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List of works by Klaus Kopka

(18)F-Labelled PSMA-1007 shows similarity in structure, biodistribution and tumour uptake to the theragnostic compound PSMA-617.

scientific article published on 25 June 2016

18F-PSMA-1007 PET/CT Detects Micrometastases in a Patient With Biochemically Recurrent Prostate Cancer

scientific article published on 29 December 2016

68Ga-PSMA PET/CT in the evaluation of bone metastases in prostate cancer

scientific article

68Ga-PSMA-11 Dynamic PET/CT Imaging in Primary Prostate Cancer

scientific article published on 7 September 2016

A Closer Look at the Bromine–Lithium Exchange with tert-Butyllithium in an Aryl Sulfonamide Synthesis ⬇️

scientific article published on 04 June 2013

A New Class of Highly Potent Matrix Metalloproteinase Inhibitors Based on Triazole-Substituted Hydroxamates: (Radio)Synthesis and in Vitro and First in Vivo Evaluation ⬇️

scientific article published on May 16, 2012

A New Generation of Radiofluorinated Pyrimidine-2,4,6-triones as MMP-Targeted Radiotracers for Positron Emission Tomography ⬇️

scientific article published on December 13, 2011

A new approach to silicon rhodamines by Suzuki-Miyaura coupling - scope and limitations

scientific article published on 29 October 2019

Beta1-adrenoceptors in rat anterior pituitary may be constitutively active. Inverse agonism of CGP 20712A on basal 3',5'-cyclic adenosine 5'-monophosphate levels

scientific journal article

Biochemical recurrence of prostate cancer: initial results with 18F-PSMA-1007 PET/CT.

scientific article

Characterization of 3-[(123)I]iodo-L-alpha-methyl tyrosine transport in astrocytes of neonatal rats

scientific article

Comparison of human cytochrome P450 1A1-catalysed oxidation of benzo[a]pyrene in prokaryotic and eukaryotic expression systems

scientific article published on 10 July 2017

Correction to NADH:Cytochrome b5 Reductase and Cytochrome b5 Can Act as Sole Electron Donors to Human Cytochrome P450 1A1-Mediated Oxidation and DNA Adduct Formation by Benzo[a]pyrene

scientific article published on 30 August 2016

Current Status of Prostate-Specific Membrane Antigen Targeting in Nuclear Medicine: Clinical Translation of Chelator Containing Prostate-Specific Membrane Antigen Ligands Into Diagnostics and Therapy for Prostate Cancer

scientific article

Cytochrome b 5 impacts on cytochrome P450-mediated metabolism of benzo[a]pyrene and its DNA adduct formation: studies in hepatic cytochrome b 5 /P450 reductase null (HBRN) mice

scientific article published on 24 January 2018

Development and Evaluation of Endothelin-A Receptor (Radio)Ligands for Positron Emission Tomography ⬇️

scientific article published on January 28, 2011

Diverse modifications of the 4-methylphenyl moiety of TAK-779 by late-stage Suzuki-Miyaura cross-coupling

scientific article published on 12 November 2013

Dual-Labelling Strategies for Nuclear and Fluorescence Molecular Imaging: Current Status and Future Perspectives

scientific article published in 2022

Early assessment of the efficacy of temozolomide chemotherapy in experimental glioblastoma using [18F]FLT-PET imaging.

scientific article

Efficient synthesis of a fluorine-18 labeled biotin derivative ⬇️

scientific article published on September 19, 2012

F-18 labelled PSMA-1007: biodistribution, radiation dosimetry and histopathological validation of tumor lesions in prostate cancer patients

scientific article

Fluorinated Isatin Derivatives. Part 3. New Side-Chain Fluoro-Functionalized Pyrrolidinyl Sulfonyl Isatins as Potent Caspase-3 and -7 Inhibitors ⬇️

scientific article published on August 1, 2009

Glu-Ureido-Based Inhibitors of Prostate-Specific Membrane Antigen: Lessons Learned During the Development of a Novel Class of Low-Molecular-Weight Theranostic Radiotracers

scientific article published in September 2017

Induction of cytochromes P450 1A1 and 1A2 suppresses formation of DNA adducts by carcinogenic aristolochic acid I in rats in vivo

scientific article published on February 2016

Influence of 4- or 5-substituents on the pyrrolidine ring of 5-[1-(2-methoxymethylpyrrolidinyl)sulfonyl]isatin derivatives on their inhibitory activities towards caspases-3 and -7 ⬇️

scientific article published on April 11, 2013

Intra-individual comparison of 18F-PSMA-1007 and 18F-DCFPyL PET/CT in the prospective evaluation of patients with newly diagnosed prostate carcinoma: A pilot study

scientific article

Intraindividual Comparison of 18F-PSMA-1007 PET/CT, Multiparametric MRI, and Radical Prostatectomy Specimens in Patients with Primary Prostate Cancer: A Retrospective, Proof-of-Concept Study

scientific article published on 4 May 2017

Linker Modification Strategies To Control the Prostate-Specific Membrane Antigen (PSMA)-Targeting and Pharmacokinetic Properties of DOTA-Conjugated PSMA Inhibitors

scientific article published on 15 February 2016

Lutathera®: The First FDA- and EMA-Approved Radiopharmaceutical for Peptide Receptor Radionuclide Therapy

scientific article published on 29 July 2019

Mechanistic interrogation of combination bevacizumab/dual PI3K/mTOR inhibitor response in glioblastoma implementing novel MR and PET imaging biomarkers

scientific article published on 15 March 2016

Metabolite Identification of a Radiotracer by Electrochemistry Coupled to Liquid Chromatography with Mass Spectrometric and Radioactivity Detection ⬇️

scientific article published on June 10, 2011

Molecular Imaging of Cardiac Sympathetic Innervation by 11C-mHED and PET: From Man to Mouse? ⬇️

scientific article published on August 1, 2010

Monomeric and Dimeric 68Ga-Labeled Bombesin Analogues for Positron Emission Tomography (PET) Imaging of Tumors Expressing Gastrin-Releasing Peptide Receptors (GRPrs).

scientific article published on 12 February 2018

Multimodal imaging reveals temporal and spatial microglia and matrix metalloproteinase activity after experimental stroke

scientific article

Non-peptidyl 18F-Labelled PET Tracers as Radioindicators for the Noninvasive Detection of Cancer ⬇️

scientific article published on January 1, 2013

Novel Preclinical and Radiopharmaceutical Aspects of [68Ga]Ga-PSMA-HBED-CC: A New PET Tracer for Imaging of Prostate Cancer

scientific article published on 30 June 2014

Preclinical Evaluation of a Tailor-Made DOTA-Conjugated PSMA Inhibitor with Optimized Linker Moiety for Imaging and Endoradiotherapy of Prostate Cancer.

scientific article published on 16 April 2015

Preclinical evaluation of a bispecific low-molecular heterodimer targeting both PSMA and GRPR for improved PET imaging and therapy of prostate cancer

scientific article published on 25 January 2014

Preclinical evaluation of an 18F-labelled beta1-adrenoceptor selective radioligand based on ICI 89,406

scientific article

Radiolabeled hydroxamate-based matrix metalloproteinase inhibitors: How chemical modifications affect pharmacokinetics and metabolic stability

scientific article published on 17 March 2016

Radiosynthesis of a 68Ga labeled matrix metalloproteinase inhibitor as a potential probe for PET imaging ⬇️

scientific article published on April 25, 2012

Recent Insights in Barium-131 as a Diagnostic Match for Radium-223: Cyclotron Production, Separation, Radiolabeling, and Imaging

scientific article published on 25 September 2020

Significance of PSMA imaging in prostate cancer

scientific article published on 22 December 2016

Synthesis of 7-halogenated isatin sulfonamides: nonradioactive counterparts of caspase-3/-7 inhibitor-based potential radiopharmaceuticals for molecular imaging of apoptosis

scientific article published on 14 November 2014

Synthesis of Geminal Difluorides by Oxidative Desulfurization−Difluorination of Alkyl Aryl Thioethers with Halonium Electrophiles in the Presence of Fluorinating Reagents and Its Application for18F-Radiolabeling ⬇️

scientific article published on September 17, 2010

Synthesis of a dihalogenated pyridinyl silicon rhodamine for mitochondrial imaging by a halogen dance rearrangement

scientific article published on 01 October 2019

Synthesis of new fluorinated, 2-substituted 5-pyrrolidinylsulfonyl isatin derivatives as caspase-3 and caspase-7 inhibitors: Nonradioactive counterparts of putative PET-compatible apoptosis imaging agents ⬇️

scientific article published on January 16, 2013

Synthesis, 18F-Radiolabeling, and in Vivo Biodistribution Studies of N-Fluorohydroxybutyl Isatin Sulfonamides using Positron Emission Tomography ⬇️

scientific article published on May 29, 2013

The MMP inhibitor (R)-2-(N-benzyl-4-(2-[18F]fluoroethoxy)phenylsulphonamido)-N-hydroxy-3-methylbutanamide: Improved precursor synthesis and fully automated radiosynthesis ⬇️

scientific article published on March 2, 2011

The Rise of PSMA Ligands for Diagnosis and Therapy of Prostate Cancer

scientific article

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