of lithium-induced nephrogenic diabetes insipidus: mechanisms for aquaporin 2 down-regulation and cellular proliferation

scholarly article

Proteomic analysis of the adaptive response of rat renal proximal tubules to metabolic acidosis

scientific article

Proteomic approaches for the study of cell signaling in the renal collecting duct

scientific article published on January 2008

Proteomic pearl diving versus systems biology in cell physiology. Focus on "proteomic mapping of proteins released during necrosis and apoptosis from cultured neonatal cardiac myocytes".

scientific article published on 15 January 2014

Proteomic profiling of nuclear fractions from native renal inner medullary collecting duct cells

scientific article published on 27 October 2015

Proteomic profiling of nuclei from native renal inner medullary collecting duct cells using LC-MS/MS

scientific article

Proteomics and the kidney

scientific article

Quantitative Proteomics of All 14 Renal Tubule Segments in Rat

scientific article published on 01 May 2020

Quantitative analysis of aquaporin-2 phosphorylation.

scientific article

Quantitative apical membrane proteomics reveals vasopressin-induced actin dynamics in collecting duct cells

scientific article

Quantitative phosphoproteomic analysis reveals cAMP/vasopressin-dependent signaling pathways in native renal thick ascending limb cells

scientific article

Quantitative phosphoproteomic analysis reveals vasopressin V2-receptor-dependent signaling pathways in renal collecting duct cells.

scientific article

Quantitative phosphoproteomics in nuclei of vasopressin-sensitive renal collecting duct cells

scientific article

Quantitative phosphoproteomics of vasopressin-sensitive renal cells: regulation of aquaporin-2 phosphorylation at two sites

scholarly article

Quantitative protein and mRNA profiling shows selective post-transcriptional control of protein expression by vasopressin in kidney cells.

scientific article

Quantitative proteomics identifies vasopressin-responsive nuclear proteins in collecting duct cells.

scientific article

Rapid isolation of urinary exosomal biomarkers using a nanomembrane ultrafiltration concentrator

scientific article published on 16 January 2007

Reduced expression of Na-K-2Cl cotransporter in medullary TAL in vitamin D-induced hypercalcemia in rats

scientific article published on 01 January 2002

Reduced expression of renal Na+ transporters in rats with PTH-induced hypercalcemia.

scientific article published on 18 November 2003

Regulation of NHE3, NKCC2, and NCC abundance in kidney during aldosterone escape phenomenon: role of NO.

scientific article published in July 2003

Regulation of collecting duct AQP3 expression: response to mineralocorticoid

scientific article published on 30 July 2002

Regulation of renal salt and water transporters during vasopressin escape

scientific article

Regulation of sodium transporters in the thick ascending limb of rat kidney: response to angiotensin II

scientific article published on 25 March 2003

Renal phenotype of UT-A urea transporter knockout mice

scientific article

Renal tubule sodium transporter abundance profiling in rat kidney: response to aldosterone and variations in NaCl intake

scientific article

Reply to Edemir: Physiological regulation and single-cell RNA sequencing.

scientific article published on 8 January 2018

Roflumilast and aquaporin-2 regulation in rat renal inner medullary collecting duct

scientific article published on January 2017

Role of multiple phosphorylation sites in the COOH-terminal tail of aquaporin-2 for water transport: evidence against channel gating

scientific article

Roles of basolateral solute uptake via NKCC1 and of myosin II in vasopressin-induced cell swelling in inner medullary collecting duct.

scientific article published on 16 April 2008

Rosiglitazone Activates Renal Sodium- and Water-Reabsorptive Pathways and Lowers Blood Pressure in Normal Rats ⬇️

scientific article published on October 30, 2003

Segment-specific ENaC downregulation in kidney of rats with lithium-induced NDI.

scientific article

Serine 269 phosphorylated aquaporin-2 is targeted to the apical membrane of collecting duct principal cells

scientific journal article

Serine/threonine phosphatases and aquaporin-2 regulation in renal collecting duct

scientific article

Sickle cell disease up-regulates vasopressin, aquaporin 2, urea transporter A1, Na-K-Cl cotransporter 2, and epithelial Na channels in the mouse kidney medulla despite compromising urinary concentration ability

scientific article published on 01 April 2019

Single-tubule RNA-Seq uncovers signaling mechanisms that defend against hyponatremia in SIADH.

scientific article published on 23 August 2017

Sodium retention in cirrhotic rats is associated with increased renal abundance of sodium transporter proteins.

scientific article published in February 2005

Sodium transporter abundance profiling in kidney: effect of spironolactone

scientific article published in November 2002

Structural biology. The atomic architecture of a gas channel.

scientific article

Structural biology: Molecular coin slots for urea.

scientific article published in December 2009

Systems biology in physiology: the vasopressin signaling network in kidney

scientific article

Systems biology of diuretic resistance

scientific article published on 20 April 2015

Systems-level analysis of cell-specific AQP2 gene expression in renal collecting duct

scholarly article

Systems-level analysis reveals selective regulation of Aqp2 gene expression by vasopressin

scientific article published on 11 October 2016

Systems-level identification of PKA-dependent signaling in epithelial cells

scientific article published on 2 October 2017

Taking aim at shotgun phosphoproteomics

scientific article published on 22 November 2007

Tamm-Horsfall protein and urinary exosome isolation

scientific article

Tandem mass spectrometry in physiology.

scientific article published on December 2007

Targeted proteomic profiling of renal Na(+) transporter and channel abundances in angiotensin II type 1a receptor knockout mice

scientific article published in February 2002

Thiazide diuretics directly induce osteoblast differentiation and mineralized nodule formation by interacting with a sodium chloride co-transporter in bone

scientific article

Time course of renal Na-K-ATPase, NHE3, NKCC2, NCC, and ENaC abundance changes with dietary NaCl restriction

scientific article published in October 2002

Tolvaptan as a tool in renal physiology

scientific article published on 04 December 2013

Towards standard protocols and guidelines for urine proteomics: a report on the Human Kidney and Urine Proteome Project (HKUPP) symposium and workshop, 6 October 2007, Seoul, Korea and 1 November 2007, San Francisco, CA, USA.

scientific article published in June 2008

Transcriptional profiling of native inner medullary collecting duct cells from rat kidney

scientific article published on 23 October 2007

Transcriptomes of Major Proximal Tubule Cell Culture Models

scientific article published on 29 October 2020

Transcriptomes of major renal collecting duct cell types in mouse identified by single-cell RNA-seq

scientific article published on 31 October 2017

Treating lithium-induced nephrogenic diabetes insipidus with a COX-2 inhibitor improves polyuria via upregulation of AQP2 and NKCC2.

scientific article published on 23 January 2008

UT-A urea transporter promoter, UT-Aalpha, targets principal cells of the renal inner medullary collecting duct.

scientific article

Ultrastructural localization of UT-A and UT-B in rat kidneys with different hydration status.

scientific article published on 22 September 2005

Upregulation of Na+ transporter abundances in response to chronic thiazide or loop diuretic treatment in rats

scientific article published on 24 September 2002

Upregulation of renal BSC1 and TSC in prenatally programmed hypertension

scientific article published on 01 July 2002

Urea and renal function in the 21st century: insights from knockout mice ⬇️

scientific article

Urea channel inhibitors: a new functional class of aquaretics

scientific article published on June 2013

Urinary Proteome Analysis Identified Neprilysin and VCAM as Proteins Involved in Diabetic Nephropathy.

scientific article published on 29 April 2018

Urinary concentrating defect in mice with selective deletion of phloretin-sensitive urea transporters in the renal collecting duct

scientific article

Urinary exosomes: is there a future?

scientific article published on 01 March 2008

Use of LC-MS/MS and Bayes' theorem to identify protein kinases that phosphorylate aquaporin-2 at Ser256.

scientific article

VAMP2-dependent exocytosis regulates plasma membrane insertion of TRPC3 channels and contributes to agonist-stimulated Ca2+ influx

scientific article

Vasopressin and the regulation of aquaporin-2

scientific article published on 13 April 2013

Vasopressin increases phosphorylation of Ser84 and Ser486 in Slc14a2 collecting duct urea transporters.

scientific article

Vasopressin inhibits apoptosis in renal collecting duct cells

scientific article published on 7 November 2012

Vasopressin-induced serine 269 phosphorylation reduces Sipa1l1 (signal-induced proliferation-associated 1 like 1)-mediated aquaporin-2 endocytosis.

scientific article published on 23 March 2017

Vasopressin-stimulated increase in phosphorylation at Ser269 potentiates plasma membrane retention of aquaporin-2.

scientific article published on 7 July 2008

Vasopressin: friend or foe?

scientific article published in January 2008

cDNA array identification of genes regulated in rat renal medulla in response to vasopressin infusion

scientific article published on 11 September 2002

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