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List of works by Laura M Heiser

A Multi-center Study on the Reproducibility of Drug-Response Assays in Mammalian Cell Lines

scientific article published on 10 July 2019

A central role for RAF→MEK→ERK signaling in the genesis of pancreatic ductal adenocarcinoma.

scientific article

A community computational challenge to predict the activity of pairs of compounds

scientific article

A community effort to assess and improve drug sensitivity prediction algorithms.

scientific article

A multi-center study on factors influencing the reproducibility of in vitro drug-response studies

A multi-encoder variational autoencoder controls multiple transformational features in single-cell image analysis

scientific article published on 23 March 2022

A multi-omic analysis of MCF10A cells provides a resource for integrative assessment of ligand-mediated molecular and phenotypic responses

scientific article published in 2022

A robust prognostic signature for hormone-positive node-negative breast cancer

scientific article published on 11 October 2013

A scalable, open-source implementation of a large-scale mechanistic model for single cell proliferation and death signaling

scientific article published in 2022

A systems analysis of the chemosensitivity of breast cancer cells to the polyamine analogue PG-11047.

scientific article

ATM suppresses SATB1-induced malignant progression in breast epithelial cells

scientific article

Abstract 731: Integrative genomic analysis to identify emergent enzalutamide resistance mechanisms in castration-resistant prostate cancer

article

Activity of distinct growth factor receptor network components in breast tumors uncovers two biologically relevant subtypes

scientific article

An omic and multidimensional spatial atlas from serial biopsies of an evolving metastatic breast cancer

scientific article published on 15 February 2022

Analysis of molecular inversion probe performance for allele copy number determination

scientific article

Annot: a Django-based sample, reagent, and experiment metadata tracking system

scientific article published on 01 November 2019

BET bromodomain inhibition blocks the function of a critical AR-independent master regulator network in lethal prostate cancer

scientific article published on 17 April 2019

Basal subtype and MAPK/ERK kinase (MEK)-phosphoinositide 3-kinase feedback signaling determine susceptibility of breast cancer cells to MEK inhibition

scientific article published on January 2009

Bayesian inference of signaling network topology in a cancer cell line

scientific article

Cabozantinib and dasatinib synergize to induce tumor regression in non-clear cell renal cell carcinoma

scientific article published on 07 May 2021

Cellular androgen content influences enzalutamide agonism of F877L mutant androgen receptor.

scientific article published on 03 June 2016

Combating subclonal evolution of resistant cancer phenotypes

scientific article published in November 2017

Context Specificity in Causal Signaling Networks Revealed by Phosphoprotein Profiling.

scientific article published on 19 December 2016

Correction: Decoupling of the PI3K Pathway via Mutation Necessitates Combinatorial Treatment in HER2+ Breast Cancer

scientific article published on 11 October 2017

Decoupling of the PI3K Pathway via Mutation Necessitates Combinatorial Treatment in HER2+ Breast Cancer

scientific article published on 16 July 2015

Erratum to: Genome co-amplification upregulates a mitotic gene network activity that predicts outcome and response to mitotic protein inhibitors in breast cancer

scientific article published on 9 February 2017

Erratum to: Modeling precision treatment of breast cancer

scientific article published on 12 May 2015

FOXA1 overexpression mediates endocrine resistance by altering the ER transcriptome and IL-8 expression in ER-positive breast cancer

scientific article published on 06 October 2016

Genome co-amplification upregulates a mitotic gene network activity that predicts outcome and response to mitotic protein inhibitors in breast cancer

scientific article published on July 2016

HER2 Reactivation through Acquisition of the HER2 L755S Mutation as a Mechanism of Acquired Resistance to HER2-targeted Therapy in HER2+ Breast Cancer

scientific article

How Machine Learning Will Transform Biomedicine

scientific article published on 01 April 2020

Individual Cells Can Resolve Variations in Stimulus Intensity along the IGF-PI3K-AKT Signaling Axis

scientific article published on 11 December 2019

Inferring causal molecular networks: empirical assessment through a community-based effort

scientific article

Integrated analysis of breast cancer cell lines reveals unique signaling pathways

scientific article published on 25 March 2009

Integrating mathematical modeling with high throughput imaging explains how polyploid populations behave in nutrient-sparse environments

scientific article published on 16 September 2020

Integrative molecular network analysis identifies emergent enzalutamide resistance mechanisms in prostate cancer.

scientific article published on 20 November 2017

LSD1 activates a lethal prostate cancer gene network independently of its demethylase function.

scientific article published on 26 March 2018

Maintenance of MYC expression promotes de novo resistance to BET bromodomain inhibition in castration-resistant prostate cancer

scientific article published on 07 March 2019

Metrics other than potency reveal systematic variation in responses to cancer drugs.

scientific article

Microenvironment-Mediated Mechanisms of Resistance to HER2 Inhibitors Differ between HER2+ Breast Cancer Subtypes.

scientific article published on 14 March 2018

Modeling precision treatment of breast cancer

scientific article published on January 2013

Overcoming endocrine resistance due to reduced PTEN levels in estrogen receptor-positive breast cancer by co-targeting mammalian target of rapamycin, protein kinase B, or mitogen-activated protein kinase kinase.

scientific article

Pathway-Enriched Gene Signature Associated with 53BP1 Response to PARP Inhibition in Triple-Negative Breast Cancer.

scientific article

Publisher Correction: Combating subclonal evolution of resistant cancer phenotypes

scientific article published on 5 February 2018

Quantification of sensitivity and resistance of breast cancer cell lines to anti-cancer drugs using GR metrics

scientific article

Src and STAT3 inhibitors synergize to promote tumor inhibition in renal cell carcinoma

scientific article published on 26 November 2015

Subtype and pathway specific responses to anticancer compounds in breast cancer

scientific article published on 14 October 2011

Targeting the Mevalonate Pathway to Overcome Acquired Anti-HER2 Treatment Resistance in Breast Cancer

scientific article published on 16 August 2019

The Library of Integrated Network-Based Cellular Signatures NIH Program: System-Level Cataloging of Human Cells Response to Perturbations

scientific article published on 24 November 2017

Therapeutic Clues from an Integrated Omic Assessment of East Asian Triple Negative Breast Cancers

article

Transcriptional signatures in histologic structures within glioblastoma tumors may predict personalized drug sensitivity and survival

scientific article published on 01 January 2020

Tumor-Derived Cell Lines as Molecular Models of Cancer Pharmacogenomics

scientific article

Upregulation of ER Signaling as an Adaptive Mechanism of Cell Survival in HER2-Positive Breast Tumors Treated with Anti-HER2 Therapy.

scientific article

Using Microarrays to Interrogate Microenvironmental Impact on Cellular Phenotypes in Cancer

scientific article published on 21 May 2019

Variational Autoencoding Tissue Response to Microenvironment Perturbation

scientific article published on 01 February 2019

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