List of works - Gregory B Melikyan

A Novel Phenotype Links HIV-1 Capsid Stability to cGAS-Mediated DNA Sensing

scientific article published on 30 July 2019

An improved labeling strategy enables automated detection of single-virus fusion and assessment of HIV-1 protease activity in single virions

scientific article published on 18 October 2017

Anionic lipids are required for vesicular stomatitis virus G protein-mediated single particle fusion with supported lipid bilayers

scientific article published on 14 March 2013

Can HIV-1 entry sites be deduced by comparing bulk endocytosis to functional readouts for viral fusion?

scientific article published in March 2015

Click labeling of unnatural sugars metabolically incorporated into viral envelope glycoproteins enables visualization of single particle fusion

scientific article published on 28 March 2016

Common principles and intermediates of viral protein-mediated fusion: the HIV-1 paradigm

scientific article published on 10 December 2008

Correlated fluorescence microscopy and cryo-electron tomography of virus-infected or transfected mammalian cells

scientific article (publication date: 15 December 2016)

Distinct requirements for HIV-cell fusion and HIV-mediated cell-cell fusion.

scientific article

Driving a wedge between viral lipids blocks infection ⬇️

scientific article published on September 27, 2010

Early steps of HIV-1 fusion define the sensitivity to inhibitory peptides that block 6-helix bundle formation

scientific article

Exploring Modifications of an HIV-1 Capsid Inhibitor: Design, Synthesis, and Mechanism of Action

article

Facile autofluorescence suppression enabling tracking of single viruses in live cells

scientific article published on 06 November 2019

Fluorescent protein-tagged Vpr dissociates from HIV-1 core after viral fusion and rapidly enters the cell nucleus

scientific article

Fusion Stage of HIV-1 Entry Depends on Virus-Induced Cell Surface Exposure of Phosphatidylserine

scientific article published on July 2017

Fusion of mature HIV-1 particles leads to complete release of a gag-GFP-based content marker and raises the intraviral pH

scientific article (publication date: 2013)

HIV enters cells via endocytosis and dynamin-dependent fusion with endosomes

scientific article

HIV entry: a game of hide-and-fuse?

scientific article

HIV-1 Fusion with CD4+ T cells Is Promoted by Proteins Involved in Endocytosis and Intracellular Membrane Trafficking

article

HIV-1 Uncoating and Nuclear Import Precede the Completion of Reverse Transcription in Cell Lines and in Primary Macrophages

scientific article published on 30 October 2020

HIV-1 integrase tetramers are the antiviral target of pyridine-based allosteric integrase inhibitors.

scientific article published on 23 May 2019

HIV-1 replication complexes accumulate in nuclear speckles and integrate into speckle-associated genomic domains

scientific article published on 14 July 2020

Hepatitis C virus is primed by CD81 protein for low pH-dependent fusion ⬇️

scientific article

High-Throughput HIV-Cell Fusion Assay for Discovery of Virus Entry Inhibitors

scientific article published on 14 April 2015

How entry inhibitors synergize to fight HIV.

scientific article published on October 2017

IFITM3 restricts influenza A virus entry by blocking the formation of fusion pores following virus-endosome hemifusion

scientific article

Imaging Single Retrovirus Entry through Alternative Receptor Isoforms and Intermediates of Virus-Endosome Fusion ⬇️

scientific article published on January 20, 2011

Imaging individual retroviral fusion events: from hemifusion to pore formation and growth

scientific article

Induction of Cell-Cell Fusion by Ebola Virus Glycoprotein: Low pH Is Not a Trigger

scientific article

Inhibition of HIV-1 endocytosis allows lipid mixing at the plasma membrane, but not complete fusion.

scientific article

Inhibition of human immunodeficiency virus type 1 entry in cells expressing gp41-derived peptides

scientific article published on January 2004

Intercellular Adhesion Molecule 1 Promotes HIV-1 Attachment but Not Fusion to Target Cells ⬇️

scientific article published on September 6, 2012

Interferon-Induced Transmembrane Protein 3 Blocks Fusion of Diverse Enveloped Viruses by Altering Mechanical Properties of Cell Membranes

scientific article published on 25 May 2021

Interferon-Induced Transmembrane Protein 3 Blocks Fusion of Diverse Enveloped Viruses by Locally Altering Mechanical Properties of Cell Membranes

scientific article published on 27 June 2020

Interferon-induced transmembrane protein 3 blocks fusion of sensitive but not resistant viruses by partitioning into virus-carrying endosomes

scientific article published on 14 January 2019

Live-Cell Imaging of Early Steps of Single HIV-1 Infection.

scientific article published on 19 May 2018

Localization and functions of native and eGFP-tagged capsid proteins in HIV-1 particles

scientific article published in 2022

Membrane Fusion Mediated by Human Immunodeficiency Virus Envelope Glycoprotein

scientific article published on January 1, 2011

Membrane-anchored inhibitory peptides capture human immunodeficiency virus type 1 gp41 conformations that engage the target membrane prior to fusion

scientific article published on April 2006

Multifaceted mechanisms of HIV-1 entry inhibition by human α-defensin

scientific article

P2X1 Receptor Antagonists Inhibit HIV-1 Fusion by Blocking Virus-Coreceptor Interactions

scientific article

Pinpointing retrovirus entry sites in cells expressing alternatively spliced receptor isoforms by single virus imaging

scientific article

Publisher Correction: HIV-1 replication complexes accumulate in nuclear speckles and integrate into speckle-associated genomic domains

scientific article published on 26 November 2020

Quantitative imaging of endosome acidification and single retrovirus fusion with distinct pools of early endosomes

scientific article

Rapamycin reduces CCR5 density levels on CD4 T cells, and this effect results in potentiation of enfuvirtide (T-20) against R5 strains of human immunodeficiency virus type 1 in vitro

scientific article published on 7 May 2007

Reduction of CCR5 with low-dose rapamycin enhances the antiviral activity of vicriviroc against both sensitive and drug-resistant HIV-1.

scholarly article

SERINC5 protein inhibits HIV-1 fusion pore formation by promoting functional inactivation of envelope glycoproteins.

scientific article

Screening and Functional Profiling of Small-Molecule HIV-1 Entry and Fusion Inhibitors

scientific article

Sec24C is an HIV-1 host dependency factor crucial for virus replication

scientific article published on 01 March 2021

Siglec-1 initiates formation of the virus-containing compartment and enhances macrophage-to-T cell transmission of HIV-1.

scientific article

Single HIV-1 Imaging Reveals Progression of Infection through CA-Dependent Steps of Docking at the Nuclear Pore, Uncoating, and Nuclear Transport

article

Structural and mechanistic bases for a potent HIV-1 capsid inhibitor

scientific article

Sub-inhibitory concentrations of human α-defensin potentiate neutralizing antibodies against HIV-1 gp41 pre-hairpin intermediates in the presence of serum

scientific article

Super-Resolution Fluorescence Imaging Reveals That Serine Incorporator Protein 5 Inhibits Human Immunodeficiency Virus Fusion by Disrupting Envelope Glycoprotein Clusters

scientific article published on 22 May 2020

Synchronized retrovirus fusion in cells expressing alternative receptor isoforms releases the viral core into distinct sub-cellular compartments

scientific article

Ternary complex formation of human immunodeficiency virus type 1 Env, CD4, and chemokine receptor captured as an intermediate of membrane fusion

scientific article published on September 2005

The role of the N-terminal segment of CCR5 in HIV-1 Env-mediated membrane fusion and the mechanism of virus adaptation to CCR5 lacking this segment

scientific article published on 8 August 2007

Time-Resolved Imaging of Single HIV-1 Uncoating In Vitro and in Living Cells

scientific article (publication date: June 2016)

Visualization of Content Release from Cell Surface-Attached Single HIV-1 Particles Carrying an Extra-Viral Fluorescent pH-Sensor

scientific article (publication date: 2016)

Visualization of retrovirus uptake and delivery into acidic endosomes ⬇️

scientific article published on March 15, 2011

pH regulation in early endosomes and interferon-inducible transmembrane proteins control avian retrovirus fusion

scientific article

List of works by Gregory B Melikyan

A Novel Phenotype Links HIV-1 Capsid Stability to cGAS-Mediated DNA Sensing

An improved labeling strategy enables automated detection of single-virus fusion and assessment of HIV-1 protease activity in single virions

Anionic lipids are required for vesicular stomatitis virus G protein-mediated single particle fusion with supported lipid bilayers

Can HIV-1 entry sites be deduced by comparing bulk endocytosis to functional readouts for viral fusion?

Click labeling of unnatural sugars metabolically incorporated into viral envelope glycoproteins enables visualization of single particle fusion

Common principles and intermediates of viral protein-mediated fusion: the HIV-1 paradigm

Correlated fluorescence microscopy and cryo-electron tomography of virus-infected or transfected mammalian cells

Distinct requirements for HIV-cell fusion and HIV-mediated cell-cell fusion.

Driving a wedge between viral lipids blocks infection ⬇️

Early steps of HIV-1 fusion define the sensitivity to inhibitory peptides that block 6-helix bundle formation

Exploring Modifications of an HIV-1 Capsid Inhibitor: Design, Synthesis, and Mechanism of Action

Facile autofluorescence suppression enabling tracking of single viruses in live cells

Fluorescent protein-tagged Vpr dissociates from HIV-1 core after viral fusion and rapidly enters the cell nucleus

Fusion Stage of HIV-1 Entry Depends on Virus-Induced Cell Surface Exposure of Phosphatidylserine

Fusion of mature HIV-1 particles leads to complete release of a gag-GFP-based content marker and raises the intraviral pH

HIV enters cells via endocytosis and dynamin-dependent fusion with endosomes

HIV entry: a game of hide-and-fuse?

HIV-1 Fusion with CD4+ T cells Is Promoted by Proteins Involved in Endocytosis and Intracellular Membrane Trafficking

HIV-1 Uncoating and Nuclear Import Precede the Completion of Reverse Transcription in Cell Lines and in Primary Macrophages

HIV-1 integrase tetramers are the antiviral target of pyridine-based allosteric integrase inhibitors.

HIV-1 replication complexes accumulate in nuclear speckles and integrate into speckle-associated genomic domains

Hepatitis C virus is primed by CD81 protein for low pH-dependent fusion ⬇️

High-Throughput HIV-Cell Fusion Assay for Discovery of Virus Entry Inhibitors

How entry inhibitors synergize to fight HIV.

IFITM3 restricts influenza A virus entry by blocking the formation of fusion pores following virus-endosome hemifusion

Imaging Single Retrovirus Entry through Alternative Receptor Isoforms and Intermediates of Virus-Endosome Fusion ⬇️

Imaging individual retroviral fusion events: from hemifusion to pore formation and growth

Induction of Cell-Cell Fusion by Ebola Virus Glycoprotein: Low pH Is Not a Trigger

Inhibition of HIV-1 endocytosis allows lipid mixing at the plasma membrane, but not complete fusion.

Inhibition of human immunodeficiency virus type 1 entry in cells expressing gp41-derived peptides

Intercellular Adhesion Molecule 1 Promotes HIV-1 Attachment but Not Fusion to Target Cells ⬇️

Interferon-Induced Transmembrane Protein 3 Blocks Fusion of Diverse Enveloped Viruses by Altering Mechanical Properties of Cell Membranes

Interferon-Induced Transmembrane Protein 3 Blocks Fusion of Diverse Enveloped Viruses by Locally Altering Mechanical Properties of Cell Membranes

Interferon-induced transmembrane protein 3 blocks fusion of sensitive but not resistant viruses by partitioning into virus-carrying endosomes

Live-Cell Imaging of Early Steps of Single HIV-1 Infection.

Localization and functions of native and eGFP-tagged capsid proteins in HIV-1 particles

Membrane Fusion Mediated by Human Immunodeficiency Virus Envelope Glycoprotein

Membrane-anchored inhibitory peptides capture human immunodeficiency virus type 1 gp41 conformations that engage the target membrane prior to fusion

Multifaceted mechanisms of HIV-1 entry inhibition by human α-defensin

P2X1 Receptor Antagonists Inhibit HIV-1 Fusion by Blocking Virus-Coreceptor Interactions

Pinpointing retrovirus entry sites in cells expressing alternatively spliced receptor isoforms by single virus imaging

Publisher Correction: HIV-1 replication complexes accumulate in nuclear speckles and integrate into speckle-associated genomic domains

Quantitative imaging of endosome acidification and single retrovirus fusion with distinct pools of early endosomes

Rapamycin reduces CCR5 density levels on CD4 T cells, and this effect results in potentiation of enfuvirtide (T-20) against R5 strains of human immunodeficiency virus type 1 in vitro

Reduction of CCR5 with low-dose rapamycin enhances the antiviral activity of vicriviroc against both sensitive and drug-resistant HIV-1.

SERINC5 protein inhibits HIV-1 fusion pore formation by promoting functional inactivation of envelope glycoproteins.

Screening and Functional Profiling of Small-Molecule HIV-1 Entry and Fusion Inhibitors

Sec24C is an HIV-1 host dependency factor crucial for virus replication

Siglec-1 initiates formation of the virus-containing compartment and enhances macrophage-to-T cell transmission of HIV-1.

Single HIV-1 Imaging Reveals Progression of Infection through CA-Dependent Steps of Docking at the Nuclear Pore, Uncoating, and Nuclear Transport

Structural and mechanistic bases for a potent HIV-1 capsid inhibitor

Sub-inhibitory concentrations of human α-defensin potentiate neutralizing antibodies against HIV-1 gp41 pre-hairpin intermediates in the presence of serum

Super-Resolution Fluorescence Imaging Reveals That Serine Incorporator Protein 5 Inhibits Human Immunodeficiency Virus Fusion by Disrupting Envelope Glycoprotein Clusters

Synchronized retrovirus fusion in cells expressing alternative receptor isoforms releases the viral core into distinct sub-cellular compartments

Ternary complex formation of human immunodeficiency virus type 1 Env, CD4, and chemokine receptor captured as an intermediate of membrane fusion

The role of the N-terminal segment of CCR5 in HIV-1 Env-mediated membrane fusion and the mechanism of virus adaptation to CCR5 lacking this segment

Time-Resolved Imaging of Single HIV-1 Uncoating In Vitro and in Living Cells

Visualization of Content Release from Cell Surface-Attached Single HIV-1 Particles Carrying an Extra-Viral Fluorescent pH-Sensor

Visualization of retrovirus uptake and delivery into acidic endosomes ⬇️

pH regulation in early endosomes and interferon-inducible transmembrane proteins control avian retrovirus fusion