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List of works by Benjamin L. Ebert

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Gene set enrichment analysis: a knowledge-based approach for interpreting genome-wide expression profiles

scientific article
MicroRNA expression profiles classify human cancers

scientific article (publication date: 9 June 2005)
The landscape of somatic copy-number alteration across human cancers

scientific article
Activating mutation in the tyrosine kinase JAK2 in polycythemia vera, essential thrombocythemia, and myeloid metaplasia with myelofibrosis

scientific article (publication date: April 2005)
Age-related clonal hematopoiesis associated with adverse outcomes

scientific article
Diagnosis and management of AML in adults: 2017 ELN recommendations from an international expert panel

scientific article
Clinical effect of point mutations in myelodysplastic syndromes

scientific article
MPLW515L is a novel somatic activating mutation in myelofibrosis with myeloid metaplasia

scientific article
Rational design of highly active sgRNAs for CRISPR-Cas9-mediated gene inactivation.

scientific article
Bone progenitor dysfunction induces myelodysplasia and secondary leukaemia.

scientific article
Densely interconnected transcriptional circuits control cell states in human hematopoiesis

scientific article
Stem cell gene expression programs influence clinical outcome in human leukemia.

scientific article published on 28 August 2011
Identification of RPS14 as a 5q- syndrome gene by RNA interference screen

scientific article
Lenalidomide Causes Selective Degradation of IKZF1 and IKZF3 in Multiple Myeloma Cells

scientific article published on November 29, 2013
Clonal hematopoiesis of indeterminate potential and its distinction from myelodysplastic syndromes

scientific article published on April 30, 2015
Ribosomopathies: human disorders of ribosome dysfunction

scientific article published on April 22, 2010
Genetic characterization of TET1, TET2, and TET3 alterations in myeloid malignancies

scientific article
( R )-2-Hydroxyglutarate Is Sufficient to Promote Leukemogenesis and Its Effects Are Reversible

scientific article published on 07 February 2013
Perivascular Gli1+ progenitors are key contributors to injury-induced organ fibrosis.

scientific article
TET2 mutations predict response to hypomethylating agents in myelodysplastic syndrome patients

scientific article
Validation of a prognostic model and the impact of mutations in patients with lower-risk myelodysplastic syndromes

scientific article
Transcriptional analysis of HIV-specific CD8+ T cells shows that PD-1 inhibits T cell function by upregulating BATF

scientific article published on 3 October 2010
Haploinsufficiency for ribosomal protein genes causes selective activation of p53 in human erythroid progenitor cells

scientific article
MicroRNA-mediated control of cell fate in megakaryocyte-erythrocyte progenitors

scientific article
Acute myeloid leukemia ontogeny is defined by distinct somatic mutations

scientific article
Lenalidomide induces ubiquitination and degradation of CK1α in del(5q) MDS.

scientific article
Physiological Jak2V617F expression causes a lethal myeloproliferative neoplasm with differential effects on hematopoietic stem and progenitor cells

scientific article published on June 2010
Generation of mouse models of myeloid malignancy with combinatorial genetic lesions using CRISPR-Cas9 genome editing

scientific article published on June 22, 2014
A germline JAK2 SNP is associated with predisposition to the development of JAK2(V617F)-positive myeloproliferative neoplasms

scientific article
Correction of sickle cell disease in adult mice by interference with fetal hemoglobin silencing

scientific article published on 13 October 2011
Musashi-2 regulates normal hematopoiesis and promotes aggressive myeloid leukemia

scientific article
Single-cell RNA-seq reveals changes in cell cycle and differentiation programs upon aging of hematopoietic stem cells

scientific article
The STAT5 inhibitor pimozide decreases survival of chronic myelogenous leukemia cells resistant to kinase inhibitors

scientific article published on January 13, 2011
Unraveling the Molecular Pathophysiology of Myelodysplastic Syndromes

scientific article published on January 10, 2011
Heterodimeric JAK-STAT activation as a mechanism of persistence to JAK2 inhibitor therapy

scientific article published on September 2012
Integrated genomic analysis illustrates the central role of JAK-STAT pathway activation in myeloproliferative neoplasm pathogenesis

scientific article
Somatic mutations predict poor outcome in patients with myelodysplastic syndrome after hematopoietic stem-cell transplantation

scientific article
Regulation of Transcription by Hypoxia Requires a Multiprotein Complex That Includes Hypoxia-Inducible Factor 1, an Adjacent Transcription Factor, and p300/CREB Binding Protein

scientific article published on July 1, 1998
Prognostic Mutations in Myelodysplastic Syndrome after Stem-Cell Transplantation

scientific article published on February 2017
Human tumors instigate granulin-expressing hematopoietic cells that promote malignancy by activating stromal fibroblasts in mice

scientific article
The genetics of myelodysplastic syndrome: from clonal haematopoiesis to secondary leukaemia

scientific article
Small-molecule inhibitors of HIF-2a translation link its 5'UTR iron-responsive element to oxygen sensing

scientific article
Macrophages support pathological erythropoiesis in polycythemia vera and β-thalassemia

scientific article published on 17 March 2013
Identification of driver and passenger mutations of FLT3 by high-throughput DNA sequence analysis and functional assessment of candidate alleles

scientific article published in December 2007
Mutations in epigenetic regulators including SETD2 are gained during relapse in paediatric acute lymphoblastic leukaemia

scientific article
Chemical genetic strategy identifies histone deacetylase 1 (HDAC1) and HDAC2 as therapeutic targets in sickle cell disease

scientific article
Physiologic Expression of Sf3b1(K700E) Causes Impaired Erythropoiesis, Aberrant Splicing, and Sensitivity to Therapeutic Spliceosome Modulation.

scientific article published on September 2016
Metagene projection for cross-platform, cross-species characterization of global transcriptional states

scholarly article
L-Leucine improves the anemia and developmental defects associated with Diamond-Blackfan anemia and del(5q) MDS by activating the mTOR pathway.

scientific article
An erythroid differentiation signature predicts response to lenalidomide in myelodysplastic syndrome

scientific article

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