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List of works by Kevin Eggan

A High-Content Screen Identifies TPP1 and Aurora B as Regulators of Axonal Mitochondrial Transport

scientific article published on 01 September 2019

A perspective on stem cell modeling of amyotrophic lateral sclerosis

scientific article

ALS-implicated protein TDP-43 sustains levels of STMN2, a mediator of motor neuron growth and repair

scientific article published on 14 January 2019

Abnormal gene expression in cloned mice derived from embryonic stem cell and cumulus cell nuclei

scientific article

Absence of Survival and Motor Deficits in 500 Repeat C9ORF72 BAC Mice

scientific article published on 28 September 2020

All-Optical Electrophysiology for High-Throughput Functional Characterization of a Human iPSC-Derived Motor Neuron Model of ALS.

scientific article published on 17 May 2018

C9orf72 suppresses systemic and neural inflammation induced by gut bacteria

scientific article published on 13 May 2020

CAT7 and cat7l Long Non-coding RNAs Tune Polycomb Repressive Complex 1 Function during Human and Zebrafish Development

scientific article published on 12 July 2016

CLP1 links tRNA metabolism to progressive motor-neuron loss

scientific article published on 10 March 2013

Comparative genomic analysis of embryonic, lineage-converted, and stem cell-derived motor neurons

scientific article published on 21 November 2018

Comparison of three congruent patient-specific cell types for the modelling of a human genetic Schwann-cell disorder

scientific article published on 08 April 2019

Comprehensive Protocols for CRISPR/Cas9-based Gene Editing in Human Pluripotent Stem Cells

scientific article published on 17 August 2016

Constructing and Deconstructing Stem Cell Models of Neurological Disease ⬇️

scientific article published on May 26, 2011

Conversion of mouse and human fibroblasts into functional spinal motor neurons

scientific article

Derivation of embryonic germ cells and male gametes from embryonic stem cells

scientific article published on 10 December 2003

Developmental reprogramming after chromosome transfer into mitotic mouse zygotes

scientific article

Digital RNA allelotyping reveals tissue-specific and allele-specific gene expression in human

scientific article published on 20 July 2009

Dipeptide repeat proteins activate a heat shock response found in C9ORF72-ALS/FTLD patients.

scientific article published on 4 July 2018

Directed differentiation and functional maturation of cortical interneurons from human embryonic stem cells

scientific article published on May 2013

Dnmt1 overexpression causes genomic hypermethylation, loss of imprinting, and embryonic lethality

scientific article

Dysregulated protocadherin-pathway activity as an intrinsic defect in induced pluripotent stem cell-derived cortical interneurons from subjects with schizophrenia

scientific article published on 21 January 2019

Effect of Ezogabine on Cortical and Spinal Motor Neuron Excitability in Amyotrophic Lateral Sclerosis: A Randomized Clinical Trial

scientific article published on 23 November 2020

Efficient CRISPR-Cas9-mediated generation of knockin human pluripotent stem cells lacking undesired mutations at the targeted locus

scientific article published on 30 April 2015

Exome sequencing in amyotrophic lateral sclerosis implicates a novel gene, DNAJC7, encoding a heat-shock protein

scientific article published on 25 November 2019

FUS is sequestered in nuclear aggregates in ALS patient fibroblasts

scientific article

Flp recombinase regulated lacZ expression at the ROSA26 locus

scientific article published on 01 February 2002

From Dish to Bedside: Lessons Learned While Translating Findings from a Stem Cell Model of Disease to a Clinical Trial

scientific article

Generation of a Motor Nerve Organoid with Human Stem Cell-Derived Neurons

scientific article published on 16 October 2017

Generation of neuropeptidergic hypothalamic neurons from human pluripotent stem cells

scientific article

Genetic validation of a therapeutic target in a mouse model of ALS.

scientific article published in August 2014

Genoppi is an open-source software for robust and standardized integration of proteomic and genetic data

scientific article published on 10 May 2021

How to make spinal motor neurons

scientific article

Human embryonic stem cell-derived motor neurons are sensitive to the toxic effect of glial cells carrying an ALS-causing mutation

scientific article

Impracticality of Egg Donor Recruitment in the Absence of Compensation ⬇️

scientific article published on October 4, 2011

Incomplete reactivation of Oct4-related genes in mouse embryos cloned from somatic nuclei

scientific article published in April 2003

Intrinsic membrane hyperexcitability of amyotrophic lateral sclerosis patient-derived motor neurons

scientific article published on 3 April 2014

Loss-of-function mutations in the C9ORF72 mouse ortholog cause fatal autoimmune disease

scientific article

Male and female mice derived from the same embryonic stem cell clone by tetraploid embryo complementation

scientific article

Mediators of reprogramming: transcription factors and transitions through mitosis

scientific article published on July 2008

Mice cloned from olfactory sensory neurons

scientific article

Micromanipulating dosage compensation: understanding X-chromosome inactivation through nuclear transplantation

scientific article published on December 2003

Modeling human disease with pluripotent stem cells: from genome association to function.

scientific article published in June 2013

Molecularly cleavable bioinks facilitate high-performance digital light processing-based bioprinting of functional volumetric soft tissues

scientific article published in 2022

Monitoring peripheral nerve degeneration in ALS by label-free stimulated Raman scattering imaging

scientific article

Nanog-independent reprogramming to iPSCs with canonical factors

scientific article published on 31 January 2014

Nuclear Cloning, Epigenetic Reprogramming and Cellular Differentiation

Nuclear cloning, epigenetic reprogramming and cellular differentiation.

scientific article

Nuclear cloning, stem cells, and genomic reprogramming

scientific article

Opportunities and challenges of pluripotent stem cell neurodegenerative disease models

scientific article

Optimal timing of inner cell mass isolation increases the efficiency of human embryonic stem cell derivation and allows generation of sibling cell lines

scientific article published in February 2009

Pathways disrupted in human ALS motor neurons identified through genetic correction of mutant SOD1.

scientific article

Progress toward the clinical application of patient-specific pluripotent stem cells

scientific article

Publisher Correction: Exome sequencing in amyotrophic lateral sclerosis implicates a novel gene, DNAJC7, encoding a heat-shock protein

scientific article published on 01 February 2020

Recipient cell nuclear factors are required for reprogramming by nuclear transfer

scientific article

Reprogramming within hours following nuclear transfer into mouse but not human zygotes ⬇️

scientific article published on October 4, 2011

SLC52A3, A Brown-Vialetto-van Laere syndrome candidate gene is essential for mouse development, but dispensable for motor neuron differentiation

scientific article published on 13 March 2016

Shushing down the epigenetic landscape towards stem cell differentiation

scientific article published on 16 June 2010

Somatic coding mutations in human induced pluripotent stem cells

scientific article (publication date: 3 March 2011)

Targeted bisulfite sequencing reveals changes in DNA methylation associated with nuclear reprogramming

scientific article

The C9orf72-interacting protein Smcr8 is a negative regulator of autoimmunity and lysosomal exocytosis

scientific article published on 27 June 2018

The mouse C9ORF72 ortholog is enriched in neurons known to degenerate in ALS and FTD.

scientific article

The role of maternal-specific H3K9me3 modification in establishing imprinted X-chromosome inactivation and embryogenesis in mice

scientific article

Two familial ALS proteins function in prevention/repair of transcription-associated DNA damage

scientific article

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