List of works - Özlem Demir

A Comparative Study of the Structural Dynamics of Four Terminal Uridylyl Transferases

scientific article

APOBEC3B Nuclear Localization Requires two Distinct N-Terminal Domain Surfaces.

scientific article

APOBEC3H Subcellular Localization Determinants Define Zipcode for Targeting HIV-1 for Restriction

scholarly article by Daniel J Salamango published in December 2018

Active site plasticity and possible modes of chemical inhibition of the human DNA deaminase APOBEC3B

scholarly article published 7 January 2019

Active site plasticity and possible modes of chemical inhibition of the human DNA deaminase APOBEC3B

scientific article published on 24 December 2019

Adapting AlphaLISA high throughput screen to discover a novel small-molecule inhibitor targeting protein arginine methyltransferase 5 in pancreatic and colorectal cancers.

scientific article published on 23 May 2017

An integrated view of p53 dynamics, function, and reactivation

scientific article published on 02 January 2021

Computational identification of a transiently open L1/S3 pocket for reactivation of mutant p53

scientific article

Computer-aided discovery of Trypanosoma brucei RNA-editing terminal uridylyl transferase 2 inhibitors

scientific article

Conformational Switch Regulates the DNA Cytosine Deaminase Activity of Human APOBEC3B.

scientific article

Designing novel inhibitors of Trypanosoma brucei

scientific article

Determinants of Oligonucleotide Selectivity of APOBEC3B

scientific article published on 10 September 2018

Development of an AlphaLISA high throughput technique to screen for small molecule inhibitors targeting protein arginine methyltransferases.

scientific article

Dynamics and Molecular Mechanisms of p53 Transcriptional Activation

article

Elements of nucleotide specificity in the Trypanosoma brucei mitochondrial RNA editing enzyme RET2.

scientific article

Ensemble Docking in Drug Discovery

scientific article published on 30 March 2018

Ensemble-based computational approach discriminates functional activity of p53 cancer and rescue mutants

scientific article

Functional and Structural Insights into a Vif/PPP2R5 Complex Elucidated using Patient HIV-1 Isolates and Computational Modeling

scientific article published on 26 August 2020

Modulation of catalytic function by differential plasticity of the active site: case study of Trypanosoma cruzi trans-sialidase and Trypanosoma rangeli sialidase

scientific article published on April 2009

Molecular docking to flexible targets

scientific article

Neolymphostin A is a Covalent Phosphoinositide-3-kinase (PI3-K)/Mammalian Target of Rapamycin (mTOR) Dual Inhibitor that Employs an Unusual Electrophilic Vinylogous Ester

scientific article published on 28 November 2018

Progress towards automated Kepler scientific workflows for computer-aided drug discovery and molecular simulations

scientific article published in January 2014

RNA Editing TUTase 1: structural foundation of substrate recognition, complex interactions and drug targeting

scientific article

Structural basis for targeted DNA cytosine deamination and mutagenesis by APOBEC3A and APOBEC3B.

scientific article published on 19 December 2016

Structure and dynamics of SARS-CoV-2 proofreading exoribonuclease ExoN

scientific article

The Binding Interface between Human APOBEC3F and HIV-1 Vif Elucidated by Genetic and Computational Approaches

scientific article

The local dinucleotide preference of APOBEC3G can be altered from 5'-CC to 5'-TC by a single amino acid substitution.

scientific article published on 11 August 2013

The substrate-binding cap of the UDP-diacylglucosamine pyrophosphatase LpxH is highly flexible, enabling facile substrate binding and product release.

scientific article

Variable ligand- and receptor-binding hot spots in key strains of influenza neuraminidase

scientific article

List of works by Özlem Demir

A Comparative Study of the Structural Dynamics of Four Terminal Uridylyl Transferases

APOBEC3B Nuclear Localization Requires two Distinct N-Terminal Domain Surfaces.

APOBEC3H Subcellular Localization Determinants Define Zipcode for Targeting HIV-1 for Restriction

Active site plasticity and possible modes of chemical inhibition of the human DNA deaminase APOBEC3B

Active site plasticity and possible modes of chemical inhibition of the human DNA deaminase APOBEC3B

Adapting AlphaLISA high throughput screen to discover a novel small-molecule inhibitor targeting protein arginine methyltransferase 5 in pancreatic and colorectal cancers.

An integrated view of p53 dynamics, function, and reactivation

Computational identification of a transiently open L1/S3 pocket for reactivation of mutant p53

Computer-aided discovery of Trypanosoma brucei RNA-editing terminal uridylyl transferase 2 inhibitors

Conformational Switch Regulates the DNA Cytosine Deaminase Activity of Human APOBEC3B.

Designing novel inhibitors of Trypanosoma brucei

Determinants of Oligonucleotide Selectivity of APOBEC3B

Development of an AlphaLISA high throughput technique to screen for small molecule inhibitors targeting protein arginine methyltransferases.

Dynamics and Molecular Mechanisms of p53 Transcriptional Activation

Elements of nucleotide specificity in the Trypanosoma brucei mitochondrial RNA editing enzyme RET2.

Ensemble Docking in Drug Discovery

Ensemble-based computational approach discriminates functional activity of p53 cancer and rescue mutants

Functional and Structural Insights into a Vif/PPP2R5 Complex Elucidated using Patient HIV-1 Isolates and Computational Modeling

Modulation of catalytic function by differential plasticity of the active site: case study of Trypanosoma cruzi trans-sialidase and Trypanosoma rangeli sialidase

Molecular docking to flexible targets

Neolymphostin A is a Covalent Phosphoinositide-3-kinase (PI3-K)/Mammalian Target of Rapamycin (mTOR) Dual Inhibitor that Employs an Unusual Electrophilic Vinylogous Ester

Progress towards automated Kepler scientific workflows for computer-aided drug discovery and molecular simulations

RNA Editing TUTase 1: structural foundation of substrate recognition, complex interactions and drug targeting

Structural basis for targeted DNA cytosine deamination and mutagenesis by APOBEC3A and APOBEC3B.

Structure and dynamics of SARS-CoV-2 proofreading exoribonuclease ExoN

Structure and dynamics of SARS-CoV-2 proofreading exoribonuclease ExoN

The Binding Interface between Human APOBEC3F and HIV-1 Vif Elucidated by Genetic and Computational Approaches

The local dinucleotide preference of APOBEC3G can be altered from 5'-CC to 5'-TC by a single amino acid substitution.

The substrate-binding cap of the UDP-diacylglucosamine pyrophosphatase LpxH is highly flexible, enabling facile substrate binding and product release.

Variable ligand- and receptor-binding hot spots in key strains of influenza neuraminidase