List of works by Jean-Pierre Changeux

14-3-3 gamma associates with muscle specific kinase and regulates synaptic gene transcription at vertebrate neuromuscular synapse

scientific journal article

35 Nicotinic receptors (nAChR) in the brain : Gene expression and contribution to learning and aging processes

article

50 years of allosteric interactions: the twists and turns of the models

scientific article published on 23 October 2013

50th anniversary of the word "allosteric".

scientific article published on 10 June 2011

A chimera encoding the fusion of an acetylcholine-binding protein to an ion channel is stabilized in a state close to the desensitized form of ligand-gated ion channels

scientific article published in March 2005

A gating mechanism of pentameric ligand-gated ion channels

scientific article published on 16 September 2013

A neuronal model of predictive coding accounting for the mismatch negativity.

scientific article published on March 2012

A neuronal network model linking subjective reports and objective physiological data during conscious perception

scientific article

A nicotinic hypothesis for Covid-19 with preventive and therapeutic implications

scientific article published on 05 June 2020

A non-radioactive ligand-binding assay for detection of cyanobacterial anatoxins using Torpedo electrocyte membranes

scientific article published on 29 May 2008

A prokaryotic proton-gated ion channel from the nicotinic acetylcholine receptor family

scientific article published on 10 December 2006

A strategy for designing allosteric modulators of transcription factor dimerization

scientific article published on 17 January 2020

A theory of the epigenesis of neuronal networks by selective stabilization of synapses

scientific article

A versatile system for the neuronal subtype specific expression of lentiviral vectors

scientific article published on 26 October 2009

Abnormal functional organization in the dorsal lateral geniculate nucleus of mice lacking the beta 2 subunit of the nicotinic acetylcholine receptor

scientific journal article

Abnormal response of dopaminergic neurons to nicotine without perturbation of nicotinic receptors in alphaCGRP knock-out mice

scientific article published on 27 June 2008

Acquisition and performance of delayed-response tasks: a neural network model.

scientific article published in September 2004

Allosteric Modulation as a Unifying Mechanism for Receptor Function and Regulation

scientific article

Allosteric interactions in aspartate transcarbamylase. 3. Interpretation of experimental data in terms of the model of Monod, Wyman, and Changeux

scientific article

Allosteric mechanisms of signal transduction

scientific article

Allosteric modulation as a unifying mechanism for receptor function and regulation.

scientific article published in September 2017

Allosteric receptors: from electric organ to cognition

scientific article published on January 2010

Allosteric regulation of pentameric ligand-gated ion channels: an emerging mechanistic perspective

scientific article

Allosteric transitions of Torpedo acetylcholine receptor in lipids, detergent and amphipols: molecular interactions vs. physical constraints.

scientific article published in September 2002

Allostery and the Monod-Wyman-Changeux model after 50 years

scientific article published on 06 January 2012

Allostery in Its Many Disguises: From Theory to Applications

scientific article published on 07 February 2019

Alpha7-nicotinic receptors modulate nicotine-induced reinforcement and extracellular dopamine outflow in the mesolimbic system in mice.

scientific article published on 8 September 2011

Alterations of cortical pyramidal neurons in mice lacking high-affinity nicotinic receptors

scientific article

Altered map of visual space in the superior colliculus of mice lacking early retinal waves.

scientific article published in July 2005

Altered paralimbic interaction in behavioral addiction

scientific article published on 4 March 2013

An H-bond between two residues from different loops of the acetylcholine binding site contributes to the activation mechanism of nicotinic receptors ⬇️

scientific article published on May 1, 2003

An extracellular protein microdomain controls up-regulation of neuronal nicotinic acetylcholine receptors by nicotine

scientific journal article

An in vitro study of the sub‐cellular distribution of nicotinic receptors ⬇️

scientific article published on September 1, 2003

Analysis of the cellular expression pattern of beta-CGRP in alpha-CGRP-deficient mice

scientific article published in August 2004

Anti-COVID-19 efficacy of ivermectin in the golden hamster

scientific article

Antibodies against extracellular domains of α4 and α7 subunits alter the levels of nicotinic receptors in the mouse brain and affect memory: possible relevance to Alzheimer's pathology.

scientific article published in January 2011

Attention-deficit/hyperactivity disorder: a plausible mouse model?

scientific article

Attenuation of clinical and immunological outcomes during SARS-CoV-2 infection by ivermectin

scientific article published on 12 July 2021

Basic consciousness of the newborn

scientific article

Behavioral sequence analysis reveals a novel role for beta2* nicotinic receptors in exploration

scientific article

Beta2-containing nicotinic receptors contribute to the organization of sleep and regulate putative micro-arousals in mice

scientific journal article

Biased Allostery

scientific article

Biosynthesis of riboflavin: 6,7-dimethyl-8-ribityllumazine synthase of Schizosaccharomyces pombe

scientific article published in January 2002

Bradykinin Induces TRPV1 Exocytotic Recruitment in Peptidergic Nociceptors.

scientific article published on 23 June 2016

Brain nicotinic receptors: structure and regulation, role in learning and reinforcement1Published on the World Wide Web on 24 October 1997.1

scholarly article by Jean-Pierre Changeux et al published May 1998 in Brain Research Reviews

Chronic nicotine exposure has dissociable behavioural effects on control and beta2-/- mice.

scientific article published on 8 July 2008

Clarifying consciousness

scientific article published in Nature

Climbing Brain Levels of Organisation from Genes to Consciousness

scientific article published on February 2017

Comparison of embryonic and adult torpedo acetylcholine receptor by sedimentation characteristics and antigenicity

scientific article

Conformational selection or induced fit? 50 years of debate resolved

scientific article

Conscious Processing and the Global Neuronal Workspace Hypothesis

scientific article published on 01 March 2020

Conscious, preconscious, and subliminal processing: a testable taxonomy

scientific article

Crucial role of alpha4 and alpha6 nicotinic acetylcholine receptor subunits from ventral tegmental area in systemic nicotine self-administration

scientific article

Crystal structures of a pentameric ligand-gated ion channel provide a mechanism for activation

scientific article

Deciding between conflicting motivations: what mice make of their prefrontal cortex.

scientific article published on 18 November 2011

Development of elementary numerical abilities: a neuronal model

scientific article

Discovery of the First Neurotransmitter Receptor: The Acetylcholine Nicotinic Receptor

scientific article published on 03 April 2020

Distinct contributions of nicotinic acetylcholine receptor subunit alpha4 and subunit alpha6 to the reinforcing effects of nicotine

scientific article

Distinct subcellular targeting of fluorescent nicotinic alpha 3 beta 4 and serotoninergic 5-HT3A receptors in hippocampal neurons

scientific article published on February 2004

Distribution and pharmacology of alpha 6-containing nicotinic acetylcholine receptors analyzed with mutant mice

scientific journal article

Do Nicotinic Receptors Modulate High-Order Cognitive Processing?

scientific article published on 23 June 2020

Docking of alpha-cobratoxin suggests a basal conformation of the nicotinic receptor

scientific article

Drug Addiction: From Neuroscience to Ethics

Electron microscopic evidence for nucleation and growth of 3D acetylcholine receptor microcrystals in structured lipid-detergent matrices

scientific article

Emergent pharmacology of conscious experience: new perspectives in substance addiction

scientific article published on July 2011

Executive and social behaviors under nicotinic receptor regulation

scientific journal article

Experimental and theoretical approaches to conscious processing

scientific article

Experimentally based model of a complex between a snake toxin and the alpha 7 nicotinic receptor

scientific article

Expression of mutant Ets protein at the neuromuscular synapse causes alterations in morphology and gene expression

scientific article

Feature Article: A Connectomic Hypothesis for the Hominization of the Brain

scientific article published on 26 December 2020

Functional nicotinic acetylcholine receptors are expressed in B lymphocyte-derived cell lines

scientific article published in October 2003

Functional organization and conformational dynamics of the nicotinic receptor: a plausible structural interpretation of myasthenic mutations

scientific article published on January 2008

Golden Anniversary of the Nicotinic Receptor

scientific article published on 01 July 2020

Heterogeneity and selective targeting of neuronal nicotinic acetylcholine receptor (nAChR) subtypes expressed on retinal afferents of the superior colliculus and lateral geniculate nucleus: identification of a new native nAChR subtype alpha3beta2(al

scientific article published on 27 July 2005

Hierarchical control of dopamine neuron-firing patterns by nicotinic receptors

scientific journal article

Historical perspective: An INTERVIEW WITH JEAN-PIERRE CHANGEUX by Ernesto Carafoli

scientific article

Identification of two critical residues within the Cys-loop sequence that determine fast-gating kinetics in a pentameric ligand-gated ion channel

scientific article published on 01 January 2006

Immunoreactive Calcitonin Gene-Related Peptide, Vasoactive Intestinal Polypeptide, and Somatostatin in Developing Chicken Spinal Cord Motoneurons

scientific article published on 01 May 1989

Implications of the quaternary twist allosteric model for the physiology and pathology of nicotinic acetylcholine receptors

scholarly article

In vitro excitation of purified membrane fragments by cholinergic agonists : IV. Ultrastructure, at high resolution, of the AcChE-Rich and ATPase-rich microsacs

scientific article

Inhibition of both alpha7* and beta2* nicotinic acetylcholine receptors is necessary to prevent development of sensitization to cocaine-elicited increases in extracellular dopamine levels in the ventral striatum

scientific article

Intermediate closed state for glycine receptor function revealed by cysteine cross-linking

scientific article published on October 2013

International Union of Basic and Clinical Pharmacology. XC. multisite pharmacology: recommendations for the nomenclature of receptor allosterism and allosteric ligands.

scientific article

Interplay of beta2* nicotinic receptors and dopamine pathways in the control of spontaneous locomotion

scientific article

Intracellular complexes of the beta2 subunit of the nicotinic acetylcholine receptor in brain identified by proteomics

scientific article

Introducing the Human Brain Project

Jean-Pierre Changeux: allostery as neuro-enlightenment

scientific article published in April 2009

Knockout and knockin mice to investigate the role of nicotinic receptors in the central nervous system

scientific article published on January 2004

Les années 2000

Live imaging of neural structure and function by fibred fluorescence microscopy

scientific article

Localization of [3H]nicotine, [3H]cytisine, [3H]epibatidine, and [125I]alpha-bungarotoxin binding sites in the brain of Macaca mulatta

scientific article published in June 2003

Long-term effects of chronic nicotine exposure on brain nicotinic receptors

scientific journal article

Long-term exposure to nicotine modulates the level and activity of acetylcholine receptors in white blood cells of smokers and model mice

scientific article

Loss of high-affinity nicotinic receptors increases the vulnerability to excitotoxic lesion and decreases the positive effects of an enriched environment

scientific article

Mechanism of Cl- selection by a glutamate-gated chloride (GluCl) receptor revealed through mutations in the selectivity filter

scientific article published on 09 March 2006

Models of the extracellular domain of the nicotinic receptors and of agonist- and Ca2+-binding sites

scientific article

Modulation of the mouse prefrontal cortex activation by neuronal nicotinic receptors during novelty exploration but not by exploration of a familiar environment

scientific article published in August 2011

Molecular evolution of the nicotinic acetylcholine receptor: an example of multigene family in excitable cells

scientific article

Molecular tuning of fast gating in pentameric ligand-gated ion channels

scientific article

Monitoring protein interactions in the living cell through the fluorescence decays of the cyan fluorescent protein

scientific article published on July 2006

Monoamine oxidase inhibitors allow locomotor and rewarding responses to nicotine.

scientific article published on 14 December 2005

Neuronal man: the biology of mind

book published in 1997

Neuronal nicotinic receptor alpha 6 subunit mRNA is selectively concentrated in catecholaminergic nuclei of the rat brain

scientific article

Nicotine activates immature "silent" connections in the developing hippocampus

scholarly article

Nicotine addiction and nicotinic receptors: lessons from genetically modified mice

scientific article published on June 2010

Nicotine and serotonin in immune regulation and inflammatory processes: a perspective

scientific article published on 15 November 2006

Nicotine differentially activates inhibitory and excitatory neurons in the dorsal spinal cord

scientific article

Nicotine enhances intracellular nicotinic receptor maturation: a novel mechanism of neural plasticity?

scientific article

Nicotine reverses hypofrontality in animal models of addiction and schizophrenia

scientific article published on 23 January 2017

Nicotine upregulates its own receptors through enhanced intracellular maturation

scientific article published on May 2005

Nicotinic modulation of network and synaptic transmission in the immature hippocampus investigated with genetically modified mice

scientific article published on 10 August 2006

Nicotinic receptors and nicotine addiction

scientific article published on 20 March 2009

Nicotinic receptors in mouse prefrontal cortex modulate ultraslow fluctuations related to conscious processing

scientific article published on 02 December 2016

Nicotinic receptors regulate B lymphocyte activation and immune response

scientific journal article

Nicotinic receptors regulate the survival of newborn neurons in the adult olfactory bulb

scholarly article

Nicotinic receptors, allosteric proteins and medicine.

scientific article published on 11 February 2008

Nicotinic receptors: allosteric transitions and therapeutic targets in the nervous system

scientific article published on September 2009

Normal mode analysis suggests a quaternary twist model for the nicotinic receptor gating mechanism

scientific article

Object memory in young and aged mice after sevoflurane anaesthesia

scientific article published in October 2009

On the nature of allosteric transitions: implications of non-exclusive ligand binding

scientific article

One-microsecond molecular dynamics simulation of channel gating in a nicotinic receptor homologue

scientific article

Ongoing spontaneous activity controls access to consciousness: a neuronal model for inattentional blindness

scientific article

Perinatal exposure to nicotine causes deficits associated with a loss of nicotinic receptor function

scientific article

Persistent decrease in synaptic efficacy induced by nicotine at Schaffer collateral-CA1 synapses in the immature rat hippocampus.

scientific article

Phosphorylation-Elicited Quaternary Changes of GA Binding Protein in Transcriptional Activation ⬇️

scientific article published on November 1, 2003

Pore conformations and gating mechanism of a Cys-loop receptor

scientific article

Prefrontal nicotinic receptors control novel social interaction between mice.

scientific article

Proactive epigenesis and ethical innovation: A neuronal hypothesis for the genesis of ethical rules

scientific article published on 9 September 2016

Protein dynamics and the allosteric transitions of pentameric receptor channels

scientific article published on 29 November 2014

Rapsyn escorts the nicotinic acetylcholine receptor along the exocytic pathway via association with lipid rafts

scientific article (publication date: 15 October 2002)

Rational understanding of nicotinic receptors drug binding

scientific article published on January 2004

Reduction of withdrawal signs after chronic nicotine exposure of alpha-calcitonin gene-related peptide knock-out mice

scientific article published in April 2004

Regional changes in the cholinergic system in mice lacking monoamine oxidase A.

scientific article

Regional differential effects of chronic nicotine on brain alpha 4-containing and alpha 6-containing receptors

scientific article

Reinforcing effects of nicotine microinjections into the ventral tegmental area of mice: dependence on cholinergic nicotinic and dopaminergic D1 receptors

scientific article published on 31 March 2006

Relationships between structural dynamics and functional kinetics in oligomeric membrane receptors

scientific article

Response by the authors

scientific article published on 25 July 2017

Reward-dependent learning in neuronal networks for planning and decision making

scientific article

Selective activation of central subtypes of the nicotinic acetylcholine receptor has opposite effects on neonatal excitotoxic brain injuries

scientific article published on 14 January 2002

Sevoflurane anesthesia alters exploratory and anxiety-like behavior in mice lacking the beta2 nicotinic acetylcholine receptor subunit

scientific article

Structural Identification of the Nicotinic Receptor Ion Channel

scientific article published in February 2018

Structural basis for cooperative interactions of substituted 2-aminopyrimidines with the acetylcholine binding protein

scientific article

Structure and pharmacology of pentameric receptor channels: from bacteria to brain

scientific article

Subunit composition of functional nicotinic receptors in dopaminergic neurons investigated with knock-out mice

scientific journal article

The Ferrier Lecture 1998. The molecular biology of consciousness investigated with genetically modified mice

scientific article published on December 2006

The Glycine Receptor Allosteric Ligands Library (GRALL)

scientific article published on 12 March 2020

The Molecular Organization of Self-awareness: Paralimbic Dopamine-GABA Interaction

scientific article published on 28 January 2020

The beta2 but not alpha7 subunit of the nicotinic acetylcholine receptor is required for nicotine-conditioned place preference in mice

scientific article

The concept of allosteric interaction and its consequences for the chemistry of the brain

scientific article

The concept of allosteric modulation: an overview

scientific article

The diversity of subunit composition in nAChRs: evolutionary origins, physiologic and pharmacologic consequences

scientific article

The emergence of human consciousness: from fetal to neonatal life

scientific article

The nicotinic acetylcholine receptor and its prokaryotic homologues: Structure, conformational transitions & allosteric modulation

scientific article published on 18 December 2014

The nicotinic acetylcholine receptor: From molecular biology to cognition

scientific article published in April 2015

The nicotinic acetylcholine receptor: a typical 'allosteric machine'

scientific article published on 01 June 2018

The nicotinic α6 subunit gene determines variability in chronic pain sensitivity via cross-inhibition of P2X2/3 receptors

scientific article published on May 2015

The origins of allostery: from personal memories to material for the future

scientific article

The role of nicotinic acetylcholine receptors in lymphocyte development

scientific journal article

Towards a cognitive neuroscience of self-awareness

scientific article

Transcription in neuromuscular junction formation: who turns on whom?

scientific article published on June 2003

Transdisciplinary EU science institute needs funds urgently.

scientific article published in February 2010

Un-gating and allosteric modulation of a pentameric ligand-gated ion channel captured by molecular dynamics.

scientific article published on 25 October 2017

Use of a snake venom toxin to characterize the cholinergic receptor protein

scientific article

X-ray structure of a pentameric ligand-gated ion channel in an apparently open conformation

scientific article

X-ray structures of general anaesthetics bound to a pentameric ligand-gated ion channel

scientific article

beta 2 nicotinic acetylcholine receptor subunit modulates protective responses to stress: A receptor basis for sleep-disordered breathing after nicotine exposure

scientific article

{alpha}7 nicotinic acetylcholine receptor regulates airway epithelium differentiation by controlling basal cell proliferation.

scientific article published on October 2009

α-Conotoxin BuIA[T5A;P6O]: a novel ligand that discriminates between α6β4 and α6β2 nicotinic acetylcholine receptors and blocks nicotine-stimulated norepinephrine release ⬇️

scientific article published on August 25, 2010

α7 and β2 nicotinic receptors control monoamine-mediated locomotor response.

scientific article published on December 2010

αCGRP is essential for algesic exocytotic mobilization of TRPV1 channels in peptidergic nociceptors

scientific article

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