Search filters

List of works by Veronika Sexl

A Kinase-Independent Function of CDK6 Links the Cell Cycle to Tumor Angiogenesis

scientific article published in August 2016

A kinase-independent function of CDK6 links the cell cycle to tumor angiogenesis

scientific article

A kinase-independent role for CDK8 in BCR-ABL1+ leukemia

scientific article published on 18 October 2019

A novel Ncr1-Cre mouse reveals the essential role of STAT5 for NK-cell survival and development

scientific article published on 2 December 2010

Adding a new facet to STAT5 in CML: Multitasking for leukemic cells ⬇️

scientific article published on June 10, 2013

Adipose triglyceride lipase activity regulates cancer cell proliferation via AMP-kinase and mTOR signaling

scientific article published on 10 May 2020

Aggressive B-cell lymphomas in patients with myelofibrosis receiving JAK1/2 inhibitor therapy

scientific article published on 14 June 2018

An ERK-Dependent Feedback Mechanism Prevents Hematopoietic Stem Cell Exhaustion.

scientific article

Antibodies directed against Lewis-Y antigen inhibit signaling of Lewis-Y modified ErbB receptors.

scientific article published on February 2004

Antigen receptor-mediated depletion of FOXP3 in induced regulatory T-lymphocytes via PTPN2 and FOXO1.

scientific article

Antineoplastic activity of the DNA methyltransferase inhibitor 5-aza-2'-deoxycytidine in anaplastic large cell lymphoma.

scientific article

Assembly of cyclin D-dependent kinase and titration of p27Kip1 regulated by mitogen-activated protein kinase kinase (MEK1)

scientific article

BCR-ABL uncouples canonical JAK2-STAT5 signaling in chronic myeloid leukemia

scientific article published on 29 January 2012

Bcl-2: Live and let die.

scientific article published on August 2012

Bcr-Abl Directly Activates Stat5 Independent of Jak2 ⬇️

scholarly article

CCL2 is a KIT D816V-dependent modulator of the bone marrow microenvironment in systemic mastocytosis.

scientific article published on 16 November 2016

CD52 is a molecular target in advanced systemic mastocytosis.

scientific article published on 23 April 2014

CDK4/6 and MAPK-Crosstalk as Opportunity for Cancer Treatment

scientific article published on 24 November 2020

CDK6 Antagonizes p53-Induced Responses during Tumorigenesis

article

CDK6 Inhibition: A Novel Approach in AML Management

scientific article published on 05 April 2020

CDK6 and p16INK4A in lymphoid malignancies

scientific article published on November 2013

CDK6 as a key regulator of hematopoietic and leukemic stem cell activation

scientific journal article

CDK6 coordinates JAK2 V617F mutant MPN via NF-κB and apoptotic networks

scientific article published on 11 January 2019

CDK6 is an essential direct target of NUP98-fusion proteins in acute myeloid leukemia

scientific article published on 28 April 2020

CDK8-Novel Therapeutic Opportunities

scientific article published on 19 June 2019

CDK8-mediated STAT1-S727 phosphorylation restrains NK cell cytotoxicity and tumor surveillance

scientific article published on 08 August 2013

Cdk4 and Cdk6 cooperate in counteracting the INK4 family of inhibitors during murine leukemogenesis

scientific article published on 25 August 2014

Cdk6 contributes to cytoskeletal stability in erythroid cells.

scientific article published on 2 March 2017

Cdk6: At the interface of Rb and p53

scientific article published on 05 September 2018

Characterization of p190-Bcr-Abl chronic myeloid leukemia reveals specific signaling pathways and therapeutic targets

scientific article published on 09 November 2020

Chronic signaling via the metabolic checkpoint kinase mTORC1 induces macrophage granuloma formation and marks sarcoidosis progression

scientific article published on 16 January 2017

Clarifying the role of Stat5 in lymphoid development and Abelson-induced transformation

scientific article

Clusterin regulates drug-resistance in melanoma cells

scientific article published on June 2005

Commentary on H. Ide et al., “Tyk2 expression and its signaling enhances the invasiveness of prostate cancer cells”

scientific article published on 17 December 2007

Conditional IFNAR1 ablation reveals distinct requirements of Type I IFN signaling for NK cell maturation and tumor surveillance

scientific article published on October 2012

Conditional Stat1 ablation reveals the importance of interferon signaling for immunity to Listeria monocytogenes infection

scientific article (publication date: 2012)

Cooperation of ETV6/RUNX1 and BCL2 enhances immunoglobulin production and accelerates glomerulonephritis in transgenic mice

scientific article published on 23 February 2016

Cytokine-induced megakaryocytic differentiation is regulated by genome-wide loss of a uSTAT transcriptional program.

scientific article

DKK2 imparts tumor immunity evasion through β-catenin-independent suppression of cytotoxic immune-cell activation

scientific article published on 12 February 2018

Decreased NK-cell tumour immunosurveillance consequent to JAK inhibition enhances metastasis in breast cancer models

scientific article published on 13 July 2016

Dendritic cells require STAT-1 phosphorylated at its transactivating domain for the induction of peptide-specific CTL.

scientific article published on 20 July 2009

Der Professorinnenclub der Medizinischen Universität Wien

article

Different mechanisms of saturated versus polyunsaturated FFA-induced apoptosis in human endothelial cells

scientific article

Differentiation of type 1 ILCs from a common progenitor to all helper-like innate lymphoid cell lineages

scientific article published in April 2014

Diverging fates of cells of origin in acute and chronic leukaemia

scientific article

ETV6/RUNX1 induces reactive oxygen species and drives the accumulation of DNA damage in B cells.

scientific article published on November 2013

Estrogen Regulates Bone Turnover by Targeting RANKL Expression in Bone Lining Cells

scientific article

Evaluation of Stat5 as a potential drug target in bcr/abl-induced leukemias

Expansion of BCR/ABL1+ cells requires PAK2 but not PAK1.

scientific article published on 14 July 2017

Generation of a Transgenic Mouse with Inducible Constitutively Active Stat5a, ⬇️

scholarly article

High STAT5 levels mediate imatinib resistance and indicate disease progression in chronic myeloid leukemia.

scientific article

High activation of STAT5A drives peripheral T-cell lymphoma and leukemia

scientific article published on 31 January 2020

Human signal transducer and activator of transcription 5b (STAT5b) mutation causes dysregulated human natural killer cell maturation and impaired lytic function

scientific article published on 07 October 2019

IL-17+ CD8+ T cell suppression by dimethyl fumarate associates with clinical response in multiple sclerosis

scientific article published on 16 December 2019

IL-6/Stat3-Dependent Induction of a Distinct, Obesity-Associated NK Cell Subpopulation Deteriorates Energy and Glucose Homeostasis

scientific article published in July 2017

Identification of CD25 as STAT5-Dependent Growth Regulator of Leukemic Stem Cells in Ph+ CML.

scientific article published on 25 November 2015

Identification of an indispensable role for tyrosine kinase 2 in CTL-mediated tumor surveillance

scientific article

Impact of Single or Combined Genomic Alterations of TP53, MYC, and BCL2 on Survival of Patients With Diffuse Large B-Cell Lymphomas: A Retrospective Cohort Study

scientific article published on December 2015

Impairment of hepatic growth hormone and glucocorticoid receptor signaling causes steatosis and hepatocellular carcinoma in mice.

scientific article published on October 2011

In vivo and in vitro primed lymphocytes correlation of cytochemically detected BLT-specific lymphoid serine protease with cytotoxic activity ⬇️

scientific article published on April 2, 1993

In vivo tumor surveillance by NK cells requires TYK2 but not TYK2 kinase activity

scientific article

Incidence and phenotype restriction of lymphoid BLT-serine protease granules in spontaneously diabetes prone BB rats compared with a normal rat strain

scientific article published on 01 October 1992

Increase by tri-iodothyronine of endothelin-1, fibronectin and von Willebrand factor in cultured endothelial cells ⬇️

scientific article published on 01 August 1997

Increased NK cell immunity in a transgenic mouse model of NKp46 overexpression

scientific article published on 12 October 2017

Inducible deletion of CDK4 and CDK6 - deciphering CDK4/6 inhibitor effects in the hematopoietic system

scientific article published on 27 August 2020

Inhibition of STAT5: a therapeutic option in BCR-ABL1-driven leukemia

scientific article

Inhibition of Xenograft Tumor Growth and Down-Regulation of ErbB Receptors by an Antibody Directed against Lewis Y Antigen

scientific article published on 08 September 2006

It is a differentiation game: STAT5 in a new role.

scientific article

JAK of all trades: JAK2-STAT5 as novel therapeutic targets in BCR-ABL1+ chronic myeloid leukemia

scientific article published on 07 August 2013

JAK/STAT Cytokine Signaling at the Crossroad of NK Cell Development and Maturation

scientific article published on 12 November 2019

Jak1 deficiency leads to enhanced Abelson-induced B-cell tumor formation

scientific article published on 06 February 2003

JunB inhibits proliferation and transformation in B-lymphoid cells

scientific article

Lactotransferrin-Cre reporter mice trace neutrophils, monocytes/macrophages and distinct subtypes of dendritic cells

scientific article published on 21 February 2014

Lapatinib and doxorubicin enhance the Stat1-dependent antitumor immune response

scientific article published on 11 July 2013

Leukemic challenge unmasks a requirement for PI3Kdelta in NK cell-mediated tumor surveillance

scientific article

Lipoxygenase mediates invasion of intrametastatic lymphatic vessels and propagates lymph node metastasis of human mammary carcinoma xenografts in mouse

scientific article

Listeria monocytogenes infection rewires host metabolism with regulatory input from type I interferons

scientific article published on 08 July 2021

Loss of HIF-1α in natural killer cells inhibits tumour growth by stimulating non-productive angiogenesis

scientific article published on 17 November 2017

Loss of JAK1 Drives Innate Immune Deficiency

scientific article published on 01 January 2018

Loss of NKG2D in murine NK cells leads to increased perforin production upon long-term stimulation with IL-2

scientific article published on 12 February 2020

Loss of STAT3 in Lymphoma Relaxes NK Cell-Mediated Tumor Surveillance

scientific article

Loss of STAT3 in murine NK cells enhances NK cell-dependent tumor surveillance

scientific article published on 02 September 2014

MAP kinase stimulation by cAMP does not require RAP1 but SRC family kinases

scientific article

MYC selects against reduced BCL2A1/A1 protein expression during B cell lymphomagenesis.

scientific article published on 03 October 2016

Macrophage and T cell produced IL-10 promotes viral chronicity

scientific article

MicroRNA-15/16 Antagonizes Myb To Control NK Cell Maturation

scientific article

MicroRNA-155 tunes both the threshold and extent of NK cell activation via targeting of multiple signaling pathways.

scientific article published on 13 November 2013

Microbiota-induced tissue signals regulate ILC3-mediated antigen presentation

scientific article published on 14 April 2020

Mir-15/16 Antagonizes Myb To Control Natural Killer Cell Differentiation and Maturation ⬇️

scholarly article

Modeling BCR/ABL-driven malignancies in the mouse

scientific article

Myeloid Cells Restrict MCMV and Drive Stress-Induced Extramedullary Hematopoiesis through STAT1

scientific article published on 01 February 2019

Myeloid STAT3 promotes formation of colitis-associated colorectal cancer in mice

scientific article published on 22 January 2015

NK Cells Require Cell-Extrinsic and -Intrinsic TYK2 for Full Functionality in Tumor Surveillance and Antibacterial Immunity

scientific article published on 04 February 2019

NK cell receptor NKG2D sets activation threshold for the NCR1 receptor early in NK cell development

scientific article published on 17 September 2018

NK cell-specific CDK8 deletion enhances antitumor responses.

scientific article

NK cells in hypoxic skin mediate a trade-off between wound healing and antibacterial defence

scientific article published on 04 August 2021

NKG2D Promotes B1a Cell Development and Protection against Bacterial Infection

scientific article published on 13 January 2017

NKp46 Receptor-Mediated Interferon-γ Production by Natural Killer Cells Increases Fibronectin 1 to Alter Tumor Architecture and Control Metastasis

scientific article published on 4 January 2018

NKp46 Receptor-Mediated Interferon-γ Production by Natural Killer Cells Increases Fibronectin 1 to Alter Tumor Architecture and Control Metastasis.

scientific article

Natural immunity enhances the activity of a DR5 agonistic antibody and carboplatin in the treatment of ovarian cancer

scientific article published on 6 April 2010

New and Highly Efficient Therapy for Treatment NPM-ALK Associated Lymphomas ⬇️

scholarly article

Novel non-canonical role of STAT1 in Natural Killer cell cytotoxicity

scientific article published on 19 May 2016

PDGFR blockade is a rational and effective therapy for NPM-ALK-driven lymphomas

scientific article

PI3Kδ is essential for tumor clearance mediated by cytotoxic T lymphocytes

scientific article

PI3Kδ is indispensable for CTL-mediated cytotoxicity.

scientific article published on 5 September 2011

Palbociclib treatment of FLT3-ITD+ AML cells uncovers a kinase-dependent transcriptional regulation of FLT3 and PIM1 by CDK6.

scientific article published on 20 April 2016

Phenotyping and Target Expression Profiling of CD34+/CD38- and CD34+/CD38+ Stem- and Progenitor cells in Acute Lymphoblastic Leukemia.

scientific article published on 15 May 2018

Phospho-Profiling Linking Biology and Clinics in Pediatric Acute Myeloid Leukemia

scientific article published on 16 December 2019

Putting the brakes on mammary tumorigenesis: loss of STAT1 predisposes to intraepithelial neoplasias

scientific article published on December 2011

Rapid functional impairment of natural killer cells following tumor entry limits anti-tumor immunity

scholarly article

Repurposing Treprostinil for Enhancing Hematopoietic Progenitor Cell Transplantation.

scientific article published on 17 March 2016

Response to interferons and antibacterial innate immunity in the absence of tyrosine-phosphorylated STAT1

scientific article published on 12 February 2016

STAT1 Isoforms Differentially Regulate NK Cell Maturation and Anti-tumor Activity

scientific article published on 11 September 2020

STAT1 Ser727 – key regulator for NK cell-mediated cytotoxicity and tumor surveillance.

scientific article published on 5 November 2008

STAT1 acts as a tumor promoter for leukemia development

scientific article published on July 2006

STAT1-S727 - the license to kill.

scientific article published on October 2014

STAT5 Is a Key Regulator in NK Cells and Acts as a Molecular Switch from Tumor Surveillance to Tumor Promotion

scientific article

STAT5 triggers BCR-ABL1 mutation by mediating ROS production in chronic myeloid leukaemia

scientific article

STAT5A and STAT5B-Twins with Different Personalities in Hematopoiesis and Leukemia

scientific article published on 04 November 2019

STAT5BN642H drives transformation of NKT cells: a novel mouse model for CD56+ T-LGL leukemia

scientific article published on 09 April 2019

STAT5BN642H is a driver mutation for T cell neoplasia

scientific article published on 4 December 2017

STATs in NK-Cells: The Good, the Bad, and the Ugly

scientific article published on January 2016

Screening for serine/threonine kinases phosphorylating Stat5.

scientific article

Second hit influences the interaction between tumor cells and the immune system in a murine model of Burkitt's lymphoma

scientific article published on 5 November 2008

Selective inhibition of STAT3 signaling using monobodies targeting the coiled-coil and N-terminal domains

scientific article published on 17 August 2020

Selective reconstitution of IFN‑γ gene function in Ncr1+ NK cells is sufficient to control systemic vaccinia virus infection

scientific article published on 05 February 2020

Selective serotonin reuptake inhibitors--a new modality for the treatment of lymphoma/leukaemia?

scientific article published on 20 July 2007

Serine phosphorylation of the Stat5a C-terminus is a driving force for transformation.

scientific article published on June 2011

Signal interception-based therapies--a double-edged sword in Bcr/abl-induced malignancies?

scientific article published on April 2008

Single-Cell RNA Sequencing of Tumor-Infiltrating NK Cells Reveals that Inhibition of Transcription Factor HIF-1α Unleashes NK Cell Activity

scientific article published on 20 May 2020

Stat5 expression is critical for mast cell development and survival ⬇️

scientific article published on April 24, 2003

Stat5 is indispensable for the maintenance of bcr/abl-positive leukaemia

scientific article published on March 2010

Stat5 is required for IL-2-induced cell cycle progression of peripheral T cells

scientific article

Stat5 tetramer formation is associated with leukemogenesis

scientific article published on 01 January 2005

Stat5a serine 725 and 779 phosphorylation is a prerequisite for hematopoietic transformation

scientific article

Stat5a/b contribute to interleukin 7–induced B-cell precursor expansion, but abl- andbcr/abl-induced transformation are independent of Stat5 ⬇️

scholarly article

Stimulation of human umbilical vein endothelial cell proliferation by A2‐adenosine and β2‐adrenoceptors ⬇️

scientific article published on April 1, 1995

TYK2 is a key regulator of the surveillance of B lymphoid tumors

scientific article

TYK2 is a key regulator of the surveillance of B lymphoid tumors

Targeting PI3Kδ: One man's meat is another man's poison.

scientific article published on January 2013

Targeting VEGF-A in myeloid cells enhances natural killer cell responses to chemotherapy and ameliorates cachexia

scientific article published on 19 August 2016

Targeting of heat shock protein 32 (Hsp32)/heme oxygenase-1 (HO-1) in leukemic cells in chronic myeloid leukemia: a novel approach to overcome resistance against imatinib

scientific article published on 16 November 2007

The Effect of CDK6 Expression on DNA Methylation and DNMT3B Regulation

scientific article published on 07 October 2020

The Oncogenic Transcription Factor STAT5 Triggers Aberrant Expression Of CD25 (IL-2RA) In Neoplastic Stem Cells In Ph+ CML ⬇️

scholarly article

The PPARα agonist fenofibrate suppresses B-cell lymphoma in mice by modulating lipid metabolism

scientific article

The RNA helicase DDX3X is an essential mediator of innate antimicrobial immunity

scientific article published on 26 November 2018

The catalytic PI3K isoforms p110gamma and p110delta contribute to B cell development and maintenance, transformation, and proliferation

scientific article published on 3 March 2010

The centrosomal protein TACC3 is essential for hematopoietic stem cell function and genetically interfaces with p53-regulated apoptosis

scientific article

The cooperating mutation or "second hit" determines the immunologic visibility toward MYC-induced murine lymphomas

scientific article published on 30 August 2011

The dark and the bright side of Stat3: proto-oncogene and tumor-suppressor

scientific article published on January 2009

The different functions of Stat5 and chromatin alteration through Stat5 proteins

scientific article

The non-receptor-associated tyrosine kinase Syk is a regulator of metastatic behavior in human melanoma cells.

scientific article published on June 2005

The oncoprotein NPM-ALK of anaplastic large-cell lymphoma induces JUNB transcription via ERK1/2 and JunB translation via mTOR signaling

scientific article published on 09 August 2007

The role of CDK6 in cancer

scientific article published on 13 May 2020

The transcription factor STAT5 drives mutation and imatinib resistance in chronic myeloid leukemia via ROS production.

scientific article

The tumor suppressor function of STAT1 in breast cancer

scientific article published on April 2013

The tyrosine kinase Btk regulates the macrophage response to Listeria monocytogenes infection

scientific journal article

Therapeutic Vulnerabilities in -Mutant AML Unmasked by Palbociclib

scientific article published on 11 December 2018

Twins with different personalities: STAT5B—but not STAT5A—has a key role in BCR/ABL-induced leukemia

scientific article published on 24 January 2019

Tyrosine kinase 2 (TYK2) in cytokine signalling and host immunity

scientific article published on June 2011

Unexpected role of STAT1 serine727 for NK cell function.

scientific article published on 12 November 2009

Unique effects of KIT D816V in BaF3 cells: induction of cluster formation, histamine synthesis, and early mast cell differentiation antigens.

scientific article

Untwining Anti-Tumor and Immunosuppressive Effects of JAK Inhibitors-A Strategy for Hematological Malignancies?

scientific article published on 26 May 2021

Variants in STAT5B Associate with Serum TC and LDL-C Levels

article published in 2011

c-JUN prevents methylation of p16INK4a (and Cdk6): the villain turned bodyguard ⬇️

scientific article published on May 1, 2011

c-JUN promotes BCR-ABL-induced lymphoid leukemia by inhibiting methylation of the 5' region of Cdk6.

scientific article published on 7 February 2011

p27 in FLT3-driven acute myeloid leukemia: many roads lead to ruin.

scientific article published on August 2017

Paulina is supported by:

About Paulina

Help