List of works - Risto Kerkelä

Activation of hypoxia response in endothelial cells contributes to ischemic cardioprotection

scientific article published on 17 June 2013

Adverse cardiac effects associated with anticancer drugs

scientific article published in January 2015

Apelin increases cardiac contractility via protein kinase Cε- and extracellular signal-regulated kinase-dependent mechanisms

scientific article (publication date: 2014)

Bone morphogenetic protein-2--a potential autocrine/paracrine factor in mediating the stretch activated B-type and atrial natriuretic peptide expression in cardiac myocytes

scientific article published on 10 September 2014

Cardiotoxicity associated with tyrosine kinase inhibitor sunitinib

scientific article published on December 2007

Cardiotoxicity of the cancer therapeutic agent imatinib mesylate.

scientific article

Cardiotoxicity of the new cancer therapeutics--mechanisms of, and approaches to, the problem

scientific article published on 02 September 2008

Characterization of apela, a novel endogenous ligand of apelin receptor, in the adult heart.

scientific article published on 26 November 2015

Collagen XV is necessary for modeling of the extracellular matrix and its deficiency predisposes to cardiomyopathy

scientific article published on 16 September 2010

Connective Tissue Growth Factor Inhibition Enhances Cardiac Repair and Limits Fibrosis After Myocardial Infarction

scientific article published on 25 February 2019

Connective tissue growth factor inhibition attenuates left ventricular remodeling and dysfunction in pressure overload-induced heart failure.

scientific article

Cytosolic phospholipase A(2)α protects against ischemia/reperfusion injury in the heart.

scientific article

Decoy oligonucleotide characterization of GATA-4 transcription factor in hypertrophic agonist induced responses of cardiac myocytes

scientific article

Deletion of GSK-3beta in mice leads to hypertrophic cardiomyopathy secondary to cardiomyoblast hyperproliferation

scientific article published on October 2008

Direct cardiac actions of erythropoietin (EPO): effects on cardiac contractility, BNP secretion and ischaemia/reperfusion injury

scientific journal article

Distinct regulation of B-type natriuretic peptide transcription by p38 MAPK isoforms

scientific article published on 24 February 2011

Distinct roles of mitogen-activated protein kinase pathways in GATA-4 transcription factor-mediated regulation of B-type natriuretic peptide gene

scientific journal article

Divergent effects of losartan and metoprolol on cardiac remodeling, c-kit+ cells, proliferation and apoptosis in the left ventricle after myocardial infarction

scientific article published on December 2009

Endothelin-1-specific activation of B-type natriuretic peptide gene via p38 mitogen-activated protein kinase and nuclear ETS factors

scientific article

Energy-sensing factors coactivator peroxisome proliferator-activated receptor γ coactivator 1-α (PGC-1α) and AMP-activated protein kinase control expression of inflammatory mediators in liver: induction of interleukin 1 receptor antagonist

scientific journal article

Functionally opposing roles of extracellular signal-regulated kinase 1/2 and p38 mitogen-activated protein kinase in the regulation of cardiac contractility.

scientific article

GATA transcription factors in the developing and adult heart

scientific article published in August 2004

GATA-4 is a nuclear mediator of mechanical stretch-activated hypertrophic program

scientific journal article

GSK-3alpha directly regulates beta-adrenergic signaling and the response of the heart to hemodynamic stress in mice

scientific journal article

Glycogen synthase kinase-3beta -- actively inhibiting hypertrophy

scientific article published on April 2007

Identification of PKCalpha isoform-specific effects in cardiac myocytes using antisense phosphorothioate oligonucleotides

scientific article published on December 2002

Inhibition of Let-7 microRNA attenuates myocardial remodeling and improves cardiac function postinfarction in mice

scientific article

Inhibition of cardiomyocyte Sprouty1 protects from cardiac ischemia-reperfusion injury

scientific article published on 11 January 2019

Inverse regulation of preproendothelin-1 and endothelin-converting enzyme-1beta genes in cardiac cells by mechanical load

scientific journal article

Key roles of endothelin-1 and p38 MAPK in the regulation of atrial stretch response ⬇️

scientific article published on November 17, 2010

M-CAT element mediates mechanical stretch-activated transcription of B-type natriuretic peptide via ERK activation ⬇️

scientific article published on August 3, 2011

Mechanisms of cardiac dysfunction associated with tyrosine kinase inhibitor cancer therapeutics

scientific article published on July 2008

Mitogen-activated protein kinases p38 and ERK 1/2 mediate the wall stress-induced activation of GATA-4 binding in adult heart

scientific article published on 29 March 2004

Molecular scaffolds regulate bidirectional crosstalk between Wnt and classical seven-transmembrane-domain receptor signaling pathways.

scientific article published on 31 July 2007

Natriuretic Peptides in the Regulation of Cardiovascular Physiology and Metabolic Events

scientific article

Neuronostatin, a novel peptide encoded by somatostatin gene, regulates cardiac contractile function and cardiomyocyte survival.

scientific article published on 14 December 2011

Parthenolide inhibits STAT3 signaling and attenuates angiotensin II-induced left ventricular hypertrophy via modulation of fibroblast activity

scientific article published on 09 January 2011

Recent insights into cardiac hypertrophy and left ventricular remodeling.

scientific article

Serine 58 of 14-3-3zeta is a molecular switch regulating ASK1 and oxidant stress-induced cell death

scientific journal article

Sunitinib-induced cardiotoxicity is mediated by off-target inhibition of AMP-activated protein kinase

scientific article

The Early-Onset Myocardial Infarction Associated PHACTR1 Gene Regulates Skeletal and Cardiac Alpha-Actin Gene Expression

scientific article published on 22 June 2015

The beta-catenin/T-cell factor/lymphocyte enhancer factor signaling pathway is required for normal and stress-induced cardiac hypertrophy

scientific article (publication date: June 2006)

VEGF-B gene therapy inhibits doxorubicin-induced cardiotoxicity by endothelial protection

scientific article published on 31 October 2016

WDR12, a Member of Nucleolar PeBoW-Complex, Is Up-Regulated in Failing Hearts and Causes Deterioration of Cardiac Function

scientific article

p38α regulates SERCA2a function.

scientific article

β-Adrenergic agonists mediate enhancement of β1-adrenergic receptor N-terminal cleavage and stabilization in vivo and in vitro.

scientific article published on 11 October 2012

List of works by Risto Kerkelä

Activation of hypoxia response in endothelial cells contributes to ischemic cardioprotection

Adverse cardiac effects associated with anticancer drugs

Apelin increases cardiac contractility via protein kinase Cε- and extracellular signal-regulated kinase-dependent mechanisms

Bone morphogenetic protein-2--a potential autocrine/paracrine factor in mediating the stretch activated B-type and atrial natriuretic peptide expression in cardiac myocytes

Cardiotoxicity associated with tyrosine kinase inhibitor sunitinib

Cardiotoxicity of the cancer therapeutic agent imatinib mesylate.

Cardiotoxicity of the new cancer therapeutics--mechanisms of, and approaches to, the problem

Characterization of apela, a novel endogenous ligand of apelin receptor, in the adult heart.

Collagen XV is necessary for modeling of the extracellular matrix and its deficiency predisposes to cardiomyopathy

Connective Tissue Growth Factor Inhibition Enhances Cardiac Repair and Limits Fibrosis After Myocardial Infarction

Connective tissue growth factor inhibition attenuates left ventricular remodeling and dysfunction in pressure overload-induced heart failure.

Cytosolic phospholipase A(2)α protects against ischemia/reperfusion injury in the heart.

Decoy oligonucleotide characterization of GATA-4 transcription factor in hypertrophic agonist induced responses of cardiac myocytes

Deletion of GSK-3beta in mice leads to hypertrophic cardiomyopathy secondary to cardiomyoblast hyperproliferation

Direct cardiac actions of erythropoietin (EPO): effects on cardiac contractility, BNP secretion and ischaemia/reperfusion injury

Distinct regulation of B-type natriuretic peptide transcription by p38 MAPK isoforms

Distinct roles of mitogen-activated protein kinase pathways in GATA-4 transcription factor-mediated regulation of B-type natriuretic peptide gene

Divergent effects of losartan and metoprolol on cardiac remodeling, c-kit+ cells, proliferation and apoptosis in the left ventricle after myocardial infarction

Endothelin-1-specific activation of B-type natriuretic peptide gene via p38 mitogen-activated protein kinase and nuclear ETS factors

Energy-sensing factors coactivator peroxisome proliferator-activated receptor γ coactivator 1-α (PGC-1α) and AMP-activated protein kinase control expression of inflammatory mediators in liver: induction of interleukin 1 receptor antagonist

Functionally opposing roles of extracellular signal-regulated kinase 1/2 and p38 mitogen-activated protein kinase in the regulation of cardiac contractility.

GATA transcription factors in the developing and adult heart

GATA-4 is a nuclear mediator of mechanical stretch-activated hypertrophic program

GSK-3alpha directly regulates beta-adrenergic signaling and the response of the heart to hemodynamic stress in mice

Glycogen synthase kinase-3beta -- actively inhibiting hypertrophy

Identification of PKCalpha isoform-specific effects in cardiac myocytes using antisense phosphorothioate oligonucleotides

Inhibition of Let-7 microRNA attenuates myocardial remodeling and improves cardiac function postinfarction in mice

Inhibition of cardiomyocyte Sprouty1 protects from cardiac ischemia-reperfusion injury

Inverse regulation of preproendothelin-1 and endothelin-converting enzyme-1beta genes in cardiac cells by mechanical load

Key roles of endothelin-1 and p38 MAPK in the regulation of atrial stretch response ⬇️

M-CAT element mediates mechanical stretch-activated transcription of B-type natriuretic peptide via ERK activation ⬇️

Mechanisms of cardiac dysfunction associated with tyrosine kinase inhibitor cancer therapeutics

Mitogen-activated protein kinases p38 and ERK 1/2 mediate the wall stress-induced activation of GATA-4 binding in adult heart

Molecular scaffolds regulate bidirectional crosstalk between Wnt and classical seven-transmembrane-domain receptor signaling pathways.

Natriuretic Peptides in the Regulation of Cardiovascular Physiology and Metabolic Events

Neuronostatin, a novel peptide encoded by somatostatin gene, regulates cardiac contractile function and cardiomyocyte survival.

Parthenolide inhibits STAT3 signaling and attenuates angiotensin II-induced left ventricular hypertrophy via modulation of fibroblast activity

Recent insights into cardiac hypertrophy and left ventricular remodeling.

Serine 58 of 14-3-3zeta is a molecular switch regulating ASK1 and oxidant stress-induced cell death

Sunitinib-induced cardiotoxicity is mediated by off-target inhibition of AMP-activated protein kinase

The Early-Onset Myocardial Infarction Associated PHACTR1 Gene Regulates Skeletal and Cardiac Alpha-Actin Gene Expression

The beta-catenin/T-cell factor/lymphocyte enhancer factor signaling pathway is required for normal and stress-induced cardiac hypertrophy

VEGF-B gene therapy inhibits doxorubicin-induced cardiotoxicity by endothelial protection

WDR12, a Member of Nucleolar PeBoW-Complex, Is Up-Regulated in Failing Hearts and Causes Deterioration of Cardiac Function

p38α regulates SERCA2a function.

β-Adrenergic agonists mediate enhancement of β1-adrenergic receptor N-terminal cleavage and stabilization in vivo and in vitro.